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Gene transfer and genome editing of T cells for cancer immunotherapy: from allogeneic HSCT to TCR gene editing
Learning Objectives
- Identify the major challenges for adoptive T-cell therapy to treat cancer, and how gene transfer and genome editing can cope with each of these challenges
- Identify pros and cons of genome editing tools currently used to engineer the genome of T cells
Cryptogenic stroke: definitions and management
Learning Objectives
- Apply diagnostic criteria for cryptogenic ischemic stroke and embolic stroke of undetermined source
- Apply data from randomized controlled trials to optimize secondary stroke prevention in patients with cryptogenic ischemic stroke and embolic stroke of undetermined source
Managing patients with a history of arterial disease and new venous thromboembolism
Learning Objectives
- Understand the incidence and risk factors for VTE in patients with arterial disease
- Select and modify antithrombotic therapy in acute and chronic arterial disease
- Balance thrombosis and bleeding risk using scoring systems and evidence from combination-therapy trials
