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Hitoshi Kiyoi
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Journal Articles

Repertoire of driver events in coding and non-coding regions identified by whole-genome sequencing of myeloid neoplasms

Free
Koji Okazaki, Ryunosuke Saiki, Yotaro Ochi, Kenichi Yoshida, Kotoe Katayama, Hidehito Fukushima, Kaito Mimura, Masahiro Nakagawa, Masanori Motomura, Akinori Yoda, Rurika Okuda, Lanying Zhao, Motohiro Kato, Tatsuki Ogasawara, Shigeo Fuji, Lee-Yung Shih, Nobuhiko Uoshima, Mitsumasa Watanabe, Yasushi Miyazaki, Motoshi Ichikawa, Takeshi Maeda, Toshiyuki Kitano, Satoshi Yoshihara, Kazunori Imada, Kinuko Mitani, Joop Jansen, Mamiko Sakata-Yanagimoto, Luca Malcovati, Akihiko Gotoh, Hitoshi Kiyoi, Nobuhiro Kanemura, Nobuo Sezaki, Nobuhiro Hiramoto, Senji Kasahara, Seiya Imoto, Akifumi Takaori-Kondo, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 1450.
https://doi.org/10.1182/blood-2025-1450
Published: 2025
Journal Articles

Reattempt of tyrosine kinase inhibitor discontinuation after maintenance therapy with ponatinib in patients with chronic myeloid leukemia in the chronic phase: Result of JALSG CML RE-STOP219 study.

Free
Noriyoshi Iriyama, Naoto Takahashi, Katsumichi Fujimaki, Takaaki Ono, Masuho Saburi, Masahide Yamamoto, Fumihiko Kimura, Eisei Kondo, Nobuyuki Aotsuka, Hiroki Yokoyama, Seiichiro Katagiri, Yosuke Minami, Maho Ishikawa, Yachiyo Kuwatsuka, Masatomo Miura, Akiko Saito, Toshiki Saito, Itaru Matsumura, Yasushi Miyazaki, Emiko Sakaida, Yoshinobu Maeda, Takahiro Yamauchi, Hitoshi Kiyoi
Journal: Blood
Blood (2025) 146 (Supplement 1): 5546.
https://doi.org/10.1182/blood-2025-5546
Published: 2025
Journal Articles

Bleximenib or placebo in combination with standard induction and consolidation therapy followed by maintenance for the treatment of patients with newly diagnosed KMT2A-rearranged or NPM1-mutant Acute Myeloid Leukemia eligible for intensive chemotherapy: A double-blind Phase 3 study (HOVON 181 AML / AMLSG 37-25)

Free
Marc Raaijmakers, Hartmut Döhner, Dimitri Breems, John Byrd, Konstanze Döhner, Jordi Esteve, Bjørn Gjertsen, Patrycja Gradowska, Gerwin A. Huls, Ain Kaare, Heeje Kim, Hitoshi Kiyoi, Mika Kontro, Janusz Krawczyk, Vladimir Lazarevic, Andrea Lenartova, Alice Mims, Jeannine Refos, Christoph Röllig, Anika Schrade, Karolina Sikorska, Alexandre Theocharides, Peter Valk, Adriano Venditti, Jianxiang Wang, Andrew Wei, Agnieszka Wierzbowska, Andrius Zucenka, Lucille Ferrante, Christina Drenberg Guttke, Angélique Langlois, Christina Loefgren, Kathryn Packman, Prathap Nagaraja Shastri, Natasha Schuier, Meena Thayu, Danielle Trancucci, Bob Lowenberg, Lars Bullinger
Journal: Blood
Blood (2025) 146 (Supplement 1): 1654.
https://doi.org/10.1182/blood-2025-1654
Published: 2025
Journal Articles

A Phase 2 study of sequential administration of gilteritinib after MEC chemotherapy in Relapsed/Refractory FLT3-mutated Acute Myeloid Leukemia in adults: Japan adult leukemia study group (JALSG) RR-FLT3-AML220 study

Free
Yuichi Ishikawa, Takahiro Yamauchi, Masashi Sawa, Tomomi Toubai, Yuho Najima, Tetsuya Nishida, Ichiro Kawashima, Yuna Katsuoka, Kazutaka Ozeki, Kensuke Usuki, Toru Kiguchi, Takeshi Saito, Satoru Takada, Ko Fujimoto, Shinya Sato, Tomoya Maeda, Hisayuki Yokoyama, Hiroki Uchida, Takumi Lee, Takashi Ishida, Matsuo Yamamoto, Akiko Saito, Emiko Sakaida, Yoshinobu Maeda, Itaru Matsumura, Yasushi Miyazaki, Hitoshi Kiyoi
Journal: Blood
Blood (2025) 146 (Supplement 1): 998.
https://doi.org/10.1182/blood-2025-998
Published: 2025
Journal Articles

JALSG Ph (-) B-ALL213 Study: Pediatric-Type Chemotherapy Improves Prognosis in Adult Ph-Negative Acute Lymphoblastic Leukemia Patients, Including Older Adults

Free
Yoshihiro Hatta, Fumihiko Hayakawa, Etsuko Yamazaki, Tohru Murayama, Takeshi Saito, Masatsugu Tanaka, Noriko Doki, Tetsuya Nishida, Yuna Katsuoka, Satoru Takada, Tatsuhiro Sakamoto, Shinya Sato, Yoshiko Atsuta, Shigeki Ohtake, Emiko Sakaida, Yoshinobu Maeda, Takahiro Yamauchi, Itaru Matsumura, Yasushi Miyazaki, Hitoshi Kiyoi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2819.
https://doi.org/10.1182/blood-2024-199435
Published: 2024
Journal Articles

Analysis of On-Target and Off-Target Resistance Factors Associated with Gilteritinib Efficacy in Relapsed or Refractory AML Patients with FLT3 Mutations

Free
Satoshi Iwata, Yuichi Ishikawa, Yoko Ushijima, Kotaro Miyao, Yasuhiko Harada, Takahiro Nishiyama, Naoko Hosono, Koichi Watamoto, Emiko Sakaida, Keiko Niimi, Miki Kobayashi, Kazutaka Ozeki, Tetsuya Nishida, Shingo Kurahashi, Yukiyasu Ozawa, Jeong Hui Kim, Seara Naruse, Marie Nakashima, Naomi Kawashima, Yachiyo Kuwatsuka, Hitoshi Kiyoi
Journal: Blood
Blood (2024) 144 (Supplement 1): 6090.
https://doi.org/10.1182/blood-2024-199957
Published: 2024
Journal Articles

Prognostic Factors for T-Cell Acute Lymphoblastic Leukemia in Children and Young Adults: ALL-T11 Study Conducted By Japan Children's Cancer Group and Japan Adult Leukemia Study Group

Free
Chihaya Imai, Yoshihiro Hatta, Atsushi Sato, Koichi Oshima, Yasuhiro Okamoto, Takao Deguchi, Yoshiko Hashii, Takashi Fukushima, Toshinori Hori, Nobutaka Kiyokawa, Motohiro Kato, Shoji Saito, Ken-ichi Anami, Tatsuhiro Sakamoto, Yoshiyuki Kosaka, Souichi Suenobu, Toshihiko Imamura, Akiko Kada, Akiko M Saito, Atsushi Manabe, Yasushi Miyazaki, Itaru Matsumura, Katsuyoshi Koh, Hitoshi Kiyoi, Keizo Horibe
Journal: Blood
Blood (2024) 144 (Supplement 1): 1426.
https://doi.org/10.1182/blood-2024-199500
Published: 2024
Journal Articles

Suppression of Super-Enhancer-Driven TAL1 Expression By KLF4 in T-Cell Acute Lymphoblastic Leukemia

Free
Mina Noura, Takahiko Yasuda, Shinobu Tsuzuki, Hidemasa Matsuo, Hitoshi Kiyoi, Fumihiko Hayakawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 1405.
https://doi.org/10.1182/blood-2023-173640
Published: 2023
Journal Articles

Analysis of Metabolic Mechanism of CD19CAR-T with CD79A/CD40 Co-Stimulatory Domain Based on Comparison with Established CAR-Ts

Free
Yuki Takeuchi, Seitaro Terakura, Shiho Hirano, Hirofumi Yokota, Shihomi Kuwano, Masahide Osaki, Yoshitaka Adachi, Kanae Imai, Jakrawadee Julamanee, Ryo Hanajiri, Makoto Murata, Hitoshi Kiyoi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2057.
https://doi.org/10.1182/blood-2023-179842
Published: 2023
Journal Articles

Real-World Data in a Prospective Clinical Observation Study for Newly Diagnosed Adult Acute Lymphoblastic Leukemia, the JALSG ALL-CS-12 : Advanced Age Is a Poor Prognostic Factor

Free
Yoshihiro Hatta, Fumihiko Hayakawa, Etsuko Yamazaki, Tohru Murayama, Takeshi Saito, Satoru Takada, Nobuaki Dobashi, Shuichi Ota, Yasuhisa Yokoyama, Masatsugu Tanaka, Shinya Sato, Shigeki Ohtake, Emiko Sakaida, Yoshinobu Maeda, Takahiro Yamauchi, Itaru Matsumura, Yasushi Miyazaki, Hitoshi Kiyoi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4199.
https://doi.org/10.1182/blood-2023-178332
Published: 2023
Journal Articles

Development and Efficacy of a Novel Bromodomain and Extraterminal Domain Degrader K-256 in MYC/BCL2-Related Lymphoma

Free
Kastuya Furukawa, Kazuyuki Shimada, Masahiro Esaki, Kentaro Tanaka, Keisuke Yamamoto, Kiyotoshi Mori, Hitoshi Kiyoi
Journal: Blood
Blood (2023) 142 (Supplement 1): 5008.
https://doi.org/10.1182/blood-2023-179334
Published: 2023
Journal Articles

Thrombotic and Bleeding Events in Japanese Adolescent and Young Adult PV and ET: Results from Japanese Multicenter Retrospective Study

Free
Yuka Sugimoto, Keiki Nagaharu, Eiko Oya, Kohshi Ohishi, Isao Tawara, Tomoki Ito, Akihiko Gotoh, Mika Nakamae, Fumihiko Kimura, Michiaki Koike, Keita Kirito, Hideho Wada, Kensuke Usuki, Takayuki Tanaka, Takehiko Mori, Satoshi Wakita, Toshiki I Saito, Akiko Kada, Akiko M Saito, Kazuya Shimoda, Toshio Kurokawa, Akihiro Tomita, Yoko Edahiro, Yoshinori Hashimoto, Hitoshi Kiyoi, Koichi Akashi, Itaru Matsumura, Katsuto Takenaka, Norio Komatsu
Journal: Blood
Blood (2023) 142 (Supplement 1): 1831.
https://doi.org/10.1182/blood-2023-180561
Published: 2023
Journal Articles

Poor Prognostic Combination of Additional Chromosomal Abnormalities in Ph + ALL : JALSG Ph+ALL TKI- SCT Study

Free
Satoshi Nishiwaki, Isamu Sugiura, Shin Fujisawa, Yoshihiro Hatta, Noriko Doki, Shingo Kurahashi, Yasunori Ueda, Nobuaki Dobashi, Tomoya Maeda, Yasuhiro Taniguchi, Masatsugu Tanaka, Shinichi Kako, Tatsuo Ichinohe, Takahiro Fukuda, Yoshiko Atsuta, Shigeki Ohtake, Yuichi Ishikawa, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki
Journal: Blood
Blood (2022) 140 (Supplement 1): 6030–6032.
https://doi.org/10.1182/blood-2022-165864
Published: 2022
Journal Articles

iPSC-Derived HLA-A2 CAR Tregs Showed Suppression of GvHD in a Xenograft Model

Free
Hisashi Yano, Takayuki Sato, Tokuyuki Shinohara, Keiko Koga, Shoichi Iriguchi, Atsushi Matsuda, Yasuyuki Miyake, Yoshiaki Kassai, Hitoshi Kiyoi, Shin Kaneko
Journal: Blood
Blood (2022) 140 (Supplement 1): 2365–2366.
https://doi.org/10.1182/blood-2022-156904
Published: 2022
Journal Articles

Risk Stratified Therapy with Nelarabine and Intensified Administration of L-Asparaginase for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia in Adolescents and Young Adults (JPLSG T-11/JALSG T-ALL-211-U): An Intergroup Phase 2 Study

Free
Yoshihiro Hatta, Atsushi Sato, Akiko Kada, Akiko Moriya Saito, Fumihiko Hayakawa, Arata Watanabe, Tatsuhiro Sakamoto, Katsuhiro Miura, Yoshifumi Shimizu, Junya Kanda, Yasushi Onishi, Noboru Asada, Yasuhiro Okamoto, Chihaya Imai, Koichi Oshima, Katsuyoshi Koh, Atsushi Manabe, Keizo Horibe, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki
Journal: Blood
Blood (2022) 140 (Supplement 1): 124–126.
https://doi.org/10.1182/blood-2022-156613
Published: 2022
Journal Articles

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations

Free
Clinical Trials & Observations
Takahiko Yasuda, Masashi Sanada, Masahito Kawazu, Shinya Kojima, Shinobu Tsuzuki, Hiroo Ueno, Eisuke Iwamoto, Yuka Iijima-Yamashita, Tomomi Yamada, Takashi Kanamori, Rieko Nishimura, Yachiyo Kuwatsuka, Satoru Takada, Masatsugu Tanaka, Shuichi Ota, Nobuaki Dobashi, Etsuko Yamazaki, Asao Hirose, Tohru Murayama, Masahiko Sumi, Shinya Sato, Naoyuki Tange, Yukinori Nakamura, Yuna Katsuoka, Emiko Sakaida, Toyotaka Kawamata, Hiroatsu Iida, Yuichi Shiraishi, Yasuhito Nannya, Seishi Ogawa, Masafumi Taniwaki, Norio Asou, Yoshihiro Hatta, Hitoshi Kiyoi, Itaru Matsumura, Keizo Horibe, Hiroyuki Mano, Tomoki Naoe, Yasushi Miyazaki, Fumihiko Hayakawa
Journal: Blood
Blood (2022) 139 (12): 1850–1862.
https://doi.org/10.1182/blood.2021011921
Published: 2022
Includes: Supplemental data
Journal Articles

Outcomes of Transplant-Eligible Patients with Myelodysplastic Syndrome-Refractory Anemia with Excess Blasts Registered in a Prospective Observational Study: The JALSG-CS11-MDS-SCT

Free
Noriharu Nakagawa, Ken Ishiyama, Kensuke Usuki, Satoru Takada, Tatsuki Tomikawa, Hiroshi Handa, Yuna Katsuoka, Daiki Hirano, Nobuo Sezaki, Masahiko Sumi, Shin Fujisawa, Yasuhiro Taniguchi, Takuro Yoshimura, Eiichi Ohtsuka, Ken Takase, Youko Suehiro, Shuichi Ota, Tomohiro Kajiguchi, Tomoya Maeda, Masahide Yamamoto, Shigeki Ohtake, Akira Katsumi, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki
Journal: Blood
Blood (2021) 138 (Supplement 1): 2925.
https://doi.org/10.1182/blood-2021-147587
Published: 2021
Journal Articles

Impact of Nelarabine, Intensive L-Asparaginase, and Protracted Intrathecal Therapy on Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia: Results from the Japanese Pediatric Leukemia/Lymphoma Study Group and the Japan Adult Leukemia Study Group

Free
Atsushi Sato, Yoshihiro Hatta, Chihaya Imai, Koichi Oshima, Yasuhiro Okamoto, Takao Deguchi, Yoshiko Hashii, Takashi Fukushima, Toshinori Hori, Nobutaka Kiyokawa, Motohiro Kato, Shoji Saito, Kenichi Anami, Tatsuhiro Sakamoto, Akiko Kada, Akiko M Saito, Atsushi Manabe, Hitoshi Kiyoi, Itaru Matsumura, Keizo Horibe, Katsuyoshi Koh, Yasushi Miyazaki, Arata Watanabe
Journal: Blood
Blood (2021) 138 (Supplement 1): 3393.
https://doi.org/10.1182/blood-2021-149110
Published: 2021
Journal Articles

Nilotinib and Dasatinib Evoked Distinct Immune Effects during Tfr Phase of Each Discontinuation Trial

Free
Yuki Fujioka, Naoto Takahashi, Shigeki Ohtake, Yoshiko Atsuta, Yosuke Minami, Noriyoshi Iriyama, Hitoshi Kiyoi, Yasushi Miyazaki, Itaru Matsumura
Journal: Blood
Blood (2021) 138 (Supplement 1): 3580.
https://doi.org/10.1182/blood-2021-147312
Published: 2021
Journal Articles

Frequent genetic alterations in immune checkpoint–related genes in intravascular large B-cell lymphoma

Free
Kazuyuki Shimada, Kenichi Yoshida, Yasuhiro Suzuki, Chisako Iriyama, Yoshikage Inoue, Masashi Sanada, Keisuke Kataoka, Masaaki Yuge, Yusuke Takagi, Shigeru Kusumoto, Yasufumi Masaki, Takahiko Ito, Yuichiro Inagaki, Akinao Okamoto, Yachiyo Kuwatsuka, Masahiro Nakatochi, Satoko Shimada, Hiroaki Miyoshi, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Yusuke Shiozawa, Yasuhito Nannya, Asako Okabe, Kei Kohno, Yoshiko Atsuta, Koichi Ohshima, Shigeo Nakamura, Seishi Ogawa, Akihiro Tomita, Hitoshi Kiyoi
Journal: Blood
Blood (2021) 137 (11): 1491–1502.
https://doi.org/10.1182/blood.2020007245
Published: 2021
Includes: Supplemental data