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Journal Articles

Secondary graft failure after PT-cy: Modeling a candidate risk assignment biomarker based on lymphocyte reconstitution. Results from the BMT CTN 1801 study.

Blood (2025) 146 (Supplement 1): 4198.

https://doi.org/10.1182/blood-2025-4198

Published: 2025

Journal Articles

T cell receptor costimulation blockade effectively prevents acute graft versus host disease without reducing the size or diversity of the T cell immune repertoire

Chiara Wychera, Alexandre Albanese, Steven Siegel, Joseph Schmalz, Stephanie Bien, Brandi Bratrude, Kayla Betz, Lev Gorfinkel, Lorenzo Cagnin, Paul Keskula, Bruce Blazar, Muna Qayed, John Horan, Amelia Langston, Benjamin Watkins, Leslie Kean

Blood (2025) 146 (Supplement 1): 819.

https://doi.org/10.1182/blood-2025-819

Published: 2025

Journal Articles

Combined TCR-seq and single-cell RNA-seq reveal distinct origins for antiviral immunity after post-transplant cyclophosphamide and tac/MTX gvhd prophylaxis: Results from the BMT CTN 1801 study

Blood (2025) 146 (Supplement 1): 818.

https://doi.org/10.1182/blood-2025-818

Published: 2025

Journal Articles

A first-in-primate In Vivo CRISPR/Cas9 screen in a rhesus macaque model identifies drivers of CAR-T expansion, tissue tropism and persistence

Francesca Alvarez Calderon, Marlana Winschel, Smriti Srikanth, Marc Schwartz, Ryan Fleming, Lev Gorfinkel, Rachel Hu, Casey Son, John Doench, Leslie Kean, Ulrike Gerdemann

Blood (2025) 146 (Supplement 1): 2329.

https://doi.org/10.1182/blood-2025-2329

Published: 2025

Journal Articles

Discovery of the transcription factor ZNF683/hobit as a central regulator of pathogenic T cell proliferation in acute gvhd

Alexandre Albanese, Edward Chen, Yvonne Suessmuth, Jiayi Dong, James Kaminski, Lev Gorfinkel, Ally Eran, Jillian Zavistaski, Lorenzo Cagnin, Paul Keskula, Brandi Bratrude, Kayla Betz, Elham Rayzan, Muna Qayed, John Horan, Amelia Langston, Benjamin Watkins, Bruce Blazar, Leslie Kean

Blood (2025) 146 (Supplement 1): 275.

https://doi.org/10.1182/blood-2025-275

Published: 2025

Journal Articles

Refined design of a CD117 antibody-drug conjugate safely and effectively conditions non-human primates for autologous transplant-based gene therapy

Blood (2025) 146 (Supplement 1): 5871.

https://doi.org/10.1182/blood-2025-5871

Published: 2025

Journal Articles

Reduced post-transplant alpha-diversity and domination by enterococcus faecium are associated with increased mortality in pediatric recipients of allogeneic hematopoietic cell transplantation.

Blood (2025) 146 (Supplement 1): 513.

https://doi.org/10.1182/blood-2025-513

Published: 2025

Journal Articles

In Vivo correction of the sickle cell disease mutation in hematopoietic stem cells using RNA gene writers

Blood (2025) 146 (Supplement 1): 2536.

https://doi.org/10.1182/blood-2025-2536

Published: 2025

Journal Articles

Superiority of Post-Transplant Cyclophosphamide-Based Graft Versus Host Disease (GvHD) Prophylaxis in Patients 70 Years and Older: A BMT CTN 1703 Post-Hoc Analysis

Blood (2024) 144 (Supplement 1): 1042.

https://doi.org/10.1182/blood-2024-193827

Published: 2024

Journal Articles

Effects of GvHD Prophylaxis with Post-Transplant Cyclophosphamide on Immune Reconstitution and TCR Repertoire after Haploidentical and HLA-Matched Transplantation Compared to Prophylaxis with Calcineurin Inhibitor Plus Methotrexate in HLA-Matched Transplantation

Michela Ansuinelli, Haesook T. Kim, Carol G. Reynolds, Francesco Malfona, Shuntaro Ikegawa, Rakuyo Tamada, Roman M. Shapiro, Mahasweta Gooptu, Rizwan Romee, Sarah Nikiforow, John Koreth, Vincent T. Ho, Corey S. Cutler, Joseph H. Antin, Leslie Kean, Robert J. Soiffer, Jerome Ritz

Blood (2024) 144 (Supplement 1): 1041.

https://doi.org/10.1182/blood-2024-201835

Published: 2024

Journal Articles

Five-Year Outcomes of the “Abatacept Combined with a Calcineurin Inhibitor and Methotrexate for Graft Versus Host Disease (GVHD) Prophylaxis: A Randomized Controlled Trial” (‘ABA2‘)

Blood (2024) 144 (Supplement 1): 3516.

https://doi.org/10.1182/blood-2024-205130

Published: 2024

Journal Articles

CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML: Dose-Escalation Results from a Phase I/II Multicenter Trial

Blood (2023) 142 (Supplement 1): 771.

https://doi.org/10.1182/blood-2023-179667

Published: 2023

Journal Articles

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

Holly Wobma, Jiayi Dong, Francesca Alvarez Calderon, Xianliang Rui, Katherine Michaelis, Bruce R Blazar, Victor Tkachev, Ulrike Gerdemann, Leslie Kean

Blood (2023) 142 (Supplement 1): 3447.

https://doi.org/10.1182/blood-2023-180218

Published: 2023

Journal Articles

Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model

Francesca Alvarez Calderon, Ryan A Fleming, Lev Gorfinkel, Katherine Michaelis, Xianliang Rui, James Kaminski, Dana Bonin, Anick Mallette, Katherine Brodeur, Heber Domingues, Jennifer Lane, Victor Tkachev, Leslie Kean, Ulrike Gerdemann

Blood (2023) 142 (Supplement 1): 2087.

https://doi.org/10.1182/blood-2023-187499

Published: 2023

Journal Articles

Highly Multiplexed Immunohistochemistry Can Predict Steroid Refractory Gastrointestinal (GI) Acute Gvhd at the Time of Endoscopy

Sara Rosenbaum, Nathalie Fiaschi, Wei Keat Lim, Sumreen Jalal, Kaitlyn Gayvert, Paula Keskula, Alexandre Albanese, Victor Tkachev, Jeffrey Goldsmith, Georgios D Kalliolias, Matthew Sleeman, Leslie Kean

Blood (2023) 142 (Supplement 1): 478.

https://doi.org/10.1182/blood-2023-189766

Published: 2023

Journal Articles

Large-Scale Post-Transplant TCR Deep Sequencing Reveals a Major T Cell Diversity Bottleneck with Post-Transplant Cyclophosphamide with Implications for Both Efficacy and Toxicity: Results of the BMT CTN 1801 Study

Blood (2023) 142 (Supplement 1): 475.

https://doi.org/10.1182/blood-2023-188032

Published: 2023

Journal Articles

In Vivo Delivery of RNA By Lipid Nanoparticles (LNP) to Hematopoietic Stem Cells and T Cells in Humanized Mice and Non-Human Primates

Blood (2023) 142 (Supplement 1): 4818.

https://doi.org/10.1182/blood-2023-187271

Published: 2023

Journal Articles

Patient-Reported Outcomes of BMT CTN 1703: A Randomized Phase III Study for Gvhd Prophylaxis - a Quality of Life Evaluation

Blood (2023) 142 (Supplement 1): 897.

https://doi.org/10.1182/blood-2023-187859

Published: 2023

Journal Articles

Abatacept for the Prevention of Gvhd in Pediatric and Adult Patients Receiving 7/8 HLA-Mismatched Unrelated Transplant for Hematologic Malignancies: A Real-World Analysis

Sharmila Raghunandan, Lev Gorfinkel, Michael Graiser, Brandi Bratrude, Kayla Betz, Yvonne Suessmuth, Scott Gillespie, Adrianna Lynn Westbrook, Kirsten M. Williams, Michelle Schoettler, Amelia Langston, Leslie Kean, Muna Qayed, John T. Horan, Benjamin Watkins

Blood (2022) 140 (Supplement 1): 7653–7655.

https://doi.org/10.1182/blood-2022-163627

Published: 2022

Journal Articles

CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts

Ulrike Gerdemann, James Kaminski, Ryan A Fleming, Victor Tkachev, Francesca Alvarez Calderon, Connor McGuckin, Xianliang Rui, Jennifer Lane, Alex K. Shalek, Leslie Kean

Blood (2022) 140 (Supplement 1): 1167–1168.

https://doi.org/10.1182/blood-2022-169435

Published: 2022

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Secondary graft failure after PT-cy: Modeling a candidate risk assignment biomarker based on lymphocyte reconstitution. Results from the BMT CTN 1801 study.

T cell receptor costimulation blockade effectively prevents acute graft versus host disease without reducing the size or diversity of the T cell immune repertoire

Combined TCR-seq and single-cell RNA-seq reveal distinct origins for antiviral immunity after post-transplant cyclophosphamide and tac/MTX gvhd prophylaxis: Results from the BMT CTN 1801 study

A first-in-primate In Vivo CRISPR/Cas9 screen in a rhesus macaque model identifies drivers of CAR-T expansion, tissue tropism and persistence

Discovery of the transcription factor ZNF683/hobit as a central regulator of pathogenic T cell proliferation in acute gvhd

Refined design of a CD117 antibody-drug conjugate safely and effectively conditions non-human primates for autologous transplant-based gene therapy

Reduced post-transplant alpha-diversity and domination by enterococcus faecium are associated with increased mortality in pediatric recipients of allogeneic hematopoietic cell transplantation.

In Vivo correction of the sickle cell disease mutation in hematopoietic stem cells using RNA gene writers

Superiority of Post-Transplant Cyclophosphamide-Based Graft Versus Host Disease (GvHD) Prophylaxis in Patients 70 Years and Older: A BMT CTN 1703 Post-Hoc Analysis

Effects of GvHD Prophylaxis with Post-Transplant Cyclophosphamide on Immune Reconstitution and TCR Repertoire after Haploidentical and HLA-Matched Transplantation Compared to Prophylaxis with Calcineurin Inhibitor Plus Methotrexate in HLA-Matched Transplantation

Five-Year Outcomes of the “Abatacept Combined with a Calcineurin Inhibitor and Methotrexate for Graft Versus Host Disease (GVHD) Prophylaxis: A Randomized Controlled Trial” (‘ABA2‘)

CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML: Dose-Escalation Results from a Phase I/II Multicenter Trial

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model

Highly Multiplexed Immunohistochemistry Can Predict Steroid Refractory Gastrointestinal (GI) Acute Gvhd at the Time of Endoscopy

Large-Scale Post-Transplant TCR Deep Sequencing Reveals a Major T Cell Diversity Bottleneck with Post-Transplant Cyclophosphamide with Implications for Both Efficacy and Toxicity: Results of the BMT CTN 1801 Study

In Vivo Delivery of RNA By Lipid Nanoparticles (LNP) to Hematopoietic Stem Cells and T Cells in Humanized Mice and Non-Human Primates

Patient-Reported Outcomes of BMT CTN 1703: A Randomized Phase III Study for Gvhd Prophylaxis - a Quality of Life Evaluation

Abatacept for the Prevention of Gvhd in Pediatric and Adult Patients Receiving 7/8 HLA-Mismatched Unrelated Transplant for Hematologic Malignancies: A Real-World Analysis

CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts

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