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Richard Larson
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Journal Articles

A dynamic comprehensive geriatric assessment demonstrates improvement in patient fitness after induction and predicts survival and treatment tolerability among older adults with newly diagnosed acute myeloid leukemia

Free
Samuel Yates, Elizabeth Terman, Lauren Miller, John Cursio, Claire Wild, Megan Huisingh-Scheetz, Michael Zhang, Nicholas Feinberg, Karteek Popuri, Mirza Faisal Beg, Varun Akella, Hamed Youshanlouei, Afsheen Noorani, Jamie Mathews, Caner Saygin, Anand Patel, Olatoyosi Odenike, Richard Larson, Mariam Nawas, Wendy Stock
Journal: Blood
Blood (2025) 146 (Supplement 1): 5153.
https://doi.org/10.1182/blood-2025-5153
Published: 2025
Journal Articles

Venetoclax (VEN) and azacitidine (AZA) with gilteritinib (GILT) in patients with newly diagnosed (ND) FLT3mut+ Acute Myeloid Leukemia (AML) ineligible for intensive induction chemotherapy (chemo): Interim results from the phase 1/2 VICEROY study

Free
Jessica Altman, Alexander Perl, Eunice Wang, Uma Borate, Elie Traer, James Dugan, Margaret Kasner, Richard Larson, Yehuda Deutsch, Aditi Shastri, Maria Baer, Steven Tsai, Deepa Jeyakumar, Hoda Pourhassan, Alireza Eghtedar, Caroline Chen, Alexandra Heinloth, Rishita Nuthethi, Stanley Gill, Jason Hill, Nahla Hasabou, Mark Levis, Naval Daver
Journal: Blood
Blood (2025) 146 (Supplement 1): 654.
https://doi.org/10.1182/blood-2025-654
Published: 2025
Journal Articles

Primary efficacy analysis of phase II study investigating tyrosine kinase inhibitor (TKI) and inotuzumab ozogamicin-based therapy for newly diagnosed Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL)

Free
Anand Patel, Adam Duvall, Caner Saygin, Howard Weiner, Emily Dworkin, Afsheen Noorani, Jamie Mathews, Angela Lager, Sandeep Gurbuxani, Peng Wang, Rafael Madero-Marroquin, Austin Wesevich, Michael Drazer, Mariam Nawas, Gregory Roloff, Satyajit Kosuri, Michael Thirman, Richard Larson, Olatoyosi Odenike, Theodore Karrison, Wendy Stock
Journal: Blood
Blood (2025) 146 (Supplement 1): 441.
https://doi.org/10.1182/blood-2025-441
Published: 2025
Journal Articles

Trial in progress – a phase 1b trial of ivosidenib combined with ruxolitinib in IDH1-mutated advanced myeloproliferative neoplasms

Free
Anand Patel, Theodore Karrison, Emily Dworkin, Rafael Madero-Marroquin, Austin Wesevich, Gregory Roloff, Caner Saygin, Mariam Nawas, Michael Drazer, Adam Duvall, Satyajit Kosuri, Michael Thirman, Wendy Stock, Richard Larson, Olatoyosi Odenike
Journal: Blood
Blood (2025) 146 (Supplement 1): 5608.
https://doi.org/10.1182/blood-2025-5608
Published: 2025
Journal Articles

Trial in progress: A Phase I/II study to investigate the combination of LP-118, ponatinib, vincristine and dexamethasone (LPVd regimen) in relapsed/refractory T-ALL/lbl

Free
Caner Saygin, Anand Patel, Hannah Levavi, Kristen O'Dwyer, Meixiao Long, Fernando Vargas Madueno, Chenyu Lin, Theodore Karrison, Howard Weiner, Adam Duvall, Satyajit Kosuri, Rafael Madero-Marroquin, Gregory Roloff, Michael Drazer, Michael Thirman, Richard Larson, Olatoyosi Odenike, L. Evan Reddick, Yu Chen, Stephen Anthony, Wendy Stock
Journal: Blood
Blood (2025) 146 (Supplement 1): 5136.
https://doi.org/10.1182/blood-2025-5136
Published: 2025
Journal Articles

Asciminib (ASC) demonstrates continued improvement in patient-reported outcomes (PROs) vs investigator-selected tyrosine kinase inhibitors (IS-TKIs) in newly diagnosed chronic myeloid leukemia (CML): ASC4FIRST week 96 analysis

Free
Jorge Cortes, Andreas Hochhaus, Kathryn Flynn, Felice Bombaci, Ghayas Issa, Richard Larson, Jianxiang Wang, Dong-Wook Kim, Dennis Kim, Jiri Mayer, Yeow Tee Goh, Philipp le Coutre, Inho Kim, Gabriel Etienne, Shruti Kapoor, Rajendra Jinwal, Kamel Malek, Lillian Yau, Timothy Hughes, Naoto Takahashi
Journal: Blood
Blood (2025) 146 (Supplement 1): 1997.
https://doi.org/10.1182/blood-2025-1997
Published: 2025
Journal Articles

Spiritual wellness and quality-of-life in adult patients with newly diagnosed acute leukemia receiving initial therapy: Patient-reported outcomes (PROs) from a prospective observational study

Free
Hannah Johnston, Abigail Sneider, Tuula Pera, Rafael Madero-Marroquin, Austin Wesevich, Gregory Roloff, Mariam Nawas, Anand Patel, Michael Drazer, Adam Duvall, Satyajit Kosuri, Michael Thirman, Olatoyosi Odenike, Richard Larson, Caner Saygin, Wendy Stock, Christopher Daugherty
Journal: Blood
Blood (2025) 146 (Supplement 1): 6382.
https://doi.org/10.1182/blood-2025-6382
Published: 2025
Journal Articles

Real world outcomes of patients with CML-CP treated with tyrosine kinase inhibitors from the h. jean khoury cure CML consortium (HJKC3)

Free
Ehab Atallah, Emily Giever, Jorge Cortes, Ryan Conrardy, Lisa Rein, Arielle Baim, Idayat Akinola, James Thompson, Yan Gao, Richard Larson, Ravi Bhatia, B. Douglas Smith, Kathryn Flynn
Journal: Blood
Blood (2025) 146 (Supplement 1): 2844.
https://doi.org/10.1182/blood-2025-2844
Published: 2025
Journal Articles

Distinct patterns of mutant ASXL1 over time and their implications for treatment failure (TF) and BCR::ABL1 mutation development in newly diagnosed patients with chronic myeloid leukemia in chronic phase (CML-CP) treated with asciminib (ASC) vs investigator-selected tyrosine kinase inhibitors (IS-TKI) in the ASC4FIRST study

Free
Susan Branford, Jorge Cortes, Naoto Takahashi, Richard Larson, Ghayas Issa, Felice Bombaci, Jianxiang Wang, Dong-Wook Kim, Dennis Kim, Jiri Mayer, Yeow Tee Goh, Philipp le Coutre, Inho Kim, Gabriel Etienne, Shruti Kapoor, Rajendra Jinwal, Kamel Malek, Amila Sarac, Andreas Bruederle, Pablo Serrano-Fernandez, Pedro Milanez-Almeida, Andreas Hochhaus, Timothy Hughes
Journal: Blood
Blood (2025) 146 (Supplement 1): 73.
https://doi.org/10.1182/blood-2025-73
Published: 2025
Journal Articles

Improved long-term tolerability with asciminib (ASC) vs investigator-selected (IS) tyrosine kinase inhibitors (TKIs) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): Week 96 exploratory analysis of the phase 3 ASC4FIRST trial

Free
Timothy Hughes, Jorge Cortes, Jennifer Vaughn, Kathryn Flynn, Naoto Takahashi, Ghayas Issa, Felice Bombaci, Jianxiang Wang, Dong-Wook Kim, Dennis Kim, Jiri Mayer, Yeow Tee Goh, Philipp le Coutre, Inho Kim, Gabriel Etienne, Rajendra Jinwal, Andrea Damon, David Wei, Gabriel Marquez, Ennan Gu, Gopi Madhav Bommidi, Andreas Hochhaus, Richard Larson
Journal: Blood
Blood (2025) 146 (Supplement 1): 5549.
https://doi.org/10.1182/blood-2025-5549
Published: 2025
Journal Articles

Asciminib (ASC) Demonstrates Favorable Safety and Tolerability Compared with Each Investigator-Selected Tyrosine Kinase Inhibitor (IS TKI) in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP) in the Pivotal Phase 3 ASC4FIRST Study

Free
Jorge E. Cortes, Andreas Hochhaus, Timothy P Hughes, Jianxiang Wang, Dong-Wook Kim, Dennis Dong Hwan Kim, Jiri Mayer, Yeow Tee Goh, Philipp le Coutre, Gabriel Etienne, Naoto Takahashi, Inho Kim, David Andorsky, Ghayas C. Issa, Felice Bombaci, Shruti Kapoor, Rajendra Jinwal, Lillian Yau, Richard Larson
Journal: Blood
Blood (2024) 144 (Supplement 1): 475.
https://doi.org/10.1182/blood-2024-203757
Published: 2024
Journal Articles

HJKC3-0006: Outcome of Patients with CML Treated on Second Line or Later Therapy in Routine Clinical Practice

Free
James E Thompson, Yan Gao, Alexis Visotcky, Kathryn E Flynn, Michael Mauro, Emily Giever, Arielle Baim, Idayat Akinola, Richard Larson, Omer Jamy, Anthony M. Hunter, Vamsi K. Kota, Jorge Cortes, Brian J. Druker, Neil P. Shah, Javier Pinilla-Ibarz, Jay Yang, Ellen K. Ritchie, Lindsay A.M Rein, B. Douglas Smith, Srinivas K. Tantravahi, Talha Badar, Michael W. Deininger, Ehab L. Atallah
Journal: Blood
Blood (2023) 142 (Supplement 1): 7420.
https://doi.org/10.1182/blood-2023-179963
Published: 2023
Journal Articles

Socioeconomic Determinants and the Biology and Outcomes of Acute Lymphoblastic Leukemia in Adults

Free
Hannah Johnston, Hamed Youshanlouei, Clinton Osei, Anand Ashwin Patel, Adam S Duvall, Peng Wang, Pankhuri Wanjari, Jeremy Segal, Girish Venkataraman, Sandeep Gurbuxani, Angela Lager, Carrie Fitzpatrick, Michael J Thirman, Christopher Daugherty, Mariam T. Nawas, Hongtao Liu, Michael Drazer, Olatoyosi Odenike, Richard Larson, Wendy Stock, Caner Saygin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1468.
https://doi.org/10.1182/blood-2023-174963
Published: 2023
Journal Articles

Interim Analysis of EFC6663, a Multicenter Phase 2 Study of Alvocidib (flavopiridol), Demonstrates Clinical Responses Among Patients with Fludarabine Refractory CLL

Free
Mark C Lanasa, MD, PhD, Leslie Andritsos, MD, Jennifer R Brown, MD, PhD, Janice Gabrilove, M.D., Federico Caligaris-Cappio, M.D., Richard Larson, M.D., Thomas J. Kipps, MD, PhD, Veronique Leblond, M.D., Donald Milligan, MD, FRCP, FRCPath, Ann Janssens, M.D., Nyla A. Heerema, Ph.D., Stephan Stilgenbauer, M.D., John C. Byrd, MD, Michael R. Grever, M.D.
Journal: Blood
Blood (2010) 116 (21): 58.
https://doi.org/10.1182/blood.V116.21.58.58
Published: 2010
Journal Articles

Efficacy and Toxicity of Rituximab and Brief Duration, High Intensity Chemotherapy with Filgrastim Support for Burkitt or Burkitt – Like Leukemia/Lymphoma: Cancer and Leukemia Group B (Calgb) Study 10002

Free
David A. Rizzieri, MD, Jeffrey L Johnson, John C. Byrd, MD, Gerard Lozanski, MD, Bayard L. Powell, MD, Thomas C. Shea, MD, Sreenivasa Nattom, Eva Hoke, Bruce D. Cheson, MD, Richard Larson, M.D.
Journal: Blood
Blood (2010) 116 (21): 858.
https://doi.org/10.1182/blood.V116.21.858.858
Published: 2010
Journal Articles

Tipifarnib Is Well Tolerated as Maintenance Therapy In Acute Myeloid Leukemia (AML). Significant, but Non-Fatal, Hematologic Toxicity Not Ameliorated by Dose Reduction. Preliminary Results of the Phase III Intergroup Trial E2902

Free
Selina Luger, MD, Xiaopan Yao, PhD, MS, Elisabeth Paietta, PhD, Rhett Ketterling, Witold Rybka, MD, Mark R. Litzow, MD, Jacob M. Rowe, Richard Larson, M.D., Martin S. Tallman, MD
Journal: Blood
Blood (2010) 116 (21): 3315.
https://doi.org/10.1182/blood.V116.21.3315.3315
Published: 2010
Journal Articles

Phase II Study of Bortezomib Added to Standard Daunorubicin and Cytarabine Induction and Dose Escalation of Bortezomib with Intermediate-Dose Cytarabine Consolidation Therapy for Patients with Previously Untreated Acute Myeloid Leukemia Age 60–75 Years: Cancer and Leukemia Group B (CALGB) Study 10502

Free
Eyal C Attar, M.D., Kathleen A. Donohue, M.A., Philip C. Amrein, MD, Martha Wadleigh, MD, Daniel J DeAngelo, MD, PhD, Jonathan E Kolitz, MD, Bayard L. Powell, MD, Peter M Voorhees, M.D., Eunice S. Wang, MD, William Blum, MD, Allison Booth, Richard M Stone, M.D., Barry K Moser, Ph.D., Richard Larson, M.D.
Journal: Blood
Blood (2010) 116 (21): 331.
https://doi.org/10.1182/blood.V116.21.331.331
Published: 2010
Journal Articles

High frequency of PTEN, PI3K , and AKT abnormalities in T-cell acute lymphoblastic leukemia

Free
Brief Report
Alejandro Gutierrez, Takaomi Sanda, Ruta Grebliunaite, Arkaitz Carracedo, Leonardo Salmena, Yebin Ahn, Suzanne Dahlberg, Donna Neuberg, Lisa A. Moreau, Stuart S. Winter, Richard Larson, Jianhua Zhang, Alexei Protopopov, Lynda Chin, Pier Paolo Pandolfi, Lewis B. Silverman, Stephen P. Hunger, Stephen E. Sallan, A. Thomas Look
Journal: Blood
Blood (2009) 114 (3): 647–650.
https://doi.org/10.1182/blood-2009-02-206722
Published: 2009
Includes: Supplemental data
Journal Articles

Phase 1/2 Study of AMG 531 in Thrombocytopenic Patients (pts) with Low-Risk Myelodysplastic Syndrome (MDS): Update Including Extended Treatment.

Free
Hagop Kantarjian, Pierre Fenaux, Mikkael A. Sekeres, Pamela Becker, Adam Boruchov, David Bowen, Richard Larson, Roger Lyons, Petra Muus, Jamile Shammo, Michael Ehrman, Kuolung Hu, Janet Nichol
Journal: Blood
Blood (2007) 110 (11): 250.
https://doi.org/10.1182/blood.V110.11.250.250
Published: 2007
Journal Articles

MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia.

Free
Shuangli Mi, PhD, Jun Lu, Ph.D., Miao Sun, M.S., Zejuan Li, Ph.D., Hao Zhang, M.S., Mary Beth Neilly, M.S., Yungui Wang, Ph.D., Zhijian Qian, Ph.D., Jie Jin, M.D., Yanming Zhang, M.D., Stefan K. Bohlander, M.D., Michelle M. Le, B.A., Richard Larson, M.D., Todd R. Golub, M.D., Janet D. Rowley, M.D., Jianjun Chen, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 231.
https://doi.org/10.1182/blood.V110.11.231.231
Published: 2007