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Journal Articles

Bleximenib or placebo in combination with standard induction and consolidation therapy followed by maintenance for the treatment of patients with newly diagnosed KMT2A-rearranged or NPM1-mutant Acute Myeloid Leukemia eligible for intensive chemotherapy: A double-blind Phase 3 study (HOVON 181 AML / AMLSG 37-25)

Free
Marc Raaijmakers, Hartmut Döhner, Dimitri Breems, John Byrd, Konstanze Döhner, Jordi Esteve, Bjørn Gjertsen, Patrycja Gradowska, Gerwin A. Huls, Ain Kaare, Heeje Kim, Hitoshi Kiyoi, Mika Kontro, Janusz Krawczyk, Vladimir Lazarevic, Andrea Lenartova, Alice Mims, Jeannine Refos, Christoph Röllig, Anika Schrade, Karolina Sikorska, Alexandre Theocharides, Peter Valk, Adriano Venditti, Jianxiang Wang, Andrew Wei, Agnieszka Wierzbowska, Andrius Zucenka, Lucille Ferrante, Christina Drenberg Guttke, Angélique Langlois, Christina Loefgren, Kathryn Packman, Prathap Nagaraja Shastri, Natasha Schuier, Meena Thayu, Danielle Trancucci, Bob Lowenberg, Lars Bullinger
Journal: Blood
Blood (2025) 146 (Supplement 1): 1654.
https://doi.org/10.1182/blood-2025-1654
Published: 2025
Journal Articles

The addition of a tyrosine kinase inhibitor to intensive chemotherapy significantly improves outcome in de novo BCR::ABL1+ acute myeloid leukemia treated with intensive chemotherapy

Free
Sarah Bertoli, Niklas Landberg, Emilie Bérard, Camille Gondran, Laetitia Largeaud, Véronique De Mas, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Sylvain Garciaz, Ludovic Gabellier, Gabrielle Roth-Guepin, Corentin Orvain, Pierre Peterlin, Rudy Birsen, Magda Alexis, Martin Carre, Emmanuelle Tavernier, Marion Boissard Simonet, Chantal Himberlin, Marc Maynadié, Kamel Laribi, Cécile Moluçon-Chabrot, Amine Belhabri, Samy Chraibi, Quentin Cabrera, Delphine Lebon, Emmanuel Raffoux, Thomas Cluzeau, Jean-Baptiste Micol, Mathieu Leclerc, Céline Berthon, Herve Dombret, Gunnar Juliusson, Anna Robelius, Sören Lehmann, Martin Jädersten, Lovisa Wennström, Pau Montesinos, Carmen Botella, Juan Miguel Bergua Burgues, Raimundo Garcia, Josefina Serrano, Mariluz Amigo, Patricia Garcia Ramirez, Claudia Sossa, Juan Manuel Alonso-Dominguez, Hartmut Döhner, Konstanze Döhner, Daniela Späth, Michael Kühn, Claudia Lengerke, Hans-Jörg Tischler, Christoph Röllig, Leo Ruhnke, Christian Thiede, Andreas Burchert, Hubert Serve, Carsten Mueller-Tidow, Claudia Baldus, Jurjen Versluis, Peter Valk, Daniel Kristensen, Anne Stidsholt Roug, Jiri Mayer, Mika Kontro, Pia Ettala, Vladimir Lazarevic, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 991.
https://doi.org/10.1182/blood-2025-991
Published: 2025
Journal Articles

Early flow cytometry-based MRD predicts relapse in intermediate-risk AML from low- and middle-income countries

Free
Leticia Marani, Maria Isabel Ayrosa Madeira, Amanda Costa, Priscilla Santos, Josiane Lilian Schivinato, Ana Silvia Gouvea de Lima, Fernanda Borges, César Alexander Ortiz Rojas, Katia Pagnano, Bruno Duarte, Wellington Fernandes da Silva Junior, Ana Beatriz Firmato Gloria, Evandro Maranhão Fagundes, Elenaide Nunes, Marcia Higashi, Rosane Bittencourt, Elisa Fraga, Arnold Ganser, Bob Lowenberg, Martin Tallman, Nancy Berliner, Peter Valk, Richard Dillon, Fabiola Traina, Eduardo Rego, Sylvie Freeman, Lorena Figueiredo-Pontes
Journal: Blood
Blood (2025) 146 (Supplement 1): 1739.
https://doi.org/10.1182/blood-2025-1739
Published: 2025
Journal Articles

Autologous stem cell transplantation versus consolidation chemotherapy as post-remission treatment in newly diagnosed favorable and intermediate risk patients with AML: A comparative analysis of HOVON-SAKK-Nordic trials

Free
Dimitrios Kotsos, Carin Hazenberg, Thomas Pabst, Patrycja Gradowska, Markus Manz, Johan Maertens, Carlos Graux, Marie-Christiane Vekemans, Bjorn Gjertsen, Soren Lehmann, Catharina Van Elssen, Peter Valk, Edo Vellenga, Gert J. Ossenkoppele, Bob Lowenberg, Marc Raaijmakers, Gerwin A. Huls, Jurjen Versluis
Journal: Blood
Blood (2025) 146 (Supplement 1): 2517.
https://doi.org/10.1182/blood-2025-2517
Published: 2025
Journal Articles

Validation of measurable residual disease as a surrogate endpoint in acute myeloid leukemia: A HARMONY Alliance study of European randomized trials

Free
Jesse Tettero, Sträng Eric, Sylvie Freeman, Richard Dillon, Jacqueline Cloos, Peter Valk, Konstanze Döhner, Michael Heuser, Christoph Röllig, Christian Thiede, Axel Benner, Luciana Carota, Daniele Dall'Olio, Ana Garcia, Alberto Hernandez Sanchez, Sean Johnson, Soren Lehmann, Javier Martinez Elicegui, Rabea Mecklenbrauck, Klaus Metzeler, Marta Sobas, Ian Thomas, Amin Turki, Laura Tur Gimenez, Brain Huntley, Nigel Russell, Jurjen Versluis, Hartmut Döhner, Jesus Maria Hernandez Rivas, Lars Bullinger, Gert J. Ossenkoppele
Journal: Blood
Blood (2025) 146 (Supplement 1): 343.
https://doi.org/10.1182/blood-2025-343
Published: 2025
Journal Articles

Transplant in older adults with AML: genomic wheat and chaff

Free
Sylvie D. Freeman, Peter Valk
Journal: Blood
Blood (2022) 139 (24): 3459–3461.
https://doi.org/10.1182/blood.2022016195
Published: 2022
Journal Articles

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

Free
Roger Mulet-Lazaro, Stanley van Herk, Claudia Erpelinck, Eric Bindels, Mathijs A. Sanders, Carlo Vermeulen, Ivo Renkens, Peter Valk, Ari M. Melnick, Jeroen de Ridder, Michael Rehli, Claudia Gebhard, Ruud Delwel, Bas J. Wouters
Journal: Blood
Blood (2021) 138 (2): 160–177.
https://doi.org/10.1182/blood.2020009244
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical and Functional Studies Reveal That TP73 Isoforms Levels Are Associated with Prognosis and RA-Resistance in Acute Promyelocytic Leukemia

Free
César Alexander Ortiz Rojas, BSc, Diego A Pereira-Martins, MSc, Isabel Weinhäuser, MSc, Luciana Yamamoto Almeida, PhD, Thiago Mantello Bianco, MSc, Lorena Lobo Figueiredo-Pontes, MD PhD, Luisa C A Koury, MD, Raul Antônio Morais Melo, MD PhD, Rosane Bittencourt, Katia B Pagnano, MD PhD, Ricardo Pasquini, MD, Elenaide C. Nunes, MD, Evandro Maranhão Fagundes, MD, Ana Beatriz F. Gloria, MD, Fabio R. Kerbauy, MD, Armand Keating, MD, Martin S. Tallman, MD, Raul Ribeiro, MD, Richard Dillon, MA, PhD MRCP, FRCPath, Arnold Ganser, MD, Bob Löwenberg, MD PhD, Peter Valk, PhD, Miguel A. Sanz, Nancy Berliner, MD, Eduardo M Rego, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2719.
https://doi.org/10.1182/blood-2019-131211
Published: 2019
Journal Articles

Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

Free
Diego A Pereira-Martins, MSc, Juan L Coelho-Silva, BSc, MSc, Isabel Weinhäuser, MSc, Luisa C A Koury, MD, Raul Antônio Morais Melo, MD PhD, Rosane Bittencourt, Katia B Pagnano, MD PhD, Ricardo Pasquini, MD, Elenaide C. Nunes, MD, Evandro Maranhão Fagundes, MD, Ana Beatriz F. Gloria, MD, Fabio R. Kerbauy, MD, Armand Keating, MD, Martin S. Tallman, MD, Raul Ribeiro, MD, Richard Dillon, MA, PhD MRCP, FRCPath, Arnold Ganser, MD, Michael Heuser, MD, Bob Löwenberg, MD PhD, Peter Valk, PhD, Miguel A. Sanz, Nancy Berliner, MD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5166.
https://doi.org/10.1182/blood-2019-131595
Published: 2019
Journal Articles

Durable Responses and Survival in High Risk AML and MDS Patients Treated with an Allogeneic Leukemia-Derived Dendritic Cell Vaccine

Free
Luca L.G. Janssen, MD, Theresia M. Westers, PhD, Jeroen Rovers, MD PhD, Peter Valk, PhD, Jacqueline Cloos, PhD, Tanja D. de Gruijl, PhD, Arjan A. Van de Loosdrecht, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1381.
https://doi.org/10.1182/blood-2019-127881
Published: 2019
Journal Articles

Immune Landscapes Predict Chemotherapy Resistance and Anti-Leukemic Activity of Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Free
Jayakumar Vadakekolathu, PhD, Mark D. Minden, MD PhD, Tressa Hood, MSc, Sarah E. Church, PhD, Stephen Reeder, BSc, Heidi Altmann, PhD, Amy H Sullivan, BSc, Elena J Viboch, MSc, Tasleema Patel, Narmin Ibrahimova, Sarah E. Warren, PhD, Andrea Arruda, Marc Schmitz, MD, Yan Liang, PhD, Alessandra Cesano, MD PhD, A. Graham Pockley, PhD, Peter Valk, PhD, Bob Löwenberg, MD PhD, Martin Bornhäuser, MD, Sarah K. Tasian, MD, Michael P. Rettig, PhD, Jan K Davidson-Moncada, MD PhD, John F. DiPersio, MD PhD, Sergio Rutella, MDPhDFRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 460.
https://doi.org/10.1182/blood-2019-121870
Published: 2019
Journal Articles

Allele-Specific Expression of GATA2 in AML with CEBPA Biallelic Mutations

Free
Roger Mulet-Lazaro, MSc, Stanley van Herk, B.Sc., Claudia Erpelinck-Verschueren, B.Sc., Mathijs A. Sanders, PhD MSc, Eric Bindels, PhD, Peter Valk, PhD, Michael Rehli, PhD, Claudia Gebhard, PhD, Ruud Delwel, PhD, B.J. Wouters
Journal: Blood
Blood (2019) 134 (Supplement_1): 1235.
https://doi.org/10.1182/blood-2019-129766
Published: 2019
Journal Articles

Clonal Evolution of Multiple Myeloma in Patients from Diagnosis to First Relapse, Who Were Treated in Subsequent Clinical Trials

Free
Mark van Duin, Annemiek Broijl, Jasper Koenders, Sonja Zweegman, Monique C. Minnema, Francois G. Kavelaars, Remco Hoogenboezem, Kazem Nasserinejad, Mario Boccadoro, Peter Valk, PhD, Pieter Sonneveld
Journal: Blood
Blood (2019) 134 (Supplement_1): 1798.
https://doi.org/10.1182/blood-2019-130086
Published: 2019
Journal Articles

A Leukemic Progression Model of Severe Congenital Neutropenia Uncovers a Novel Mechanism of AML Development Involving Elevated Inflammatory Responses, Mutation of CXXC4 and Decreased TET2 Levels

Free
Patricia Olofsen, MSc, Szabolcs Fatrai, PhD, Paulette van Strien, BSc, Julia Obenauer, MSc, Remco Hoogenboezem, MSc, Claudia Erpelinck-Verschueren, B.Sc., Onno Roovers, BSc, Torsten Haferlach, MD, Peter Valk, PhD, Rebekka Schneider, MDPhD, Emma De Pater, PhD, Ivo Touw, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 540.
https://doi.org/10.1182/blood-2018-99-115914
Published: 2018
Journal Articles

Whole Transcriptome RNA Sequencing As a Comprehensive Diagnostic Tool for Acute Myeloid Leukemia

Free
Marieke Griffioen, PhD, Wibowo Arindrarto, Daniel M. Borras, PhD, Irene J. Locher, Saskia A.M.E. van Diessen, Rosalie van der Holst, Edith D. van der Meijden, M. Willy Honders, Rick H. de Leeuw, Inge Jedema, PhD, Wilma G.M. Kroes, Jeroen Knijnenburg, PhD, Joost Vermaat, MD PhD, Peter Valk, PhD, Bart Janssen, PhD, Peter de Knijff, PhD, Cornelis A.M. van Bergen, PhD, Erik B. van den Akker, PhD, Peter A.C. 't Hoen, PhD, Szymon M. Kielbasa, PhD, Jeroen F.J. Laros, PhD, Hendrik Veelken, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2762.
https://doi.org/10.1182/blood-2018-99-111115
Published: 2018
Journal Articles

Complex 3q26/EVI1 Rearrangements Genocopy Inv(3)/t(3;3) Acute Myeloid Leukemias By Enhancer Hijacking, EVI1 Overexpression, Absent MDS1-EVI1 and Low GATA2 Expression

Free
Sophie Ottema, MSc, Roger Mulet-Lazaro, B.Sc., Berna Beverloo, PhD, Marije Havermans, Ir, Claudia Erpelinck-Verschueren, B.Sc., Tim Grob, MD, Peter Valk, PhD, Eric Bindels, PhD, Torsten Haferlach, MD, Claudia Haferlach, MD, Leonie Smeenk, PhD, Ruud Delwel, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2766.
https://doi.org/10.1182/blood-2018-99-113339
Published: 2018
Journal Articles

Slit-Robo Pathway Is Clinically Relevant and May Represent a Potential Target in Acute Promyelocytic Leukemia

Free
Isabel Weinhäuser, MSc, Diego Antonio Pereira-Martins, MSc, Cesar Ortiz, BS, Josiane Lilian Schiavinato, PhD, Camila Bonaldo, Luisa C Koury, Virginia Mara De Deus Wagatsuma, PhD, Raul Antônio Morais Melo, MD PhD, Rosane Bittencourt, MD, Katia B Pagnano, MD, Evandro Maranhão Fagundes, MD, Ana Beatriz F. Gloria, MD, Fabio R. Kerbauy, MD, Maria de Lourdes Chauffaille, MD PhD, Ricardo Pasquini, MD, Martin S. Tallman, MD, Raul Ribeiro, MD, Richard Dillon, MA, PhD MRCP, FRCPath, Armand Keating, MD, Arnold Ganser, MD, Bob Lowenberg, MD, Peter Valk, PhD, Francesco Lo-Coco, MD, Miguel A. Sanz, MD, Nancy Berliner, MD, Antonio R. Lucena-Araujo, PhD, Eduardo Magalhães Rego, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1533.
https://doi.org/10.1182/blood-2018-99-115370
Published: 2018
Journal Articles

Metformintreatment Overcomes ATRA-Resistance in Acute Promyelocytic Leukemia and Increases FOXO3A Expression

Free
Diego Antonio Pereira-Martins, MSc, Cesar Ortiz, BS, Pedro Luis Franca-Neto, MSc, Isabel Weinhäuser, MSc, Josiane Lilian Schiavinato, PhD, Patrícia Vianna Bonini Palma, BSc, Camila Bonaldo, Luisa C A Koury, MD, Mariane Cristina Do Nascimento, BSc, Raul Antônio Morais Melo, MD PhD, Rosane Bittencourt, MD, Katia B B Pagnano, MD PhD, Ricardo Pasquini, MD, Evandro Maranhão Fagundes, MD, Ana Beatriz F. Gloria, MD, Fabio R. Kerbauy, MD, Maria de Lourdes Chauffaille, MD PhD, Armand Keating, MD, Martin S. Tallman, MD, Raul Ribeiro, MD, Richard Dillon, MA, PhD MRCP, FRCPath, Arnold Ganser, MD, Bob Lowenberg, MD, Peter Valk, PhD, Francesco Lo-Coco, MD, Miguel A. Sanz, MD, Nancy Berliner, MD, Antonio R. Lucena-Araujo, PhD, Eduardo Magalhães Rego, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1532.
https://doi.org/10.1182/blood-2018-99-115068
Published: 2018
Journal Articles

Molecular Minimal Residual Disease Detection in Acute Myeloid Leukemia

Free
Peter Valk, PhD
Journal: Blood
Blood (2016) 128 (22): SCI-30.
https://doi.org/10.1182/blood.V128.22.SCI-30.SCI-30
Published: 2016
Journal Articles

The Impact of Novel Molecular Markers on Risk Stratification in Acute Myeloid Leukemia

Free
Bob Löwenberg, MD, PhD, Peter Valk, PhD, Ivo P. Touw, PhD, Ruud Delwel, PhD
Journal: Blood
Blood (2012) 120 (21): SCI-33.
https://doi.org/10.1182/blood.V120.21.SCI-33.SCI-33
Published: 2012