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Journal Articles

Up-front blinatumomab improves MRD clearance and outcome in adult Ph – B-lineage ALL: the GIMEMA LAL2317 phase 2 study

Available to Purchase
Clinical Trials & Observations
Renato Bassan, Sabina Chiaretti, Irene Della Starza, Alessandra Santoro, Orietta Spinelli, Manuela Tosi, Loredana Elia, Deborah Cardinali, Maria Stefania De Propris, Matteo Piccini, Federico Lussana, Mario Annunziata, Patrizia Chiusolo, Patrizia Zappasodi, Erika Borlenghi, Matteo Leoncin, Catello Califano, Monica Bocchia, Francesco Di Raimondo, Francesco Grimaldi, Mario Tiribelli, Anna Candoni, Albana Lico, Ernesta Audisio, Monia Lunghi, Anna Maria Mianulli, Mariangela Di Trani, Valentina Arena, Monica Messina, Alfonso Piciocchi, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2025) 145 (21): 2447–2459.
https://doi.org/10.1182/blood.2024027500
Published: 2025
Includes: Supplemental data
Journal Articles

Acute promyelocytic leukemia: long-term outcomes from the HARMONY project

Available to Purchase
Clinical Trials & Observations
Maria Teresa Voso, Luca Guarnera, Söhren Lehmann, Konstanze Döhner, Hartmut Döhner, Uwe Platzbecker, Nigel Russell, Richard Dillon, Ian Thomas, Gert Ossenkoppele, Torsten Haferlach, Marco Vignetti, Edoardo La Sala, Alfonso Piciocchi, Paola Fazi, Angela Villaverde Ramiro, Laura Tur Giménez, Carmelo Gurnari, Lars Bullinger, Jesús María Hernández-Rivas
Journal: Blood
Blood (2025) 145 (2): 234–243.
https://doi.org/10.1182/blood.2024026186
Published: 2025
Includes: Supplemental data
Journal Articles

Venetoclax and Azacitidine for Relapse Prevention in NPM1 -Mutated Acute Myeloid Leukemia in Molecular Failure: Results from the Ongoing Gimema AML2521 Phase 2 Trial

Free
Chiara Sartor, Anna Candoni, Alfonso Piciocchi, Giovanni Marsili, Paola Fazi, Cristina Papayannidis, Stefania Paolini, Gianluca Cristiano, Luca Maurillo, Mario Tiribelli, Antonino Mulè, Melissa Campanelli, Giovanni Marconi, Paola Minetto, Emanuela Ottaviani, Maria Teresa Voso, Francesca Bonifazi, Attilio Olivieri, Pellegrino Musto, Francesco Di Raimondo, Roberto Massimo Lemoli, Maria Paola Martelli, Brunangelo Falini, Michele Cavo, Adriano Venditti, Francesco Buccisano, Antonio Curti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2893.
https://doi.org/10.1182/blood-2024-210315
Published: 2024
Journal Articles

Survival Analysis of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Saveria Capria, Michela Rondoni, Matteo Giovanni Della Porta, Germana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Anna Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2024) 144 (Supplement 1): 2891.
https://doi.org/10.1182/blood-2024-207842
Published: 2024
Journal Articles

Molecular Outcome of Chronic Myeloid Leukemia Affected Patients Not in Deep Molecular Response: The “Others” from the Gimema Labnet Network

Free
Fabio Stagno, Rosalba Cucci, Giovanni Marsili, Fausto Castagnetti, Sara Galimberti, Barbara Izzo, Federica Sorà, Simona Soverini, Monica Messina, Alfonso Piciocchi, Massimiliano Bonifacio, Daniela Cilloni, Alessandra Iurlo, Giovanni Martinelli, Gianantonio Rosti, Paola Fazi, Marco Vignetti, Massimo Breccia, Alessandro Allegra, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 992.
https://doi.org/10.1182/blood-2024-210201
Published: 2024
Journal Articles

Severe COVID-19 Infection in Patients with Chronic Lymphocytic Leukemia or Indolent B-Cell Non-Hodgkin Lymphoma Who Received Pre-Exposure Prophylaxis with Tixagevimab and Cilgavimab in Italy: Preliminary Results of the Observational Study By the Gimema Working Party on Chronic Lymphoproliferative Disorders and By the Fondazione Italiana Linfomi

Free
Gian Matteo Rigolin, Antonio Urso, Stefano Soddu, Riccardo Moia, Riccardo Dondolin, Attilio Olivieri, Ilaria Scortechini, Annamaria Frustaci, Marina Deodato, Giulia Daghia, Francesca Romana Mauro, Sara Pepe, Marina Motta, Antonella Anastasia, Lydia Scarfo, Emanuela Sant'Antonio, Pellegrino Musto, Annamaria Giordano, Andrea Mengarelli, Martina Tomassi, Sara Martinelli, Caterina Patti, Marika Porrazzo, Alessandro Sanna, Rossella Riccioni, Clara Virginia Vigano', Francesca Paola Paoloni, Alfonso Piciocchi, Paola Fazi, Guido Gini, Andrés José María Ferreri, Paolo Ghia, Antonio Cuneo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1872.
https://doi.org/10.1182/blood-2024-199014
Published: 2024
Journal Articles

Digital Twins As Control Groups to Accelerate Assessment of Safety and Efficacy of Novel Treatment Strategies in Ph-Negative Acute Lymphoblastic Leukemia

Free
Alfonso Piciocchi, Monica Messina, Giovanni Marsili, Marta Cipriani, Francesca Paola Paoloni, Davide Lazzarotto, Anna Candoni, Alessandro Rambaldi, Matteo Leoncin, Paola Fazi, Marco Vignetti, Robin Foà, Sabina Chiaretti
Journal: Blood
Blood (2024) 144 (Supplement 1): 274.
https://doi.org/10.1182/blood-2024-200643
Published: 2024
Journal Articles

Identification of Genomic Structural Variants (SVs) with Adverse Prognostic Significance in Normal-Karyotype (nk) Acute Myeloid Leukemia (AML) Patients

Free
Niccolò Bartalucci, Francesco Mannelli, Danilo Tarantino, Barbara Scappini, Alessio Enderti, Giacomo Gianfaldoni, Matteo Piccini, Simone Romagnoli, Daniele Colazzo, Leonardo Signori, Fiorenza Irushani, Silvia Salmoiraghi, Tiziana Ottone, Alfonso Piciocchi, Margherita Vannucchi, Maria Chiara Siciliano, Roberto Boccacci, Silvia Orsi, Alessia Civini, Paola Fazi, Raffaella Santi, Marco Vignetti, Stefania Bortoluzzi, Alberto Bosi, Adriano Venditti, Alessandro Rambaldi, Maria Teresa Voso, Paola Guglielmelli, Alessandro M. Vannucchi
Journal: Blood
Blood (2024) 144 (Supplement 1): 65.
https://doi.org/10.1182/blood-2024-198342
Published: 2024
Journal Articles

Efficacy and Toxicity of Frontline Ponatinib Plus Blinatumomab for Adult Ph+ ALL Patients of All Ages. Intermediate Analysis of the Gimema ALL2820

Free
Sabina Chiaretti, Matteo Leoncin, Loredana Elia, Stefano Soddu, Alfonso Piciocchi, Mabel Matarazzo, Mariangela Di Trani, Maurizio Martelli, Erika Borlenghi, Marina Parisi, Valentina Mancini, Caterina Alati, Daniele G. Mattei, Maria Paola Martelli, Prassede Salutari, Patrizia Chiusolo, Ernesta Audisio, Mario Luppi, Lara Pochintesta, Crescenza Pasciolla, Bianca Serio, Barbara Scappini, Antonella Cucca, Martina Chiarucci, Massimiliano Bonifacio, Nicola Fracchiolla, Silvia Imbergamo, Lucia Ammirati, Federico Mosna, Patrizia Zappasodi, Sara Mastaglio, Daniela Pietrasanta, Monica Bocchia, Monia Lunghi, Elisabetta Todisco, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2024) 144 (Supplement 1): 835.
https://doi.org/10.1182/blood-2024-207892
Published: 2024
Journal Articles

ASXL1 Mutations at Diagnosis Did Not Impact on the Depth of Molecular Response (MR) and on Treatment-Free Remission (TFR) Eligibility in Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Patients (pts) Receiving either Nilotinib (NIL) First-Line or Imatinib (IM) with Early Switch to NIL in Case of No Optimal Response in the SUSTRENIM Clinical Trial

Free
Simona Soverini, Sara De Santis, Cecilia Monaldi, Manuela Mancini, Valentina Giai, Marco Cerrano, Isabella Capodanno, Massimiliano Bonifacio, Elisabetta Abruzzese, Alessandra Iurlo, Fausto Castagnetti, Rosaria Sancetta, Luciano Levato, Carmen Fava, Mario Tiribelli, Francesco Cavazzini, Maria Cristina Miggiano, Niccolò Bolli, Agostino Tafuri, Alessandro Lucchesi, Daniele Vallisa, Monia Lunghi, Caterina Musolino, Samantha Bruno, Cristina Mosca, Mauro Ciriello, Giovanni Marsili, Alfonso Piciocchi, Paola Fazi, Michele Cavo, Jeroen J.W.M. Janssen, Peter E. Westerweel, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 3158.
https://doi.org/10.1182/blood-2024-205465
Published: 2024
Journal Articles

Evaluating the Impact of Cross-over from Imatinib to Nilotinib on the Overall Survival in Chronic Myeloid Leukemia Using Inverse Probability of Censoring Weighting: Results from the Gimema Sustrenim Study

Free
Alfonso Piciocchi, Giovanni Marsili, Ylenia Belperio, Monica Messina, Francesca Paola Paoloni, Stefano Soddu, Isabella Capodanno, Rosaria Sancetta, Elisabetta Abruzzese, Alessandro Pulsoni, Monia Lunghi, Giovanni Caocci, Fausto Castagnetti, Paola Fazi, Marco Vignetti, Massimo Breccia, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 4530.
https://doi.org/10.1182/blood-2024-198366
Published: 2024
Journal Articles

Factors Predicting Short-Term Symptom Burden in Patients with Aggressive B-Cell Lymphomas Treated with CAR T-Cell Therapy: A Real-World Study By the Gimema

Free
Fabio Efficace, Francesca Bonifazi, Pier Luigi Zinzani, Ilaria Cutini, Annalisa Chiappella, Barbara Botto, Maria Chiara Tisi, Stefania Bramanti, Thomas Baldi, Francesca Tartaglia, Mirko Farina, Simone Ragaini, Massimiliano Gambella, Enrico Orciuolo, Massimo Martino, Maurizio Martelli, Claudio Cartoni, Paolo Corradini, Paola Fazi, Marco Vignetti, Alice Di Rocco
Journal: Blood
Blood (2024) 144 (Supplement 1): 7823.
https://doi.org/10.1182/blood-2024-199498
Published: 2024
Journal Articles

Centralized MRD Assessment in Gimema AML1718 Trial, a Phase 2 Open-Label Study of Venetoclax Combined with Intensified FLAI Chemotherapy (V-FLAI) As Induction Therapy of Non Low-Risk AML

Free
Paola Minetto, Fabio Guolo, Sara Rosellini, Alfonso Piciocchi, Giovanni Marconi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Giovanni Marsili, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo Giovanni Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Valentina Arena, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Elisabetta Tedone, Giovanni Martinelli, Roberto Massimo Lemoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 1574.
https://doi.org/10.1182/blood-2024-198139
Published: 2024
Journal Articles

Decitabine in older patients with AML: quality of life results of the EORTC-GIMEMA-GMDS-SG randomized phase 3 trial

Available to Purchase
Clinical Trials & Observations
Fabio Efficace, Michal Kicinski, Corneel Coens, Stefan Suciu, Walter J. F. M. van der Velden, Richard Noppeney, Sylvain Chantepie, Laimonas Griskevicius, Andreas Neubauer, Ernesta Audisio, Mario Luppi, Stephan Fuhrmann, Robin Foà, Martina Crysandt, Gianluca Gaidano, Radovan Vrhovac, Adriano Venditti, Eduardus F. M. Posthuma, Anna Candoni, Frédéric Baron, Olivier Legrand, Andrea Mengarelli, Paola Fazi, Marco Vignetti, Anne Giraut, Pierre W. Wijermans, Gerwin Huls, Michael Lübbert
Journal: Blood
Blood (2024) 144 (5): 541–551.
https://doi.org/10.1182/blood.2023023625
Published: 2024
Includes: Supplemental data
Journal Articles

Real World Outcome of Unfit Patients with Acute Myeloid Leukemia Treated with the Combination Venetoclax Plus Hypomethylating Agents in the Gimema AML2320 Observational Trial

Free
Adriano Venditti, Alfonso Piciocchi, Stefano Soddu, Marco Frigeni, Raffaele Palmieri, Erika Borlenghi, Nicola Fracchiolla, Maria Paola Martelli, Ernesta Audisio, Giacomo Gianfaldoni, Calogero Vetro, Nicola di Rienzo, Daniela Esposito, Ambra Di Veroli, Carmine Selleri, Federica Gigli, Antonio Curti, Antonino Mulè, Catello Califano, Sara Bigliardi, Massimo Breccia, Claudio Fozza, Monica Bocchia, Albana Lico, Federico Simonetti, Elisabetta Pierdomenico, Francesco Buccisano, Maria Ilaria Del Principe, Luca Maurillo, Paola Fazi, Marco Vignetti, Felicetto Ferrara, Roberto Cairoli, Giuseppe Rossi, Alessandro Rambaldi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1514.
https://doi.org/10.1182/blood-2023-178505
Published: 2023
Journal Articles

36-Month Follow-up Results of the Gimema ‘Veritas’ Trial of Front-Line Venetoclax and Rituximab (VenR) in Young and Fit Patients with Chronic Lymphocytic Leukemia and an Adverse Biologic Profile

Free
Francesca Romana Mauro, Irene Della Starza, Monica Messina, Gianluigi Reda, Livio Trentin, Marta Coscia, Paolo Sportoletti, Lorella Orsucci, Valentina Arena, Gianluca Gaidano, Roberto Marasca, Roberta Murru, Luca Laurenti, Caterina Stelitano, Donato Mannina, Fiorella Ilariucci, Massimo Massaia, Gian Matteo Rigolin, Lydia Scarfo, Monia Marchetti, Luciano Levato, Monica Tani, Annalisa Arcari, Gerardo Musuraca, Marina Deodato, Piero Galieni, Valeria Belsito Patrizi, Daniela Gottardi, Anna Marina Liberati, Annamaria Giordano, Maria Chiara Molinari, Sara Pepe, Costanza Andriola, Veronica Mattiello, Andrea Visentin, Candida Vitale, Francesco Albano, Antonino Neri, Maria Stefania De Propris, Mauro Nanni, Ilaria Del Giudice, Anna Guarini, Paola Fazi, Marco Vignetti, Alfonso Piciocchi, Antonio Cuneo, Robin Foà
Journal: Blood
Blood (2023) 142 (Supplement 1): 1905.
https://doi.org/10.1182/blood-2023-181597
Published: 2023
Journal Articles

Final Analysis for the Primary End-Point of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Capria Saveria, Michela Rondoni, Matteo Giovanni Della Porta, Geramana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1536.
https://doi.org/10.1182/blood-2023-184678
Published: 2023
Journal Articles

LONG-TERM Results of the Frontline Dasatinib/Blinatumomabprotocol (D-ALBA, GIMEMA LAL2116) for Adult Ph+ Acutelymphoblastic Leukemia

Free
Robin Foà, Renato Bassan, Loredana Elia, Alfonso Piciocchi, Stefano Soddu, Monica Messina, Felicetto Ferrara, Monia Lunghi, Antonino Mulè, Massimiliano Bonifacio, Nicola Fracchiolla, Prassede Salutari, Paola Fazi, Anna Guarini, Alessandro Rambaldi, Sabina Chiaretti
Journal: Blood
Blood (2023) 142 (Supplement 1): 4250.
https://doi.org/10.1182/blood-2023-187773
Published: 2023
Journal Articles

Patients' Perception of Usability and Utility of a Digital Health Tool for Electronic Patient-Reported Outcomes Monitoring in Real-Life Hematology Practice: Evidence from the Gimema-Alliance Platform

Free
Fabio Efficace, Mario Luppi, Leonardo Potenza, Francesco Sparano, Giovanni Caocci, Francesca Fazio, Massimo Breccia, Maria Teresa Petrucci, Andrea Patriarca, Thomas Baldi, Michelina Santopietro, Roberta Battistini, Agostino Tafuri, Gloria Margiotta Casaluci, Elisabetta Colaci, Davide Giusti, Valeria Pioli, Paolo De Fabritiis, Nicolina Rita Ardu, Pasquale Niscola, Olga Mulas, Claudio Fozza, Sergio Siragusa, Salvatrice Mancuso, Paola Boggione, Lorenzo De Paoli, Anna Paola Leporace, Maria Paola Bianchi, Ida Carmosino, Claudio Cartoni, Alice Di Rocco, Isabella Capodanno, Massimo Pini, Alessandra Romano, Paola Fazi, Marco Vignetti
Journal: Blood
Blood (2023) 142 (Supplement 1): 3714.
https://doi.org/10.1182/blood-2023-180574
Published: 2023
Journal Articles

International, Prospective Study Comparing Nilotinib Versus Imatinib with Early Switch to Nilotinib to Obtain Sustained Treatment-Free Remission in Patients with Chronic Myeloid Leukemia (SUSTRENIM trial): Analysis of the Eligibility to Treatment Discontinuation

Free
Fabrizio Pane, Fausto Castagnetti, Alfonso Piciocchi, Elisabetta Abruzzese, Renato Bassan, Gianni Binotto, Massimiliano Bonifacio, Giovanni Caocci, Francesco Cavazzini, Giuseppe Cimino, Antonella Gozzini, Monia Lunghi, Roberto Marasca, Bruno Martino, Francesco Muriano, Gianantonio Rosti, Antonella Russo Rossi, Simona Sica, Agostino Tafuri, Daniele Vallisa, Monica Messina, Francesca Paola Paoloni, Paola Fazi, Peter E Westerweel, Jeroen J.W.M. Janssen, Giuseppe Saglio, Massimo Breccia
Journal: Blood
Blood (2023) 142 (Supplement 1): 3169.
https://doi.org/10.1182/blood-2023-182220
Published: 2023