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Journal Articles

An Orally Active Pan-BCR::ABL1 Degrader Tgrx-3247 Potently Targets a Wide Spectrum of Orthosteric, Allosteric and Compound Mutations Resistant to TKI Therapies

Yanxia Shi, Fengli He, Li Hu, Nannan Yu, Linxin Li, Cuifang Zheng, Shuzhen Jiang, Tingting Yan, Shuo Zhang, Yinghui Li, Xiangyu Hong, Yun Liu, Yixin Ai, Jiuyang Zhao, Jingrong Cao, Yihan Wang

Blood (2024) 144 (Supplement 1): 1387.

https://doi.org/10.1182/blood-2024-198975

Published: 2024

Journal Articles

Tgrx-678, a Novel Allosteric Inhibitor of BCR-ABL1, Demonstrates Preclinical Anti-Leukemia Activity, High Oral Bioavailability and Synergism with Ponatinib to Suppress the Highly Resistant Compound Mutations

Yanxia Shi, Qian Jiang, Linxin Li, Shuzhen Jiang, Tingting Yan, Cuifang Zheng, Yixin Ai, Yihan Wang

Blood (2023) 142 (Supplement 1): 2807.

https://doi.org/10.1182/blood-2023-181391

Published: 2023