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Journal Articles

2025 Update on MRD in Acute Myeloid Leukemia: A Consensus Document from the ELN-DAVID MRD Working Party

Open Access
Jacqueline Cloos, Peter J.M. Valk, Christian Thiede, Konstanze Döhner, Gail J Roboz, Brent L. Wood, Roland B. Walter, Sa A Wang, Agnieszka Wierzbowska, Andrew H Wei, David Wu, Francois Vergez, Adriano Venditti, Bert A. van der Reijden, Arjan A van de Loosdrecht, Ing Soo Tiong, Felicitas R Thol, Marion Subklewe, Christophe Roumier, Tom Reuvekamp, Farhad Ravandi, Claude Preudhomme, Adriana Plesa, Jad Othman, Gert J. Ossenkoppele, Yishai Ofran, Aguirre Mimoun, Luca Maurillo, Agata Majchrzak, David C. de Leeuw, Wolfgang Kern, Dennis Dong Hwan Dong Hwan Kim, Maura Rosane Valério Ikoma-Colturato, Lukas H. Haaksma, Monica L Guzman, Michaela Feuring, Barbara Depreter, Anna Czyz, Veit L. Bücklein, Constance Baer, Costa Bachas, Sylvie D Freeman, Francesco Buccisano, Christopher S Hourigan, Richard James Dillon, Michael Heuser
Journal: Blood
Blood blood.2025031480.
https://doi.org/10.1182/blood.2025031480
Published: 2025
Includes: Supplemental data
Journal Articles

Establishing contemporary benchmarks for Acute Myeloid Leukemia outcomes and measurable residual disease: Real-world data utilization from the ELN-david MRD international working group

Free
Gail Roboz, Tom Reuvekamp, Jacqueline Cloos, Malte Von Bonin, Francesco Buccisano, Lukas Haaksma, Maura Ikoma-Colturato, Joana Brioso Infante, Dennis Kim, Chrysavgi Lalayanni, David de Leeuw, Josephine Anne Lucero, Francesco Mannelli, Luca Maurillo, Federico Moretti, Josep F Nomdedeu Guinot, Apostolia Papalexandri, Guillermo Ramil López, Maximilian Röhnert, Christoph Röllig, Anderson João Simione, Daniela Späth, Felicitas R Thol, Anne Tierens, Adriano Venditti, Francois Vergez, Michael Heuser, Konstanze Döhner
Journal: Blood
Blood (2025) 146 (Supplement 1): 5183.
https://doi.org/10.1182/blood-2025-5183
Published: 2025
Journal Articles

The PDI-ATF6-axis as a novel treatment target in CSF3R driven chronic neutrophilic leukemia (CNL)

Free
Alessandra Hartke, Annika Lange, Gerin Prince, Jasmin Osius, Axel Künstner, Yamil Maluje, Anke Fähnrich, Nancy Ernst, Ralf Ludwig, Julian Baumeister, Hauke Busch, Timo Gemoll, Heike Pahl, Florian Heidel, Konstanze Döhner, Martin Griesshammer, Andreas Reiter, Justus Duyster, Tim H. H. Brümmendorf, Steffen Koschmieder, Manja Meggendorfer, Torsten Haferlach, Nikolas C. C. von Bubnoff, Sivahari P. Gorantla
Journal: Blood
Blood (2025) 146 (Supplement 1): 1453.
https://doi.org/10.1182/blood-2025-1453
Published: 2025
Journal Articles

Proteogenomic analysis of NPM1-mutated AML reveals clinical heterogeneity related to differentiation states and mitochondrial metabolism

Free
Sebastian Wolf, Josefine Jakob, Björn Häupl, Annika Meid, Daniela Späth, Felicitas R Thol, Hubert Serve, Konstanze Döhner, Hartmut Döhner, Thomas Oellerich
Journal: Blood
Blood (2025) 146 (Supplement 1): 660.
https://doi.org/10.1182/blood-2025-660
Published: 2025
Journal Articles

Independent, international validation of the unsupervised harmony classification of Acute Myeloid Leukemia

Free
Amin Turki, Daniele Dall'Olio, Luciana Carota, Stefano Polizzi, Mireya Morote, Matteo Della Porta, Yanmin Zhao, Luca Lanino, Marta Sobas, Yeqian Zhao, Alberto Hernandez Sanchez, Sträng Eric, Laura Tur Gimenez, María Abáigar, Javier Martinez Elicegui, Angela Villaverde Ramiro, Konstanze Döhner, Jesse Tettero, Jordi Esteve, Joaquin Martinez-Lopez, Klaus Metzeler, Torsten Haferlach, Soren Lehmann, Marta Pratcorona, Christian Thiede, Jurjen Versluis, Rabea Mecklenbrauck, Michael Heuser, Axel Benner, Brain Huntley, Jesus Maria Hernandez Rivas, Gert J. Ossenkoppele, Hartmut Döhner, Gastone Castellani, Lars Bullinger
Journal: Blood
Blood (2025) 146 (Supplement 1): 451.
https://doi.org/10.1182/blood-2025-451
Published: 2025
Journal Articles

Ruxolitinib versus allogeneic stem cell transplantation for patients with myelofibrosis according to donor availability: A prospective multicenter phase II trial

Free
Nico Gagelmann, Christine Wolschke, Tobias A.W. Holderried, Eva Eßeling, Wolfgang Bethge, Martin Kaufmann, Edgar Jost, Konstanze Döhner, Judith Niederland, Martin Schumacher, Inken Hilgendorf, Guido Kobbe, Eva-Maria Wagner Drouet, Matthias Stelljes, Kerstin Schäfer-Eckart, Haifa Kathrin Al-Ali, Martin Griesshammer, Francis Ayuk, Iris Alpers, Marion Heinzelmann, Beatrice Charamba, Hannes Buchner, Nicolaus Kroeger
Journal: Blood
Blood (2025) 146 (Supplement 1): 911.
https://doi.org/10.1182/blood-2025-911
Published: 2025
Journal Articles

Validation of measurable residual disease as a surrogate endpoint in acute myeloid leukemia: A HARMONY Alliance study of European randomized trials

Free
Jesse Tettero, Sträng Eric, Sylvie Freeman, Richard Dillon, Jacqueline Cloos, Peter Valk, Konstanze Döhner, Michael Heuser, Christoph Röllig, Christian Thiede, Axel Benner, Luciana Carota, Daniele Dall'Olio, Ana Garcia, Alberto Hernandez Sanchez, Sean Johnson, Soren Lehmann, Javier Martinez Elicegui, Rabea Mecklenbrauck, Klaus Metzeler, Marta Sobas, Ian Thomas, Amin Turki, Laura Tur Gimenez, Brain Huntley, Nigel Russell, Jurjen Versluis, Hartmut Döhner, Jesus Maria Hernandez Rivas, Lars Bullinger, Gert J. Ossenkoppele
Journal: Blood
Blood (2025) 146 (Supplement 1): 343.
https://doi.org/10.1182/blood-2025-343
Published: 2025
Journal Articles

Unleashing intrinsic inflammation in AML using therapeutic cytokines overcomes pro-survival pathways and induces deep and durable remission In Vivo.

Free
Ulrike Hoeckendorf, Sayantanee Dutta, Arnold Kloos, Marah Runtsch, Carina Zoetsch, yongjie wang, Bianca Perfler, Sebastian Vosberg, Torsten Haferlach, Konstanze Döhner, Katharina S. Götze, Florian Bassermann, Mathias Heikenwälder, Johannes Schmoellerl, Johannes Zuber, Adam Wahida, Ann-Cathrin Burk, Robert Zeiser, Heinz Sill, Ashok Kumar Jayavelu, Armin Zebisch, Michael Heuser, Michael Dengler, Philipp Jost
Journal: Blood
Blood (2025) 146 (Supplement 1): 3280.
https://doi.org/10.1182/blood-2025-3280
Published: 2025
Journal Articles

A phase II Study of fedratinib and nivolumab combination in patients with myelofibrosis and resistance or suboptimal response to JAK-inhibitor treatment – fraction Study / IKF051 / gsg-MPN-006

Free
Susanne Isfort, Nikolas Von Bubnoff, Haifa Kathrin Al-Ali, Heiko Becker, Frank Stegelmann, Thorsten Götze, Philipp le Coutre, Martin Griesshammer, Adrian Schwarzer, Luisa Wohn, Salah-Eddin Al-Batran, Johanna Riedel, Francesca Palandri, Kirsi Manz, Andreas Hochhaus, Konstanze Döhner, Florian Heidel
Journal: Blood
Blood (2025) 146 (Supplement 1): 5589.
https://doi.org/10.1182/blood-2025-5589
Published: 2025
Journal Articles

Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)

Free
Carmelo Gurnari, Tiziana Ottone, Alfonso Piciocchi, Daniela Späth, Annika Meid, Giovanni Marsili, Emiliano Fabiani, Francesca Romano, Maria Rosaria Pascale, Patrizia Chiusolo, Mauro Di Ianni, Marta Sobas, Lorenzo Brunetti, Guadalupe Oñate, Joana Brioso Infante, Jacopo Nanni, Calogero Vetro, Matilde Boada, Anna Candoni, Jorge Sierra, Nicola Potter, Amanda Gilkes, Sean Johnson, Ian Thomas, Brain Huntley, Nigel Russell, Richard Dillon, Hartmut Döhner, Konstanze Döhner, Maria Teresa Voso
Journal: Blood
Blood (2025) 146 (Supplement 1): 217.
https://doi.org/10.1182/blood-2025-217
Published: 2025
Journal Articles

Ropeginterferon alfa-2b in essential thrombocythemia of all risk levels ineligible for standard cytoreduction: 12-month primary endpoint analysis from the ROP-ET phase 3 study

Free
Jean-Jacques Kiladjian, Haifa Kathrin Al-Ali, Jiri Mayer, Ciprian Tomuleasa, Francesca Palandri, Eloise Beggiato, Valentín García Gutiérrez, Andreas Reiter, Florian Heidel, Joanna Gora Tybor, Mihaela Lazaroiu, alberto Alvarez-Larran, Konstanze Döhner, Massimo Breccia, Arpád Illés, Sebastian Grosicki, Chloe James, Francisca Ferrer Marin, Evangelos Terpos, Ana Crisan, Veronika Buxhofer-Ausch, Stefan Schmidt, Albert Woelfler, Zsolt Nagy, Steffen Koschmieder, Olga Cerna, Vassiliki Pappa, Tomasz Sacha, Stefanie Schlager, Victoria Empson, Martin Unger, Kurt Krejcy, Christoph Klade
Journal: Blood
Blood (2025) 146 (Supplement 1): 485.
https://doi.org/10.1182/blood-2025-485
Published: 2025
Journal Articles

MPN with multiple driver clones show distinct patterns of therapy response and progression - “MPN double driver”

Free
Kirsi Manz, Tina Schnoeder, Francesca Palandri, Filippo Branzanti, Heike Pahl, Martin Griesshammer, Haifa Kathrin Al-Ali, Carl Crodel, Jochen J Frietsch, Juliana Schwaab, Andreas Reiter, Marta Sobas, Olga Chyrko, Patrick Sobieralski, Krzysztof Lewandowski, Weronika Lebowa, Dominik Wolf, Konstanze Döhner, Steffen Koschmieder, Frank Stegelmann, Klaus Metzeler, Susanne Isfort, Andreas Hochhaus, Wencke Walter, Torsten Haferlach, Florian Heidel
Journal: Blood
Blood (2025) 146 (Supplement 1): 1021.
https://doi.org/10.1182/blood-2025-1021
Published: 2025
Journal Articles

Bleximenib or placebo in combination with standard induction and consolidation therapy followed by maintenance for the treatment of patients with newly diagnosed KMT2A-rearranged or NPM1-mutant Acute Myeloid Leukemia eligible for intensive chemotherapy: A double-blind Phase 3 study (HOVON 181 AML / AMLSG 37-25)

Free
Marc Raaijmakers, Hartmut Döhner, Dimitri Breems, John Byrd, Konstanze Döhner, Jordi Esteve, Bjørn Gjertsen, Patrycja Gradowska, Gerwin A. Huls, Ain Kaare, Heeje Kim, Hitoshi Kiyoi, Mika Kontro, Janusz Krawczyk, Vladimir Lazarevic, Andrea Lenartova, Alice Mims, Jeannine Refos, Christoph Röllig, Anika Schrade, Karolina Sikorska, Alexandre Theocharides, Peter Valk, Adriano Venditti, Jianxiang Wang, Andrew Wei, Agnieszka Wierzbowska, Andrius Zucenka, Lucille Ferrante, Christina Drenberg Guttke, Angélique Langlois, Christina Loefgren, Kathryn Packman, Prathap Nagaraja Shastri, Natasha Schuier, Meena Thayu, Danielle Trancucci, Bob Lowenberg, Lars Bullinger
Journal: Blood
Blood (2025) 146 (Supplement 1): 1654.
https://doi.org/10.1182/blood-2025-1654
Published: 2025
Journal Articles

The addition of a tyrosine kinase inhibitor to intensive chemotherapy significantly improves outcome in de novo BCR::ABL1+ acute myeloid leukemia treated with intensive chemotherapy

Free
Sarah Bertoli, Niklas Landberg, Emilie Bérard, Camille Gondran, Laetitia Largeaud, Véronique De Mas, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Sylvain Garciaz, Ludovic Gabellier, Gabrielle Roth-Guepin, Corentin Orvain, Pierre Peterlin, Rudy Birsen, Magda Alexis, Martin Carre, Emmanuelle Tavernier, Marion Boissard Simonet, Chantal Himberlin, Marc Maynadié, Kamel Laribi, Cécile Moluçon-Chabrot, Amine Belhabri, Samy Chraibi, Quentin Cabrera, Delphine Lebon, Emmanuel Raffoux, Thomas Cluzeau, Jean-Baptiste Micol, Mathieu Leclerc, Céline Berthon, Herve Dombret, Gunnar Juliusson, Anna Robelius, Sören Lehmann, Martin Jädersten, Lovisa Wennström, Pau Montesinos, Carmen Botella, Juan Miguel Bergua Burgues, Raimundo Garcia, Josefina Serrano, Mariluz Amigo, Patricia Garcia Ramirez, Claudia Sossa, Juan Manuel Alonso-Dominguez, Hartmut Döhner, Konstanze Döhner, Daniela Späth, Michael Kühn, Claudia Lengerke, Hans-Jörg Tischler, Christoph Röllig, Leo Ruhnke, Christian Thiede, Andreas Burchert, Hubert Serve, Carsten Mueller-Tidow, Claudia Baldus, Jurjen Versluis, Peter Valk, Daniel Kristensen, Anne Stidsholt Roug, Jiri Mayer, Mika Kontro, Pia Ettala, Vladimir Lazarevic, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 991.
https://doi.org/10.1182/blood-2025-991
Published: 2025
Journal Articles

Acute promyelocytic leukemia: long-term outcomes from the HARMONY project

Available to Purchase
Clinical Trials & Observations
Maria Teresa Voso, Luca Guarnera, Söhren Lehmann, Konstanze Döhner, Hartmut Döhner, Uwe Platzbecker, Nigel Russell, Richard Dillon, Ian Thomas, Gert Ossenkoppele, Torsten Haferlach, Marco Vignetti, Edoardo La Sala, Alfonso Piciocchi, Paola Fazi, Angela Villaverde Ramiro, Laura Tur Giménez, Carmelo Gurnari, Lars Bullinger, Jesús María Hernández-Rivas
Journal: Blood
Blood (2025) 145 (2): 234–243.
https://doi.org/10.1182/blood.2024026186
Published: 2025
Includes: Supplemental data
Journal Articles

Genetic Diversity Drives Differing Morphological and Clinical Presentation and Survival in Myelodysplastic-Type CMML with a Low Absolute Monocyte Count

Free
Curtis A Lachowiez, Georgios Asimomitis, Elsa Bernard, Yanis Tazi, Maria Creignou, Ulrich Germing, Norbert Gattermann, Amanda Gilkes, Ian Thomas, Lars Bullinger, Konstanze Döhner, Luca Malcovati, Nigel H. Russell, Mario Cazzola, Hartmut Döhner, Brian J P Huntly, Robert P Hasserjian, Eva Hellstrom Lindberg, Sanam Loghavi, Elli Papaemmanuil
Journal: Blood
Blood (2024) 144 (Supplement 1): 1830.
https://doi.org/10.1182/blood-2024-209450
Published: 2024
Journal Articles

CSF3R T618I Is Stabilized By Calnexin and Induces Unfolded Protein Response (UPR) and ER-Phagy: A Pro-Survival Pathway for Oncogenic Misfolded CSF3R Proteins in Chronic Neutrophilic Leukemia (CNL)

Free
Alessandra Hartke, Julia Klotz, Axel Künstner, Anke Fähnrich, Hauke Busch, Timo Gemoll, Jasmin Osius, Steffen Koschmieder, Tim H. H. Brummendorf, Heike L. Pahl, Florian H. Heidel, Konstanze Döhner, Martin Griesshammer, Andreas Reiter, Justus Duyster, Nikolas C. C. von Bubnoff, Sivahari P. Gorantla
Journal: Blood
Blood (2024) 144 (Supplement 1): 1348.
https://doi.org/10.1182/blood-2024-202513
Published: 2024
Journal Articles

The Prognostic Impact of Myelodysplasia-Related Gene Mutations in Acute Myeloid Leukemia with FLT3 -ITD Mutations

Free
Rabea Mecklenbrauck, Angela Villaverde Ramiro, Eric Sträng, Razif Gabdoulline, Javier Martínez Elicegui, Marta Sobas, Lisa Pleyer, Maria Teresa Voso, Axel Benner, Alberto Hernández Sánchez, Jesse M. Tettero, Laura Tur, Klaus H Metzeler, Guadalupe Onate, Soren Lehmann, Brian J P Huntly, Ian Thomas, Felicitas R Thol, Florian Heidel, Peter J. M. Valk, Konstanze Döhner, Torsten Haferlach, Ken I Mills, Hartmut Döhner, Gastone Castellani, Gert Ossenkoppele, Jesus Maria Hernandez Rivas, Lars Bullinger, Michael Heuser
Journal: Blood
Blood (2024) 144 (Supplement 1): 844.
https://doi.org/10.1182/blood-2024-202362
Published: 2024
Journal Articles

ROP-ET: A Prospective Phase III Trial Investigating the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythemia Patients with Limited Treatment Options

Free
Jean-Jacques Kiladjian, Francisca Ferrer Marin, Haifa Kathrin Al-Ali, Alberto Alvarez-Larran, Eloise Beggiato, Maria Bieniaszewska, Massimo Breccia, Veronika Buxhofer-Ausch, Olga Cerna, Ana Manuela Crisan, Catalin Danaila, Valerio De Stefano, Konstanze Döhner, Victoria Empson, Joanna Gora Tybor, Martin Griesshammer, Sebastian Grosicki, Paola Guglielmelli, Valentín García Gutiérrez, Sr., Florian Heidel, Arpad Illes, Chloe James, Steffen Koschmieder, Krauth Maria-Theresa, Kurt Krejcy, Mihaela Cornelia Lazaroiu, Jiri Mayer, Zsolt Nagy, Francesca Palandri, Vasiliki Pappa, Andreas Reiter, Tomasz Sacha, Stefanie Schlager, Stefan Ulrich Schmidt, Evangelos Terpos, Ciprian Tomuleasa, Jose Miguel Torregrosa Diaz, Martin Unger, Albert Woelfler, Blanca Xicoy, Christoph Klade
Journal: Blood
Blood (2024) 144 (Supplement 1): 6635.
https://doi.org/10.1182/blood-2024-199028
Published: 2024
Journal Articles

10 Year Follow-up of CALGB 10603/Ratify: Midostaurin Versus Placebo Plus Intensive Chemotherapy in Newly Diagnosed FLT3 Mutant Acute Myeloid Leukemia Patients Aged 18-60 Years

Free
Richard M Stone, Jun Yin, Sumithra J Mandrekar, Axel Benner, Maral Saadati, Ilene A. Galinsky, Ben L. Sanford, Rebecca Teske, Susan M. Geyer, Thomas Prior, Sergio Amadori, Frederick R. Appelbaum, Joseph Brandwein, Konstanze Döhner, Gerhard Ehninger, Arnold Ganser, Rebecca B. Klisovic, Jürgen Krauter, Guido Marcucci, Bruno Medeiros, Dietger W. Niederwieser, Miguel A. Sanz, Richard F. Schlenk, Hubert Serve, Jorge Sierra, Martin S. Tallman, Andrew H Wei, Theo J.M. de Witte, Christian Thiede, Hartmut Döhner, Richard A. Larson
Journal: Blood
Blood (2024) 144 (Supplement 1): 218.
https://doi.org/10.1182/blood-2024-201058
Published: 2024