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First Edition

Review Article February 19 2025
How I treat patients who are refractory to platelet transfusions
Susan Nahirniak,Veera Sekaran Nadarajan,Simon J Stanworth
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Review Article February 19 2025
Clinical-genomic profiling of MDS to inform allo-HSCT:Recommendations from an international panel on behalf of the EBMT
Carmelo Gurnari,Marie Robin,Lionel Adès,Mahmoud Aljurf,Antonio M Almeida,Fernando Barroso Duarte,Elsa Bernard,Corey S. Cutler,Matteo Giovanni Della Porta,Theo M de Witte,Amy E. DeZern,Joanna Drozd-Sokolowska,Eric J Duncavage,Pierre Fenaux,Nico Gagelmann,Guillermo Garcia-Manero,Claudia Haferlach,Torsten Haferlach,Robert P. Hasserjian,Eva S Hellstrom-Lindberg,Meagan A Jacoby,Austin G Kulasekararaj,R. Coleman Lindsley,Jaroslaw P. Maciejewski,Hideki Makishima,Luca Malcovati,Moshe Mittelman,Anders Eivind Myhre,Seishi Ogawa,Francesco Onida,Elli Papaemmanuil,Jakob R Passweg,Uwe Platzbecker,Lisa Pleyer,Kavita Raj,Valeria Santini,Anna Sureda,Magnus Tobiasson,Maria Teresa Voso,Ibrahim Yakoub-Agha,Amer M. Zeidan,Matthew J Walter,Nicolaus Kröger,Donal P McLornan,Mario Cazzola
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Review Article February 19 2025
Immunoactinopathies revisited: Understanding clinical manifestations and biological pathways
Fleur Hiensch,Loic Dupre,Elisabeth Salzer
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Research Article February 12 2025
Outcomes Among Adult Recipients of CAR T-cell Therapy for Burkitt Lymphoma
Laura Samples,Hossein Sadrzadeh,Matthew J. Frigault,Caron A. Jacobson,Mehdi Hamadani,Ashwath Gurumurthi,Paolo Strati,Roni Shouval,Ariela Noy,Peter A Riedell,Saurabh Dahiya,David G Maloney,Brian G Till,Alexandre V. Hirayama,Jordan Gauthier,Ajay K Gopal,Stephen D Smith,Christina Poh,Ryan C Lynch,Chaitra Ujjani,Mengyang Di,Vikram Raghunathan,Mehrdad Shakib-Azar,Kikkeri N Naresh,Ted A Gooley,Jean A. Yared,Michael D Jain,Frederick L Locke,Lori A. Leslie,Narendranath Epperla,Monalisa Ghosh,Alan P Skarbnik,Brian T. Hill,Manali Kamdar,Valentín Ortiz-Maldonado,Nuria Martínez-Cibrian,Leyla Shune,Mazyar Shadman
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Research Article February 12 2025
Three-year follow-up analysis of first-line axicabtagene ciloleucel in high-risk large B-cell lymphoma (ZUMA-12)
Julio C. Chavez,Michael Dickinson,Javier Munoz,Matthew L. Ulrickson,Catherine Thieblemont,Olalekan O. Oluwole,Alex F. Herrera,Chaitra Ujjani,Yi Lin,Peter A. Riedell,Natasha Kekre,Sven de Vos,Jacob Wullf,Chad M. Williams,Joshua Winters,Ioana Magdalena Kloos, Dr,Hairong Xu,Sattva S. Neelapu
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Research Article February 10 2025
N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation
Lin-Qi Zhang,Chang-Xiao Che,Ya-Qin Du,Lu-lu Han,Jia-le Wang,Chen-Yu Zhang,Shen-Ming Huang,Zhong-Yuan Zheng,Qing-Tao He,Zhao Yang,Long Zhang,Nan Chen,Fan Yang,Ying-Li Jia,Shi-Min Zhao,Demin Zhou,Chu Wang,Xian Wang,Jin-Peng Sun,Lu Tie
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Brief Report February 7 2025
The JAK2 46/1 haplotype influences PD-L1 expression.
Gonzalo Carreño-Tarragona,Maria Tiana,Raquel Rouco,Alejandra Leivas,Jesús Victorino,Roberto Garcia-Vicente,Andrew J Chase,Andrea Maidana,William J Tapper,Rosa Ayala,Nicholas C.P. Cross,Joaquín Martínez-López,Miguel Manzanares
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Research Article February 6 2025
Targeting Caseinolytic Mitochondrial Matrix Peptidase, a Novel Contributor to High-risk Behavior, in Multiple Myeloma
Li Qin,Luz Yurany Moreno Rueda,Upasana Ray,Iqbal Mahmud,Lin Tan,Philip L Lorenzi,Suyu Liu,Heather Yan Lin,David E. Mery,Fenghuang Zhan,John D. Shaughnessy, Jr,Qing Yi,Maria Jose Acevedo Calado,Hua Wang,Elisabet E. Manasanch,Hans C. Lee,Krina K. Patel,Isere Kuiatse,David E. Symer,Robert Z. Orlowski
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Review Article February 5 2025
EMZL at various sites: learning from each other
Ming-Qing Du
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Research Article February 3 2025
Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD
Michael C. Zaiken,Sujeong Jin,Cameron McDonald-Hyman,Christina Hartigan,Peter Sage,Keli L. Hippen,Brent H Koehn,Angela Panoskaltsis-Mortari,Megan J Riddle,Cindy Eide,Jakub Tolar,Geoffrey R Hill,Leo Luznik,Corey S. Cutler,Jerome Ritz,Leslie S Kean,Ageliki Tsagaratou,Anjana Rao,Bruce R Blazar
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Research Article February 3 2025
Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interface
Zohreh Mansoori Moghadam,Bei Zhao,Candice Raynaud, RWTH University Hospital,Valentina Strohmeier,Jana Neuber,Anne Kathrin Lösslein,Sabrina Qureshi,Vitka Gres,Tara Ziegelbauer,Sebastian Baasch,Christoph Schell,Klaus Warnatz,Naohiro Inohara,Gabriel Nunez,Thomas Clavel,Stephan Patrick Rosshart,Julia Kolter,Philipp Henneke
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Research Article February 3 2025
IL-10 from tumoral B cells modulates the diffuse large B-cell lymphoma microenvironment and response to immunotherapy
Marcos Garcia-Lacarte,Sara C Grijalba,Javier Melchor Sánchez,Marién Pascual,Enrique Goñi,Iñigo Clemente-Larramendi,Sandra Morales-Sánchez,Maria A Burrell,Oscar Blanco,Adrián Arnaiz-Leché,Blanca S Berrozpe,Maria Amann,Christian Klein,Pablo Umaña,Miguel Angel Canales,José Ángel Martínez-Climent,Juan Jose Lasarte,Pablo Sarobe,Francisco J Novo,Sergio Roa
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Review Article February 3 2025
How I approach pharmacological thromboprophylaxis in children
Anthony A. Sochet,Amy Kiskaddon,Neil A Goldenberg
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Research Article January 27 2025
Protection of β2GPI-Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation
Paresh P Kulkarni,Ravi Kumar Alluri,Matthew J Godwin,Gabriel L Forbes,Alona A Merkulova,Sylviane Lambert,Aatira Vijay,Maierdan Palihati,Suman Kundu,Young Jun Shim,Kevin N Kalonji,Alvin H. Schmaier,Michael Holinstat,SCOTT J CAMERON,Keith R McCrae
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Review Article January 27 2025
Platelet activation and signaling in thrombus formation
Frauke Swieringa,Johan W.M. Heemskerk,Alice Assinger
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Review Article January 27 2025
Factor XIII: Driving (Cross-)Links in Hemostasis, Thrombosis, and Disease
James P Luyendyk,Matthew J. Flick,Alisa S. Wolberg
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Research Article January 27 2025
Integrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody response
Sravya Tumuluru,James K. Godfrey,Alan Cooper,Jovian Yu,Xiufen Chen,Brendan MacNabb,Girish Venkataraman,Yuanyuan Zha,Benedikt Pelzer,Joo Y. Song,Gerben Duns,Brian Sworder,Sandeep S Raj,Christopher R Bolen,Elicia Penuel,Ekaterina Postovalova,Nikita Kotlov,Aleksander Bagaev,Nathan H Fowler,Roni Shouval,Sonali M Smith,Ash A Alizadeh,Christian Steidl,Justin P. Kline
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Review Article January 27 2025
Frontline treatment of follicular lymphoma: What will it take to change current practice?
Emmanuel Bachy,Kim Linton
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Research Article January 27 2025
IAP dependency of T-cell prolymphocytic leukemia identified by high-throughput drug screening.
Marcel F. Pohly,Kerstin Putzker,Sebastian Scheinost,Lena Ben Taarit,Tatjana Walther,Sandra Kummer,Tobias Wertheimer,Minqi Lin,Thi Huong Lan Do,Kristina Handler,Jan Michler,Jarno Kivioja,Karsten Bach,Samanta Kisele,James Kim,Sascha Dietrich,Beat Bornhauser,Wendy Wei-Lynn Wong,Burkhard Becher,Andreas Moor,Joe David Lewis,Xenia Maria Ficht,Junyan Lu,Wolfgang Huber,Thorsten Zenz
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Review Article January 27 2025
Advances in RNA editing in hematopoiesis and associated malignancies
Shuangshuang Pu,Tao Cheng,Hui Cheng
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Research Article January 27 2025
Babesiosis and Sickle Red blood Cells: Loss of Deformability, Heightened Osmotic fragility, and Hypervesiculation
Divya Beri,Marilis A Rodriguez,Manpreet Singh,Daniel McLaughlin,Yunfeng Liu,Hui Zhong,Avital Mendelson,Xiuli An,Deepa G Manwani,Karina Yazdanbakhsh,Cheryl A Lobo
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Review Article January 24 2025
The Fit Older Adult with Acute Myeloid Leukemia: Clinical Challenges to Providing Evidence-Based Frontline Treatment
Sameem M Abedin,Geoffrey L Uy,Laura C. Michaelis
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Research Article January 24 2025
One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them
Ainsley V.C. Knox,Lauren Y. Cominsky,Di Sun,Emylette Cruz Cabrera,Brian E. Nolan,Edann Ofray,Elisa Benetti,Camilla Visconti,Federica Barzaghi,Sergio D. Rosenzweig,Monica Ghei Lawrence,Kathleen E. Sullivan,Samuel Yoon,Suzanna Rachimi,Nurcicek Padem,Erin Conboy,Maja Stojanovic,Gordana Petrovic,Srdjan Pasic,Joseph A. Church,Ronald M. Ferdman,Fabio Candotti,Tiphaine Arlabosse,Katerina Theodoropoulou,Cullen M. Dutmer,László Maródi,Gabriella Szücs,Arnon Broides,Amit Nahum,Jacov Levy,Kaisa Maria Kettunen,Ravindra Daddali, Ravi,Mikko R J Seppänen,Markku Vänttinen,Timi Martelius,Juha Grönholm,Matilde Peri,Chiara Azzari,Silvia Ricci,Samar Ojaimi,Emily SJ Edwards,Menno C. van Zelm,Jinqiao Sun,Hassan Abolhassani,Qiang Pan-Hammarström,Hakon Hakonarson,Daniel Mayr,Kaan Boztug,Bertrand Boisson,Jean-Laurent Casanova,Carole Le Coz,Gregory M.K. Poon,Neil Romberg
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Research Article January 22 2025
FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells
Joana L Araújo,Elvin Wagenblast,Veronique Voisin,Jessica McLeod,Olga I. Gan,Suraj Bansal,Liqing Jin,Amanda Mitchell,Blaise Gratton,Sarah Kristen Cutting,Andrea Arruda,Monica Doedens,Anthea Travas,Dennis Dong Hwan Kim,Jose-Mario Capo-Chichi,Sagi Abelson, Ph.D.,Mark D Minden,Jean CY Wang,Manuel A Sobrinho-Simões,Perpétua Pinto-do-Ó,Eric R Lechman,John E. Dick
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Research Article January 22 2025
CpG island methylator phenotype classification improves risk assessment in pediatric T-cell Acute Lymphoblastic Leukemia
Fernanda Schäfer Hackenhaar,Nina Refhagen,Melanie M Hagleitner,Frank N. van Leeuwen,Hanne Vibeke Marquart,Hans Ole Madsen,Mattias Landfors,Pia Osterman,Kjeld Schmiegelow,Trond Flaegstad,Olafur G Jonsson,Jukka Kanerva,Jonas Abrahamsson,Mats Heyman,Ulrika Noren-Nystrom,Magnus Hultdin,Sofie Degerman
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Research Article January 22 2025
NETs persisting in vasculature undergo self-renewal with consequences for subsequent infection: a mouse model study
Michal Santocki,Anna Such,Dominika Drab,Gabriela Burczyk,Elzbieta Kolaczkowska
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Research Article January 22 2025
Dual Biological Role and Clinical Impact of De Novo Chromatin Activation in Chronic Lymphocytic Leukemia
Vicente Chapaprieta,Alba Maiques-Diaz,Ferran Nadeu,Guillem Clot,Ramon Massoni-Badosa,Pablo Mozas,Judith Mateos-Jaimez,Anna Vidal Crespo,Stella Charalampopoulou,Martí Duran-Ferrer,Romina Royo,Núria Russiñol,Laura Llaó Cid,Juan A. Piñeyroa,Neus Villamor,Holger Heyn,Sophie A. Herbst,Junyan Lu,Dean J. Bryant,Jonathan C. C. Strefford,Sascha Dietrich,Thorsten Zenz,Julio Delgado,Armando López-Guillermo,Elías Campo,Jose Ignacio Martin-Subero
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Research Article January 22 2025
GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia.
Fatemeh Alikarami,Hongbo M Xie,Simone S Riedel,Haley Goodrow,Declan Raymond Barrett,Leila Mahdavi,Alexandra Lenard,Changya Chen,Taylor Yamauchi,Etienne Danis,Zhendong Cao,Vu Le-Huy Tran,Mabel Minji Jung,Yapeng Li,Hua Huang,Junwei Shi,Kai Tan,David Trent Teachey,Emery H Bresnick,Tobias Neff,Kathrin Maria Bernt
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Research Article January 22 2025
Evaluating the impact of CRBN mutations on response to immunomodulatory drugs and novel CRBN-binding agents in myeloma
Yakinthi Chrisochoidou,Andrea Scarpino, Dr,Salomon Morales,Shannon Martin,Sarah Anne Bird,Yigen Li, Dr,Brian A Walker,John Caldwell,Yann-Vai Le Bihan, Dr,Charlotte Pawlyn, Dr
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Research Article January 22 2025
Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone Induction in Newly Diagnosed Myeloma: Analysis of the MIDAS Trial
Aurore Perrot,Cyrille Touzeau,Jerome Lambert,Cyrille Hulin,Denis Caillot,Lionel Karlin,Bertrand Arnulf,Philippe Rey,Laurent Garderet,Margaret Macro, Dr,Martine Escoffre-Barbe,Julie Gay,Thomas Chalopin,Romain Gounot,Jean Marc Schiano de Colella,Mourad Tiab,Mohamad Mohty,Frédérique Kuhnowski,Jean Fontan,Salomon Manier,Frederique Orsini Piocelle,Laure Vincent,Sophie Rigaudeau,Xavier Leleu,Benjamin Hébraud,Laurent Flet,Jean-Valère Malfuson,Caroline Jacquet,Driss Chaoui,Nathalie Meuleman,Wajed Abarah,Lydia Montes,Riad Benramdane,Cécile Sonntag,Hacene Zerazhi,Alina Danu,Olivier Allangba,Mamoun Dib,Murielle Roussel,Sophie Cereja,Julien Depaus,Nicolas Branche,Hélène Demarquette,Valentine Richez,Cherel Bruiec,Laurent Frenzel,Marie-Christiane MB Vekemans,Noemie Bigot,Hervé Avet-Loiseau,Jill Corre,Philippe Moreau
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Research Article January 15 2025
Defining 2 Biologically and Clinically Distinct Groups in Acute Leukemia with a Mixed Phenotype
Pallavi Galera,Deepika Dilip,Andriy Derkach,Alexander Chan,Yanming Zhang,Sonali Persaud,Tanmay Mishra,Kyle Kramer,Mahak Kathpalia,Ying Liu,Christopher A Famulare,Qi Gao,Douglas Alexander Mata,Maria E. Arcila,Mark B. Geyer,Eytan M. Stein,Ahmet Dogan,Mikhail Roshal,Ross L Levine,Jacob L. Glass,Wenbin Xiao
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Review Article January 14 2025
How I Treat Higher-Risk MDS
Alain Mina,Rami S. Komrokji
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Review Article January 14 2025
Precision Medicine for High-Risk Gene Fusions in Paediatric AML: a focus on KMT2A, NUP98, and GLIS2 Rearrangements
Grace Egan,Sarah K Tasian
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Research Article January 10 2025
Donor Regulatory T-Cell Therapy to Prevent Graft-Versus-Host Disease
Everett Meyer,Anna Pavlova,Alejandro Villar-Prados,Cameron S Bader,Bryan Xie,Lori Muffly,Paige Kim,Katherine C. Sutherland,Sushma Bharadwaj,Saurabh Dahiya,Matthew J Frank,Sally Arai,Laura Johnston,David B Miklos,Andrew R. Rezvani,Parveen Shiraz,Surbhi Sidana,Judith A. Shizuru,Wen-Kai Weng,Vaibhav Agrawal,Amy Putnam,Nathanial B Fernhoff,John Tamaresis,Ying Lu,Rahul D Pawar,J Scott McClellan,Robert Lowsky,Robert S. Negrin
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Research Article January 7 2025
Measurable residual disease and posttransplantation gilteritinib maintenance for patients with FLT3-ITD-mutated AML
Mark J. Levis,Mehdi Hamadani,Brent R. Logan,Richard J. Jones,Anurag K Singh,Mark R Litzow,John R. Wingard,Esperanza B. Papadopoulos,Alexander E. Perl,Robert J. Soiffer,Celalettin Ustun,Masumi Ueda Oshima,Geoffrey L Uy,Edmund K. Waller,Sumithira Vasu,Melhem M Solh,Asmita Mishra,Lori Muffly,Hee-Je Kim,Matthias Stelljes,Yuho Najima,Masahiro Onozawa,Kirsty J Thomson,Arnon Nagler,Andrew H Wei,Guido Marcucci,Caroline Chen,Nahla Hasabou,Matt Rosales,Jason E. Hill,Stanley C. Gill,Rishita Nuthethi,Denise King,Adam M Mendizabal,Steven M. Devine,Mary M Horowitz,Yi-Bin Chen
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Review Article December 30 2024
How I use noninvasive prenatal testing for red blood cell and platelet antigens
Renske Marijke van 't Oever,E.J.T. (Joanne) Verweij,Masja De Haas
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Review Article December 24 2024
How I Treat AML relapse after allogeneic HCT
Mahasweta Gooptu,H. Moses Murdock,Robert J. Soiffer
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Research Article December 16 2024
DLBclass: A Probabilistic Molecular Classifier to Guide Clinical Investigation and Practice in DLBCL
Björn Chapuy,Timothy R. Wood,Chip Stewart,Andrew J. Dunford,Kirsty Wienand,Sumbul J. Khan,Nazli Serin,Meng Wang,Eleonora Calabretta,Joji Shimono,Samantha Van Seters,Sam Wiseman,Saveliy Belkin,David Isaac Heiman,Robert A Redd,Margaret A. Shipp,Gad Getz
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Research Article December 6 2024
A New Severe Congenital Neutropenia Syndrome Associated with Autosomal Recessive COPZ1 Mutations
Natalia Borbaran Bravo,Ekaterina Deordieva,Larissa Doll,Mohammad ElGamacy,Benjamin Dannenmann,Joana Azevedo,Alberto Iannuzzo,Selket Delafontaine,Moritz Lehners,Marius Sebastian Theo Kolodziej,Birte Hernandez Alvarez,Anna-Sophia Hellmuth,Malte Ritter,Betül Findik,Viktoria Zakharova,Sandro Bräuning,Sergey Kandabarau,Claudia Lengerke,Robert Feil,Isabelle Meyts,Jérôme Delon,Markus F. Templin,Marc Sturm,Olaf Rieß,Cornelia Zeidler,Karl Welte,Anna Shcherbina,Maksim Klimiankou,Julia Skokowa
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Review Article November 14 2024
Approaching a therapeutic inflection point for FLT3-mutated AML
Alexander E. Perl
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Review Article October 7 2024
How I diagnose and treat cardiorespiratory complications of transfusion
Alexander P Vlaar,Jaap Jan Zwaginga,Johanna C Wiersum-Osselton
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Review Article September 6 2024
Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia in Adults over 70 years old
Roland B. Walter,Victoria Potter,Charles Craddock
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Review Article September 5 2024
TP53-Mutated Acute Myeloid Leukemia: How Can We Improve Outcomes?
David A Sallman,Maximilian Stahl
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Review Article June 7 2024
How I manage major hemorrhage
Jeannie L Callum,Ronald B George,Keyvan Karkouti
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Review Article May 14 2024
How I manage pregnant patients who are alloimmunized to RBC antigens
Helen Frances Savoia,Anna Parakh,Stefan Charles Kane
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Review Article May 10 2024
How I Treat Challenging Transfusion Cases in Sickle Cell Disease
Stella T. Chou,Jeanne E Hendrickson
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