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Journal Articles

NEAT1-triggered collateral activity of CRISPR/Cas13 exhibits antileukemic activity

Ruka Shimura, Keita Yamamoto, Yu-Hsuan Chang, Ken Suzaki, Zongru Yang, Tomohiro Yabushita, Wenyu Zhang, Kohei Iida, Kaito Mimura, Kenichi Yoshida, Mark Wunderlich, Benjamin Mizukawa, Toshio Kitamura, Susumu Goyama

Blood (2025) 146 (Supplement 1): 1470.

https://doi.org/10.1182/blood-2025-1470

Published: 2025

Journal Articles

Whole-genome analysis reveals shared early genetic alterations and subtype-specific immune evasion pathways in intravascular large B-cell lymphoma and immune-privileged large B-cell lymphoma

Takuto Mori, Kazuyuki Shimada, Kaito Mimura, Suguru Fukuhara, Koji Izutsu, Daisuke Kawauchi, Yoshitaka Narita, Akiko Miyagi Maeshima, Ryosuke Koyamada, Nobuhiro Hiramoto, Nobuyuki Kakiuchi, Hirona Maeda, Ai Okada, Kenichi Chiba, Yuichi Shiraishi, Akifumi Takaori-Kondo, Seishi Ogawa, Akihiro Tomita, Kenichi Yoshida

Blood (2025) 146 (Supplement 1): 7061.

https://doi.org/10.1182/blood-2025-7061

Published: 2025

Journal Articles

Repertoire of driver events in coding and non-coding regions identified by whole-genome sequencing of myeloid neoplasms

Blood (2025) 146 (Supplement 1): 1450.

https://doi.org/10.1182/blood-2025-1450

Published: 2025

Journal Articles

Genoprime-Perturb-seq: Functional dissection of GATA2 variants via simultaneous Genotyping-coupled Prime-editing Perturb-seq

Shigeki Hirabayashi, June Takeda, Kyoko Fukushi, Momoka Tsuruhara, Jumpei Nogami, Yuichiro Semba, Shoko Tarumoto, Ami Kamano, Moe Shinagawa, Daisuke Ishihara, Yuta Kikuchi, Kohta Miyawaki, Koichi Akashi, Takuya Yamamoto, Masahito Ohue, Masataka Ishimura, Kenichi Yoshida, Taro Tsujimura, Takahiro Maeda

Blood (2025) 146 (Supplement 1): 3215.

https://doi.org/10.1182/blood-2025-3215

Published: 2025

Journal Articles

Targeting metabolic vulnerabilities in Acute Myeloid Leukemia: Therapeutic potential of l-asparaginase and synergy with venetoclax

Blood (2025) 146 (Supplement 1): 3283.

https://doi.org/10.1182/blood-2025-3283

Published: 2025

Journal Articles

Genetic landscape of pediatric myelodysplastic syndrome in Japan

Masataka Hasegawa, Kaito Mimura, Rintaro Ono, Dai Keino, Shin-Ichi Tsujimoto, Kiyotaka Isobe, Takao Deguchi, Hideto Iwafuchi, Hiroshi Moritake, Hironori Goto, Atsushi Manabe, Seishi Ogawa, Kenichi Yoshida, Daisuke Hasegawa

Blood (2025) 146 (Supplement 1): 5612.

https://doi.org/10.1182/blood-2025-5612

Published: 2025

Journal Articles

DNA methylation profiling identifies two epigenetic subgroups with prognostic implications in pediatric acute promyelocytic leukemia: The JCCG study, JPLSG AML-P05

Etsuko Murayama, Tomoko Kawai, Genki Yamato, Norio Shiba, Kentaro Ohki, Yusuke Hara, Taeko Kaburagi, Takumi Takizawa, Hirohide Kawasaki, Kenichi Yoshida, Daisuke Tomizawa, Takashi Taga, Souichi Adachi, Yuki Yuza, Hiroyuki Takahashi, Seishi Ogawa, Yasuhide Hayashi

Blood (2025) 146 (Supplement 1): 3474.

https://doi.org/10.1182/blood-2025-3474

Published: 2025

Journal Articles

Whole-Genome Analysis Revealed the Genetic Landscape of Intravascular Large B-Cell Lymphoma

Takuto Mori, Kazuyuki Shimada, Kaito Mimura, Nobuyuki Kakiuchi, Hirona Maeda, Akifumi Takaori-Kondo, Seishi Ogawa, Akihiro Tomita, Kenichi Yoshida

Blood (2024) 144 (Supplement 1): 2983.

https://doi.org/10.1182/blood-2024-204466

Published: 2024

Journal Articles

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

Blood (2024) 144 (Supplement 1): 2673.

https://doi.org/10.1182/blood-2024-208773

Published: 2024

Journal Articles

Whole-Genome Sequencing of 95 Japanese Patients with Pediatric Acute Myeloid Leukemia

Kaito Mimura, Norio Shiba, Ai Okada, Kenichi Chiba, Kentaro Watanabe, Takao Deguchi, Kentaro Ohki, Kotoe Katayama, Seiya Imoto, Akiko M Saito, Yasuhiro Okamoto, Souichi Adachi, Daisuke Tomizawa, Takashi Taga, Yuichi Shiraishi, Hiroshi Moritake, Motohiro Kato, Kenichi Yoshida

Blood (2024) 144 (Supplement 1): 5720.

https://doi.org/10.1182/blood-2024-200476

Published: 2024

Journal Articles

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko M. Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito

Blood (2024) 143 (25): 2627–2643.

https://doi.org/10.1182/blood.2023022247

Published: 2024

Includes: Supplemental data

Journal Articles

Metabolic Reprogramming By PRDM16 Drives Cytarabine Resistance in Acute Myeloid Leukemia

Blood (2023) 142 (Supplement 1): 2740.

https://doi.org/10.1182/blood-2023-181740

Published: 2023

Journal Articles

Genetic Profile of Myeloid Neoplasms Developed with Fanconi Anemia and Aldehyde Degradation Deficiency Syndrome

Mayu Morishita, Miharu Yabe, Nobuyuki Kakiuchi, Minoru Takata, Kotoe Katayama, Seiya Imoto, Seishi Ogawa, Hiromasa Yabe, Kenichi Yoshida

Blood (2023) 142 (Supplement 1): 2738.

https://doi.org/10.1182/blood-2023-184552

Published: 2023

Journal Articles

Genomic Characterization of Acute Myeloid Leukemia with Aberrations of Chromosome 7: A Multinational Cohort of 523 Patients

Blood (2023) 142 (Supplement 1): 63.

https://doi.org/10.1182/blood-2023-185627

Published: 2023

Journal Articles

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro M. Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin G. Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa

Blood (2023) 141 (5): 534–549.

https://doi.org/10.1182/blood.2022018221

Published: 2023

Includes: Supplemental data

Journal Articles

Cooperative Effects of SRSF2 and STAG2 mutations on Development of Myelodysplastic Syndrome and Its Related Disorders

Blood (2022) 140 (Supplement 1): 4022–4023.

https://doi.org/10.1182/blood-2022-158748

Published: 2022

Journal Articles

Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia C. Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro Marshall Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa

Blood (2022) 140 (Supplement 1): 208–210.

https://doi.org/10.1182/blood-2022-158851

Published: 2022

Journal Articles

Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study

Blood (2022) 140 (Supplement 1): 9134–9135.

https://doi.org/10.1182/blood-2022-163226

Published: 2022

Journal Articles

EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia

Blood (2021) 138 (Supplement 1): 610.

https://doi.org/10.1182/blood-2021-152800

Published: 2021

Journal Articles

Clonal Evolution Pattern and Prognostic Significance of Clonal Architecture in KMT2A -Rearranged Acute Myeloid Leukemia

Blood (2021) 138 (Supplement 1): 2358.

https://doi.org/10.1182/blood-2021-146699

Published: 2021

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NEAT1-triggered collateral activity of CRISPR/Cas13 exhibits antileukemic activity

Whole-genome analysis reveals shared early genetic alterations and subtype-specific immune evasion pathways in intravascular large B-cell lymphoma and immune-privileged large B-cell lymphoma

Repertoire of driver events in coding and non-coding regions identified by whole-genome sequencing of myeloid neoplasms

Genoprime-Perturb-seq: Functional dissection of GATA2 variants via simultaneous Genotyping-coupled Prime-editing Perturb-seq

Targeting metabolic vulnerabilities in Acute Myeloid Leukemia: Therapeutic potential of l-asparaginase and synergy with venetoclax

Genetic landscape of pediatric myelodysplastic syndrome in Japan

DNA methylation profiling identifies two epigenetic subgroups with prognostic implications in pediatric acute promyelocytic leukemia: The JCCG study, JPLSG AML-P05

Whole-Genome Analysis Revealed the Genetic Landscape of Intravascular Large B-Cell Lymphoma

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

Whole-Genome Sequencing of 95 Japanese Patients with Pediatric Acute Myeloid Leukemia

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Metabolic Reprogramming By PRDM16 Drives Cytarabine Resistance in Acute Myeloid Leukemia

Genetic Profile of Myeloid Neoplasms Developed with Fanconi Anemia and Aldehyde Degradation Deficiency Syndrome

Genomic Characterization of Acute Myeloid Leukemia with Aberrations of Chromosome 7: A Multinational Cohort of 523 Patients

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Cooperative Effects of SRSF2 and STAG2 mutations on Development of Myelodysplastic Syndrome and Its Related Disorders

Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study

EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia

Clonal Evolution Pattern and Prognostic Significance of Clonal Architecture in KMT2A -Rearranged Acute Myeloid Leukemia

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