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Nirali N Shah
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Journal Articles

T-ICAHT: Grading and Prognostic Impact of Thrombocytopenia After CAR T-cell Therapy

Available to Purchase
Kai Rejeski, Jaime Sanz, Teng Fei, Monica S Nair, Hamza Hashmi, Abraham Avigdor, Ofrat Beyar-Katz, Veit L. Bücklein, Kevin J. Curran, Sigrun Einarsdottir, Jonathan H Esensten, Netta Glaubach, Dr, Noa Golan-Accav, Marina Gomez-Llobell, Iris Halamis, Orit Itzhaki, Frederick L. Locke, Sham Mailankody, Ronit Marcus, Marcela V. Maus, M. Lia Palomba, Jae H Park, Marcelo C. Pasquini, Sandeep S Raj, Sridevi Rajeeve, Gilles A. Salles, Michael Scordo, Gunjan L Shah, Avichai Shimoni, Marion Subklewe, Tobias Tix, Saad Z Usmani, Ori Ben Valid, Yannis K. Valtis, Tsila Zuckerman, Nirali N Shah, Miguel-Angel Perales, Roni Shouval
Journal: Blood
Blood blood.2025028833.
https://doi.org/10.1182/blood.2025028833
Published: 2025
Includes: Supplemental data
Journal Articles

Project EVOLVE: An international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia

Open Access
Sara K Silbert, Alexander W Rankin, Chloe N Hoang, Alexandra Semchenkova, Regina M Myers, Elena Zerkalenkova, PhD, Hao-Wei Wang, Alexandra E Kovach, Constance M Yuan, Dana Delgado Colon, Loic Vasseur, Alex Bataller, Samuel John, Kaylyn Utley Lyons, Barbara D. Friedes, Anna Alonso-Saladrigues, Hisham Abdel-Azim, Estelle Balducci, Ahmed Aljudi, Marie Balsat, D. Nathan Biery, Aghiad Chamdin, Bill H Chang, Raymund S Cuevo, MD, Barbara De Moerloose, David S. Dickens, Ulrich A Duffner, Nicolas Duployez, Firas El Chaer, Michelle Ann Elliott, Gabriele Escherich, Sneha Fernandes, Mandi R Fitzjohn, Zhubin J Gahvari, Stephan A. Grupp, Rui Rochelle He, M.D., Cynthia Harrison, Christopher Bruce Hergott, Emily M. Hsieh, Annette S Kim, Dennis John Kuo, Daniel P Larson, Benjamin J Lee, Thibaut TL Leguay, R. Coleman Lindsley, Abhishek A. Mangaonkar, Kerstin Mezger, Holly L Pacenta, Jing Pan, Marlie R. M. Provost, Latika Puri, Sunil Sudhir Raikar, Armando Jose Martinez, Isabella Quijada Bristol, Kyle Daniel Murphy, Lauren Reiman, Michele S Redell, Kelly Reed, Gabrielle Roth Guepin, Jeremy D Rubinstein, Süreyya Savaşan, Kristian T Schafernak, Alexandra McLean Stevens, Aimee C Talleur, Naomi Torres Carapia, Jacques Vargaftig, Anant Vatsayan, Matthias Wölfl, Lipng Zhao, Susana Rives, Vanessa A. Fabrizio, Koji Sasaki, Ibrahim Aldoss, Nicolas Boissel, Susan R Rheingold, Kara L Davis, Sara Ghorashian, Elad Jacoby, Alexander Popov, Adam Joseph Lamble, Nirali N Shah
Journal: Blood
Blood blood.2024026655.
https://doi.org/10.1182/blood.2024026655
Published: 2025
Includes: Supplemental data
Journal Articles

Development of ALL-Hematotox: predicting post-CAR T-cell hematotoxicity in B-cell acute lymphoblastic leukemia

Open Access
Clinical Trials & Observations
Monica S. Nair, Sara K. Silbert, Kai Rejeski, Karilynn A. Wilson, Adam J. Lamble, Yannis Valtis, Bonnie Yates, Alexa Morales Arana, Roni Shouval, Kevin Curran, Rebecca A. Gardner, Haneen Shalabi, Colleen Annesley, Jae H. Park, Marion Subklewe, Nirali N. Shah
Journal: Blood
Blood (2025) 145 (11): 1136–1148.
https://doi.org/10.1182/blood.2024025910
Published: 2025
Includes: Supplemental data
Journal Articles

How I treat postimmunotherapy relapsed B-ALL

Available to Purchase
Adam J. Lamble, Alexandra E. Kovach, Nirali N. Shah
Journal: Blood
Blood (2025) 145 (1): 64–74.
https://doi.org/10.1182/blood.2024024517
Published: 2025
Journal Articles

A CD33-Deleted Allograft (Trem-cel) Enables Post-Hematopoietic Cell Transplant (HCT) Maintenance Dosing of Gemtuzumab Ozogamicin (GO) with Therapeutic Levels of Drug Exposure and Low Hematologic and Hepatic Toxicity in Patients with High-Risk Acute Myeloid Leukemia (AML)

Free
John F. DiPersio, Guenther Koehne, Nirali N. Shah, Lea Bernard, Hyung C Suh, Divya Koura, Miguel Angel Perales, Roni Tamari, Muhammad Umair Mushtaq, Joseph E. Maakaron, Michael R. Loken, Darren A Stanizzi, Melissa M. Lee-Sundlov, Sanjana Thosar, Sharon L Hyzy, Glen D Raffel, Brenda W Cooper
Journal: Blood
Blood (2024) 144 (Supplement 1): 2873.
https://doi.org/10.1182/blood-2024-205641
Published: 2024
Journal Articles

Autologous CD33CART for Children and Adolescents/Young Adults with Relapsed/Refractory AML: Phase 1/2 Clinical Trial Correlative Biology Analyses Demonstrate Potent in Vitro , In Vivo , and Ex Vivo Anti-Leukemia Activity

Free
Tommaso Balestra, Camilo Arenas Merizalde, Robert K Chen, John Roach, Brian Bowser, Rachelle Salomon, Anthony Welch, Bonnie Yates, Kristin Schaller, Michael R Verneris, Susanne H.C. Baumeister, Emily M. Hsieh, M. Eric Kohler, Katherine Tarlock, Steven M. Devine, Richard Aplenc, Nirali N. Shah, Terry J Fry, Sarah K. Tasian
Journal: Blood
Blood (2024) 144 (Supplement 1): 369.
https://doi.org/10.1182/blood-2024-211517
Published: 2024
Journal Articles

Initial Experience with CD19/CD22 BiCistronic CAR T-Cells in Children and Young Adults with Recurrent or Refractory B-Cell Malignancies

Free
Brynn B. Duncan, Sara K. Silbert, Alexander W. Rankin, Bonnie Yates, Lauren Little, Toni Foley, Hao-Wei Wang, Constance M. Yuan, Dana I. Delgado Colon, Yanyu Wang, Jon Inglefield, John A Ligon, Hannah W. Song, Steven L. Highfill, Haneen Shalabi, David F. Stroncek, Naomi Taylor, Nirali N. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 680.
https://doi.org/10.1182/blood-2024-198259
Published: 2024
Journal Articles

Real World Data of Novel Talicabtagene Autoleucel (humanized CD19 CAR-T) from India; Ensuring Equitable Access with Excellent Safety and Efficacy Profile

Free
Hasmukh Jain, Atharva Karulkar, Devanshi Kalra, Smrithi Ravikumar, Shreshtha Shah, Afrin Firfiray, Juber Pendhari, Manivasagam S, Anand Vaibhaw, Ashish Saroha, Ankesh K. Jaiswal, Alok Shetty, Lingaraj Nayak, Bhausaheb Bagal, Neeraj Siddharthan, Esha Kaul, Prashant Mehta, Anshul Gupta, Navin Khattry, Nishant Jindal, Sanket P Shah, Rakesh Kumar Boya, Pavan Kumar Boyella, Preeti Desai, Anisha Navkudkar, Shalini Purwar, Manju Sengar, Nirali N. Shah, Sattva S. Neelapu, Rahul Purwar
Journal: Blood
Blood (2024) 144 (Supplement 1): 3755.
https://doi.org/10.1182/blood-2024-202335
Published: 2024
Journal Articles

Monocytic Differentiation in B-Lymphoblastic Leukemia with CRLF2 rearrangement at Diagnosis: Implications for Pathogenesis and Post-Therapeutic Lineage Switch

Free
Alexandra E. Kovach, Sara K. Silbert, Annie Luong, Gerald Lu, Michael Lu, Hao-Wei Wang, Karen M Chisholm, Andrew Doan, Deepa Bhojwani, Adam Lamble, Nirali N. Shah, Chintan Parekh, Gordana Raca, Brent L. Wood
Journal: Blood
Blood (2024) 144 (Supplement 1): 2799.
https://doi.org/10.1182/blood-2024-198961
Published: 2024
Journal Articles

Proliferation of a Novel CD3 neg Hyperactivated T-Cell Population Characterizes Adult Hemophagocytic Lymphohistiocytosis and Associates with Disease Activity

Free
Joseph M. Rocco, Elizabeth Laidlaw, Bonnie Yates, Brett Schroeder, Emily Limerick, William T. Johnson, Joseph H. Oved, Frances Galindo, Whitney Ewing, Courtney Fitzhugh, Maura Manion, Andrea Lisco, Steven Holland, Nirali N. Shah, Irini Sereti
Journal: Blood
Blood (2024) 144 (Supplement 1): 5382.
https://doi.org/10.1182/blood-2024-210363
Published: 2024
Journal Articles

Clinical Factors Associated with Prolonged Cytopenias after CD19 Chimeric Antigen Receptor T-Cell Therapy for Pediatric B-Cell Acute Lymphoblastic Leukemia

Free
Regina M. Myers, Yimei Li, Adam Lamble, Emily M. Hsieh, Samuel John, Gregory Dolan, Hongyan Liu, Lee Chen, Jennifer Sheppard, Amanda M. DiNofia, Colleen Annesley, Stephan A. Grupp, Deepa Bhojwani, Rebecca A. Gardner, Lia Gore, Susan R Rheingold, Nirali N. Shah, Michael A. Pulsipher
Journal: Blood
Blood (2024) 144 (Supplement 1): 4827.
https://doi.org/10.1182/blood-2024-202027
Published: 2024
Journal Articles

PAX5 Loss Compromises CD22 Protein Levels and Responses to Inotuzumab Ozogamicin in B-Cell Acute Lymphoblastic Leukemia

Free
Jacinta Davis, JuanCarlos Balandrán, Katharina Hayer, Sisi Zheng, Zhiwei Ang, Evelyn Liu, Bonnie Yates, Nirali N. Shah, Iannis Aifantis, Andrei Thomas-Tikhonenko
Journal: Blood
Blood (2024) 144 (Supplement 1): 4170.
https://doi.org/10.1182/blood-2024-208185
Published: 2024
Journal Articles

Development of a Novel Humanized BCMA-Directed CAR for Multiple Myeloma: Robust Activity and Low Toxicity in Preclinical Studies

Free
Aalia N. Khan, Jayant S. Goda, Sweety Asija, Atharva Karulkar, Pranoti Palkar, Ambalika Chowdury, Ankesh K. Jaiswal, Deepti Phadnis, Shreshtha Shah, Afrin Firfiray, Juber Pendhari, Pranali Patil, Nirali N. Shah, Manju Sengar, Hasmukh Jain, Rahul Purwar
Journal: Blood
Blood (2024) 144 (Supplement 1): 4809.
https://doi.org/10.1182/blood-2024-203862
Published: 2024
Journal Articles

Early Leukapheresis in Patients with B-ALL Yields an Activated, Early Memory T-Cell Phenotype Associated with Response to CAR T-Cell Therapy

Free
Alexandra Dreyzin, Yihua Cai, Kyu Lee Han, Michaela Prochazkova, Jennifer Webb, Keri Toner, Kathryn Bushnell, Bonnie Yates, Ping Jin, David F. Stroncek, Nirali N. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 4853.
https://doi.org/10.1182/blood-2024-199264
Published: 2024
Journal Articles

Talicabtagene Autoleucel (humanized CD19 CAR-T) As a Second Line Therapy in r/r B-Cell Lymphoma: Sub-Analysis from a Phase I/II Trial

Free
Hasmukh Jain, Atharva Karulkar, Ankesh K. Jaiswal, Devanshi Kalra, Smrithi Ravikumar, Shreshtha Shah, Afrin Firfiray, Juber Pendhari, Neha Sharma, Alok Shetty, Lingaraj Nayak, Bhausaheb Bagal, Shripad Banavali, Gaurav Narula, Sameer Ramesh Melinkeri, Anil Aribandi, Narendra Agrawal, Lovin Wilson, Preeti Desai, Anisha Navkudkar, Prashant Tembhare, Navin Khattry, Epari Sridhar, Nikhil Patkar, Tanuja Shet, Uma Sakhadeo, Papagudi Ganesan Subramanian, Jayshree Thorat, Kinjalka Ghosh, Archi Agrawal, Yash Jain, Venkatesh Rangarajan, Shilpushp Bhosle, Siddhartha Laskar, Sangeeta Kakoti, Nitin Shetty, Vasundhara Patil, Akshay Baheti, Sanjay Biswas, Gaurav Salunkhe, Kunal Gala, Shalini Purwar, Manju Sengar, Nirali N. Shah, Sattva S. Neelapu, Rahul Purwar
Journal: Blood
Blood (2024) 144 (Supplement 1): 7203.
https://doi.org/10.1182/blood-2024-201984
Published: 2024
Journal Articles

CARdinal signs of variant ICANS

Free
Juliane Gust, Nirali N. Shah
Journal: Blood
Blood (2024) 144 (13): 1352–1354.
https://doi.org/10.1182/blood.2024025664
Published: 2024
Journal Articles

Project Evolve, Evaluation of Lineage Switch (LS), an International Initiative: Preliminary Results Reveal Dismal Outcomes in Patients with LS

Free
Sara K. Silbert, Cynthia Harrison, D. Nathan Biery, Alexandra Semchenkova, Elena Zerkalenkova, Anna Alonso-Saladrigues, Kaylyn Utley, Ibrahim Aldoss, Liping Zhao, Sneha Fernandes, Jeremy D. Rubinstein, Naomi Torres Carapia, Bill H. Chang, Anant Vatsayan, Barbara De Moerloose, Holly L. Pacenta, Dennis John Kuo, Gabriele Escherich, Benjamin J. Lee, Michele S. Redell, Mandi R. Fitzjohn, Daniel P. Larson, Nicolas Duployez, Raymund S. Cuevo, Rui Rochelle He, David Dickens, Firas El Chaer, Kelly Reed, Matthias Wolfl, Sunil S. Raikar, Süreyya Savaşan, Latika Puri, Zhubin J. Gahvari, Aimee C. Talleur, Hisham Abdel-Azim, Aghiad Chamdin, Marlie R.M. Provost, Vanessa A. Fabrizio, Kerstin Mezger, Alexandra McLean Stevens, Emily M. Hsieh, Hao-Wei Wang, Constance M. Yuan, Ulrich A. Duffner, Jing Pan, Sara Ghorashian, Susana Rives, Chloe Hoang, Kara L. Davis, Elad Jacoby, Alexander Popov, Adam Lamble, Nirali N. Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 4202.
https://doi.org/10.1182/blood-2023-182293
Published: 2023
Journal Articles

Generation of Hinge-Modified Human CD19 Chimeric Antigen Receptor (CAR) T Cells for the Treatment of CD19-Low Leukemia

Free
Victoria M. Giordani, Justin Mirazee, Marie Pouzolles, Mehdi Benzaoui, Chris Daniel Chien, Saliha Majdoul, Sooraj Achar, Adam Kenet, Madison Wahlsten, Gregoire Altan-Bonnet, James N Kochenderfer, Nirali N. Shah, Taisuke Kondo, Naomi Taylor
Journal: Blood
Blood (2023) 142 (Supplement 1): 6819.
https://doi.org/10.1182/blood-2023-187954
Published: 2023
Journal Articles

CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML: Dose-Escalation Results from a Phase I/II Multicenter Trial

Free
Nirali N. Shah, Sarah K. Tasian, M. Eric Kohler, Emily M. Hsieh, Susanne H.C. Baumeister, Corinne Summers, Haneen Shalabi, Jessica A. Pollard, Bonnie Yates, Ruta Brazauskas, Eric Ndifon, Constance M. Yuan, Hao-Wei Wang, Hati K Kobusingye, Kayla Christianson, Allison A Weiss, Erin Leckrone, Bronwen E. Shaw, Jeffery J. Auletta, Hemalatha G. Rangarajan, John Roach, Julie Blake, Dennis Michiel, Brian Bowser, Sheryl Ruppel, George Mitra, Anthony Welch, Jason Yovandich, Rachelle Salomon, Leslie Kean, Katherine Tarlock, Michael A. Pulsipher, Michael R Verneris, Larisa Broglie, Terry J. Fry, Steven M. Devine, Richard Aplenc
Journal: Blood
Blood (2023) 142 (Supplement 1): 771.
https://doi.org/10.1182/blood-2023-179667
Published: 2023
Journal Articles

Trem-Cel, a CRISPR/Cas9 Gene-Edited Allograft Lacking CD33, Shows Rapid Primary Engraftment with CD33-Negative Hematopoiesis in Patients with High-Risk Acute Myeloid Leukemia (AML) and Avoids Hematopoietic Toxicity during Gemtuzumab Ozogamicin (GO) Maintenance Post-Hematopoietic Cell Transplant (HCT)

Free
John DiPersio, Brenda W Cooper, Hyung C Suh, Divya Koura, Lea Bernard, Nirali N. Shah, Roland B. Walter, Miguel-Angel Perales, Markus Mapara, Roni Tamari, Michael R. Loken, Kyle Breitschwerdt, Sritama Nath, Glen D Raffel, Guenther Koehne
Journal: Blood
Blood (2023) 142 (Supplement 1): 483.
https://doi.org/10.1182/blood-2023-190037
Published: 2023