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Hervé Dombret
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Journal Articles

Randomized study of high-dose cytarabine with or without dexamethasone as post-remission therapy in younger adults with newly diagnosed AML – the french backbone intergroup (BIG)-1 study on behalf of the filo, ALFA, and SFGM-TC study groups

Free
Christian Recher, Marie-Anne Hospital, Thibaut Leguay, Martin Carre, Corentin Orvain, Caroline Bonmati, Emmanuel Raffoux, Celestine Simand, Romain Guieze, Jamilé Frayfer, Juliette Lambert, Sylvain Chantepie, Marc Bernard, Pierre Peterlin, Magda Alexis, Pascal Turlure, Cecile Pautas, Sarah Bertoli, Ludovic Gabellier, Edouard Forcade, Nicolas Duployez, Isabelle Luquet, Dominique Penther, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Pierre-Yves Dumas, Eric Delabesse, Claude Preudhomme, Jean-François Hamel, Herve Dombret, Arnaud Pigneux, Hunault-Berger Mathilde, Stephane De Botton
Journal: Blood
Blood (2025) 146 (Supplement 1): 881.
https://doi.org/10.1182/blood-2025-881
Published: 2025
Journal Articles

Blinatumomab consolidation in high-risk Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia in adults: Final report of the graall-2014/b-QUEST study.

Free
Nicolas Boissel, Francoise Huguet, Thibaut Leguay, Hunault-Berger Mathilde, Rathana KIM, Yosr Hicheri, Patrice Chevallier, Marie Balsat, Sebastien Maury, Anne Thiebaut, Florence Van Obbergh, Thomas Cluzeau, Martine Escoffre-Barbe, Marie Passet, Nicole Straetmans, Cedric Pastoret, Johanna Konopacki, Eric Delabesse, Amine Belhabri, Alban Villate, Florence Pasquier, Iona Vaida, Laurence Sanhes, Sabine Blum, Magda Alexis, Mathlide Lamarque, Laure Farnault, Céline Berthon, Véronique Lheritier, Norbert Ifrah, Carlos Graux, Yves Chalandon, Emmanuelle Clappier, Hervé Dombret
Journal: Blood
Blood (2025) 146 (Supplement 1): 643.
https://doi.org/10.1182/blood-2025-643
Published: 2025
Journal Articles

Venetoclax in combination with hypomethylating agents in adult patients with newly diagnosed AML with CBFB::MYH11 or RUNX1::RUNX1T1 fusions: Real-world outcomes based on international registry data

Free
Leo Ruhnke, Christoph Röllig, Lydia Kretschmer, Jan Moritz Middeke, Sylvia Herold, David Poitz, Pau Montesinos, Maria Del Carmen Martinez Chamorro, Josefina Serrano, Joaquín Sánchez-García, Lara María Gómez García, Francisco-Javier Peñalver, Guillermo Quintero, Virginia Abello, Pierre Yves Dumas, Sarah Bertoli, Christian Recher, Arnaud Pigneux, Jenny O'Nions, Hannah Al-Yousuf, Jad Othman, Richard Dillon, Jiri Mayer, Stephane De Botton, Raphael Itzykson, Herve Dombret, Magdalena Czemerska, Agnieszka Wierzbowska, Anne Weigert, Madlen Jentzsch, Uwe Platzbecker, Karsten Spiekermann, Tim Sauer, Carsten Müller-Tidow, Hubert Serve, Claudia Baldus, Martin Bornhäuser, Klaus Metzeler
Journal: Blood
Blood (2025) 146 (Supplement 1): 5230.
https://doi.org/10.1182/blood-2025-5230
Published: 2025
Journal Articles

Real-life CD34+CD38- leukemic stem cell (LSC) flow quantification in adult AML at diagnosis independently predicts survival of intensively but not AZA-VEN treated patients: A study of prospective observational ALFA-PPP acute leukemia french association

Free
Adriana Plesa, Alexandra COELHO, Stéphanie Mathis, Veronique Saada, Isabelle Arnoux, Valerie Bardet, Florent Dumezy, Clémentine Chauvel, Jaja Zhu, Vanessa Nivaggioni, Delphine Manzoni, Iole Oster, Dominique Penther, Nicolas Duployez, Karine Celli-Lebras, Nicole Raus, Emmanuel Raffoux, Lionel Ades, Christophe Willekens, Jean-Baptiste Micol, Stephane De Botton, Laure Farnault, Sylvain Chantepie, Thomas Cluzeau, Julia HIEULLE, Céline Berthon, Ahmad Aljijakli, Claire Bories, Kevin-James Wattebled, Renaud Buffet, Raphael Itzykson, Hervé Dombret, Claude Preudhomme, Christophe Roumier
Journal: Blood
Blood (2025) 146 (Supplement 1): 3483.
https://doi.org/10.1182/blood-2025-3483
Published: 2025
Journal Articles

Frequency and impact of FLT3-ITD microclones in younger AML patients

Free
Nicolas Duployez, Romane Joudinaud, Augustin Boudry, Mathilde Hunault, Emmanuelle Tavernier, Cecile Pautas, Sarah Bertoli, Suzanne Tavitian, Emmanuel Raffoux, Marie-Anne Hospital, Raja Prince-Eladnani, Mael Heiblig, Sylvain Chantepie, Martin Carre, Pierre Peterlin, Maria Pilar Gallego Hernanz, Romain Guieze, Célestine Simand, Pascal Turlure, Anne Huynh, Emilie Lemasle, Ludovic Gabellier, Juliette Lambert, Felipe Suarez, Samy Chraibi, Laurence Sanhes, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Isabelle Luquet, Dominique Penther, Raphael Itzykson, Eric Delabesse, Jean-François Hamel, Stephane De Botton, Arnaud Pigneux, Herve Dombret, Christian Recher, Claude Preudhomme, Pierre-Yves Dumas
Journal: Blood
Blood (2025) 146 (Supplement 1): 456.
https://doi.org/10.1182/blood-2025-456
Published: 2025
Journal Articles

Real-world patterns of treatment intensity and prognostic model performance in older AML: Insights from the french ALFA-PPP cohort

Free
Lin-Pierre Zhao, Céline Berthon, Lauren Fenwarth, Stephane De Botton, Thomas Cluzeau, Laure Farnault, Sylvain Chantepie, Pierre Arnautou, Thorsten Braun, Mathieu Leclerc, Delphine Lebon, Ahmad Aljijakli, Isabelle Plantier, Ollivier Legrand, Juliette Lambert, Christophe Willekens, Emmanuel Raffoux, Claire Bories, Emilie Lemasle, Kevin-James Wattebled, Ambroise Marçais, Celia Salanoubat, Pascal Turlure, Jamilé Frayfer, Benjamin Carpentier, Madalina Uzunov, Reda Garidi, Ioana Vaida, Renaud Buffet, Alexandra COELHO, Karine Celli-Lebras, Raphael Itzykson, Claude Preudhomme, Nicolas Duployez, Hervé Dombret, Lionel Ades
Journal: Blood
Blood (2025) 146 (Supplement 1): 454.
https://doi.org/10.1182/blood-2025-454
Published: 2025
Journal Articles

Real life treatments and outcomes of older patients aged more than 60 years with FLT3-mutated acute myeloid leukemia: Report from the multicentric french observational ALFA-PPP study

Free
Ramy Rahmé, Emmanuel Raffoux, Lionel Ades, Stephane De Botton, Nicolas Duployez, Alexandra COELHO, Jean-Baptiste Micol, Sylvain Chantepie, Thomas Cluzeau, Delphine Lebon, Pierre Arnautou, Mathieu Leclerc, Laure Farnault, Ollivier Legrand, Ahmad Aljijakli, Céline Berthon, Juliette Lambert, Claire Bories, Ambroise Marçais, Julia HIEULLE, Celia Salanoubat, Pascal Turlure, Kevin-James Wattebled, Benjamin Carpentier, Jamile Frayfer, Ioana Vaida, Madalina Uzunov, Reda Garidi, Luca Inchiappa, Karine Celli-Lebras, Dominique Penther, Raynier Devillier, Raphael Itzykson, Claude Preudhomme, Renaud Buffet, Herve Dombret, Thorsten Braun
Journal: Blood
Blood (2025) 146 (Supplement 1): 449.
https://doi.org/10.1182/blood-2025-449
Published: 2025
Journal Articles

High prognostic value of NGS-based measurable residual FLT3-ITD in AML patients positive for FLT3-ITD treated with ponatinib in combination with cytarabine in first complete remission.

Free
Laurene Fenwarth, Claude Preudhomme, Thibaut Leguay, Augustin Boudry, Nais Prade, Eric Delabesse, Lisa Boureau, Audrey Bidet, Sebastian Stasik, Christian Thiede, Sandrine Geffroy, Melody Fort, Juliette Lambert, Emmanuel Raffoux, Sylvain Chantepie, Ollivier Legrand, Pierre Peterlin, Herve Dombret, Arnaud Pigneux, Pierre Yves Dumas, Nicolas Duployez, Philippe Rousselot
Journal: Blood
Blood (2025) 146 (Supplement 1): 5295.
https://doi.org/10.1182/blood-2025-5295
Published: 2025
Journal Articles

Treatments and outcomes of adult patients with TP53-mutated acute myeloid leukemia (AML) in the real-life –Report of the prospective french observational ALFA-PPP study.

Free
Jean-Baptiste Micol, Raphael Itzykson, Laure Farnault, Thomas Cluzeau, Jean-Valère Malfuson, Sylvain Chantepie, Delphine Lebon, Claire Bories, Ramy Rahme, Mathieu Leclerc, Ahmad Aljijakli, Laurene Fenwarth, Alexandra COELHO, Renaud Buffet, Emmanuel Raffoux, Christophe Willekens, Marie Sebert, Stephane De Botton, Claude Preudhomme, Herve Dombret, Dominique Penther, Nicolas Duployez, Elsa Bernard
Journal: Blood
Blood (2025) 146 (Supplement 1): 6386.
https://doi.org/10.1182/blood-2025-6386
Published: 2025
Journal Articles

Outcome after relapse in older patients with Philadelphia Chromosome–Negative B-cell ALL treated with inotuzumab ozogamicin and low-dose chemotherapy in first-line therapy: A graall study

Free
Perrine Moyer, Thibaut Leguay, Francoise Huguet, Gabrielle Roth-Guepin, Yosr Hicheri, Amine Belhabri, Thomas Cluzeau, Ana Berceanu, Emmanuelle Tavernier, Stephane Lepretre, Karin Bilger, Pascal Turlure, Jean-Noel Bastie, Marie Balsat, Magda Alexis, Eolia Brissot, Delphine Lebon, Emmanuel Raffoux, Stefan Wickenhauser, Victoria Cacheux, Anne Banos, Sarah Bonnet, Nicolas Boissel, Herve Dombret, Maxime Jullien, Philippe Rousselot, Patrice Chevallier
Journal: Blood
Blood (2025) 146 (Supplement 1): 3340.
https://doi.org/10.1182/blood-2025-3340
Published: 2025
Journal Articles

Comprehensive mutational profiling and clinical outcome of adults AML with NUP98 rearrangement

Free
Ducourneau Benoit, Arnaud Pages, Stéphanie Struski, Matthieu Decamp, Emmanuel Raffoux, Céline Berthon, Laurene Fenwarth, Vincent Marmouset, Cecile Pautas, Thomas Cluzeau, Delphine Lebon, Madalina Uzunov, Patricio Pereyra, Mael Heiblig, Jean-Valère Malfuson, Laure Farnault, Pierre-Yves Dumas, Julia HIEULLE, Sarah Bertoli, Sylvain Chantepie, Nathalie Auger, Audrey Bidet, Marie Joelle Mozziconacci, Augustin Boudry, Isabelle Luquet, Laureen Chat, Romain Loyaux, Lina EL-MURR, Emmanuelle Clappier, Claude Gardin, Mathilde Hunault, Stephane De Botton, Arnaud Pigneux, Dominique Penther, Eric Delabesse, Raphael Itzykson, Claude Preudhomme, Herve Dombret, Christian Recher, Nicolas Duployez, Jean-Baptiste Micol
Journal: Blood
Blood (2025) 146 (Supplement 1): 7002.
https://doi.org/10.1182/blood-2025-7002
Published: 2025
Journal Articles

Impact of midostaurin in younger AML patients intensively treated with high-dose anthracycline

Free
Pierre-Yves Dumas, Mathieu Leclerc, Mathilde Hunault, Emmanuelle Tavernier, Cecile Pautas, Sarah Bertoli, Thibaut Leguay, Suzanne Tavitian, Emmanuel Raffoux, Marie-Anne Hospital, Sylvain Chantepie, Mael Heiblig, Martin Carre, Pierre Peterlin, Maria Pilar Gallego Hernanz, Romain Guieze, Célestine Simand, Pascal Turlure, Anne Huynh, Emilie Lemasle, Ludovic Gabellier, Juliette Lambert, Delphine Lebon, Madalina Uzunov, Jean-Valère Malfuson, Thomas Cluzeau, Samy Chraibi, Laurence Sanhes, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Isabelle Luquet, Dominique Penther, Eric Delabesse, Jean-François Hamel, Raphael Itzykson, Claude Preudhomme, Stephane De Botton, Nicolas Duployez, Arnaud Pigneux, Herve Dombret, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 1682.
https://doi.org/10.1182/blood-2025-1682
Published: 2025
Journal Articles

Secondary-type acute myeloid leukemia is associated with a higher risk of invasive fungal infection during intensive induction therapy. a correlative study on the ALFA 0702 trial.

Free
Jean-Eudes Fahrner, Mauricette Michallet, Laurene Fenwarth, Mohamad Sobh, Stéphane Morisset, Alexandre Deloire, Emmanuel Raffoux, Stephane De Botton, Sylvain Chantepie, Stephane Girault, Céline Berthon, Sarah Bertoli, Stephane Lepretre, Pierre Yves Dumas, Juliette Lambert, Delphine Lebon, Cecile Pautas, Jean Valère Malfuson, Norbert Vey, Thorsten Braun, Felipe Suarez, Aline Schmidt, Remy Gressin, Caroline Bonmati, Karine Celli-Lebras, Mael Heiblig, Mohamed El-Hamri, Claude Preudhomme, Hervé Dombret, Anne Bergeron, Nicolas Duployez, Raphael Itzykson
Journal: Blood
Blood (2025) 146 (Supplement 1): 994.
https://doi.org/10.1182/blood-2025-994
Published: 2025
Journal Articles

The addition of a tyrosine kinase inhibitor to intensive chemotherapy significantly improves outcome in de novo BCR::ABL1+ acute myeloid leukemia treated with intensive chemotherapy

Free
Sarah Bertoli, Niklas Landberg, Emilie Bérard, Camille Gondran, Laetitia Largeaud, Véronique De Mas, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Sylvain Garciaz, Ludovic Gabellier, Gabrielle Roth-Guepin, Corentin Orvain, Pierre Peterlin, Rudy Birsen, Magda Alexis, Martin Carre, Emmanuelle Tavernier, Marion Boissard Simonet, Chantal Himberlin, Marc Maynadié, Kamel Laribi, Cécile Moluçon-Chabrot, Amine Belhabri, Samy Chraibi, Quentin Cabrera, Delphine Lebon, Emmanuel Raffoux, Thomas Cluzeau, Jean-Baptiste Micol, Mathieu Leclerc, Céline Berthon, Herve Dombret, Gunnar Juliusson, Anna Robelius, Sören Lehmann, Martin Jädersten, Lovisa Wennström, Pau Montesinos, Carmen Botella, Juan Miguel Bergua Burgues, Raimundo Garcia, Josefina Serrano, Mariluz Amigo, Patricia Garcia Ramirez, Claudia Sossa, Juan Manuel Alonso-Dominguez, Hartmut Döhner, Konstanze Döhner, Daniela Späth, Michael Kühn, Claudia Lengerke, Hans-Jörg Tischler, Christoph Röllig, Leo Ruhnke, Christian Thiede, Andreas Burchert, Hubert Serve, Carsten Mueller-Tidow, Claudia Baldus, Jurjen Versluis, Peter Valk, Daniel Kristensen, Anne Stidsholt Roug, Jiri Mayer, Mika Kontro, Pia Ettala, Vladimir Lazarevic, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 991.
https://doi.org/10.1182/blood-2025-991
Published: 2025
Journal Articles

Induction chemotherapy with a single anthracycline-containing cycle in younger adults with newly diagnosed AML – the french backbone intergroup (BIG)-1 study on behalf of the filo, ALFA, and SFGM-TC study groups

Free
Christian Recher, Cecile Pautas, Sarah Bertoli, Pierre-Yves Dumas, Emmanuel Raffoux, Marie-Anne Hospital, Raja Prince-Eladnani, Mael Heiblig, Martin Carre, Sylvain Chantepie, Pierre Peterlin, Maria Pilar Gallego Hernanz, Juliette Lambert, Corentin Orvain, Romain Guieze, Pascal Turlure, Celestine Simand, Emilie Lemasle, Chantal Himberlin, Caroline Bonmati, Jean Valère Malfuson, Delphine Lebon, Thomas Cluzeau, Emmanuelle Tavernier, Jean-Baptiste Micol, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Anne Huynh, Thibaut Leguay, Isabelle Luquet, Dominique Penther, Nicolas Duployez, Eric Delabesse, Claude Preudhomme, Herve Dombret, Jean-François Hamel, Arnaud Pigneux, Hunault-Berger Mathilde
Journal: Blood
Blood (2025) 146 (Supplement 1): 43.
https://doi.org/10.1182/blood-2025-43
Published: 2025
Journal Articles

Therapy-related core binding factor Acute Myeloid Leukemia – a Study of the french acute leukemia intergroup

Free
Mathilde Chanut, Loïc Vasseur, Matthieu Duchmann, Pierre Hirsch, Céline Berthon, Mael Heiblig, Thorsten Braun, Mathieu Leclerc, Jean Valère Malfuson, Delphine Lebon, Madalina Uzunov, Jean-Noel Bastie, Gian Matteo Pica, Marie-Anne Hospital, Thomas Cluzeau, Juliette Lambert, Lauris Gastaud, Karine Celli-Lebras, Arnaud Pigneux, Stephane De Botton, Christian Recher, Claude Preudhomme, Eric Jourdan, Herve Dombret, Nicolas Boissel, Nicolas Duployez, Raphael Itzykson, Jean-Baptiste Micol
Journal: Blood
Blood (2025) 146 (Supplement 1): 37.
https://doi.org/10.1182/blood-2025-37
Published: 2025
Journal Articles

Age‐adapted chemotherapy and MRD‐oriented transplant for Ph-negative acute lymphoblastic leukemia: the GRAALL-2014 trial

Available to Purchase
Clinical Trials & Observations
Nicolas Boissel, Sylvie Chevret, Françoise Rigal-Huguet, Thibaut TL Leguay, Mathilde Hunault, Carlos Graux, Yves Chalandon, Eric Delabesse, Yosr Hicheri, Patrice Chevallier, Marie Balsat, Cedric Pastoret, Martine Escoffre-Barbe, Florence Pasquier, Magalie Joris, Anne Thiebaut, Anne Huynh, Nathalie Dhedin, Emilie Lemasle, Caroline Bonmati, Sebastien Maury, Gaelle Guillerm, Ana Berceanu, Urs Schanz, Thomas Cluzeau, Pascal Turlure, Philippe Rousselot, Bernard De Prijck, Nathalie Grardel, Marie-Christine Béné, Marina Lafage-Pochitaloff, Wendy Cuccuini, Norbert H Ifrah, Véronique Lheritier, Vahid Asnafi, Emmanuelle Clappier, Hervé Dombret
Journal: Blood
Blood blood.2025029611.
https://doi.org/10.1182/blood.2025029611
Published: 2025
Includes: Supplemental data
Journal Articles

LEF1 Intragenic Deletion Induces a Dominant-Negative isoform and unveils a Wnt/β3-Catenin Vulnerability in T-ALL

Available to Purchase
Clinical Trials & Observations
Manon Delafoy, Mickaël Frédéric Bonnet, Etienne Lengliné, Agata Cieslak, Aurore Touzart, Estelle Balducci, Mathieu Simonin, Véronique Lheritier, Marie-Emilie Dourthe, Benoit Heid-Picard, Sylvain Latour, Hervé Dombret, Philippe Rousselot, André Baruchel, Nicolas Boissel, Guillaume P. Andrieu, Vahid Asnafi
Journal: Blood
Blood blood.2025030161.
https://doi.org/10.1182/blood.2025030161
Published: 2025
Includes: Supplemental data
Journal Articles

Surface pTα expression predicts LCK activation and preclinical synergy of LCK and JAK coinhibition in adult T-ALL

Available to Purchase
Lucien Courtois, Antoine Pinton, Aurélie Cabannes-Hamy, Mathieu Simonin, Guillaume P. Andrieu, Mélodie Queri, Charlotte Smith, Guillaume Charbonnier, Marie-Emilie Dourthe, Marianne Courgeon, Grégoire Huré, Nicolas Gaidot, Elizabeth Macintyre, Hervé Dombret, André Baruchel, Nicolas Boissel, Aurore Touzart, Ludovic Lhermitte, Philippe Rousselot, Vahid Asnafi
Journal: Blood
Blood (2025) 145 (24): 2903–2913.
https://doi.org/10.1182/blood.2024027982
Published: 2025
Includes: Supplemental data
Journal Articles

Introduction to a review series on acute lymphoblastic leukemia

Free
Hervé Dombret
Journal: Blood
Blood (2025) 145 (14): 1439.
https://doi.org/10.1182/blood.2024028229
Published: 2025