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Journal Articles

Microenvironmental cell interactions are essential for sustaining functionality of myelofibrosis malignant stem cells

Min Lu, Md. Babu Mia, Lijuan Xia, Gohar Mosoyan, Momina Hayat, Christoph Schaniel, Ronald Hoffman

Blood blood.2025031454.

https://doi.org/10.1182/blood.2025031454

Published: 2025

Includes: Supplemental data

Journal Articles

Clonal persistence and early cooperative mutations shape transformation in myelofibrosis

Noushin Farnoud, Kamal Menghrajani, Paola Guglielmelli, Christopher Famulare, Erin McGovern, Giuseppe Gaetano Loscocco, Andriy Derkach, Andrew Dunbar, Naseema Gangat, Vikas Gupta, Andrea Arruda, Taghi Manshouri, Srdan Verstovsek, Andrew Kuykendall, Vincent Ho, Auro Viswabandya, Joachim Deeg, Thomas Monahan, Tania Jain, Jeanne Palmer, Alla Keyzner, Aaron Gerds, Alexandra Gomez-Arteaga, Nikolai Podoltsev, Roni Tamari, Helen Ajufo, Satyajit Kosuri, Haris Ali, Idoroenyi Amanam, Jordan Chervin, Minal Patel, Jesús Gutiérrez-Abril, Sarun Sereewattanawoot, Juan Arango Ossa, Francesco Passamonti, Francesco Maura, Maymona Abdelmagid, Ahmed Abdelrheem, Yassin Bashir, Muhammad Yousuf, Animesh Pardanani, Kapila Viges, David Shoultz, Rick Winneker, Omar Abdel-Wahab, John Mascarenhas, Ronald Hoffman, Ross Levine, Elli Papaemmanuil, Alessandro Vannucchi, Ayalew Tefferi, Raajit Rampal

Blood (2025) 146 (Supplement 1): 2046.

https://doi.org/10.1182/blood-2025-2046

Published: 2025

Journal Articles

The antibiotic linezolid targets the Jak2V617F mutation in polycythemia vera.

Huihui Li, Christoph Schaniel, Anisa Azatovna Gumerova, Zixing Huang, Althea Agdamag, Francisco Fueyo Gonzalez, Alessandro Principi, Jacob Kazmi, Xin Gao, Caliana Yang, Tony Yuen, Paul Frenette, Jeffrey Glassberg, Shozeb Haider, Yelena Ginzburg, Mone Zaidi, Ronald Hoffman

Blood (2025) 146 (Supplement 1): 642.

https://doi.org/10.1182/blood-2025-642

Published: 2025

Journal Articles

Disruption of the gut microbiota promotes chronic inflammation in JAK2V617F-driven MPN: Evidence from mouse and human studies

Althea Agdamag, Zixing Huang, Anisa Azatovna Gumerova, Georgii Pevnev, Christoph Schaniel, Paul Frenette, Rahul Patel, Mone Zaidi, Jeffrey Glassberg, Yelena Ginzburg, Douglas Tremblay, Ronald Hoffman, Huihui Li

Blood (2025) 146 (Supplement 1): 360.

https://doi.org/10.1182/blood-2025-360

Published: 2025

Journal Articles

Therapy resistance and disease relapse in patients with MPN-blast phase are associated with clonal evolution and transcriptomic changes in MPN- blast phase stem cells

Xiaoli Wang, Cing Siang Hu, Xiaoping Su, Raajit Rampal, Noushin Farnoud, Erin McGovern, Andrew Davis, Sophia Jiang, Marina Kremyanskaya, John Mascarenhas, Ronald Hoffman

Blood (2025) 146 (Supplement 1): 359.

https://doi.org/10.1182/blood-2025-359

Published: 2025

Journal Articles

Phase II study of reparixin in patients with myelofibrosis. myeloproliferative neoplasms research consortium (MPN-RC) 120 trial

Marina Kremyanskaya, Aaron Gerds, Rupali Bhave, Andrew Kuykendall, Eunice Wang, Heidi Kosiorek, Amylou Dueck, Carolyn Mead-Harvey, Kathryn Johnson, Ashley Yu, Anna Rita Migliaccio, Ruben Mesa, Ronald Hoffman, John Mascarenhas

Blood (2025) 146 (Supplement 1): 3829.

https://doi.org/10.1182/blood-2025-3829

Published: 2025

Journal Articles

Bone marrow adipocytes (BMA) as a novel biomarker of molecular response in patients with essential thrombocythemia (ET) and polycythemia vera (PV) treated with pegylated interferon alfa-2A

John Mascarenhas, Justin Johnson, Heidi Kosiorek, Megan Metzger, Tiziano Barbui, Josef Prchal, Alessandro Rambaldi, Abdulraheem Yacoub, Ashley Yu, Ruben Mesa, Marina Kremyanskaya, Amylou Dueck, Ronald Hoffman, Mohamed Salama

Blood (2025) 146 (Supplement 1): 5590.

https://doi.org/10.1182/blood-2025-5590

Published: 2025

Journal Articles

Myelofibrosis stem cell fitness requires microenvironmental cell interactions

Min Lu, MD Babu Mia, Lijuan Xia, Gohar Mosoyan, Momina Hayat, Christoph Schaniel, Ronald Hoffman

Blood (2025) 146 (Supplement 1): 1981.

https://doi.org/10.1182/blood-2025-1981

Published: 2025

Journal Articles

Single cell transcriptional profiling reveals distinct subsets of human megakaryocytes in myelofibrosis

MD Babu Mia, Lilian Varricchio, Ronald Hoffman

Blood (2025) 146 (Supplement 1): 3017.

https://doi.org/10.1182/blood-2025-3017

Published: 2025

Journal Articles

Long term outcomes of ET and PV patients after clinical trial treatment with interferon alfa

Megan Metzger, Heidi Kosiorek, Ashley Yu, Veer Shah, Nooshin Beygui, Marina Kremyanskaya, Amylou Dueck, Ronald Hoffman, John Mascarenhas

Blood (2025) 146 (Supplement 1): 7345.

https://doi.org/10.1182/blood-2025-7345

Published: 2025

Journal Articles

A phase 2 study of canakinumab in patient with myelofibrosis: Results from part 1

Andrew Kuykendall, Rupali Roy, Abdulraheem Yacoub, Marina Kremyanskaya, Aaron Gerds, Ronald Paquette, Jeanne Palmer, Kathryn Johnson, Heidi Kosiorek, Amylou Dueck, Carolyn Mead-Harvey, Ashley Yu, Rami Komrokji, Raajit Rampal, Ruben Mesa, Ronald Hoffman, John Mascarenhas

Blood (2025) 146 (Supplement 1): 483.

https://doi.org/10.1182/blood-2025-483

Published: 2025

Journal Articles

Preliminary data from the Phase I/II study of nuvisertib, an oral investigational selective PIM1 inhibitor, in combination with momelotinib showed clinical responses in patients with relapsed/refractory myelofibrosis

Blood (2025) 146 (Supplement 1): 482.

https://doi.org/10.1182/blood-2025-482

Published: 2025

Journal Articles

Mismatched unrelated and haploidentical transplant with post-transplant cyclophosphamide-based graft versus host disease prophylaxis are effective for myelofibrosis

Richard Sheppard, Noa Rippel, Hulya Kocyigit, Erin Moshier, Kyle Wiatrowski, John Levine, John Mascarenhas, Ronald Hoffman, Alla Keyzner

Blood (2025) 146 (Supplement 1): 2530.

https://doi.org/10.1182/blood-2025-2530

Published: 2025

Journal Articles

Cytoreductive therapy reduces recurrent thrombosis in patients with myeloproliferative neoplasm-associated splanchnic vein thrombosis: A global abdominal/splanchnic thrombosis retrospective observational study (GASTRO-MPN) study of 757 patients

Blood (2025) 146 (Supplement 1): 1026.

https://doi.org/10.1182/blood-2025-1026

Published: 2025

Journal Articles

Evaluation of the novel TMPRSS6 antisense inhibitor sapablursen for treatment of polycythemia vera: Results of the imprssion clinical trial

Jeanne Palmer, Jonathan How, Prithviraj Bose, Pankit Vachhani, Adam Mead, Jonathan Sillar, Aaron Gerds, Angela Fleischman, Caitlin O'Neill, Ross Baker, Ronald Hoffman, Shiangtung Jung, Jon Ruckle, Keyvan Yousefi, Sanjay Bhanot, Terry Barrett, Ruben Mesa

Blood (2025) 146 (Supplement 1): 82.

https://doi.org/10.1182/blood-2025-82

Published: 2025

Journal Articles

Menin inhibition as a new therapeutic option for the myeloproliferative neoplasms

John Crispino, Jeremy Wen, Anitria Cotton, Rashid Mehmood, Amber Broadhurst, Trent Hall, Bridget Marcellino, John Mascarenhas, Ronald Hoffman, Laura Janke, Sandeep Gurbuxani, Gerard McGeehan

Blood (2025) 146 (Supplement 1): 67.

https://doi.org/10.1182/blood-2025-67

Published: 2025

Journal Articles

Modulators of the Hepcidin Pathway in Polycythemia Vera and Myelofibrosis

Marina Kremyanskaya, Yelena Z Ginzburg, Ronald Hoffman

Blood blood.2025028643.

https://doi.org/10.1182/blood.2025028643

Published: 2025

Journal Articles

Thrombocytopenia in myelofibrosis is characterized by inflammatory megakaryocytes with reduced G6B expression

Lilian Varricchio, Gohar Mosoyan, Sebastian Elghaity-Beckley, Md. Babu Mia, Shivani Handa, Christian Salib, John Mascarenhas, Ronald Hoffman

Blood (2025) 146 (13): 1612–1624.

https://doi.org/10.1182/blood.2024027363

Published: 2025

Includes: Supplemental data

Journal Articles

High-Resolution Chromosomal Microarrays Reveals Exon-Level Deletion in Chromosome 12q14.3 in Patients with Myeloproliferative Neoplasms

Joseph Tripodi, Shivani Handa, Christoph Schaniel, Daiva Ahire, Ronald Hoffman, Vesna Najfeld

Blood (2024) 144 (Supplement 1): 4520.

https://doi.org/10.1182/blood-2024-206440

Published: 2024

Journal Articles

Role of HMGA2 Overexpression Caused By Specific Genetic HMGA2 Aberrations in Disease Progression in Calreticulin-Mutated Myelofibrosis Patients

Christoph Schaniel, Shivani Handa, Joseph Tripodi, MD Babu Mia, Christian Salib, Jeff Vierstra, Allison J Cote, Daiva Ahire, Douglas Tremblay, Bridget Kelly Marcellino, John A Stamatoyannopoulos, Vesna Najfeld, Ronald Hoffman

Blood (2024) 144 (Supplement 1): 4512.

https://doi.org/10.1182/blood-2024-205834

Published: 2024

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Microenvironmental cell interactions are essential for sustaining functionality of myelofibrosis malignant stem cells

Clonal persistence and early cooperative mutations shape transformation in myelofibrosis

The antibiotic linezolid targets the Jak2V617F mutation in polycythemia vera.

Disruption of the gut microbiota promotes chronic inflammation in JAK2V617F-driven MPN: Evidence from mouse and human studies

Therapy resistance and disease relapse in patients with MPN-blast phase are associated with clonal evolution and transcriptomic changes in MPN- blast phase stem cells

Phase II study of reparixin in patients with myelofibrosis. myeloproliferative neoplasms research consortium (MPN-RC) 120 trial

Bone marrow adipocytes (BMA) as a novel biomarker of molecular response in patients with essential thrombocythemia (ET) and polycythemia vera (PV) treated with pegylated interferon alfa-2A

Myelofibrosis stem cell fitness requires microenvironmental cell interactions

Single cell transcriptional profiling reveals distinct subsets of human megakaryocytes in myelofibrosis

Long term outcomes of ET and PV patients after clinical trial treatment with interferon alfa

A phase 2 study of canakinumab in patient with myelofibrosis: Results from part 1

Preliminary data from the Phase I/II study of nuvisertib, an oral investigational selective PIM1 inhibitor, in combination with momelotinib showed clinical responses in patients with relapsed/refractory myelofibrosis

Mismatched unrelated and haploidentical transplant with post-transplant cyclophosphamide-based graft versus host disease prophylaxis are effective for myelofibrosis

Cytoreductive therapy reduces recurrent thrombosis in patients with myeloproliferative neoplasm-associated splanchnic vein thrombosis: A global abdominal/splanchnic thrombosis retrospective observational study (GASTRO-MPN) study of 757 patients

Evaluation of the novel TMPRSS6 antisense inhibitor sapablursen for treatment of polycythemia vera: Results of the imprssion clinical trial

Menin inhibition as a new therapeutic option for the myeloproliferative neoplasms

Modulators of the Hepcidin Pathway in Polycythemia Vera and Myelofibrosis

Thrombocytopenia in myelofibrosis is characterized by inflammatory megakaryocytes with reduced G6B expression

High-Resolution Chromosomal Microarrays Reveals Exon-Level Deletion in Chromosome 12q14.3 in Patients with Myeloproliferative Neoplasms

Role of HMGA2 Overexpression Caused By Specific Genetic HMGA2 Aberrations in Disease Progression in Calreticulin-Mutated Myelofibrosis Patients

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