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Stephan A. Grupp
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Journal Articles

Project EVOLVE: An international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia

Sara K Silbert, Alexander W Rankin, Chloe N Hoang, Alexandra Semchenkova, Regina M Myers, Elena Zerkalenkova, PhD, Hao-Wei Wang, Alexandra E Kovach, Constance M Yuan, Dana Delgado Colon, Loic Vasseur, Alex Bataller, Samuel John, Kaylyn Utley Lyons, Barbara D. Friedes, Anna Alonso-Saladrigues, Hisham Abdel-Azim, Estelle Balducci, Ahmed Aljudi, Marie Balsat, D. Nathan Biery, Aghiad Chamdin, Bill H Chang, Raymund S Cuevo, MD, Barbara De Moerloose, David S. Dickens, Ulrich A Duffner, Nicolas Duployez, Firas El Chaer, Michelle Ann Elliott, Gabriele Escherich, Sneha Fernandes, Mandi R Fitzjohn, Zhubin J Gahvari, Stephan A. Grupp, Rui Rochelle He, M.D., Cynthia Harrison, Christopher Bruce Hergott, Emily M. Hsieh, Annette S Kim, Dennis John Kuo, Daniel P Larson, Benjamin J Lee, Thibaut TL Leguay, R. Coleman Lindsley, Abhishek A. Mangaonkar, Kerstin Mezger, Holly L Pacenta, Jing Pan, Marlie R. M. Provost, Latika Puri, Sunil Sudhir Raikar, Armando Jose Martinez, Isabella Quijada Bristol, Kyle Daniel Murphy, Lauren Reiman, Michele S Redell, Kelly Reed, Gabrielle Roth Guepin, Jeremy D Rubinstein, Süreyya Savaşan, Kristian T Schafernak, Alexandra McLean Stevens, Aimee C Talleur, Naomi Torres Carapia, Jacques Vargaftig, Anant Vatsayan, Matthias Wölfl, Lipng Zhao, Susana Rives, Vanessa A. Fabrizio, Koji Sasaki, Ibrahim Aldoss, Nicolas Boissel, Susan R Rheingold, Kara L Davis, Sara Ghorashian, Elad Jacoby, Alexander Popov, Adam Joseph Lamble, Nirali N Shah
Journal: Blood
Blood blood.2024026655.
https://doi.org/10.1182/blood.2024026655
Published: 2025
Includes: Supplemental data
Journal Articles

TCL1A Is Associated with Blinatumomab Response and Immune Activation in Pediatric B-ALL

Andrew Hughes, Rawan Shraim, Lahari Uppuluri, Haley Newman, Gongping Shi, Julie Asare, Theresa Ryan, Elizabeth A. Raetz, James A. Whitlock, Maureen M. O'Brien, Deepa Bhojwani, Rachel E. Rau, Kara L. Davis, Stacy Cooper, Patrick Brown, Stephen P. Hunger, Mignon L. Loh, Laura E. Hogan, Stephan A. Grupp, Jun J. Yang, David T. Teachey, Caroline Diorio
Journal: Blood
Blood (2024) 144 (Supplement 1): 634.
https://doi.org/10.1182/blood-2024-203756
Published: 2024
Journal Articles

Durable Clinical Benefits with Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia

Franco Locatelli, Peter Lang, Roland Meisel, Donna Wall, Selim Corbacioglu, Amanda M Li, Josu de la Fuente, Ami J. Shah, Ben Carpenter, Janet L. Kwiatkowski, Markus Y Mapara, Robert I. Liem, Maria Domenica Cappellini, Mattia Algeri, Antonis Kattamis, Sujit Sheth, Stephan A. Grupp, Hayley Lynne Merkeley, Kevin H.M. Kuo, Joachim Rupprecht, Puja Kohli, Gang Xu, Leorah Ross, Yael Bobruff, Bo Tong, William Hobbs, Haydar Frangoul
Journal: Blood
Blood (2024) 144 (Supplement 1): 512.
https://doi.org/10.1182/blood-2024-205779
Published: 2024
Journal Articles

Preinfusion Risk Factors for the Development of Severe Immune Effector Cell Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T-Cell Infusion in Pediatric Patients

Caroline Diorio, Regina M. Myers, Yimei Li, Amanda M. Dinofia, Hongyan Liu, Allison Barz Leahy, Haley Newman, Jillian Dolan, Zachary Martinez, Amira Elhachimi, Cassidy Mullen, Alexander Lai Li, John Kim, David T. Teachey, Shannon L. Maude, Jennifer McGuire, Stephan A. Grupp
Journal: Blood
Blood (2024) 144 (Supplement 1): 3454.
https://doi.org/10.1182/blood-2024-204993
Published: 2024
Journal Articles

In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing

Caitlin R. Hopkins, Amanda M. DiNofia, Shannon L. Maude, Gregory M. Chen, Kwame Attah M. Boateng-Antwi, Jessica Perazzelli, Andres F. Mendez Corea, Alexander Shestov, Mercy Gohil, Yimei Li, Wei-Ting Hwang, Bakir Valentić, Shannon Christensen, Julie Jadlowsky, Regina M. Myers, Caroline Diorio, Megan M. Davis, Theresa Colligon, Gabriela Plesa, Don L. Siegel, Bruce Levine, Carl H. June, Roddy S. O'Connor, Stephan A. Grupp, Joseph A. Fraietta
Journal: Blood
Blood (2024) 144 (Supplement 1): 3473.
https://doi.org/10.1182/blood-2024-210324
Published: 2024
Journal Articles

Cost-Effective Manufacture and Promising Initial Efficacy of huCART19 Cells Manufactured Using the Clinimacs Prodigy Platform

Allison Barz Leahy, Jennifer Brogdon, Lucy Cain, Amanda M. Dinofia, Joseph A. Fraietta, Richard Hanna, Stephan Kadauke, Raabia Khan, Yimei Li, Shannon L. Maude, Regina M. Myers, Laura Shinehouse, Anna Sparrow, Melissa Varghese, Lei Wang, Yongping Wang, Stephan A. Grupp
Journal: Blood
Blood (2024) 144 (Supplement 1): 3470.
https://doi.org/10.1182/blood-2024-204300
Published: 2024
Journal Articles

Clinical Factors Associated with Prolonged Cytopenias after CD19 Chimeric Antigen Receptor T-Cell Therapy for Pediatric B-Cell Acute Lymphoblastic Leukemia

Regina M. Myers, Yimei Li, Adam Lamble, Emily M. Hsieh, Samuel John, Gregory Dolan, Hongyan Liu, Lee Chen, Jennifer Sheppard, Amanda M. DiNofia, Colleen Annesley, Stephan A. Grupp, Deepa Bhojwani, Rebecca A. Gardner, Lia Gore, Susan R Rheingold, Nirali N. Shah, Michael A. Pulsipher
Journal: Blood
Blood (2024) 144 (Supplement 1): 4827.
https://doi.org/10.1182/blood-2024-202027
Published: 2024
Journal Articles

Durable Clinical Benefits with Exagamglogene Autotemcel for Severe Sickle Cell Disease

Haydar Frangoul, Franco Locatelli, Akshay Sharma, Monica Bhatia, Markus Y Mapara, Robert I. Liem, Donna Wall, Lyndsay Molinari, Laurence Dedeken, Kevin H.M. Kuo, Paul Telfer, Ami J. Shah, Marina Cavazzana, Selim Corbacioglu, Michael J. Eckrich, Damiano Rondelli, Roland Meisel, Stephan Lobitz, Mariane De Montalembert, Martin H. Steinberg, Mark C. Walters, Laura Bower, Suzan Imren, Tina Liu, Weiyu Zhou, William Hobbs, Stephan A. Grupp
Journal: Blood
Blood (2024) 144 (Supplement 1): 4954.
https://doi.org/10.1182/blood-2024-204001
Published: 2024
Journal Articles

Impact of Current Manufacturing on Kymriah Real-World Effectiveness and Functional Persistence in Acute Lymphoblastic Leukemia (ALL) (KareALL): A Retrospective Study of Tisagenlecleucel (tisa-cel)-Treated Pediatric and Young Adult Patients (pts) with ALL

Rayne Rouce, J. Gregory Dolan, Christine L. Phillips, Muna Qayed, Michael A. Pulsipher, Lauren M. Vernau, Thomas J. Galletta, Sarah Votaw, Gabriela Llaurador Caraballo, Hongbo Yang, Yao Wang, Shashank Ghantoji, Mimi Tesfaye, Soyon Lee, Emer O'Sullivan, Stephan A. Grupp
Journal: Blood
Blood (2024) 144 (Supplement 1): 7724.
https://doi.org/10.1182/blood-2024-203376
Published: 2024
Journal Articles

Health-Related Quality-of-Life Improvements after Exagamglogene Autotemcel in Patients with Severe Sickle Cell Disease

Akshay Sharma, Haydar Frangoul, Franco Locatelli, Kevin H.M. Kuo, Monica Bhatia, Markus Y Mapara, Michael J. Eckrich, Suzan Imren, Nanxin Li, Jaime Rubin, Siyu Zhang, Tina Liu, William Hobbs, Stephan A. Grupp
Journal: Blood
Blood (2024) 144 (Supplement 1): 7453.
https://doi.org/10.1182/blood-2024-204112
Published: 2024
Journal Articles

Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents

Clinical Trials & Observations
Caroline Diorio, Laura Hernandez-Miyares, Diego A. Espinoza, Brenda L. Banwell, Amit Bar-Or, Amanda M. DiNofia, Allison Barz Leahy, Zachary Martinez, Regina M. Myers, Sarah E. Hopkins, Susan R. Rheingold, David T. Teachey, Angela N. Viaene, Lisa M. Wray, Shannon L. Maude, Stephan A. Grupp, Jennifer L. McGuire
Journal: Blood
Blood (2024) 144 (13): 1387–1398.
https://doi.org/10.1182/blood.2024023933
Published: 2024
Includes: Supplemental data
Journal Articles

Novel MAGIC composite scores using both clinical symptoms and biomarkers best predict treatment outcomes of acute GVHD

Clinical Trials & Observations
Yu Akahoshi, Nikolaos Spyrou, Daniela Weber, Paibel Aguayo-Hiraldo, Francis Ayuk, Chantiya Chanswangphuwana, Hannah K. Choe, Matthias Eder, Aaron M. Etra, Stephan A. Grupp, Elizabeth O. Hexner, William J. Hogan, Carrie L. Kitko, Sabrina Kraus, Monzr M. Al Malki, Pietro Merli, Muna Qayed, Ran Reshef, Tal Schechter, Evelyn Ullrich, Ingrid Vasova, Matthias Wölfl, Robert Zeiser, Janna Baez, Rahnuma Beheshti, Gilbert Eng, Sigrun Gleich, Nikolaos Katsivelos, Steven Kowalyk, George Morales, Rachel Young, Yi-Bin Chen, Ryotaro Nakamura, John E. Levine, James L. M. Ferrara
Journal: Blood
Blood (2024) 144 (9): 1010–1021.
https://doi.org/10.1182/blood.2024025106
Published: 2024
Includes: Supplemental data
Journal Articles

Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy

Clinical Trials & Observations
Haley Newman, Yimei Li, Hongyan Liu, Regina M. Myers, Vicky Tam, Amanda DiNofia, Lisa Wray, Susan R. Rheingold, Colleen Callahan, Claire White, Diane Baniewicz, Lena E. Winestone, Stephan Kadauke, Caroline Diorio, Carl H. June, Kelly D. Getz, Richard Aplenc, David T. Teachey, Shannon L. Maude, Stephan A. Grupp, Kira Bona, Allison Barz Leahy
Journal: Blood
Blood (2023) 141 (6): 609–619.
https://doi.org/10.1182/blood.2022017866
Published: 2023
Includes: Supplemental data
Journal Articles

CD22-Targeted CAR-Modified T-Cells Safely Induce Remissions in Children and Young Adults with Relapsed, CD19-Negative B-ALL after Treatment with CD19-Targeted CAR T-Cells

Regina M. Myers, Amanda M. DiNofia, Yimei Li, Caroline Diorio, Richard Aplenc, Diane Baniewicz, Jennifer L Brogdon, Colleen Callahan, Boris Engels, Joseph A. Fraietta, Vanessa Gonzalez, Emma Iannone, Allison Barz Leahy, Hongyan Liu, Susan E. McClory, Susan R. Rheingold, Laura Shinehouse, Gerald Wertheim, Lisa Wray, Noelle V. Frey, Shannon L. Maude, Stephan A. Grupp
Journal: Blood
Blood (2022) 140 (Supplement 1): 2376–2377.
https://doi.org/10.1182/blood-2022-168139
Published: 2022
Journal Articles

Targeting CD38 in T-ALL Upregulates the Targetable Polyamine Metabolism Pathway

Caroline Diorio, Tiffaney L. Vincent, Tori Fuller, Rawan Shraim, Tina Glisovic-Aplenc, Theresa Ryan, Kimberly Veliz, Haley Newman, Gerald Wertheim, Hamid Bassiri, Annette Vu, Michael Hogarty, Carl H June, Stephan A. Grupp, Sarah K Tasian, Richard Aplenc, Saar Gill, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 10285–10286.
https://doi.org/10.1182/blood-2022-167893
Published: 2022
Journal Articles

Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL

Caroline Diorio, Ryan Murray, Mark Naniong, Luis Barrera, Adam Camblin, John Chukinas, Lindsey Coholan, Aaron Edwards, Tori Fuller, Claudia Gonzales, Stephan A. Grupp, Alden Ladd, Melissa Le, Angelica Messana, Faith Musenge, Haley Newman, Yeh-Chuin Poh, Henry Poulin, Theresa Ryan, Rawan Shraim, Sarah K. Tasian, Tiffaney Vincent, Lauren Young, Yingying Zhang, Giuseppe Ciaramella, Jason Gehrke, David T. Teachey
Journal: Blood
Blood (2022) 140 (6): 619–629.
https://doi.org/10.1182/blood.2022015825
Published: 2022
Includes: Supplemental data
Journal Articles

Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy

Clinical Trials & Observations
Allison Barz Leahy, Kaitlin J. Devine, Yimei Li, Hongyan Liu, Regina Myers, Amanda DiNofia, Lisa Wray, Susan R. Rheingold, Colleen Callahan, Diane Baniewicz, Maria Patino, Haley Newman, Stephen P. Hunger, Stephan A. Grupp, David M. Barrett, Shannon L. Maude
Journal: Blood
Blood (2022) 139 (14): 2173–2185.
https://doi.org/10.1182/blood.2021012727
Published: 2022
Includes: Supplemental data
Journal Articles

Ex Vivo T-Cell Receptor αβ + /CD19 + depletion of Peripheral Stem Cell Grafts for Pediatric Patients with Bone Marrow Failure (BMF) Undergoing Unrelated Donor Transplantation

Joseph H Oved, Caitlin W Elgarten, Yongping Wang, Stephan Kadauke, Dimitri S. Monos, David M. Barrett, Stephan A. Grupp, Nancy Bunin, Timothy S. Olson
Journal: Blood
Blood (2021) 138 (Supplement 1): 171.
https://doi.org/10.1182/blood-2021-154305
Published: 2021
Journal Articles

Comprehensive Secretome Profiling Elucidates Novel Disease Biology and Identifies Pre-Infusion Candidate Biomarkers to Predict the Development of Severe Cytokine Release Syndrome in Pediatric Patients Receiving CART19

Caroline Diorio, Rawan Shraim, Regina M. Myers, Chakkapong Burudpakdee, Allison Barz Leahy, Richard Aplenc, Michele P. Lambert, Hamid Bassiri, Edward M Behrens, Vanessa E. Gonzalez, Fang Chen, Bruce L Levine, Shannon L. Maude, Amanda M. DiNofia, Alix E. Seif, J. Joseph Melenhorst, Simon F Lacey, Carl H June, David Barrett, Stephan A. Grupp, David T. Teachey
Journal: Blood
Blood (2021) 138 (Supplement 1): 167.
https://doi.org/10.1182/blood-2021-149477
Published: 2021
Journal Articles

A Phase 3, Randomized, Adaptive Study of Defibrotide (DF) Vs Best Supportive Care (BSC) for the Prevention of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) in Patients (pts) Undergoing Hematopoietic Cell Transplantation (HCT): Preliminary Results

Stephan A. Grupp, Selim Corbacioglu, Hyoung Jin Kang, Takanori Teshima, Michelle Zanette, Paty Lopez, Vian Amber, Antonio Pagliuca, Paul G. Richardson
Journal: Blood
Blood (2021) 138 (Supplement 1): 749.
https://doi.org/10.1182/blood-2021-147284
Published: 2021