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Alexander Perl
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Journal Articles

Preliminary Results of A phase 1 study of the safety and tolerability of the combination of revumenib (REV) with gilteritinib (GILT) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Free
Uma Borate, Jayanshu Jain, Ying Huang, Kaitlyn Dvorak-Kornaus, Alexander Perl, Joshua Zeidner, Alice Mims
Journal: Blood
Blood (2025) 146 (Supplement 1): 3427.
https://doi.org/10.1182/blood-2025-3427
Published: 2025
Journal Articles

Revumenib for patients with relapsed or refractory (R/R) Nucleophosmin 1–Mutated (NPM1m) Acute Myeloid Leukemia (AML): Outcomes by prior treatment in the phase 2 AUGMENT-101 study

Free
Martha Arellano, Michael Thirman, John DiPersio, Mael Heiblig, Eytan Stein, Andre Schuh, Andrius Zucenka, Stephane De Botton, Carolyn Grove, Gabriel Mannis, Cristina Papayannidis, Alexander Perl, Ghayas Issa, Ibrahim Aldoss, Ashish Bajel, David Dickens, Michael Kühn, Ioannis Mantzaris, Emmanuel Raffoux, Elie Traer, Irina Amitai, Hartmut Döhner, Corinna Greco, Tibor Kovacsovics, Christine McMahon, Pau Montesinos, Arnaud Pigneux, Paul Shami, Richard Stone, Ofir Wolach, John Harpel, Yakov Chudnovsky, Li Yu, Rebecca Bagley, Angela R. Smith, James Blachly
Journal: Blood
Blood (2025) 146 (Supplement 1): 3418.
https://doi.org/10.1182/blood-2025-3418
Published: 2025
Journal Articles

Time from AML diagnosis to HCT and pre-HCT FLT3 inhibition impact pre-transplant MRD and benefit from post-HCT gilteritinib

Free
Mark Levis, Mehdi Hamadani, Brent Logan, Richard Jones, Anurag Singh, Mark Litzow, John Wingard, Esperanza Papadopoulos, Alexander Perl, Robert Soiffer, Celalettin Ustun, Masumi Ueda Oshima, Geoffrey Uy, Edmund Waller, Sumithira Vasu, Melhem Solh, Asmita Mishra, Lori Muffly, Heeje Kim, Matthias Stelljes, Yuho Najima, Masahiro Onozawa, Kirsty Thomson, Caroline Chen, Nahla Hasabou, Mathew Rosales, Jason Hill, Stanley Gill, Rishita Nuthethi, Denise King, Adam Mendizabal, Steven Devine, Mary Horowitz, Yi-Bin Chen
Journal: Blood
Blood (2025) 146 (Supplement 1): 1058.
https://doi.org/10.1182/blood-2025-1058
Published: 2025
Journal Articles

Venetoclax (VEN) and azacitidine (AZA) with gilteritinib (GILT) in patients with newly diagnosed (ND) FLT3mut+ Acute Myeloid Leukemia (AML) ineligible for intensive induction chemotherapy (chemo): Interim results from the phase 1/2 VICEROY study

Free
Jessica Altman, Alexander Perl, Eunice Wang, Uma Borate, Elie Traer, James Dugan, Margaret Kasner, Richard Larson, Yehuda Deutsch, Aditi Shastri, Maria Baer, Steven Tsai, Deepa Jeyakumar, Hoda Pourhassan, Alireza Eghtedar, Caroline Chen, Alexandra Heinloth, Rishita Nuthethi, Stanley Gill, Jason Hill, Nahla Hasabou, Mark Levis, Naval Daver
Journal: Blood
Blood (2025) 146 (Supplement 1): 654.
https://doi.org/10.1182/blood-2025-654
Published: 2025
Journal Articles

IL18-armored CAR T cells in relapsed/refractory B cell acute lymphoblastic leukemia

Free
Matthew Connor, Wei-Ting Hwang, Saar Gill, Alexander Perl, Ximena Jordan Bruno, Nasheed Hossain, Catherine Lai, Alison Loren, Selina Luger, Andrew Matthews, Shannon McCurdy, Pashna Munshi, Keith Pratz, Amanda Cervini, Jean McConville, Joanne Shea, Charles Tongue, Heather Difilippo, Jacob Kesselman, Amy Marshall, Megan Four, Shannon Christensen, Vanessa Gonzalez, Julie Jadlowsky, Gabriela Plesa, Don Siegel, Rachel Leskowitz, Joseph Fraietta, Bruce Levine, David Porter, Elizabeth Hexner, Carl June, Jakub Svoboda, Noelle Frey
Journal: Blood
Blood (2025) 146 (Supplement 1): 812.
https://doi.org/10.1182/blood-2025-812
Published: 2025
Journal Articles

Fried's frailty phenotype predicts survival in pts with relapsed/refractory lymphoma or myeloma undergoing chimeric antigen receptor T-cell therapy – a prospective, observational Study

Free
Nikita Dave, Shannon Gier, Marni Kessler, Miguel Rodriguez, Stefan Barta, Elise Chong, Adam Cohen, Noelle Frey, Saar Gill, Shannon Heck, Elizabeth Hexner, Nasheed Hossain, Shivani Kapur, Daniel Landsburg, Alison Loren, Selina Luger, Mary Ellen Martin, Pashna Munshi, Sunita Dwivedy Nasta, Alexander Perl, David Porter, Stephen Schuster, Edward Stadtmauer, Sandra Susanibar-Adaniya, Jakub Svoboda, Abby Togliatii, Dan Vogl, Adam Waxman, Daniel Wu, Shannon McCurdy
Journal: Blood
Blood (2025) 146 (Supplement 1): 7189.
https://doi.org/10.1182/blood-2025-7189
Published: 2025
Journal Articles

Effect of FLT3 maintenance in older FLT3-ITD+ adults undergoing allogeneic HCT. a post hoc analysis of BMT CTN 1506

Free
Sameem Abedin, Victor Baidoo, Aniko Szabo, Richard Jones, Anurag Singh, Mark Litzow, John Wingard, Esperanza Papadopoulos, Alexander Perl, Robert Soiffer, Celalettin Ustun, Masumi Ueda Oshima, Geoffrey Uy, Edmund Waller, Sumithira Vasu, Melhem Solh, Asmita Mishra, Lori Muffly, Heeje Kim, Matthias Stelljes, Yuho Najima, Masahiro Onozawa, Caroline Chen, Nahla Hasabou, Mathew Rosales, Jason Hill, Stanley Gill, Rishita Nuthethi, Denise King, Adam Mendizabal, Steven Devine, Mary Horowitz, Yi-Bin Chen, Mark Levis, Mehdi Hamadani
Journal: Blood
Blood (2025) 146 (Supplement 1): 170.
https://doi.org/10.1182/blood-2025-170
Published: 2025
Journal Articles

Results from paradigm - a phase 2 randomized multi-center study comparing azacitidine and venetoclax to conventional induction chemotherapy for newly diagnosed fit adults with acute myeloid leukemia

Free
Amir Fathi, Alexander Perl, Geoffrey Fell, Brian Jonas, Brittany Ragon, Alice Mims, Uma Borate, Gabriel Mannis, Karen Quillen, Max Stahl, Paul Koller, Andrew Artz, Monzr M. Al Malki, Guido Marcucci, Mary Linton Peters, Timothy Graubert, Peter Westervelt, Philip Amrein, Hanno Hock, Andrew Brunner, Gabriela Hobbs, Rupa Narayan, Michelle Lee, Brandon Aubrey, Alyssa Watson, Richard Hao, Shilton Dhaver, Michael Grunwald, Yi-Bin Chen, Andrew Matthews, Christopher Hourigan, Brent Wood, Donna Neuberg, Areej El-Jawahri, Ibrahim Aldoss
Journal: Blood
Blood (2025) 146 (Supplement 1): 6.
https://doi.org/10.1182/blood-2025-6
Published: 2025
Journal Articles

Age-ing study: A prospective evaluation of geriatric, patient-reported and frailty assessments to predict outcomes in older adults with acute myeloid leukemia

Free
Catherine Lai, Thomas Greenwood, E. Paul Wileyto, Nisha Singh, Ashlena Livingston, Amanda Lopez, Selina Luger, Alexander Perl, Ximena Jordan Bruno, Elizabeth Hexner, Shannon McCurdy, Saar Gill, Gary Okano, Ali McBride, Carmelo Alonso, Keith Pratz
Journal: Blood
Blood (2025) 146 (Supplement 1): 2843.
https://doi.org/10.1182/blood-2025-2843
Published: 2025
Journal Articles

Revumenib for patients with relapsed or refractory (R/R) KMT2Ar acute leukemia: Outcomes by leukemia type in the phase 2 AUGMENT-101 study

Free
Ibrahim Aldoss, Ghayas Issa, James Blachly, Michael Thirman, Gabriel Mannis, Martha Arellano, John DiPersio, Elie Traer, C. Zwaan, Neerav Shukla, Branko Cuglievan, Carolyn Grove, Matthew Greenwood, Christine McMahon, Alexander Perl, Richard Stone, Cristina Papayannidis, David Dickens, Mael Heiblig, Andrius Zucenka, Pau Montesinos, Ioannis Mantzaris, Tibor Kovacsovics, Paul Shami, Li Yu, Rebecca Bagley, Angela R. Smith, Eytan Stein
Journal: Blood
Blood (2025) 146 (Supplement 1): 1001.
https://doi.org/10.1182/blood-2025-1001
Published: 2025
Journal Articles

Outcomes of patients with relapsed/refractory FLT3mut+ Acute Myeloid Leukemia who resumed gilteritinib therapy after HSCT: Post hoc analysis from the ADMIRAL and COMMODORE trials

Free
Mark Levis, Alexander Perl, Jianda Hu, Heeje Kim, Vladimir Ivanov, Hisayuki Yokoyama, Naoko Hosono, Er-Lie Jiang, Dong-Yeop Shin, Bartlomiej Getta, Ashish Bajel, Jamie Jung-Hee An, Dina Elsouda, Juan Ariza, Jianxiang Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 42.
https://doi.org/10.1182/blood-2025-42
Published: 2025
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study

Free
Ibrahim Aldoss, Ghayas C. Issa, Michael Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander Perl, David S. Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G. Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-5.
https://doi.org/10.1182/blood-2023-192042
Published: 2023
Journal Articles

Quantum-First: Safety By Treatment Phase and By Age in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD) Positive Acute Myeloid Leukemia (AML)

Free
Harry P. Erba, Herve Dombret, Alexander Perl, Tsvetomir Mitov, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Youngsook Choi, Mark J. Levis, Richard F Schlenk
Journal: Blood
Blood (2023) 142 (Supplement 1): 972.
https://doi.org/10.1182/blood-2023-186206
Published: 2023
Journal Articles

Hypomethylating Agents Are Associated with High Rates of Hematologic Toxicity in Patients with Secondary MDS/AML That Develops after Acquired Aplastic Anemia

Free
Matthew P Connor, Neeharika Prathapa, Noelle V. Frey, Saar Gill, Elizabeth O Hexner, Ximena Jordan Bruno, Catherine Lai, Alison W Loren, Selina M Luger, Andrew H Matthews, Shannon R McCurdy, Alexander Perl, David L. Porter, Arlene Zeringue, Joseph H. Oved, Timothy S Olson, Keith W Pratz, Daria V Babushok
Journal: Blood
Blood (2023) 142 (Supplement 1): 2720.
https://doi.org/10.1182/blood-2023-179383
Published: 2023
Journal Articles

Evolving Racial/Ethnic Disparities in AML Survival in the Novel Therapy Era: Real-World Evidence of Improved Survival in Older Patients with the Largest Improvement in Non-Hispanic Black Patients

Free
Xin Wang, Phyllis Gimotty, Andrew H Matthews, Ronac Mamtani, Selina M Luger, Elizabeth O Hexner, Daria V Babushok, Shannon R McCurdy, Noelle V. Frey, Ximena Jordan Bruno, David L. Porter, Saar Gill, Mary Ellen Martin, Vikram R Paralkar, Ivan Maillard, Alison W Loren, Alexander Perl, Keith W Pratz, Kelly D. Getz, Catherine Lai
Journal: Blood
Blood (2023) 142 (Supplement 1): 955.
https://doi.org/10.1182/blood-2023-180185
Published: 2023
Journal Articles

Cytokine Release Syndrome Results in Reduced AML Killing By CD123 CAR T Cells

Free
Anand S Bhagwat, Leonel Torres, Olga Shestova, Maksim Shestov, Noelle V. Frey, Elizabeth O Hexner, Selina M Luger, Alison W Loren, Mary Ellen Martin, Shannon R McCurdy, Alexander Perl, Edward A. Stadtmauer, James K. Mangan, Jennifer Brogdon, Joseph A Fraietta, Wei-Ting Hwang, Don L. Siegel, Saad S. Kenderian, David L. Porter, Carl June, Saar Gill
Journal: Blood
Blood (2023) 142 (Supplement 1): 217.
https://doi.org/10.1182/blood-2023-182104
Published: 2023
Journal Articles

Kinetics of Complete Remission (CR) and CR Duration and Its Impact on Overall Survival (OS) and Event-Free Survival (EFS) in Quantum-First

Free
Pau Montesinos, Alexander Perl, Mikkael A. Sekeres, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Richard F Schlenk, Harry P. Erba, Hervé Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 4254.
https://doi.org/10.1182/blood-2023-187286
Published: 2023
Journal Articles

Patient-Reported Outcome Measures Associated with Overall Survival and Acute Care Use in Patients with Newly Diagnosed Myelodysplastic Syndrome, Acute Myelogenous Leukemia, or Acute Lymphoblastic Leukemia

Free
Seiichi Villalona, Xin Wang, Peter Gabriel, Abigail Doucette, Shannon R McCurdy, Alexander Perl, Selina M Luger, Noelle V. Frey, Ximena Jordan Bruno, Elizabeth O Hexner, Daria V Babushok, David L. Porter, Alison W Loren, Keith W Pratz, Catherine Lai
Journal: Blood
Blood (2023) 142 (Supplement 1): 5183.
https://doi.org/10.1182/blood-2023-178247
Published: 2023
Journal Articles

Multiomic Single-Cell Sequencing May Distinguish BCR-ABL-Mutated Acute Myeloid Leukemia (AML) from Blast Crisis Chronic Myelogenous Leukemia (BC-CML)

Free
Vanessa E. Kennedy, Cheryl A C Peretz, Andrew Koh, Elaine Tran, Dalia Dhingra, Saurabh Gulati, Adam Sciambi, Olga Sala-Torra, Lan Beppu, Aaron C. Logan, Alexander Perl, Wendy Stock, Geoffrey L Uy, Ann-Kathrin Eisfeld, Jerald P. Radich, Catherine C. Smith
Journal: Blood
Blood (2023) 142 (Supplement 1): 4334.
https://doi.org/10.1182/blood-2023-182454
Published: 2023
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study

Free
Ibrahim Aldoss, Ghayas C. Issa, Michael J Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel Mannis, Alexander Perl, David Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2023-189762
Published: 2023