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Journal Articles

Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells

Gentaro Kawano, Riichiro Ikeda, Daisuke Ishihara, Takahiro Shima, Teppei Sakoda, Shunsuke Yamamoto, Yu Kochi, Yuichiro Semba, Sanae Ashitani, Yasuo Mori, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Tomoyoshi Soga, Koichi Akashi, Yoshikane Kikushige

Blood blood.2025030209.

https://doi.org/10.1182/blood.2025030209

Published: 2025

Includes: Supplemental data

Journal Articles

SRSF2 mutation induces BH3 mimetics sensitivity via BCL2L2 mis-splicing

Takumi Matsushima, Takuji Yamauchi, Yuichiro Semba, Koji Kato, Takahiro Maeda, Koichi Akashi

Blood (2025) 146 (Supplement 1): 5158.

https://doi.org/10.1182/blood-2025-5158

Published: 2025

Journal Articles

Platelet decrease and efficacy of platelet-rich plasma return for CAR-T lymphocyte apheresis in low-weight patients

Takahiro Shima, Tomoko Henzan, Ikumi Yamanaka, Yuichiro Semba, Shunsuke Yamamoto, Utako Oba, Yuhki Koga, Shouichi Ohga, Takahiro Maeda, Koichi Akashi

Blood (2025) 146 (Supplement 1): 7702.

https://doi.org/10.1182/blood-2025-7702

Published: 2025

Journal Articles

Efficacy of upfront blinatumomab combined with reduced-intensity chemotherapy for newly diagnosed adult Philadelphia chromosome–negative B-lineage acute lymphoblastic leukemia: Interim analysis of two prospective studies of JSCT ALL/MRD2023 and ALL/MRD2019 in Japan

Blood (2025) 146 (Supplement 1): 5116.

https://doi.org/10.1182/blood-2025-5116

Published: 2025

Journal Articles

Genoprime-Perturb-seq: Functional dissection of GATA2 variants via simultaneous Genotyping-coupled Prime-editing Perturb-seq

Shigeki Hirabayashi, June Takeda, Kyoko Fukushi, Momoka Tsuruhara, Jumpei Nogami, Yuichiro Semba, Shoko Tarumoto, Ami Kamano, Moe Shinagawa, Daisuke Ishihara, Yuta Kikuchi, Kohta Miyawaki, Koichi Akashi, Takuya Yamamoto, Masahito Ohue, Masataka Ishimura, Kenichi Yoshida, Taro Tsujimura, Takahiro Maeda

Blood (2025) 146 (Supplement 1): 3215.

https://doi.org/10.1182/blood-2025-3215

Published: 2025

Journal Articles

The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia

Yuichiro Semba, Takuji Yamauchi, Daniel E. Bauer, Seishi Ogawa, Koichi Akashi, Takahiro Maeda

Blood blood.2025028918.

https://doi.org/10.1182/blood.2025028918

Published: 2025

Includes: Supplemental data

Journal Articles

A Novel and Highly-Specific qRT-PCR System for Mutant NPM1 MRD Detection

Mayu Ikeda, Yuki Namba, Rinko Sasaki, Ryotaro Miyamoto, Hikaru Hattori, Michitaka Notoya, Motonari Daito, Yuichiro Semba, Koichi Akashi, Takahiro Maeda

Blood (2024) 144 (Supplement 1): 2225.

https://doi.org/10.1182/blood-2024-199401

Published: 2024

Journal Articles

Functional Annotation of DDX41 Variants Using Base-Editing and cDNA Expression Library Screenings

Shigeki Hirabayashi, Momoka Tsuruhara, Kyoko Fukushi, Shoko Tarumoto, Moe Shinagawa, Yuichiro Semba, Takuya Yamamoto, Yuichi Shiraishi, Kiyoko Miyata, Taro Tsujimura, Takahiro Maeda

Blood (2024) 144 (Supplement 1): 2706.

https://doi.org/10.1182/blood-2024-206451

Published: 2024

Journal Articles

ctDNA improves prognostic prediction for patients with relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone

Blood (2024) 143 (23): 2401–2413.

https://doi.org/10.1182/blood.2023022540

Published: 2024

Includes: Supplemental data

Journal Articles

Genome-Wide CRISPR/Cas9 Screens Identify DDX19A/DDX19B As a Critical Regulator of Intrinsic Apoptosis By Regulating MCL1 mRNA Cellular Localization

Tatsuya Terasaki, Yuichiro Semba, Kensuke Sasaki, Kiyoko Miyata, Takuji Yamauchi, Hiroshi Imanaga, Fumihiko Nakao, Shigeki Hirabayashi, Jumpei Nogami, Koshi Akahane, Takeshi Inukai, Koichi Akashi, Takahiro Maeda

Blood (2023) 142 (Supplement 1): 1445.

https://doi.org/10.1182/blood-2023-182620

Published: 2023

Journal Articles

The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53 -Mutated AML

Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Takahiro Maeda, Koichi Akashi

Blood (2023) 142 (Supplement 1): 2741.

https://doi.org/10.1182/blood-2023-188986

Published: 2023

Journal Articles

CELMoD for ALL: an exciting prospect

Takahiro Maeda

Blood (2023) 142 (7): 614–615.

https://doi.org/10.1182/blood.2023020923

Published: 2023

Journal Articles

The XPO7/Npat Axis Is a Potential Therapeutic Target for TP53 -Mutated AML

Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Koichi Akashi, Takahiro Maeda

Blood (2022) 140 (Supplement 1): 91–92.

https://doi.org/10.1182/blood-2022-168650

Published: 2022

Journal Articles

A Genome-Wide CRISPR-Cas9 Screen Reveals GATOR1 Complex Is a Critical Regulator of Glucocorticoid Sensitivity in B-Cell Precursor Acute Lymphoblastic Leukemia

Hiroshi Imanaga, Yuichiro Semba, Kensuke Sasaki, Kiyoko Miyata, Takuji Yamauchi, Tatsuya Terasaki, Fumihiko Nakao, Shigeki Hirabayashi, Jumpei Nogami, Koichi Akashi, Takahiro Maeda

Blood (2022) 140 (Supplement 1): 5979.

https://doi.org/10.1182/blood-2022-164647

Published: 2022

Journal Articles

Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2- rearranged Ph-like ALL

Kensuke Sasaki, Takuji Yamauchi, Yuichiro Semba, Jumpei Nogami, Hiroshi Imanaga, Tatsuya Terasaki, Fumihiko Nakao, Koshi Akahane, Takeshi Inukai, Els Verhoeyen, Koichi Akashi, Takahiro Maeda

Blood (2022) 139 (5): 748–760.

https://doi.org/10.1182/blood.2021012976

Published: 2022

Includes: Supplemental data

Journal Articles

Genome-Wide CRISPR-Cas9 Screen Identifies Rationally Designed Combination Therapies Relevant for CRLF2-Rearranged Ph-like ALL

Kensuke Sasaki, Takuji Yamauchi, Yuichiro Semba, Jumpei Nogami, Hiroshi Imanaga, Tatsuya Terasaki, Fumihiko Nakao, Koshi Akahane, Takeshi Inukai, Els Verhoeyen, Koichi Akashi, Takahiro Maeda

Blood (2021) 138 (Supplement 1): 2257.

https://doi.org/10.1182/blood-2021-152027

Published: 2021

Journal Articles

Platelet Decrease and Efficacy of Platelet-Rich Plasma Return for Peripheral Blood Stem Cell Apheresis

Takahiro Shima, MD PhD, Teppei Sakoda, MD, Tomoko Henzan, MD, Yuya Kunisaki, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD, Toshihiro Miyamoto, MD PhD

Blood (2020) 136 (Supplement 1): 29–30.

https://doi.org/10.1182/blood-2020-142316

Published: 2020

Journal Articles

Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug–induced thrombocytopenia

Taro Tochigi, Toshihiro Miyamoto, Kiwamu Hatakeyama, Teppei Sakoda, Daisuke Ishihara, Hidetoshi Irifune, Takahiro Shima, Koji Kato, Takahiro Maeda, Takumi Ito, Hiroshi Handa, Koichi Akashi, Yoshikane Kikushige

Blood (2020) 135 (24): 2146–2158.

https://doi.org/10.1182/blood.2019003749

Published: 2020

Includes: Supplemental data

Journal Articles

A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells

Fumiaki Jinnouchi, Takuji Yamauchi, Ayano Yurino, Takuya Nunomura, Michitaka Nakano, Chika Iwamoto, Teppei Obara, Kohta Miyawaki, Yoshikane Kikushige, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Eishi Baba, Koichi Akashi, Katsuto Takenaka

Blood (2020) 135 (19): 1661–1672.

https://doi.org/10.1182/blood.2019002194

Published: 2020

Includes: Supplemental data

Journal Articles

CRISPR-Cas9 Screen Identifies XPO7 As a Potential Therapeutic Target for TP53 -Mutated AML

Yuichiro Semba, MD PhD, Takuji Yamauchi, MD PhD, Fumihiko Nakao, MD, Jumpei Nogami, PhD, Matthew C. Canver, MD PhD, Luca Pinello, PhD, Daniel E. Bauer, MD PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD

Blood (2019) 134 (Supplement_1): 3784.

https://doi.org/10.1182/blood-2019-129623

Published: 2019

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Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells

SRSF2 mutation induces BH3 mimetics sensitivity via BCL2L2 mis-splicing

Platelet decrease and efficacy of platelet-rich plasma return for CAR-T lymphocyte apheresis in low-weight patients

Efficacy of upfront blinatumomab combined with reduced-intensity chemotherapy for newly diagnosed adult Philadelphia chromosome–negative B-lineage acute lymphoblastic leukemia: Interim analysis of two prospective studies of JSCT ALL/MRD2023 and ALL/MRD2019 in Japan

Genoprime-Perturb-seq: Functional dissection of GATA2 variants via simultaneous Genotyping-coupled Prime-editing Perturb-seq

The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia

A Novel and Highly-Specific qRT-PCR System for Mutant NPM1 MRD Detection

Functional Annotation of DDX41 Variants Using Base-Editing and cDNA Expression Library Screenings

ctDNA improves prognostic prediction for patients with relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone

Genome-Wide CRISPR/Cas9 Screens Identify DDX19A/DDX19B As a Critical Regulator of Intrinsic Apoptosis By Regulating MCL1 mRNA Cellular Localization

The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53 -Mutated AML

CELMoD for ALL: an exciting prospect

The XPO7/Npat Axis Is a Potential Therapeutic Target for TP53 -Mutated AML

A Genome-Wide CRISPR-Cas9 Screen Reveals GATOR1 Complex Is a Critical Regulator of Glucocorticoid Sensitivity in B-Cell Precursor Acute Lymphoblastic Leukemia

Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2- rearranged Ph-like ALL

Genome-Wide CRISPR-Cas9 Screen Identifies Rationally Designed Combination Therapies Relevant for CRLF2-Rearranged Ph-like ALL

Platelet Decrease and Efficacy of Platelet-Rich Plasma Return for Peripheral Blood Stem Cell Apheresis

Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug–induced thrombocytopenia

A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells

CRISPR-Cas9 Screen Identifies XPO7 As a Potential Therapeutic Target for TP53 -Mutated AML

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