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Journal Articles

2025 Update on MRD in Acute Myeloid Leukemia: A Consensus Document from the ELN-DAVID MRD Working Party

Open Access
Jacqueline Cloos, Peter J.M. Valk, Christian Thiede, Konstanze Döhner, Gail J Roboz, Brent L. Wood, Roland B. Walter, Sa A Wang, Agnieszka Wierzbowska, Andrew H Wei, David Wu, Francois Vergez, Adriano Venditti, Bert A. van der Reijden, Arjan A van de Loosdrecht, Ing Soo Tiong, Felicitas R Thol, Marion Subklewe, Christophe Roumier, Tom Reuvekamp, Farhad Ravandi, Claude Preudhomme, Adriana Plesa, Jad Othman, Gert J. Ossenkoppele, Yishai Ofran, Aguirre Mimoun, Luca Maurillo, Agata Majchrzak, David C. de Leeuw, Wolfgang Kern, Dennis Dong Hwan Dong Hwan Kim, Maura Rosane Valério Ikoma-Colturato, Lukas H. Haaksma, Monica L Guzman, Michaela Feuring, Barbara Depreter, Anna Czyz, Veit L. Bücklein, Constance Baer, Costa Bachas, Sylvie D Freeman, Francesco Buccisano, Christopher S Hourigan, Richard James Dillon, Michael Heuser
Journal: Blood
Blood blood.2025031480.
https://doi.org/10.1182/blood.2025031480
Published: 2025
Includes: Supplemental data
Journal Articles

Real-world effectiveness of gilteritinib beyond second-line therapy in relapsed/refractory FLT3-mutated acute myeloid leukemia: A european multicenter study of 171 patients

Free
Matteo Molica, Gema Miralles, Richard Dillon, Mario Annunziata, Faisal Basheer, Juan Miguel Bergua Burgues, Ferran Vall-Llovera Calmet, Victoria Campbell, Denis Cetin, Gaetano Cimino, Giulia Ciotti, andrea corbingi, LAURA DE FAZIO, Hasim Atakan Erol, Vincenzo Federico, Cristina Gil, Yasa Mutlu Gulu, Amaia Balerdi Malcorra, Sabrina Mariani, Maria Paola Martelli, Carla Mazzone, Antonino Mulè, Gerardo Musuraca, Anjum Khan, Mariana Norata, Jenny O'Nions, Fanny Palumbo, Cristina Papayannidis, Annalina Piccioni, Maria Teresa Olave Rubio, Jackeline Sanchez-Tovar, Istemi Serin, Alessandra Serrao, Omur Sevindik, Giuseppe Sucato, Marina Aurora Urbano, Calogero Vetro, Susana Vives, Marco Rossi, Pau Montesinos, Jad Othman, Salvatore Perrone
Journal: Blood
Blood (2025) 146 (Supplement 1): 1662.
https://doi.org/10.1182/blood-2025-1662
Published: 2025
Journal Articles

Re-treatment of relapse in elderly AML with time-limited venetoclax-based regimen: A case report and literature review.

Free
Jun Yen Ng, Veena Gullapalli, Jad Othman, Dipti Talaulikar
Journal: Blood
Blood (2025) 146 (Supplement 1): 6997.
https://doi.org/10.1182/blood-2025-6997
Published: 2025
Journal Articles

Real world outcomes in 355 patients with Acute Myeloid Leukemia arising from chronic myelomonocytic leukemia: A multinational retrospective study

Free
Laura Cicconi, Jad Othman, Alessandra Spagnoli, Enrico Attardi, Eleonora De Bellis, Pilar Lloret Madrid, Tamara Castaño, Juan Miguel Bergua Burgues, Arianna Savi, Ida Carmosino, Roberta Mazzarella, Armando Mena Duran, Mar Tormo, Susana Vives, Emília Cortesão, Fernanda Trigo, Mercedes Colorado, Lorenzo Algarra, Olga Salamero, José Antonio Pérez-Simón, Esther Perez, ANA Yurena Oliva Hernandez, Teresa Bernal Del Castillo, Pilar Martinez Sanchez, Claudia Lucia Scossa Melo, Cristina Gil, Marta Valero Núñez, Luis Felipe Casado Montero, Teresa Olave, Maria Vidriales Vicente, Carla Amigo, Irene Navarro Vicente, Cristian Escolano Escobar, Pilar Herrera Puente, Kenny Galvez, Rosalia Riaza Grau, Annalina Piccioni, Davide Facchinelli, Enrico Santinelli, Raffaele Palmieri, Giovanni Luzi, Monica Piedimonte, Sabrina Mariani, Luana Fianchi, Carmela Gurrieri, Ilaria Tanasi, Davide Lanzarotto, Fabio Guolo, Salvatore Perrone, Elisabetta Todisco, Anjum Khan, Victoria Campbell, Maria Teresa Voso, Daniela Cilloni, Adriano Venditti, Roberto Latagliata, Richard Dillon, Massimo Breccia, Luca Maurillo, Susanna Fenu, Alessandro Pulsoni, Pau Montesinos
Journal: Blood
Blood (2025) 146 (Supplement 1): 3437.
https://doi.org/10.1182/blood-2025-3437
Published: 2025
Journal Articles

Outcomes of mecom rearranged AML undergoing intensive chemotherapy in the NCRI AML17 and AML19 trials.

Free
Mike Dennis, Jad Othman, Joanna Canham, Ian Thomas, Sean Johnson, Nick Telford, Beth Harrison, Jeyaprakash Ramachandran, James Cavenagh, Claire Arnold, Claus Marcher, Richard Kelly, Mhairi Copland, Alan Burnett, Richard Dillon, Nigel Russell
Journal: Blood
Blood (2025) 146 (Supplement 1): 3435.
https://doi.org/10.1182/blood-2025-3435
Published: 2025
Journal Articles

Venetoclax in combination with hypomethylating agents in adult patients with newly diagnosed AML with CBFB::MYH11 or RUNX1::RUNX1T1 fusions: Real-world outcomes based on international registry data

Free
Leo Ruhnke, Christoph Röllig, Lydia Kretschmer, Jan Moritz Middeke, Sylvia Herold, David Poitz, Pau Montesinos, Maria Del Carmen Martinez Chamorro, Josefina Serrano, Joaquín Sánchez-García, Lara María Gómez García, Francisco-Javier Peñalver, Guillermo Quintero, Virginia Abello, Pierre Yves Dumas, Sarah Bertoli, Christian Recher, Arnaud Pigneux, Jenny O'Nions, Hannah Al-Yousuf, Jad Othman, Richard Dillon, Jiri Mayer, Stephane De Botton, Raphael Itzykson, Herve Dombret, Magdalena Czemerska, Agnieszka Wierzbowska, Anne Weigert, Madlen Jentzsch, Uwe Platzbecker, Karsten Spiekermann, Tim Sauer, Carsten Müller-Tidow, Hubert Serve, Claudia Baldus, Martin Bornhäuser, Klaus Metzeler
Journal: Blood
Blood (2025) 146 (Supplement 1): 5230.
https://doi.org/10.1182/blood-2025-5230
Published: 2025
Journal Articles

Prognostic risk integration for survival modeling (PRISM) in newly diagnosed acute myeloid leukemia treated with venetoclax:  a multinational retrospective cohort study

Free
Curtis Lachowiez, Andy Kaempf, Jad Othman, Seongseok Yun, Mael Heiblig, Michael Heuser, Rabia Shahswar, Anand Patel, Rafael Madero-Marroquin, Joseph Cannova, Irene Zacheo, Federica Monaco, Dimitrios Drekolias, Fatima Tuz Zahra, Amine Belhabri, Urbain Tauveron-Jalenques, Emmanuelle Tavernier, Martin Carre, Gaspar Aspas Requena, Nicola Long, Rachel Cook, Elie Traer, Ronan Swords, Jennifer Saultz, Jenny O'Nions, Faisal Basheer, John Laurie, Shivani Handa, Eytan Stein, Maria Baer, Wendy Stock, Rebecca Olin, William Blum, Gary Schiller, Tara Lin, Emily Curran, Ying Huang, Rina Welkie, Ashley Yocum, Giovanni Marconi, Ellen Madarang, Justin Watts, Yazan Madanat, Richard Dillon, Sanam Loghavi, Joshua Zeidner, Daniel Pollyea, Elsa Bernard
Journal: Blood
Blood (2025) 146 (Supplement 1): 453.
https://doi.org/10.1182/blood-2025-453
Published: 2025
Journal Articles

Outcomes following lower-intensity therapy with venetoclax in patients with NPM1-mutated Acute Myeloid Leukemia are highly dependent upon co-occurring mutations

Free
Curtis Lachowiez, Seongseok Yun, Mael Heiblig, Michael Heuser, Rabia Shahswar, Anand Patel, Rafael Madero-Marroquin, Joseph Cannova, Dimitrios Drekolias, Fatima Tuz Zahra, Amine Belhabri, Urbain Tauveron-Jalenques, Emmanuelle Tavernier, Martin Carre, Gaspar Aspas Requena, Jenny O'Nions, Faisal Basheer, John Laurie, Ellen Madarang, Richard Dillon, Sanam Loghavi, Joshua Zeidner, Dan Pollyea, Justin Watts, Jad Othman
Journal: Blood
Blood (2025) 146 (Supplement 1): 5278.
https://doi.org/10.1182/blood-2025-5278
Published: 2025
Journal Articles

Detection of KMT2A fusion transcripts after induction chemotherapy is strongly predictive of outcome in KMT2A rearranged AML: Results of an international collaborative study

Free
Jad Othman, Hsin-An Hou, Nicola Potter, Hannah Al-Yousuf, Pablo Prieto-Martinez, John Chadwick, Marzia Rahman, Sun Loo, Wen-Chien Chou, Yu-Sung Chang, Ing Tiong, Rea Grace Maamari, Hans Ommen, Robert Baker, Adam Ivey, Jelena Jovanovic, Manohursingh Runglall, Raminta Batiuskaite, Tautvile Smalinskaite, Joanna Canham, Ian Thomas, Sean Johnson, Amanda Gilkes, Alan Burnett, Andrius Zucenka, Pramila Krishnamurthy, Andrew Wei, Mike Dennis, Jenny O'Nions, Nigel Russell, Richard Dillon
Journal: Blood
Blood (2025) 146 (Supplement 1): 346.
https://doi.org/10.1182/blood-2025-346
Published: 2025
Journal Articles

FLT3-ITD NGS-MRD refines risk stratification in NPM1 and FLT3 co-mutated AML beyond NPM1 PCR-MRD: Analysis of the UK NCRI AML17 and AML19 trials

Free
Aditya Tedjaseputra, Nicola Potter, Jelena Jovanovic, Adam Ivey, Manohursingh Runglall, William Villiers, Phoebe Aucken, Michael Lim, Thadsha Arumugam, Olivia Grimwade, Amanda Gilkes, Joanna Canham, Sean Johnson, Ian Thomas, Hans Ommen, Ulrik Overgaard, Ruth Spearing, Mike Dennis, Jenny O'Nions, Andrew King, Paul Cahalin, Priyanka Mehta, David Taussig, Ellen Solomon, Alan Burnett, Sylvie Freeman, Steve Knapper, Andrew Wei, Jad Othman, Nigel Russell, Richard Dillon
Journal: Blood
Blood (2025) 146 (Supplement 1): 345.
https://doi.org/10.1182/blood-2025-345
Published: 2025
Journal Articles

Induction chemotherapy and molecular MRD influence outcomes in KMT2A -rearranged AML

Available to Purchase
Clinical Trials & Observations
Jad Othman, Nicola Potter, Sylvie D. Freeman, Nicholas McCarthy, Jelena Jovanovic, Manohursingh Runglall, Joanna Canham, Ian Thomas, Sean Johnson, Amanda Gilkes, Jamie Cavenagh, Panagiotis Kottaridis, David Taussig, Claire Arnold, Claire Hemmaway, Dominic Culligan, Ulrik Malthe Overgaard, Mike Dennis, Alan K. Burnett, Nigel H. Russell, Richard Dillon
Journal: Blood
Blood (2025) 146 (15): 1862–1867.
https://doi.org/10.1182/blood.2025029556
Published: 2025
Includes: Supplemental data
Journal Articles

Refined ELN 2024 risk stratification improves survival prognostication following venetoclax-based therapy in AML

Available to Purchase
Curtis A. Lachowiez, Vishvaas I. Ravikumar, Jad Othman, Jenny O’Nions, Daniel T. Peters, Christine McMahon, Ronan Swords, Rachel Cook, Jennifer N. Saultz, Jeffrey W. Tyner, Richard Dillon, Joshua F. Zeidner, Daniel A. Pollyea
Journal: Blood
Blood (2024) 144 (26): 2788–2792.
https://doi.org/10.1182/blood.2024026925
Published: 2024
Includes: Supplemental data
Journal Articles

Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A- rearranged acute myeloid leukemia

Free
Sun Loo, Nicola Potter, Adam Ivey, Jenny O’Nions, Roderick Moon, Jelena Jovanovic, Chun Y. Fong, Natasha S. Anstee, Ing Soo Tiong, Jad Othman, Chong Chyn Chua, Hanna Renshaw, Robert Baker, Shaun Fleming, Nigel H. Russell, David Ritchie, Ashish Bajel, Hsin-An Hou, Richard Dillon, Andrew H. Wei
Journal: Blood
Blood (2024) 144 (24): 2554–2557.
https://doi.org/10.1182/blood.2024026605
Published: 2024
Includes: Supplemental data
Journal Articles

Impact of Cytogenetics, Induction Chemotherapy and MRD on Outcomes of Intensively Treated AML with KMT2A Rearrangements - Experience from UK NCRI AML17 and AML19

Free
Jad Othman, Nicola Potter, Sylvie D Freeman, Nicholas McCarthy, Jelena Jovanovic, Manohursingh Runglall, Joanna Canham, Ian Thomas, Sean Johnson, Jamie Cavenagh, Panagiotis Kottaridis, David Taussig, Claire Arnold, Claire Hemmaway, Dominic J. Culligan, Ulrik Malthe Overgaard, Alan K. Burnett, Mike Dennis, Richard Dillon, Nigel H. Russell
Journal: Blood
Blood (2024) 144 (Supplement 1): 845.
https://doi.org/10.1182/blood-2024-201097
Published: 2024
Journal Articles

Revumenib As Pre-Emptive Therapy for Measurable Residual Disease in NPM1 mutated or KMT2A- rearranged Acute Myeloid Leukemia: A Domain of the Multi-Arm ALLG AMLM26 Intercept Platform Trial

Free
Sun Loo, Harry Iland, Ing Soo Tiong, David Westerman, Jad Othman, Paula Marlton, Chong Chyn Chua, Duncan Purtill, Hannah Rose, Shaun Fleming, Deepak Singhal, Anoop K Enjeti, William S. Stevenson, Teng Fong Ng, McCulloch Derek, Lachlin Vaughan, Robin Gasiorowski, Adam Ivey, Amanda Souza, Revati Pattani, Natasha S. Anstee, Rachel Koldej, David S. Ritchie, Sanam Loghavi, Naval Daver, Courtney D. DiNardo, Andrew W. Roberts, Carolyn S. Grove, John Reynolds, Andrew H Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 223.
https://doi.org/10.1182/blood-2024-202895
Published: 2024
Journal Articles

A Phase II Randomized Trial Comparing Low-Dose Cytarabine and Venetoclax +/- Midostaurin in Non-Adverse Cytogenetic Risk Acute Myeloid Leukemia: The ALLG AMLM25 Intervene Trial

Free
Chong Chyn Chua, Blake Hsu, Anoop K Enjeti, Ashish Bajel, Paula Marlton, Shaun Fleming, Devendra Hiwase, Chun Kei Kris Ma, Peter J. Browett, Travis Perera, Carolyn S. Grove, Shuhying Tan, Jad Othman, Julian Cooney, Hannah Rose, Edward S Morris, Rachel Koldej, David S. Ritchie, Kate Mason, Natasha S. Anstee, John Reynolds, Andrew H Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 217.
https://doi.org/10.1182/blood-2024-199882
Published: 2024
Journal Articles

Molecular, clinical, and therapeutic determinants of outcome in NPM1 -mutated AML

Free
Clinical Trials & Observations
Jad Othman, Nicola Potter, Adam Ivey, Yanis Tazi, Elli Papaemmanuil, Jelena Jovanovic, Sylvie D. Freeman, Amanda Gilkes, Rosemary Gale, Tanya Rapoz-D’Silva, Manohursingh Runglall, Michelle Kleeman, Pawan Dhami, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panagiotis Kottaridis, Claire Arnold, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Alan Burnett, Charlotte Wilhelm-Benartzi, Brian Huntly, Nigel H. Russell, Richard Dillon
Journal: Blood
Blood (2024) 144 (7): 714–728.
https://doi.org/10.1182/blood.2024024310
Published: 2024
Includes: Supplemental data
Journal Articles

Postinduction molecular MRD identifies patients with NPM1 AML who benefit from allogeneic transplant in first remission

Free
Clinical Trials & Observations Brief Report
Jad Othman, Nicola Potter, Adam Ivey, Jelena Jovanovic, Manohursingh Runglall, Sylvie D. Freeman, Amanda Gilkes, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panagiotis Kottaridis, Claire Arnold, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Alan Burnett, Charlotte Wilhelm-Benartzi, Richard Dillon, Nigel H. Russell
Journal: Blood
Blood (2024) 143 (19): 1931–1936.
https://doi.org/10.1182/blood.2023023096
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular MRD is strongly prognostic in patients with NPM1 -mutated AML receiving venetoclax-based nonintensive therapy

Free
Clinical Trials & Observations Brief Report
Jad Othman, Ing S. Tiong, Jenny O'Nions, Mike Dennis, Katya Mokretar, Adam Ivey, Michael Austin, Anne-Louise Latif, Mariam Amer, Wei Yee Chan, Charles Crawley, Francesca Crolla, Joe Cross, Ray Dang, Johnathon Elliot, Chun Y. Fong, Sofia Galli, Paolo Gallipoli, Francesca Hogan, Pallavi Kalkur, Anjum Khan, Pramila Krishnamurthy, John Laurie, Sun Loo, Scott Marshall, Priyanka Mehta, Vidhya Murthy, Sateesh Nagumantry, Srinivas Pillai, Nicola Potter, Rob Sellar, Tom Taylor, Rui Zhao, Nigel H. Russell, Andrew H. Wei, Richard Dillon
Journal: Blood
Blood (2024) 143 (4): 336–341.
https://doi.org/10.1182/blood.2023021579
Published: 2024
Includes: Supplemental data
Journal Articles

Interaction between Presenting Features, Co-Occurring Mutations, MRD and Induction Treatment Influences Outcome in Adults with NPM1 Mutated AML - an Analysis of 1357 Patients in the UK NCRI AML17 and AML19 Studies

Free
Jad Othman, Nicola Potter, Adam Ivey, Yanis Tazi, Elli Papaemmanuil, Jelena Jovanovic, Sylvie D Freeman, Amanda Gilkes, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panos Kottaridis, Claire Arnold, Ulrik Malthe Overgaard, Mike Dennis, Charlotte Wilhelm-Benartzi, Brian Huntly, Alan K. Burnett, Richard Dillon, Nigel Russell
Journal: Blood
Blood (2023) 142 (Supplement 1): 2939.
https://doi.org/10.1182/blood-2023-179036
Published: 2023