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First Edition

Review Article August 22 2025
Remestemcel-L-rknd (Ryoncil): the first approved cellular therapy for steroid-refractory acute GVHD
Aaron M. Etra,James L.M. Ferrara,John E Levine
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Research Article August 22 2025
Mitochondrial DNA via recipient TLR9 acts as a potent first-hit in murine transfusion-related acute lung injury (TRALI)
Johan Rebetz,Hilma Cederholm,David McGauran,Ellen Moore,Catherine Chi,Karlijn Tabak,Maria Allhorn,Martin L Olsson,Arne Egesten,John W. Semple,Genevieve Marcoux
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Research Article August 22 2025
F8 gene variants influence the response to desmopressin in hemophilia A carriers
Benoît Guillet,Roseline D'Oiron,Marc Trossaert,Bénédicte Wibaut,Brigitte Pan-Petesch,Birgit Frotscher,Fabienne Genre-Volot,Laurent Ardillon,Stéphanie Desage,Céline Falaise,Christine Biron-Andreani,Vincent Cussac,Brigitte Tardy,Yoann Huguenin,Herve Chambost,Sophie Bayart,Sabine-Marie Castet,Xavier Delavenne
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Review Article August 22 2025
Artificial Intelligence in Hematology
Aziz Nazha,Olivier Elemento,Sanjay Ahuja,Barbara D Lam,Moses Miles,Roni Shouval,Shannon K. McWeeney,Shireen Sirhan,Andrew Srisuwananukorn,Torsten Haferlach
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Research Article August 20 2025
Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy
Padmavathi Kavadipula,Shiva Keshava,Kaushik Das,Jhansi Magisetty,Christian DeJong,Josthna Penchalaneni,Usha Pendurthi,L. Vijaya Mohan Rao
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Discussion August 20 2025
Gene Therapy for HbSC Disease and other Compound Heterozygous Sickle Hemoglobinopathies: A Time for Inclusion
Andrew Wilks,Martin H Steinberg,Haydar Frangoul
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Research Article August 20 2025
Challenging the Concept of Functional High-Risk Myeloma through Transcriptional and Genetic Profiling
Sina Alexandra Beer,David A Cairns,Charlotte Pawlyn, Dr,Amy Elizabeth Holroyd,Elsa Ferris,Gordon Cook,Mark Drayson,Kevin D Boyd,Paula Zuzanna Proszek,Faith E Davies,Ruth M de Tute,Matthew W Jenner,Gareth J Morgan,Roger G. Owen,Michael J Hubank,Richard S. Houlston,Graham H Jackson,Martin F Kaiser
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Research Article August 19 2025
Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease
Rebecca A Mellema,Kimberly A Queisser,Abigail Ajanel,Nansy Albtoush,Lydia Smith,Matt Rondina,Julie Will,John F Valentine,Aaron C. Petrey
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Research Article August 19 2025
A T-cell-based metric of immune age predicts outcomes in older patients with myeloma receiving daratumumab-based therapy
Wassilis S.C. Bruins,Febe Smits,Carolien Duetz,Kaz Groen,Charlotte L.B.M. Korst,A. Vera de Jonge, dr.,Christie P.M. Verkleij,Rosa Rentenaar,Meliha Cosovic,Merve Eken,Inoka Twickler,Paola M. Homan-Weert,Pieter Sonneveld,Philippe Moreau,Jürgen Claesen,Niels W.C.J. van de Donk,Sonja Zweegman,Tuna Mutis
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Research Article August 19 2025
A phase 2 study of zanubrutinib in combination with rituximab and lenalidomide in de novo diffuse large B-cell lymphoma
Pengpeng Xu,YUE ZHU,Zi-Yang Shi,Li Wang,Shu Cheng,Ying Qian,Yan Zhao,Yang He,Hongmei Yi,Binshen Ouyang,Xu-Feng Jiang,Biao Li,Qi Song,Rong-Ji Mu,Weili Zhao
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Research Article August 19 2025
Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside aging
Wenyan Cheng,Xiao Yi,Zhenyi Wang,Jian-Feng Li,Jun-Yi Zhang,Rui-Hong Zhang,Qian-Qian Zhang,Xiangqin Weng,Ting Huang,Yong-Mei Zhu,Chao Wang,Wei Yin,Jia-Nan Zhang,Hui-Yi Wu,Jun-Min Li,Hongming Zhu,Li Chen,Wen-Fang Wang,Yuting Dai,Chen-Xu Gao,Xuan Liu,Shan Wang,Shengyue Wang,Bo Jiao,Zhu Chen,Hai Fang,Tong Yin,Yang Shen,Sai-Juan Chen
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Research Article August 18 2025
Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency
Jianli Tao,Luca Alessandri,Alessandro Gasparetto,Lijuan Zhao,Xuefei Zhang,Frederick W Alt,Roberto Chiarle
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Review Article August 14 2025
Treatment of Relapsed and Refractory Follicular Lymphoma: Which Treatment for Which Patient for Which Line of Therapy?
Carla Casulo,Laurie H. Sehn
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Research Article August 14 2025
Molecular Determinants of Thrombosis Recurrence Risk Across Venous Thromboembolism Subtypes
Gaëlle Munsch,Florian Thibord,Ohanna C Bezerra,Jennifer A Brody,Astrid van Hylckama Vlieg,Lenaick Gourhant,Ming-Huei Chen,Floriane Samaria,Marine Germain,Ilana Caro,Pierre Suchon,Robert Olaso,Kerri L Wiggins,Noémie Saut,Céline Besse,Louisa Goumidi,Delphine Bacq,Laura B Harrington,Anne Boland,Joseph Emmerich,David M Smadja,Catherine A Lemarie,Sven Danckwardt,Stephanie Debette,Jean-François Deleuze,Hélène Jacqmin-Gadda,Marc A Rodger,France Gagnon,Frits R Rosendaal,Andrew D Johnson,Nicholas L. Smith,Francis Couturaud,Pierre-Emmanuel Morange,David-Alexandre Tregouet
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Research Article August 14 2025
Epidemiology, Clinical Features, and Molecular Basis of TTMV::RARA-driven Acute Promyelocytic Leukemia
Xiaosu Zhou,Jiaqi Chen,Yan‑Lai Tang,Haibo Sun,Qihui Chen,Xue Chen,Yang Zhang,Jiancheng Fang,Panxiang Cao,Xiaoli Ma,Li Chen,Yangyang Xie,Lijun Wen,Li-Bin Huang,Zhong Fan,Jiacheng Lou,Wenning Xu,Nan Zhang,Jing Li,Yu Luo,Yan Dai,Huan Du,Kun Yang,Zhixu He,Xiaoyan Yang,Linya Wang,Bing Liu,Danna Lin,Yajie Zhang,Fang Xu,Min Zhang,Yang Wang,Shu Yan,Hua Nan,Jing Zhang,Li Xu,Xiujuan Ma,Ruijie Tang,Fang Wang,Lili Yuan,Ming Liu,Lei Wang,Qisheng Wu,Lina Zhang,Siyuan Liu,Chengcheng Yan,Jianfeng Zhou,Fanyong Lyu,Ping Wu,Tong Wang,Xian Zhang,Yue Lu,Deyan Liu,Junfang Yang,Min Xiong,Yanli Zhao,Gaowei Fan,Xia Xiao,Futian Ma,Lihua Yang,Xue-Qun Luo,Jun-Min Li,Shuhong Shen,Huyong Zheng,Suning chen,Hongwei Chen,Jianhong Zhao,Zhanglin Zhang,KanKan Wang, Prof.,Peihua Lu,Hongxing Liu
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Research Article August 14 2025
Pooled CAR-T screening in nonhuman primates identifies designs with enhanced proliferation, trafficking, and persistence
Lucy H. Maynard,Eric J Cavanaugh,Haiying Zhu,Carly E Starke,Sarah M Doherty,Teresa K Einhaus,Ailyn C. Pérez-Osorio,Laurence Stensland,Cameron Blair,Aoife M Roche,John K. Everett,Robert D Murnane,Michelle E Hoffman,Veronica Nelson,Sarah Althea Herrin,Chad Littlewood,Kaycee Camou,Erica Wilson,Christopher Wessel,Frederic Bushman,Keith R Jerome,Hans-Peter Kiem,Christopher William Peterson
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Brief Report August 14 2025
Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia
Lindsey E. Montefiori,Ilaria Iacobucci,Qingsong Gao,Jamila Moore,William C Wright,Huimei Wei,Pradyumna Baviskar,Surbhi Sona,Hongjian Jin,Amit Budhraja,Josi Lott,Qi Zhang Tatarata,Zhongshan Cheng,Tanya M Khan,Emily A. Backhaus,Melissa D. Johnson,Cyrus M Mehr,Burgess B. Freeman, III,Laura J Janke,Torsten Haferlach,Paul Geeleher,Paul E. Mead,Marina Y. Konopleva,Joseph T. Opferman,Charles G. Mullighan
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Research Article August 14 2025
Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism
Josepha C Sedzro,Amanda L. Photenhauer,Fabienne Birkle,Katarina Meze,Alex Mortenson,Cade Duckworth,Po-Chao Wen,Sarah Kearns,Michael A. Cianfrocco,Emad Tajkhorshid,Melanie D. Ohi,James H. Morrissey
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Research Article August 14 2025
Improved diagnostic screening and classification of clonal mast cell diseases by ultrasensitive KIT p.D816V detection
Paula Navarro-Navarro,María González-Tablas,Alba Pérez-Pons,Laura Sánchez-Muñoz,Ana Henriques,Iván Álvarez-Twose,Paula Nafria,David Araco-Sánchez,Cristina Morales-Cabeza,Horacio Caligaris,Lei Chen,David González-de-Olano,Óscar González-López,Luis Escribano Mora,Andrés C. García-Montero,María Jara-Acevedo,Alberto Orfao
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Discussion August 11 2025
Chilling Controversy: Cold-Stored Platelets for Prophylactic Transfusions
Moritz Stolla,Andrew P. Cap,Philip C Spinella
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Research Article August 11 2025
HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3 and bind inactive integrins more strongly than active integrins
Janita Oosterhoff,Wendy Stam,Suze Rosanne van Brummelen,Arthur Bentlage,Thijs de Vos,Jose Maria de Pereda,Leendert Porcelijn,Rick Kapur,Masja De Haas,C Ellen van der Schoot,Gestur Vidarsson,Coert Margadant
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Research Article August 11 2025
Risk factors and outcomes of asparaginase-associated pancreatitis in pediatric patients with ALL
Changcheng Chen,Jiaoyang Cai,Xuedong Wu,Qun Hu,Xiaoyan Wu,Xia Guo,Shaoyan Hu,Xiaowen Zhai,Benquan Qi,Weina Zhang,Ningling Wang,Fengling Xu, Dr.,Yongjun Fang,Chi-kong Li,Changda Liang,Lingzhen Wang,Jiashi Zhu,Wenjun Deng,Xin Tian,Xiuli Ju,Ge Zhang,Jingyan Tang,Cheng Cheng,Jun J Yang,Shuhong Shen,Ching-Hon Pui
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Letter August 6 2025
Induction chemotherapy and molecular MRD influence outcomes in KMT2A-rearranged AML
Jad Othman,Nicola Potter,Sylvie D Freeman,Nicholas McCarthy,Jelena Jovanovic,Manohursingh Runglall,Joanna Canham,Ian Thomas,Sean Johnson,Amanda Frances Gilkes,James Durrell Cavenagh,Panagiotis Kottaridis,David C Taussig,Claire Arnold,Claire Jane Hemmaway, Dr,Dominic Culligan,Ulrik Malthe Overgaard,Mike Dennis,Alan K Burnett,Nigel H. Russell,Richard James Dillon
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Review Article August 4 2025
How I Manage Chronic Myeloid Leukemia During Pregnancy
Elisabetta Abruzzese,Ekaterina Chelysheva
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Review Article August 4 2025
A precision medicine approach to the myelodysplastic syndrome with isolated deletion 5q 50 years after its discovery
Marco Roncador,Elsa Bernard,Robert P Hasserjian,Jacqueline Boultwood,Chiara Elena,Anna Galli,Carmelo Gurnari,Cristina Mecucci,Lucienne Michaux,Moshe Mittelman,Martina Sarchi,Erica Travaglino,Donal P McLornan,Seishi Ogawa,Elli Papaemmanuil,Eva S Hellstrom-Lindberg,Luca Malcovati,Mario Cazzola
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Research Article August 4 2025
Deciphering neutrophil dynamics in the focal lesion tumor microenvironment to overcome immunosuppression in multiple myeloma
Joshua Rivera,Qi Yan,Saeed Daneshmandi,Romain Lannes,Eriko Katsuta,Jee Eun Choi,Prashant K. Singh,Ahmed Belal,Ronald Alberico,Ian Lund,Magan Schaefer,Hamza Hassan,Sarah Parker,Kenneth C. Anderson,Nikhil C. Munshi,Mehmet K. Samur,Philip L. McCarthy,Jens Hillengass,Hemn Mohammadpour
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Research Article August 1 2025
Disrupting tRNA modifications to target mitochondrial vulnerabilities in drug-resistant leukemia cells
Cornelius Pauli,Michael Kienhöfer,Maximilian Felix Blank,Oguzhan Begik,Christian Rohde,Sarah MN Zimmermann,Laura Werner,Daniel Heid,Fu Xu,Katharina Weidenauer,Sylvain Delaunay,Nadja Krall,Katrin Trunk,Duoduo Zhao,Fengbiao Zhou,Laia Llovera,Ollivier Alexane,Anke Heit-Mondrzyk,Uwe Platzbecker,Claudia D. Baldus,Hubert Serve,Martin Bornhäuser,Cathrine B Vågbø,Salvador Aznar Benitah,Jeroen Krijgsveld,Eva Maria Novoa,Carsten Müller-Tidow,Michaela Frye
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Research Article August 1 2025
Metabolic Adaptation of Regenerative Hematopoiesis Depends on Docking-Independent Mitochondrial Connexin-43
Abhishek K Singh,Angelo D'Alessandro,Ashley Wellendorf,Daniel Gonzalez-Nieto,Matthew Kofron,Monika Dzieciatkowska,Leo Mejia,Luis Barrio,Marie-Dominique Filippi,Jose A. Cancelas
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Research Article August 1 2025
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues, ameliorating GVHD post-HSCT
Duneia McManus,Sabrina N Copsel,Brent J Pfeiffer,Dietlinde Wolf,Henry Barreras,Symon Ma,Ali Khodor,Seitaro Komai,Marina Burgos da Silva,Hajar Hazime,Miguel Gallardo,Sarah Grace R Lime,Marcel R.M. van den Brink,Jung-Hyun Park,Maria T Abreu,Geoffrey R Hill,Victor L Perez,Robert B Levy
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Research Article August 1 2025
Preclinical advances in glofitamab combinations: a new frontier for non-Hodgkin lymphoma
Johannes Sam,Gabrielle Leclercq-Cohen,Samuel Gebhardt,Marlena Surowka,Sylvia Herter,Katharina Lechner,James Relf,Stefanie Briner,Ahmet Varol,Birte Appelt,Ioana Domocos,Valeria G. Nicolini,Miriam Bez,Esther Bommer,Silvia Jenni,Anne Schoenle,Marine Le Clech,Sara Colombetti,Christian Klein,Pablo Umaña,Pontus Lundberg,Koorosh Korfi,Alessia Bottos,Marina Bacac
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Research Article August 1 2025
Sequential Targeting in Multiple Myeloma: Talquetamab, a GPRC5D bispecific antibody, as a Bridge to BCMA CAR-T cell therapy
Binod Dhakal,Othman Salim Akhtar,David Fandrei,Alexandria Jensen,Rahul Banerjee,Darren Pan,Shambavi Richard,Reed Friend,Matthew James Rees,Patrick Costello,Mariola Alejandra Vazquez Martinez,Oren Pasvolsky,Charlotte B. Wagner,James A Davis,Omar A. Castaneda Puglianini,Ran Reshef,Aimaz Afrough,Danai Dima,Manisha Bhutani,Omar Nadeem,Ricardo D Parrondo,Ciara L Freeman,Lekha Mikkilineni,Shahzad Raza,Larry D. Anderson, Jr.,Prashant Kapoor,Hitomi Hosoya,Saurabh Chhabra,Ariel Grajales-Cruz,Mahmoud R. Gaballa,Shonali Midha,Melissa Alsina,Douglas W Sborov,Krina K. Patel,Yi Lin,Christopher J Ferreri,Nico Gagelmann,Anupama Deepa Kumar,Doris K Hansen,Andrew J Cowan,Luciano J. Costa,Maximilian Merz,Surbhi Sidana
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Review Article July 30 2025
New prognostic systems for multiple myeloma in the context of contemporary therapies
Andrew Spencer
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Research Article July 30 2025
Multiomics analysis reveals the genetic and epigenetic features of high-risk NK cell-type chronic active EBV infection
Ryo Akazawa,Takashi Mikami,Masaki Yamada,Itaru Kato,Hirohito Kubota,Satoshi Saida,Yoshinori Uchihara,Yuriko Ishikawa,Tatsuya Kamitori,Keiji Tasaka,Kiyotaka Isobe,Tomoya Isobe,Kazushi Izawa,Katsutsugu Umeda,Hidefumi Hiramatsu,Keita Jinnouchi,Masahiro Hirata,Masakazu Fujimoto,Tomoo Daifu,Hiroo Ueno,Seishiro Nodomi,Machiko Sawada,Hisanori Fujino,Katsuyoshi Koh,Mitsuteru Hiwatari,Motohiro Kato,Hiroaki Goto,Ikumi Katano,Ryoji Ito,Mamoru Ito,Nobuyuki Kakiuchi,Masahiro Marshall Nakagawa,Yuichi Shiraishi,Yoshitaka Honda,Hiroyuki Yoshitomi,Hideki Ueno,Maho Sato,Satoru Miyano,Hironori Haga,Akihisa Sawada,Ken-Ichi Imadome,Seishi Ogawa,Junko Takita
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Research Article July 30 2025
Final analysis of the RESONATE-2 study: up to 10 years of follow-up of first-line ibrutinib treatment for CLL/SLL
Jan A. Burger,Paul M. Barr,Tadeusz Robak, Prof.,Carolyn Owen,Alessandra Tedeschi,Anita Sarma,Piers EM Patten,Sebastian Grosicki,Helen McCarthy, Dr,Fritz Offner,Edith Szafer Glusman,Cathy Zhou,Anita Szoke,Lynne Neumayr,James P. Dean,Paolo Ghia,Thomas Kipps
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Research Article July 30 2025
Disease risk but not remission status determines transplant outcomes in AML: long-term outcomes of the ASAP trial
Matthias Stelljes,Jan Moritz Middeke,Gesine Bug,Eva Maria Wagner-Drouet,Lutz P. Mueller,Christoph Schmid,Stefan W Krause,Wolfgang Andreas Bethge,Edgar Jost,Uwe Platzbecker,Stefan Klein,Judith Niederland,Martin Kaufmann,Kerstin Schäfer-Eckart,Henning Baldauf,Friedrich Stölzel,Sarah Trost,Christoph Röllig,Malte von Bonin,Katharina Egger-Heidrich,Desiree Kunadt,Björn Steffen,Beate Hauptrock,Christoph Schliemann,Katja Sockel,Fabian Lang,Oliver Kriege,Judith Schaffrath,Christian Reicherts,Wolfgang E. Berdel,Hubert Serve,Gerhard Ehninger,Alexander H. Schmidt,Jan-Henrik Mikesch,Martin Bornhäuser,Johannes Schetelig
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Research Article July 30 2025
XPO1 Drives Resistance to Eprenetapopt and Azacitidine and Can Be Targeted in TP53-Mutated Myeloid Malignancies
Traci L Kruer,Ariel Quintana-Gonzalez,Hannah L Newman,Meghan C. Ferrall-Fairbanks,Ling Zhang,Amy F McLemore,Surendra Neupane,Qin Yang,Nana Adjoa Ben-Crentsil,Maria E. Balasis,Christopher T Letson,Rami S Komrokji,Sana Chaudhry,Tulasigeri M Totiger,Joshua A Traina,Maria E Figueroa,Christopher B Ryder,Thomas Cluzeau,Justin Taylor,David A Sallman,Eric Padron
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Research Article July 29 2025
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients
Alastair Smith,Nicholas David Robert Denny,Catherine Chahrour,Kim Sharp,Marta Arachi,Ana Maria Dopico-Fernandez,Natalina Elliott,Joe Harman,Thomas Jackson,Huimin Geng,Owen Smith, Professor,Jonathan Bond,Irene Roberts,Ronald W. W. Stam,Nicholas Crump,James Davies,Anindita Roy,Thomas A Milne
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Research Article July 29 2025
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
Paul Breillat,Francesco Carbone,Emilie Lereclus,Quentin Riller,Thibaut d'Izarny-Gargas,Celine Posseme,Marie Templé,Lin-Pierre Zhao,Marine Luka,Estibaliz Lazaro, Pr,Roderau Outh,Guillaume Le Guenno,Francois Lifermann,Yannick Dieudonné,Marie Berleur,Cédric Lenormand,Karl Balabanian,Thierry Weitten,Vivien Guillotin,Marie Kostine,Barbara Burroni,Adrien Bigot,Alexandra Audemard-Verger,Aldric Manuel,Antoine Dossier,Cécile Golden,Jean-Philippe Martellosio,Benoit Faucher,Benjamin De Sainte Marie,Nadine Magy-Bertrand,Valentin Lacombe,Stéphane Vinzio,Sylvie Grosleron,Léa Dionet,Pierre-Louis Tharaux,Darragh Duffy,Mickaël Mathieu Ménager,Nicolas Dulphy,Olivier Kosmider,Benjamin Terrier
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Letter July 29 2025
Time to complete remission is an independent determinant of survival after intensive chemotherapy in AML
Rithin Nedumannil,Michael Ashby,James P Rowland, Dr,Jacques A J Malherbe,Jared Fairbank,Kelli Gray,Sun Loo,Matthew Wright,John Reynolds,Devendra K. Hiwase,Paula Marlton,Shaun A Fleming,Ashish Bajel,Andrew H Wei
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Research Article July 29 2025
Casein kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization
Ferdinand Kollotzek,Kristina Mott,Melina Fischer,Betül Findik,Vanessa Göb,Mailin-Christin Manke,Carla Emilia Borst,Amin Polzin,Martin D. Burkhalter,Anita E Eckly,Tamam Bakchoul,Melanie Philipp,Samuel Josua Holzmayer,Leticia Quintanilla-Fend,Claudia Lengerke,Meinrad Gawaz,Catherine Leon,David Stegner,Bernhard Nieswandt,William Vainchenker,Markus Bender,Julia Skokowa,Harald Schulze,Patrick Münzer,Oliver Borst
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Review Article July 29 2025
How I treat patients with CLL after prior treatment with a covalent BTK inhibitor and a BCL-2 inhibitor
Mazyar Shadman,Matthew S. Davids
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Review Article July 29 2025
A clinical guide to TP53 mutations in myeloid neoplasms
Samuel Urrutia,Terrence N Wong,Daniel C. Link
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Brief Report July 25 2025
Safety and Efficacy of Elranatamab in Patients with Relapsed and/or Refractory immunoglobulin Light-Chain Amyloidosis
Pedro Vianna,Rajshekhar Chakraborty,Shahrier Hossain,Divaya Bhutani,Shannon Miller,Annemarie Rossi,Sarah AM Cuddy,Rodney H Falk,Suzanne Lentzsch,Jacob Laubach,Giada Bianchi
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Research Article July 25 2025
Donor-derived CD7 CAR T cells for pediatric and adult relapsed/refractory T-ALL/LBL: a phase 2 trial
Jing Pan,Liping Zhao,Yibing Zhang,Samuel Seery,Yue Tan,Biping Deng,Lingling Shan,Zhuojun Ling,Fan Wu,Quangang Wang,Xinjian Yu,Qinlong Zheng,Xiuwen Xu,Ying Yuan,Zhenglong Tian,Yanlei Zhang,Shuixiu Peng,Alex H. H. Chang,Xiaoming Feng
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Research Article July 25 2025
HiJAKing the Hematopoietic System: A Low-Frequency JAK2V617F Clone Drives Myeloproliferative Neoplasm Pathology
Dennis M Bonal,Alissa Oakes,Anna Chorzalska,Makayla Pardo,Max Petersen,Michael Yeh Clarke,Seo-Ho Lee,Adam J Olszewski,Diana Olguta Treaba,John L Reagan,Mark S Dooner,John Morgan,Paul Bertone,Ting Zhao,Wentian Yang,Corey E. Ventetuolo,Gabriela S Hobbs,Joslyn Mills,Patrycja M. Dubielecka
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Research Article July 23 2025
CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis
Yuanyuan Ji,Yi Huang,Toby Thomas,Eda Gozel Kapti,Reiko Tachibana,Jacob Alan Lark,Iryna Berezniuk,Liang Guo,Mohamed A. E. Ali,Karin Mims,Benjamin Kroger,Wenhuo Hu,Christopher Y Park,Stephen S Chung
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Research Article July 23 2025
TCA cycle mode switch determines the fate of pirtobrutinib-tolerant persister cells in mantle cell lymphoma
Wei Wang,Qingsong Cai,Yang Liu,Lei Nie,Heng-Huan Lee,Fangfang Yan,Yue Fei,Yixin Yao,Yijing Li,Lin Tan,Philip L Lorenzi,Ying-Nai Wang,Jun Yao,Zhihong Chen,Joseph McIntosh,Cheng-tai Yu,Preetesh Jain,Vivian Jiang,Jovanny Vargas,Xiaolin Li,Tianci Zhang,Shaoying Li,David Santos,Selvi Thirumurthi,Erin Heather Seeley,Lukas Mikolaj Simon,Christopher R. Flowers,Chi Young Ok,Michael L Wang
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Research Article July 23 2025
CircFUT8 promotes proplatelet formation by interacting with IGF2BP2 and stabilizing TNS1 mRNA in megakaryocytes
Huang Wu,Yao Lu,Denglian Sun,Zeqing Miao,Siyuan Chen,Wenjun Xia,Yanhua Chen,Yun Yu,Weiwei Zhang,Wei Chen,David Stegner,Su Hao Lo,Aiqing Wen
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Research Article July 23 2025
Inflammasome-resistant IPSC-derived myeloid-derived suppressor cells ameliorate xenogeneic graft-versus-host disease
Lie Ma,Brent H Koehn,Michael C. Zaiken,Keli L. Hippen,Kyle D Smith,Jeremy R Allred,Robin L Williams,Ke Yao,Jordan Fink,Asim Saha,Benjamin Kopp,Nathaniel Payne,Renata Widelak,Angela Panoskaltsis-Mortari,Megan J Riddle,Jakub Tolar,Cindy Eide,Lily Xia,Alec Drake Witty,Amit K. Mehta,Matthew Denholtz,Mehrdad Hefazi,Sophia Hani,Saad S. Kenderian,Jeffrey S. Miller,Jeffrey J. Molldrem,Leslie S Kean,Bahram Valamehr,Bruce R. Blazar
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Research Article July 23 2025
A BCMA-mRNA vaccine is a promising therapeutic for multiple myeloma
Debasmita Dutta,Jiye Liu,Kenneth Wen,Arghya Ray,Alessandro Salatino,Xiangdong Liu,Annamaria Gulla,Teru Hideshima,Yan Song,Kenneth C. Anderson
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