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Journal Articles

Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients

Alastair Smith, Nicholas David Robert Denny, Catherine Chahrour, Kim Sharp, Marta Arachi, Ana Maria Dopico-Fernandez, Natalina Elliott, Joe Harman, Thomas Jackson, Huimin Geng, Owen Smith, Professor, Jonathan Bond, Irene Roberts, Ronald W. W. Stam, Nicholas Crump, James Davies, Anindita Roy, Thomas A Milne

Blood blood.2024028019.

https://doi.org/10.1182/blood.2024028019

Published: 2025

Includes: Supplemental data

Journal Articles

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells

Blood blood.2024025536.

https://doi.org/10.1182/blood.2024025536

Published: 2025

Includes: Supplemental data

Journal Articles

PKCδ-Mediated Phosphorylation of CD25 Initiates Feedback Control of Oncogenic Tyrosine Kinases in Acute Lymphoblastic Leukemia

Ruifeng Sun, Jaewoong Lee, Dewan Artadji, Mark E Robinson, Kohei Kume, Zhangliang Cheng, Kadriye Nehir Cosgun, Lai N Chan, Etienne Leveille, Ning Ma, Huimin Geng, Elisabeth Paietta, Nagarajan Vaidehi, Markus Müschen

Blood (2024) 144 (Supplement 1): 632.

https://doi.org/10.1182/blood-2024-211038

Published: 2024

Journal Articles

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

Venkata Sesha Sai Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Loftus, Sung June Lee, Anil Kumar, Srividya Swaminathan, Rahul S Bhansali, Wayne Childers, Huimin Geng, Thomas A Milne, Xianxin Hua, Kathrin M. Bernt, Thierry Besson, Junwei Shi, John D. Crispino, Martin P Carroll, Sarah K. Tasian, Christian Hurtz

Blood (2024) 144 (Supplement 1): 1455.

https://doi.org/10.1182/blood-2024-206134

Published: 2024

Journal Articles

Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma

Michael P Randall, Huimin Geng, Lingjing Chen, Aishwarya Ballapuram, Chitoh Yung, Ming Lu, Gregory Chin, Michael Mish, Jamie Bates, James L. Rubenstein

Blood (2024) 144 (Supplement 1): 978.

https://doi.org/10.1182/blood-2024-212194

Published: 2024

Journal Articles

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

Alastair L Smith, Nicholas Denny, Catherine M Chahrour, Natalina Elliott, Thomas Jackson, Joe Harman, Huimin Geng, Irene Roberts, Nicholas Crump, James Oliver Davies, Anindita Roy, Thomas A Milne

Blood (2024) 144 (Supplement 1): 201.

https://doi.org/10.1182/blood-2024-208035

Published: 2024

Journal Articles

CD48: Friend or Foe in NK-Cell Immunosurveillance of Multiple Myeloma?

Bonell Patiño-Escobar, Lucy Perez-Lugo, Huimin Geng, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, Oscar A Aguilar, Arun P Wiita

Blood (2024) 144 (Supplement 1): 4646.

https://doi.org/10.1182/blood-2024-206465

Published: 2024

Journal Articles

BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models

Jun Ma, Michael P Randall, Ming Lu, Lingjing Chen, Huimin Geng, Aishwarya Kumar, Saloni Malla, Mark Noviski, Ryan Rountree, James L. Rubenstein

Blood (2024) 144 (Supplement 1): 2988.

https://doi.org/10.1182/blood-2024-211266

Published: 2024

Journal Articles

Inhibiting Free Fatty Acid Transport to Improve CAR-T Cell Therapy of Relapsed B-Cell Acute Lymphoblastic Leukemia

Clarissa Garcia, Kaylyn Lyons, Tian Liu, Ilaria Iacobucci, Amanda Novak, Amy Argabright, Alexis Donnelly, Julian Grandvallet Contreras, Huimin Geng, Sabrina Smith, Xin Zhou, Markus Müschen, John Edgar Dick, Julie R Haines, Angelo D'Alessandro, Charles G. Mullighan, Tzu Phang, M. Eric Kohler, Matthew Witkowski

Blood (2024) 144 (Supplement 1): 1446.

https://doi.org/10.1182/blood-2024-201015

Published: 2024

Journal Articles

Targeting the SWI/SNF Chromatin Remodeling Complex Subunit SMARCA4 in ALL

Venkata Sesha Sai Abhinav Ayyadevara, Ashley Paik, Ria Perencsik, Monika Toma, Tomasz Skorski, Rozbeh Jafari, Gerald Wertheim, Huimin Geng, Christian Hurtz

Blood (2024) 144 (Supplement 1): 4216.

https://doi.org/10.1182/blood-2024-205936

Published: 2024

Journal Articles

Trial in Progress: A Phase I/II Study of Tafasitamab Plus Lenalidomide in Patients with Relapsed CNS Lymphoma

Michael P Randall, Andreas Rauschecker, Liam Gima-Lange, Jenai Wilmoth, Lingjing Chen, Ming Lu, Huimin Geng, Haifaa Abdulhaq, James L. Rubenstein

Blood (2023) 142 (Supplement 1): 3104.

https://doi.org/10.1182/blood-2023-190698

Published: 2023

Journal Articles

Affinity Matured CD72 CAR-T Improves Efficacy Versus Low Antigen Density B-Cell Non-Hodgkin Lymphoma Models

Adila Izgutdina, William C Temple, Matthew Andrew Nix, Huimin Geng, Emilio Ramos, Akul Naik, Rebecca Larson, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Ons Zakraoui, Isa Tariq, Marcela V Maus, Veronica Steri, Arun P Wiita

Blood (2023) 142 (Supplement 1): 2068.

https://doi.org/10.1182/blood-2023-182873

Published: 2023

Journal Articles

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Blood (2023) 142 (Supplement 1): 465.

https://doi.org/10.1182/blood-2023-182578

Published: 2023

Journal Articles

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Blood (2022) 140 (Supplement 1): 1698–1699.

https://doi.org/10.1182/blood-2022-170324

Published: 2022

Journal Articles

BCL6-Mediated Escape from Negative Selection Enables RAS-Driven B-Cell Transformation

Lai N. Chan, Christian Hurtz, Mark E. Robinson, Etienne Leveille, Huimin Geng, Rebecca Caeser, Liang Xu, Kohei Kume, Gang Xiao, Markus Müschen

Blood (2022) 140 (Supplement 1): 9177–9178.

https://doi.org/10.1182/blood-2022-169946

Published: 2022

Journal Articles

Next-Generation Sequencing of Newly-Diagnosed Primary CNS Lymphoma Reveals Alterations in BTG1, ETV6, and 6p Are Associated with Chemoresistance and Inferior Progression-Free Survival

Shirley S. Mo, Huimin Geng, Miguel Cerejo, Kwun Wah Wen, David A. Solomon, James L. Rubenstein

Blood (2022) 140 (Supplement 1): 3516–3517.

https://doi.org/10.1182/blood-2022-170569

Published: 2022

Journal Articles

Structural Elements of the BCR Determine Permissiveness to Oncogenic RAS-Driven B-Cell Transformation

Lai N. Chan, Mark E. Robinson, Kadriye Nehir Cosgun, Xiaohui Yu, Etienne Leveille, Huimin Geng, Markus Müschen

Blood (2022) 140 (Supplement 1): 8758–8759.

https://doi.org/10.1182/blood-2022-170079

Published: 2022

Journal Articles

Functional Multi-Omics Reveals Genetic and Pharmacologic Regulation of Surface CD38 in Multiple Myeloma

Priya Choudhry, Olivia Gugliemini, Huimin Geng, Vishesh Sarin, Letitia Sarah, Yu-Hsiu T. Lin, Neha Paranjape, Poornima Ramkumar, Makeba Marcoulis, Donghui Wang, Paul Phojanakong, Veronica Steri, Byron Hann, Martin Kampmann, Arun P Wiita

Blood (2021) 138 (Supplement 1): 2648.

https://doi.org/10.1182/blood-2021-147007

Published: 2021

Journal Articles

Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid Malignancies

Jaewoong Lee, Mark E. Robinson, Ning Ma, Kohei Kume, Dewan Artadji, Teresa Sadras, Kadriye Nehir Cosgun, Huimin Geng, Elisabeth M. Paietta, Maike Buchner, Nagarajan Vaidehi, David M. Weinstock, Markus Müschen

Blood (2021) 138 (Supplement 1): 355.

https://doi.org/10.1182/blood-2021-149189

Published: 2021

Journal Articles

BTG1 Mutation Promotes Aggressive Lymphoma Development By Lowering the Threshold to MYC Activation and Generating "Super-Competitor" B Cells

Blood (2021) 138 (Supplement 1): 359.

https://doi.org/10.1182/blood-2021-149921

Published: 2021

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Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells

PKCδ-Mediated Phosphorylation of CD25 Initiates Feedback Control of Oncogenic Tyrosine Kinases in Acute Lymphoblastic Leukemia

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

CD48: Friend or Foe in NK-Cell Immunosurveillance of Multiple Myeloma?

BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models

Inhibiting Free Fatty Acid Transport to Improve CAR-T Cell Therapy of Relapsed B-Cell Acute Lymphoblastic Leukemia

Targeting the SWI/SNF Chromatin Remodeling Complex Subunit SMARCA4 in ALL

Trial in Progress: A Phase I/II Study of Tafasitamab Plus Lenalidomide in Patients with Relapsed CNS Lymphoma

Affinity Matured CD72 CAR-T Improves Efficacy Versus Low Antigen Density B-Cell Non-Hodgkin Lymphoma Models

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

BCL6-Mediated Escape from Negative Selection Enables RAS-Driven B-Cell Transformation

Next-Generation Sequencing of Newly-Diagnosed Primary CNS Lymphoma Reveals Alterations in BTG1, ETV6, and 6p Are Associated with Chemoresistance and Inferior Progression-Free Survival

Structural Elements of the BCR Determine Permissiveness to Oncogenic RAS-Driven B-Cell Transformation

Functional Multi-Omics Reveals Genetic and Pharmacologic Regulation of Surface CD38 in Multiple Myeloma

Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid Malignancies

BTG1 Mutation Promotes Aggressive Lymphoma Development By Lowering the Threshold to MYC Activation and Generating "Super-Competitor" B Cells

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