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Journal Articles

Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells and averts lupus nephritis

Kory Hamane, Zunsong Hu, Joao Rodrigues Lima-Junior, Adeleh Taghi Khani, Anil Kumar, Ashly Sanchez Ortiz, Da Hae Jung, Hanjun Qin, Shu Tao, Ignacio Sanz, Eric Meffre, Katherine Marzan, Jean Koff, Zhaohui Gu, Xiwei Wu, Ameae Walker, Srividya Swaminathan

Blood (2025) 146 (Supplement 1): 3003.

https://doi.org/10.1182/blood-2025-3003

Published: 2025

Journal Articles

Tumor-induced dendritic cell dysfunction impairs T-cell proliferation and confers poor prognosis in high-risk acute lymphoblastic leukemia

Blood (2025) 146 (Supplement 1): 5138.

https://doi.org/10.1182/blood-2025-5138

Published: 2025

Journal Articles

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

Venkata Sesha Sai Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Loftus, Sung June Lee, Anil Kumar, Srividya Swaminathan, Rahul S Bhansali, Wayne Childers, Huimin Geng, Thomas A Milne, Xianxin Hua, Kathrin M. Bernt, Thierry Besson, Junwei Shi, John D. Crispino, Martin P Carroll, Sarah K. Tasian, Christian Hurtz

Blood (2024) 144 (Supplement 1): 1455.

https://doi.org/10.1182/blood-2024-206134

Published: 2024

Journal Articles

The NK Cell Receptor NKp46 Acts As an Essential Regulator of ILC1 Proliferation, Effector Function and Anti-AML Activity

Rui Ma, Zhenlong Li, Hejun Tang, Lei Tian, Zahir Shah, Tasha Barr, Amy Peng, Jianying Zhang, Srividya Swaminathan, Michael A Caligiuri, Jianhua Yu

Blood (2023) 142 (Supplement 1): 3925.

https://doi.org/10.1182/blood-2023-191070

Published: 2023

Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

V. S. S. Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll, Christian Hurtz

Blood (2022) 140 (Supplement 1): 3486–3488.

https://doi.org/10.1182/blood-2022-162782

Published: 2022

Journal Articles

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Blood (2022) 140 (Supplement 1): 2975–2977.

https://doi.org/10.1182/blood-2022-162619

Published: 2022

Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Christian Hurtz, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll

Blood (2021) 138 (Supplement 1): 506.

https://doi.org/10.1182/blood-2021-144476

Published: 2021

Journal Articles

Suppressing Synthesis of the Long Isoform of the Prolactin Receptor Is a Targeted Strategy to Prevent and Treat B Cell Malignancies

Adeleh Taghi Khani, Anil Kumar, Kelly Radecki, Sung June Lee, Mary Lorenson, Xiwei Wu, Zhaohui Gu, Ameae Walker, Srividya Swaminathan

Blood (2021) 138 (Supplement 1): 1135.

https://doi.org/10.1182/blood-2021-147055

Published: 2021

Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan

Blood (2021) 138 (16): 1465–1480.

https://doi.org/10.1182/blood.2020009871

Published: 2021

Includes: Supplemental data

Journal Articles

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Martin P. Carroll, MD, Sarah K Tasian, MD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, MDPhD, Sung June Lee, BA, Anil Kumar, PhD, Anne Lehman, Joseph Patrick Loftus, BS, Grace Jeschke, PhD, John D. Crispino, PhD, Thierry Besson, PhD, Junwei Shi, PhD, Srividya Swaminathan, PhD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-141258

Published: 2020

Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD

Blood (2020) 136 (Supplement 1): 39.

https://doi.org/10.1182/blood-2020-140044

Published: 2020

Journal Articles

MYC Oncogene Abrogates Natural Killer (NK) Cell-Mediated Immune Surveillance of B- and T- Lymphoid Malignancies By Suppressing STAT1/2-Type I IFN Signaling

Srividya Swaminathan, PhD, Line Dam Heftdal, MD, Daniel Liefwalker, PhD, Renumathy Dhanasekaran, MD, Anja Deutzmann, PhD, Crista Horton, BS, Adriane Mosley, BS, Mariola Liebersbach, BS, Andrew Gentles, PhD, Holden T. Maecker, PhD, Dean Felsher, MD PhD

Blood (2019) 134 (Supplement_1): 730.

https://doi.org/10.1182/blood-2019-122607

Published: 2019

Journal Articles

MYC Functions As a Master Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid Malignancies

Srividya Swaminathan, PhD, Line Dam Heftdal, MS, Daniel F Liefwalker, PhD, Renumathy Dhanasekaran, MD, Anja Deutzmann, PhD, Crista Horton, BS, Adriane Mosley, BS, Mariola Liebersbach, BS, Holden T. Maecker, PhD, Dean Felsher, MD PhD

Blood (2018) 132 (Supplement 1): 2619.

https://doi.org/10.1182/blood-2018-99-110472

Published: 2018

Journal Articles

Exposure to Inflammatory Immune Responses As Driver of Clonal Evolution in Childhood Acute Lymphoblastic Leukemia

Lars Klemm, BSc, MSc, Srividya Swaminathan, DPhil, Elli Papaemmanuil, PhD, Anthony M Ford, Mel Greaves, Rafael Casellas, David Schatz, Michael R. Lieber, MDPhD, Markus Muschen, MD PhD

Blood (2015) 126 (23): 166.

https://doi.org/10.1182/blood.V126.23.166.166

Published: 2015

Journal Articles

BACH2 promotes Lineage-Specific Fate Decisions in BCR-ABL1 -Driven Leukemia

Eugene Park, Srividya Swaminathan, PhD, Mohammed Firas Sadiyah, PhD, Kazuhiko Igarashi, PhD, Ari Melnick, MD, Markus Muschen, MDPhD

Blood (2014) 124 (21): 513.

https://doi.org/10.1182/blood.V124.21.513.513

Published: 2014

Journal Articles

Mechanisms of Clonal Evolution of Pre-Leukemic Clones in Childhood Pre-B Acute Lymphoblastic Leukemia

Srividya Swaminathan, PhD, Lars Klemm, Eugene Park, Anthony M Ford, PhD, Soo-mi Kweon, PhD, Daniel Trageser, Brian Hasselfeld, Nadine Henke, Huimin Geng, PhD, Klaus Schwarz, MD, Rafael Casellas, David G. Schatz, PhD, Michael R Lieber, MD PhD, Elli Papaemmanuil, PhD, Mel Greaves, PhD, Markus Muschen, MD PhD

Blood (2014) 124 (21): 861.

https://doi.org/10.1182/blood.V124.21.861.861

Published: 2014

Journal Articles

The Linker Protein GAS7 Negatively Regulates Pre-B Cell Differentiation and Amplifies Proliferation and Survival Signals in Acute Lymphoblastic Leukemia

Jae-Woong Lee, PhD, Maike Buchner, PhD, Huimin Geng, PhD, Srividya Swaminathan, PhD, Eugene Park, Angela Park, Sue Lin-Chao, Chi Wai So, Markus Muschen, MD PhD

Blood (2014) 124 (21): 3777.

https://doi.org/10.1182/blood.V124.21.3777.3777

Published: 2014

Journal Articles

Gas7 Induces The Proliferation Of Ph + ALL Cells and Prevents The Differentiation Of Early B Cell Progenitors Into CD25 high Small Pre-B Cells

Jaewoong Lee, PhD, Maike Buchner, PhD, Huimin Geng, PhD, Srividya Swaminathan, PhD, Eugene Park, Lars Klemm, Sue Lin-Chao, Chi Wai So, Markus Muschen, MD, PhD

Blood (2013) 122 (21): 2506.

https://doi.org/10.1182/blood.V122.21.2506.2506

Published: 2013

Journal Articles

The Plasma Cell Transcription Factor XBP1 is Required To Mitigate The Unfolded Protein Response In Ph + ALL

Behzad Kharabi Masouleh, MD, Huimin Geng, PhD, Christian Hurtz, PhD, Chuanxin Huang, PhD, Lai N. Chan, PhD, Srividya Swaminathan, PhD, Haibo Sun, PhD, H. Phillip Koeffler, MD, Ari Melnick, MD, Elisabeth Paietta, PhD, Laurie H. Glimcher, MD, Markus Muschen, MD, PhD

Blood (2013) 122 (21): 836.

https://doi.org/10.1182/blood.V122.21.836.836

Published: 2013

Journal Articles

Cooperation Between Aid and the Rag1/Rag2 V(D)J Recombinase Drives Clonal Evolution of Childhood Acute Lymphoblastic Leukemia

Srividya Swaminathan, B Tech, Lars Klemm, MSc, Anthony M. Ford, PhD, Klaus Schwarz, MD, Rafael Casellas, Lothar Hennighausen, Huimin Geng, PhD, David G. Schatz, Michael R. Lieber, MD, PhD, Mel Greaves, MD, PhD, Markus Muschen, MD

Blood (2012) 120 (21): 519.

https://doi.org/10.1182/blood.V120.21.519.519

Published: 2012

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Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells and averts lupus nephritis

Tumor-induced dendritic cell dysfunction impairs T-cell proliferation and confers poor prognosis in high-risk acute lymphoblastic leukemia

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

The NK Cell Receptor NKp46 Acts As an Essential Regulator of ILC1 Proliferation, Effector Function and Anti-AML Activity

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Suppressing Synthesis of the Long Isoform of the Prolactin Receptor Is a Targeted Strategy to Prevent and Treat B Cell Malignancies

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

MYC Oncogene Abrogates Natural Killer (NK) Cell-Mediated Immune Surveillance of B- and T- Lymphoid Malignancies By Suppressing STAT1/2-Type I IFN Signaling

MYC Functions As a Master Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid Malignancies

Exposure to Inflammatory Immune Responses As Driver of Clonal Evolution in Childhood Acute Lymphoblastic Leukemia

BACH2 promotes Lineage-Specific Fate Decisions in BCR-ABL1 -Driven Leukemia

Mechanisms of Clonal Evolution of Pre-Leukemic Clones in Childhood Pre-B Acute Lymphoblastic Leukemia

The Linker Protein GAS7 Negatively Regulates Pre-B Cell Differentiation and Amplifies Proliferation and Survival Signals in Acute Lymphoblastic Leukemia

Gas7 Induces The Proliferation Of Ph + ALL Cells and Prevents The Differentiation Of Early B Cell Progenitors Into CD25 high Small Pre-B Cells

The Plasma Cell Transcription Factor XBP1 is Required To Mitigate The Unfolded Protein Response In Ph + ALL

Cooperation Between Aid and the Rag1/Rag2 V(D)J Recombinase Drives Clonal Evolution of Childhood Acute Lymphoblastic Leukemia

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