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First Edition

Research Article July 23 2025
α-Ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development
Carine Jaafar,Purushoth Ethiraj,Zhijun Qiu,An-Ping Lin,Pedro Simonis Seabra Martins Ferrari,Ricardo Aguiar
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Research Article July 23 2025
Preclinical characterization of TGRX-678, a brain-penetrant allosteric inhibitor of BCR::ABL1
Yanxia Shi,Qian Jiang,Linxin Li,Yingying Zuo,Shuzhen Jiang,Tingting Yan,Cuifang Zheng,Shuo Zhang,Nannan Yu,Jingrong Cao,Yun Liu,Yixin Ai,Yihan Wang
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Research Article July 23 2025
Fusion Oncoproteins and Cooperating Mutations Define Disease Phenotypes in NUP98-Rearranged Leukemia
Masayuki Umeda,Ryan Lea Hiltenbrand,Nicole L Michmerhuizen,Juan M Barajas,Melvin E Thomas, III,Bright Arthur,Michael P Walsh,Guangchun Song,Jing J. Ma,Tamara Westover,Amit Kumar,Petri Pölönen,Cristina Mecucci,Danika Di Giacomo,Franco Locatelli,Riccardo Masetti,Salvatore Nicola Bertuccio,Martina Pigazzi,Shondra M Pruett-Miller,Stanley B Pounds,Jeffrey Rubnitz,Hiroto Inaba,Kyriakos P Papadopoulos,Michael J Wick,Ilaria Iacobucci,Charles G. Mullighan,Jeffery M Klco
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Research Article July 18 2025
The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy
Heike C. Hawerkamp,Aoife Yeow,Ciara Byrne,Anne Chevalier,Laura Matarazzo,Alexander George Lawrence,Daniel Ivers,Tatenda Murangi,Niamh Helen O'Dowd,Anne-Marije Hulshof,Ferdows Atiq,Jamie M O'Sullivan,Vincent Patrick Kelly,Conor M Finlay,Henry McSorley,Bagirath M Gangadharan,Birgit M Reipert,James O'Donnell,Peter L Turecek,Padraic G. Fallon
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Research Article July 18 2025
­­­RGI-2001 for the Prophylaxis of Acute Graft-Versus-Host Disease Following Allogeneic HCT
Zachariah DeFilipp,Hannah K Choe,Yvonne A. Efebera,Ayman Saad,Shatha Farhan,Lazaros J. Lekakis,Jean A. Yared,Gary J. Schiller,Markus Y Mapara,Amer Assal,Ted A Gooley,Jack D Bui,Dana D Lee,Hayley Lane,Yi-Bin Chen
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Research Article July 15 2025
Clinical presentation, management, and outcome of TIAN in CNS lymphoma treated with CD19-CAR T-cell Therapy
Leon D. Kaulen,Maria Martinez-Lage,Jeremy S. Abramson,Philipp Karschnia,Sofia Doubrovinskaia,Ganesh M. Shankar,Bryan D. Choi,Christopher Michael Ramundo,Felix Ehret,Jeffrey A. Barnes,Areej El-Jawahri,Ephraim Hochberg,P. Connor Johnson,Jacob D Soumerai,Scott R. Plotkin,Tracy T Batchelor,Wolfgang Wick,Marcela V. Maus,Yi-Bin Chen,Matthew J. Frigault,Jorg Dietrich
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Research Article July 15 2025
Factor IXa and Factor X Influence Factor VIIIa Stability and Inactivation Mechanisms In Vitro and In Vivo
Johnathan J. Morris,Nicole A. Parsons,Amelia R. Wilhelm,Robert J Davidson,Lauren K. Olenick,Connor T. Watson,Andrew R. Vanden Heuvel,Lindsey A. George
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Review Article July 15 2025
Visualizing amyloidosis: The role of radionuclide imaging in systemic amyloidosis
Nirija Ranjit Anderson,Sharmila Dorbala,Peter Mollee
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Research Article July 15 2025
The acute myeloid leukemia microenvironment impairs neutrophil maturation and function through NFκB signaling
Paran Goel,Sajesan Aryal,Alana M. Franceski,Valeriya Kuznetsova,Amanda Fernandes De Oliveira Costa,Francesca Luca,Ashley N Connelly,Daniel W Phillips,Caroline C Ennis,Brittany M. Curtiss,Sourajeet Karfa,Brittany L Crown,Christina R Larson,Estelle Carminita,Virginia Camacho,Doug Welsch,Changde Cheng,Asumi Yokota,Isidoro Cobo,Hideyo Hirai,Rui Lu,Ravi Bhatia,Pran K Datta,Paul Brent Ferrell, Jr.,Robert S. Welner
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Review Article July 15 2025
The Treatment of Marginal Zone Lymphoma
Juan Pablo Alderuccio,Ariela Noy
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Research Article July 15 2025
Real-world outcomes of patients with aggressive B-cell lymphoma treated with epcoritamab or glofitamab
Taylor R Brooks,Emily C Zabor,Yohanna Bedelu,Xi Yang, MD,Yasmin H. Karimi,Adrienne N Nedved,Yucai Wang,Nikita K Dave,Daniel J. Landsburg,Kelsey Baron,Boyu Hu,Daniel Trotier,Priyanka A Pophali,Jordan Miller, PharmD,Natalie S. Grover,Catherine Reinert,Ajay Major,Tenley Schwarz,Krish Patel,Kiarash Salafian, MD,Emily C. Ayers,Suchitra Sundaram,Joshua D. Brody,Marshall McKenna,Yun Kyoung Ryu Tiger,Megan Sears-Smith,Nilanjan Ghosh,Chelsea Peterson, DO,Cyrus Khan,Sean P Bliven, MD,Mayur Narkhede,Alyssa Gibson,Justin Kline,Javier Munoz,Rodolfo Garza Morales,Carrie Ho,Stephen D Smith,Alex Niu, MD,Francisco J. Hernandez-Ilizaliturri,Fadzai Chinyengetere, MDPhD,Sandeep S. Dave,Nayef Abdel-Razeq,Muhamad Alhaj Moustafa,Paolo Caimi,Brian T. Hill
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Brief Report July 15 2025
A New Prognostic Index (CLIPI) for Advanced Cutaneous Lymphoma Enables Precise Patient Risk Stratification
Julia J Scarisbrick,Pietro Quaglino,Sean J Whittaker,Martine Bagot,Emmanuella Guenova,Evangelia Papadavid,H. Miles Prince,Jose Antonio Sanches,Denis Miyashiro,Octavio Servitje,Christiane Querfeld,Oleg E Akilov,Arvind Arumainathan,Luke Bennett,Maxime Battistella,Kim Benstead, Dr,Emilio francesco Berti,Marie Beylot-Barry,Anne-Marie Busschots,Richard Andrew Cowan,Reinhard Dummer,Giles Dunnill,Maria Teresa Estrach,Felicity Evison,Abraham Ellahi Bashir,Larisa J Geskin,Alejandro Gru,Joan Guitart,Melba C Herrera,Emmilia Hodak,Steven M Horwitz,Constanze Jonak,Claus-Detlev Klemke,Robert Knobler,Pamela McKay,Marta Marschalkó,Cesare Massone,Rubeta Matin,Christina Mitteldorf,Roberto Andres Novoa,Pablo L. Ortiz-Romero,Nicola Pimpinelli,Ramon M Pujol,Annmari Ranki,Liisa Vankeva,Kerri E. Rieger,Rudolf Stadler,Franz Trautinger,Johanna Latzka,Maarten H. Vermeer,Rachel Wachsmuth,Sophie Weatherhead,Ulrike Wehkamp,Marion Wobser,Youn H Kim
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Research Article July 15 2025
A novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variants
Sophie Hordijk,Stijn A. Groten,Petra E. Bürgisser,Sebastiaan N.J. Laan,Georg-Christoph Korenke,Tomáš Honzík,Diane Beysen,Frank W.G. Leebeek,Paul A. Skehel,Maartje van den Biggelaar,Tom Carter,Ruben Bierings
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Review Article July 11 2025
How I Treat Pediatric Pulmonary Embolism
Ayesha Zia,Neil A Goldenberg,Madhvi Rajpurkar
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Research Article July 11 2025
Profiling the spatial architecture of multiple myeloma in human bone marrow trephine biopsy specimens with spatial transcriptomics
Raymond K.H. Yip,Jeremy Er,Lei Qin,Quoc Hoang Nguyen,Allan Motyer,Joel S Rimes,Amanda Light,Ruvimbo D Mishi,Ling Ling,Casey J.A. Anttila,Ellen Tsui,Daniela Amann-Zalcenstein,Mark R Dowling,Kelly L. Rogers,Rory Bowden,Yunshun Chen,Simon J Harrison,Edwin D Hawkins
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Research Article July 10 2025
Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis
Pengfei Xu,Xiuli Zhang,Donghe Li,Bo Jiao,Jiawei Nie,Yi Huang,Zhizhou Xia,Jiaoyang Li,Yuqing Dan,Xu Huang,Lei Yan,Rui Zhang,Wei Huang,Xinru Wang,Shiyu Ji,Yong Cang,Ruibao Ren,Ping Liu
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Research Article July 10 2025
Thrombocytopenia in myelofibrosis is characterized by inflammatory megakaryocytes with reduced G6B expression
Lilian Varricchio,Gohar Mosoyan,Sebastian El Ghaity-Beckley,Md. Babu Mia,Shivani Handa,Christian Salib,John O. Mascarenhas,Ronald Hoffman
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Research Article July 10 2025
Matched donor allogeneic CAR-T for adult B-ALL: toxicity, efficacy, repeat dosing, and the importance of lymphodepletion
Claire Roddie,Juliana Dias,Maeve O'Reilly,Mahnaz Abbasian,Amaia Cadinanos-Garai,Ketki Vispute,Leticia Bosshard-Carter,Marina Mitsikakou,Eftychia Charalambous,Vedika Mehra,Harriet Roddy,Gordon Weng-Kit Cheung,John A. Hartley,Nasir Galal Mahmoud,Leah Ensell,Yashma Patel,Maria A. V. Marzolini,Farzin Farzaneh,Lauren Nickolay,Nourredine Himoudi,Farhatullah Syed,Bilyana Popova,Sevasti Galani,Alexander Day,Mark W Lowdell,Karl S Peggs
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Review Article July 10 2025
Structure and interactions of the proteins from the contact system
Jonas Emsley,Yujie Ma,Joost C.M. Meijers
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Research Article July 10 2025
Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens
Leonie Rieger,Kilian Irlinger,Franziska Füchsl,Marlene Tietje,Anna Purcarea,Nicolas Mathis Barbian,Melanie Faber,Carolin Vogelsang,Lisa Pfeuffer,Sonja Stotz,Oleksandra Karpiuk,Tobias Schulze,Abirami Augsburger,Nadine Glaisner,Verena Konetzki,Sabrina Friedel,Andrej Besse,Lenka Besse,Christoph Driessen,Maike Buchner,Kristina Schwamborn,Katja Steiger,Piero Giansanti,Sebastian Theurich,Johannes M. Waldschmidt,Klaus Martin Kortüm,Michael Hudecek,Hermann Einsele,Marion Högner,Bernhard Kuster,Angela Krackhardt,Judith S. Hecker,Florian Bassermann
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Research Article July 10 2025
A noncoding mutation in the NOTCH1 gene initiates oncogenic NOTCH signaling via wild-type NICD stabilization in CLL
Min Guo,Tugba Memis,Alena Sophie Ehrmann,Anselm Pittrof,Bernd Baumann,Francesca Ferrante,Eugen Tausch,Kirsten Fischer,Hartmut Döhner,Tilman Borggrefe,Stephan Stilgenbauer,Ulrich Pannicke,Klaus Schwarz,Daniel Mertens,Franz Oswald
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Review Article July 7 2025
Immune Alterations in Myeloma Evolution and Outcomes: Quo Vadis?
Madhav V. Dhodapkar,Bruno Paiva
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Research Article July 3 2025
Marstacimab Prophylaxis in Hemophilia A/B Without Inhibitors: Results from the Phase 3 BASIS Trial
Davide Matino,Andrew Palladino,Carrie Turich Taylor,Eunhee Hwang,Sangeeta Raje,Satyaprakash Nayak,Regina McDonald,Suchitra Acharya,Johnny Mahlangu,Victor Jiménez-Yuste,Nirmalkumar G Choraria, Dr.,Renchi Yang,Chi-kong Li,Murtadha Al-Khabori,Yasser Ahmed Mohamed Soliman Wali,Javier De Jesus Morales-Adrian,Young-Shil Park,Osman Bülent Zülfikar,John Teeter
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Review Article July 3 2025
Deciphering the dynamics of histone acetylation and chromatin remodeling in multiple myeloma: a tale beyond the tails
Sinan Xiong,Jianbiao Zhou,Wee Joo Chng
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Research Article July 3 2025
Restoring p53 wild-type conformation in TP53-Y220C-mutant acute myeloid leukemia
Bing Z Carter,Po Yee Mak,Edward Ayoub,Xiaogang Wu,Baozhen Ke,Yuki Nishida,Andrew Futreal,Lauren B Ostermann,Andrea D Bedoy,Steffen Boettcher,Courtney D. DiNardo,Anna Puzio-Kuter,Masha V Poyurovsky,Arnold J. Levine,Michael Andreeff
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Research Article June 26 2025
Association of Epstein-Barr virus genomic alterations with human pathologies
Htet Thiri Khine,Yoshitaka Sato,Motoharu Hamada,Miki Umeda,Akira Iizuka,Shika Son,Haruto Arai,Yuki Kojima,Takahiro Watanabe,Azumi Naruse,Kimitoshi Goto,Koichi Ohshima,Yuta Akutsu,Masato Nakaguro,Akira Satou,Hiromi Kataoka,Yoshinori Ito,Akihisa Sawada,Seiichi Kato,Jun-ichi Kawada,Takayuki Murata,Yusuke Okuno,Hiroshi Kimura
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Brief Report June 25 2025
Clinical and molecular features of immunodeficiency in patients with telomere biology disorders
Luiz Fernando B. Catto,Nidhi Aggarwal,Ruba N Shalhoub,Xiaoyang Ma,Ivana Darden,Tania Machado,Yue Zhang,Neelam Redekar,Natthakan Thongon,Simona Colla,Geraldine Aubert,Cynthia E. Dunbar,Colin O. Wu,Neal S. Young,Bhavisha A. Patel,Fernanda Gutierrez-Rodrigues,Emma M Groarke
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Review Article June 25 2025
Inflammatory Memory of Stem Cells: Implications for Hematological Diseases
Dongchang Zhao,Pavan Reddy
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Research Article June 25 2025
Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome
Natalina Elliott,Neha Bhatnagar,Gemma Buck,David Cruz Hernandez,Kelly Perkins,Adam J. de Smith,Amélie Chaussade,Nizery Laure,Marlen Metzner,Garnett Catherine,Alice Norton,Kennedy Alison,Triya Chakravorty,Dylan Zhao,Lars Hanssen,Georgina W. Hall,Paresh Vyas,Irene Roberts
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Research Article June 25 2025
Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML
Aristi Damaskou,Rachael Wilson,Malgorzata Gozdecka,George Giotopoulos,Ryan Asby,Maria Eleftheriou,Muxin Gu,Christian Récher,Véronique Mansat- De Mas,Francois Vergez,Ambrine Sahal,Binje Vick,Evangelia K Papachristou,Ashley Sawle,Eliza Yankova,Monika Dudek,Xiaoxuan Liu,James Russell,Justyna Rak,Christine Hilcenko,Clive S D'Santos,Irmela Jeremias,Jean-Emmanuel Sarry,Konstantinos Tzelepis,Brian JP Huntly,Alan J Warren,Omid Tavana,George S Vassiliou
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Research Article June 25 2025
Deciphering opsonized zymosan-induced phosphorylation of p47phox and NADPH oxidase activation in human neutrophils
Jie Liu,Coralie Pintard,Nathalie Thieblemont,Pham My-Chan Dang,Jamel El Benna
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Research Article June 25 2025
IPSS-M risk and specific sex-associated somatic mutations predict response to ESA therapy in LR-MDS: building a new score
Marco Gabriele Raddi,Sophie Park,Michaela Fontenay,Olivier Kosmider,María Díez-Campelo,Juan Carlos Caballero Berrocal,Marie Sébert,Lionel Adès,Uwe Platzbecker,Matteo G Della Porta,Giorgio Mattiuz,Sven Julien Maria De Pourcq,Lorenzo Tofani,Giulia Maggioni,Elena Tofacchi,Angela Consagra,Luca Rigodanza,Gloria Andreossi,Cristina Amato,Mathieu Meunier,Célia Orlando,Emmanuelle Clappier,Nicolas Chapuis,Pierre Walczak,Katharina Zoldan,Anne Sophie Kubasch,Valeria Santini
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Research Article June 25 2025
The endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis
Wenting Zhao,Peina Wang,Zhengxun Liu,Dongyuan Zhang,Yi Xia,Teng Xu,Fei Wang,Mingyang Cui,Xu Zhang,Shuaishuai Zhou,Zhixi Wei,Min Ma,Sitong Wan,Jingyi Qi,Zhengyang Zhang,Juan Chen,Libing Liu,Yinhua Zhu,Junjie Luo,Yongting Luo,Peng An
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Research Article June 25 2025
Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer
Bernd Zeisig,Chiou-Tsun Tsai,Clemence Virely,Tsz Kan Kan Fung,Ali Tugrul Akin,Estelle Troadec,Bo Jiao,Richard Thompson,Priscilla Nga Ieng Lau,Nanjun Li,Andriani Charalambous,Larissa Bomfim,Jennifer Lynch,Athina Georgiou,Robbert Hoogeboom,Claire Lynn,Si Yi Zhang,Piers EM Patten,Cynthia Fisher,Anna Schuh,Seishi Ogawa,Ghulam J Mufti, Professor,Mohammad M. Karimi,Chi Wai Eric So
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Research Article June 25 2025
Plasminogen as a Ribonucleoprotein: Regulatory small RNA Cargo Modulates Fibrinolysis and Inflammation
Danielle L Michell,Clark Massick,Kaustubh S Koya,Ashley B Cavnar,Elizabeth M Semler,Chase Raby,Breanne H Y Gibson,Stephanie N Moore-Lotridge,Wanying Zhu,Marisol Ramirez-Solano,Quanhu Sheng,Ryan M Allen,MacRae F Linton,Jonathan G Schoenecker,Kasey Vickers
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Research Article June 20 2025
Loss of BAP1 defines a unique subtype of TP53-mutated de novo AML and confers sensitivity to BCL-xL inhibitors
Jaclyn Andricovich,Coen Johannes Lap,Alexandros Tzatsos
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Research Article June 20 2025
LRRC8 complexes are ATP release channels regulating platelet activation and arterial thrombosis
John David Tranter,Ryan Takayuki Mikami,Ashutosh Kumar,Gavriel Brown,Tarek Mohamed Abd El-Aziz,Yonghui Zhao,Prakash Arullampalam,Katrina J Ashworth,Vishwanath Jha,Nihil Abraham,Chloe Meyer,Abigail Ajanel,Litao Xie,Yongmei Feng,Juan Hong,Haixia Zhang,Tripti Kumari,Adam Balutowski,Alice Liu,David Bark,Vinayak K Nair,Nina M Lasky,Nathan O Stitziel,Daniel J Lerner,Robert A Campbell,Jorge Di Paola,Jaehyung Cho,Rajan Sah
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Research Article June 20 2025
Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone
Tsuyoshi Isojima,Blessing Crimeen-Irwin,Narelle E McGregor,Ryan C Chai,Ingrid J Poulton,Emma C Walker,Mriga Dutt,Benjamin L Parker,Natalie A Sims
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Research Article June 20 2025
Somatic IRF4 Mutations and Thymic Tropism in Primary Mediastinal Large B-cell Lymphoma
Shinya Rai,Gerben Duns,Fabian Frontzek,Jasper Chun Hei Wong,Yifan Yin,Michael Y. Li,Makoto Kishida,Manabu Fujisawa,Shannon Healy,Elena Viganò,Aixiang Jiang,Bruce Woolcock,Adèle Telenius,Susana Ben-Neriah,Barbara Meissner,Merrill Boyle,Hisae Nakamura,Luke O`Brien,Claudia Cassidy,Andrew Lytle,Pedro Farinha,Graham W. Slack,Laura K Hilton,Ryan D Morin,Leandro Venturutti,Tomohiro Aoki,Nicole Wretham,Jonathan Willard Bush,Laura Evgin,Kerry J. Savage,David W. Scott,Christian Steidl
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Research Article June 12 2025
A single dose of a CD137 antibody-drug conjugate protects nonhuman primate allogeneic HCT recipients against acute GVHD
Ulrike Gerdemann,Kyle Kimler,Matthew R Warren,Connor McGuckin,Ryan A Fleming,Matthew R D'Ambra,Alal Eran,Alexandre Albanese,Edward Chen,Marlana B Winschel,Lorenzo Cagnin,Jennifer Lane,Lev Gorfinkel,Bartley W. Adams,Jean Kwun,Leanne Lanieri,Megan D Hoban,Tahirih L Lamothe,Sharon L. Hyzy,Lisa M. Olson,Angela Panoskaltsis-Mortari,Susan E Prockop,Bruce R Blazar,Leslie S Kean,Victor Tkachev
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Research Article June 12 2025
RhoA GAP Myo9b regulates β2-integrin activity and neutrophil recruitment during murine acute kidney injury
Anika Cappenberg,Marina Oguama,Mathis Richter,Andreas Margraf,Wida Amini,Pia Lindental,Sina Mersmann,Bernadette Bardel,Helena Block,Thomas Vogl,Oliver Soehnlein,Klaus Ley,Jan Rossaint,Alexander Zarbock
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Research Article June 12 2025
Remission conversion drives outcomes after CAR T-cell therapy for multiple myeloma: a registry analysis from the DRST
Maximilian Merz,Nico Gagelmann,Samih Smaili,Sarah Flossdorf,Sandra Sauer,Christof Scheid,Bastian von Tresckow,Gerald Georg Wulf,Katja C Weisel,Igor Blau,Monika Engelhardt,Ralph Wäsch,Natalie Schub,Raphael Teipel,Judith S. Hecker,Johannes M. Waldschmidt,Britta Besemer,Ben-Niklas Baermann,Simon Call,Leo Hansmann,Francis Ayuketang Ayuk,Marc S. Raab,Hermann Einsele,Uwe Platzbecker,Nicolaus Kröger
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Brief Report June 12 2025
Comparison of the safety profiles of CD19-targeting CAR T-cell therapy in patients with SLE and B-cell lymphoma
Fabian Müller,Nora Rebecca Schwingen,Melanie Hagen,Julia Katharina Scholz,Michael Aigner,Andreas Wirsching,Jule Taubmann,Sascha Kretschmann,Soraya Kharboutli,Tobias Krickau,Nora Naumann-Bartsch,Giulia Benintende,Silvia Spoerl,Tobias Rothe,Heiko Bruns,Ricardo Grieshaber-Bouyer,Markus Metzler,David B. Blumenthal,Frederik Graw,Georg Schett,Andreas Mackensen,Simon Völkl
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Research Article June 11 2025
Array Genotyping of Transfusion Relevant Blood Cell Antigens in 6946 Ancestrally Diverse Subjects
Nicholas S Gleadall,Lianne Koets,Olga Shamardina,Jeremy Gollub,Aaron J Gottschalk,Orod Razeghi,Gorka Ochoa,Jonathan Stephens,Ram Varma,Jennifer Martin,Elias Allara,Colin J Brown,James Daly,Emanuele Di Angelantonio,Shane Grimsley,W Martin Howell,Kati Hyvärinen,Ute Jentsch,Nathalie Kingston,Celina Montemayor,Celeste Moya-Valera,John Ord,Jukka Partanen,David J Roberts,Kathleen E. Stirrups,Sunitha Vege,Lindsay Walker,Andrea Harmer,Shantanu Kaushikkar,Willem H Ouwehand,C Ellen van der Schoot,Connie M Westhoff,Barbera Veldhuisen,William J Lane
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Research Article June 11 2025
High-dose busulfan-melphalan vs melphalan and reinforced VRD for newly diagnosed multiple myeloma: a phase 3 GEM trial
Juan-Jose Lahuerta,Jesús F. San-Miguel,Ana Jiménez-Ubieto,Rafael Alonso Fernández,Bruno Paiva,Noemi Puig,Maria-Teresa Cedena,Norma C Gutierrez,Maria José Calasanz,Manuela Fernandez,Rafael Ríos-Tamayo,Albert Oriol,María-Jesús Blanchard,Estrella Carrillo-Cruz,Rafael Martínez-Martínez,Joan Bargay,Anna Sureda,Javier de la Rubia,Miguel-Teodoro T. Hernandez Garcia,Valentín Cabañas,Luis Felipe Casado Montero,Luis Palomera Bernal,Yolanda Gonzalez-Montes,Joaquín Martínez-López,Paula Rodriguez-Otero,Isabel Krsnik,Jose M Arguiñano,María Esther Gonzalez-Garcia,Enrique M. Ocio,Javier de la Cruz,Maria-Victoria Mateos,Laura Rosiñol,Joan Bladé
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Research Article June 11 2025
Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 16-Year Longitudinal Study of 6976 Women
Yash Pershad,Md Mesbah Uddin,Liying Xue,Jeffrey Haessler,Jason M Collins,Taralynn Mack,Elena Glick,Veronica Glaser,Kun Zhao,Siddhartha Jaiswal,JoAnn E Manson,Urvashi Pandey,Pinkal Desai,Pradeep Natarajan,Michael C. Honigberg,Charles Kooperberg,Eric A Whitsel,Jacob Kitzman,Alexander G. Bick,Alex P Reiner
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Research Article June 10 2025
Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment
Nicolas A. Gort-Freitas,Maria Moscvin,Matteo Claudio Da Viá,Francesca Lazzaroni,Alice Nevone,Sam Sadigh,Samuel Boullt,Benjamin Evans,Tianzeng Chen,Tanya T Karagiannis,Albert Tai,Sean Rowell,Srinidhi Raghav,Antonia Faustina Chen,Jacob P Laubach,Caitlin Edwards,Jon C Aster,Zizhang Sheng,Joao A Paulo,Chi N Chan,Mario Nuvolone,Niccolò Bolli,Raymond L. Comenzo,Allon Klein,Giada Bianchi
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Supplementary data
Research Article June 10 2025
An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis
Justin Loke,Peter Geon Kim,Thuy T.P. Nguyen,Meaghan Boileau,Marie McConkey,Aidan P Miller,Wesley Shin,Christopher B Hergott,Maria Ericsson,Anja Nordstrom,Paula Montero-Llopis,Scott A. Armstrong,Joseph D. Mancias,Benjamin L Ebert
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Supplementary data
Research Article June 10 2025
Biallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma.
Benjamin T. Diamond,Linda B Baughn,Mansour Poorebrahim,Alexandra M Poos,Holly Lee,Marcella Kaddoura,J Erin Wiedmeier-Nutor,Michael A. Durante,Gregory E Otteson,Dragan Jevremovic,Hongwei Tang,Stefan Fröhling,Marc-Andrea Baertsch,Marios Papadimitriou,Bachisio Ziccheddu,Tomas Jelínek,Cendrine Lemoine,Alexey Rak,Damian J Green,Carl Ola Landgren,Paola Neri,Peter Leif Bergsagel,Esteban Braggio,Shaji K Kumar,Marc S. Raab,Rafael Fonseca,Nizar Bahlis,Niels Weinhold,Francesco Maura
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Supplementary data
Research Article May 30 2025
Phase 1/2 Trial of Anti-CD7 Allogeneic WU-CART-007 in patients with Relapsed/Refractory T-cell Malignancies
Armin Ghobadi,Ibrahim Aldoss,Shannon L. Maude,Deepa Bhojwani,Alan S. Wayne,Ashish Bajel,Bhagirathbhai Dholaria,Rawan G. Faramand,Ryan J Mattison,Anita W Rijneveld,C. Michel Zwaan,Friso G. Calkoen,André Baruchel,Nicolas Boissel,Michael P Rettig,Brent Wood,Kenneth Jacobs,Stephanie Christ,Haley Irons,Ben Capoccia,Deborah Masters,Justo Gonzalez,Tony Wu,Maria del Rosario,Alexander Hamil,Ouiam Bakkacha,John Muth,Brett Ramsey,Eileen McNulty,Jan Baughman,Matthew L Cooper,Jan K Davidson-Moncada,John F. DiPersio
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Supplementary data
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