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Masataka Seki
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Journal Articles

Preliminary data from the Phase I/II study of nuvisertib, an oral investigational selective PIM1 inhibitor, in combination with momelotinib showed clinical responses in patients with relapsed/refractory myelofibrosis

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John Mascarenhas, Joseph Scandura, Vikas Gupta, Kazuya Shimoda, James McCloskey, Firas El Chaer, Prithviraj Bose, Raajit Rampal, Andrew Srisuwananukorn, Timothy Devos, Ruben Mesa, Professor Francesco Passamonti, Srinivas Tantravahi, David Ross, Lindsay Rein, Jean-Jacques Kiladjian, Takanori Teshima, Takuji Yamauchi, Noboru Asada, Anna Halpern, Tamanna Haque, Etienne Paubelle, Noriko Fukuhara, Pankit Vachhani, Michiko Ichii, Ronald Hoffman, Marcello Rotta, Michael Keng, Stefan Wickenhauser, Karen Ansaldo, Masataka Seki, Jinny Lee, Vincent Loksa, Zhonggai Li, Jason Foulks, Sujan Kabir, Jatin Shah, Claire Harrison
Journal: Blood
Blood (2025) 146 (Supplement 1): 482.
https://doi.org/10.1182/blood-2025-482
Published: 2025
Journal Articles

Nuvisertib, an oral investigational selective PIM1 kinase inhibitor, showed clinical responses strongly correlating with cytokine modulation in patients with relapsed/refractory myelofibrosis in the ongoing global phase I/II study

Free
Lindsay Rein, Firas El Chaer, Junichiro Yuda, Joseph Scandura, Shuichi Shirane, Kazuya Shimoda, Prithviraj Bose, Akiyoshi Takami, Alessandra Iurlo, Michiko Ichii, James McCloskey, Michael Keng, Samah Alimam, Noriko Fukuhara, Nikki Granacher, Giulia Benevolo, Alessandro Lucchesi, Tamanna Haque, Jean-Jacques Kiladjian, Srinivas Tantravahi, Pankit Vachhani, Anand Patel, Stanley Cheung, Paul Yeh, Francesca Palandri, Ashwin Kishtagari, Ciro Rinaldi, Marcello Rotta, Vincent Ribrag, Michael Loschi, Idoroenyi Amanam, Terrence Bradley, Karen Ansaldo, Masataka Seki, Guia Guffanti, Jinny Lee, Prasanthi Pellakuru, Zhonggai Li, Jason Foulks, Sujan Kabir, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2025) 146 (Supplement 1): 2018.
https://doi.org/10.1182/blood-2025-2018
Published: 2025
Journal Articles

A Phase 1/2 Study of Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, in Combination with JAK Inhibitors Ruxolitinib or Momelotinib in Patients with Myelofibrosis

Free
John O. Mascarenhas, Raajit Rampal, Firas El Chaer, Vikas Gupta, Kazuya Shimoda, Jean-Jacques Kiladjian, Francesco Passamonti, Prithviraj Bose, Joseph M. Scandura, Ruben Mesa, Lindsay A.M. Rein, Junichiro Yuda, David M Ross, Timothy Devos, Moshe Talpaz, Ronald Hoffman, Sujan Kabir, Zhonggai Li, Jason M. Foulks, Karen Ansaldo, Masataka Seki, Vishnu Peddagali, Jatin Shah, Claire Harrison
Journal: Blood
Blood (2024) 144 (Supplement 1): 6629.
https://doi.org/10.1182/blood-2024-200268
Published: 2024
Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Free
Lindsay A.M. Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, Raajit Rampal, Joseph M. Scandura, Akiyoshi Takami, James McCloskey, Michiko Ichii, Shuichi Shirane, Alessandra Iurlo, Prithviraj Bose, Alessandro Lucchesi, Giulia Benevolo, Idoroenyi Amanam, Pankit Vachhani, Srinivas K Tantravahi, Marcello Rotta, Yasushi Onishi, Jean-Jacques Kiladjian, Ciro Rinaldi, Nikki Granacher, Terrence Bradley, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Masataka Seki, Karen Ansaldo, Guia Guffanti, Jinny Lee, Steven L. Warner, Jason M. Foulks, Ruben Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3179.
https://doi.org/10.1182/blood-2024-200999
Published: 2024
Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Free
Firas El Chaer, Lindsay A.M. Rein, Junichiro Yuda, Kazuya Shimoda, Akiyoshi Takami, Michiko Ichii, James McCloskey, Joseph M. Scandura, Alessandra Iurlo, Prithviraj Bose, Tamanna Haque, Alessandro Lucchesi, Shuichi Shirane, Giulia Benevolo, Idoroenyi Amanam, Jean-Jacques Kiladjian, Pankit Vachhani, Srinivas K Tantravahi, Yasushi Onishi, Ciro Rinaldi, Marcello Rotta, Nikki Granacher, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Terrence Bradley, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Karen Ansaldo, Masataka Seki, Vincent Loksa, Zhonggai Li, Jason M. Foulks, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 655.
https://doi.org/10.1182/blood-2024-200312
Published: 2024
Journal Articles

Phase 1/2 Study of TP-3654, a Selective PIM1 Kinase Inhibitor: Preliminary Data Showed Clinical Activity and Cytokine Reductions in Relapsed/Refractory Myelofibrosis Patients

Free
Lindsay A.M Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, James McCloskey, Akiyoshi Takami, Tamanna Haque, Michiko Ichii, Shuichi Shirane, Masafumi Fukaya, Joseph M. Scandura, Terrence Bradley, Pankit Vachhani, Takayuki Tabayashi, Steven Green, Stanley Cheung, Prithviraj Bose, Sharad Khurana, Casey L. O'Connell, Idoroenyi Amanam, David M. Ross, Sujan Kabir, Masataka Seki, Mark Wade, Vishnu Peddagali, Zhonggai Li, Jatin Shah, Raajit K. Rampal
Journal: Blood
Blood (2023) 142 (Supplement 1): 626.
https://doi.org/10.1182/blood-2023-180164
Published: 2023