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Martha Arellano
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Journal Articles

Mechanistic dissection of venetoclax sensitivity in AML through single-molecule BCL2 protein complex profiling and mutation-specific apoptotic rewiring

Free
Jaewon Choi, Lilly Gu, Yunseo Lee, Yunchan Choi, Saem Hong, Byungsan Choi, Eunyoung Kim, Fizza Iftikhar, Martha Arellano, William Blum, Tae Young Yoon, Hongwon Lee, Janghee Woo
Journal: Blood
Blood (2025) 146 (Supplement 1): 341.
https://doi.org/10.1182/blood-2025-341
Published: 2025
Journal Articles

Revumenib for patients with relapsed or refractory (R/R) KMT2Ar acute leukemia: Outcomes by leukemia type in the phase 2 AUGMENT-101 study

Free
Ibrahim Aldoss, Ghayas Issa, James Blachly, Michael Thirman, Gabriel Mannis, Martha Arellano, John DiPersio, Elie Traer, C. Zwaan, Neerav Shukla, Branko Cuglievan, Carolyn Grove, Matthew Greenwood, Christine McMahon, Alexander Perl, Richard Stone, Cristina Papayannidis, David Dickens, Mael Heiblig, Andrius Zucenka, Pau Montesinos, Ioannis Mantzaris, Tibor Kovacsovics, Paul Shami, Li Yu, Rebecca Bagley, Angela R. Smith, Eytan Stein
Journal: Blood
Blood (2025) 146 (Supplement 1): 1001.
https://doi.org/10.1182/blood-2025-1001
Published: 2025
Journal Articles

RAS mutations negate the favorable impact of NPM1 in older patients with newly diagnosed Acute Myeloid Leukemia treated with ven/HMA

Free
Fieke Hoff, Alexander Li, Ying Huang, Rina Welkie, Ronan Swords, Elie Traer, Eytan Stein, Tara Lin, Maria Baer, Vu Duong, William Blum, Martha Arellano, Wendy Stock, Olatoyosi Odenike, Joshua Zeidner, Rebecca Olin, Catherine Smith, Gary Schiller, Emily Curran, Shivani Handa, Nyla Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Marcus, Leonard Rosenberg, Brian Druker, Ross Levine, Ashley Yocum, Uma Borate, Alice Mims, John Byrd, Yazan Madanat
Journal: Blood
Blood (2025) 146 (Supplement 1): 995.
https://doi.org/10.1182/blood-2025-995
Published: 2025
Journal Articles

Revumenib for patients with relapsed or refractory (R/R) Nucleophosmin 1–Mutated (NPM1m) Acute Myeloid Leukemia (AML): Outcomes by prior treatment in the phase 2 AUGMENT-101 study

Free
Martha Arellano, Michael Thirman, John DiPersio, Mael Heiblig, Eytan Stein, Andre Schuh, Andrius Zucenka, Stephane De Botton, Carolyn Grove, Gabriel Mannis, Cristina Papayannidis, Alexander Perl, Ghayas Issa, Ibrahim Aldoss, Ashish Bajel, David Dickens, Michael Kühn, Ioannis Mantzaris, Emmanuel Raffoux, Elie Traer, Irina Amitai, Hartmut Döhner, Corinna Greco, Tibor Kovacsovics, Christine McMahon, Pau Montesinos, Arnaud Pigneux, Paul Shami, Richard Stone, Ofir Wolach, John Harpel, Yakov Chudnovsky, Li Yu, Rebecca Bagley, Angela R. Smith, James Blachly
Journal: Blood
Blood (2025) 146 (Supplement 1): 3418.
https://doi.org/10.1182/blood-2025-3418
Published: 2025
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study

Free
Ibrahim Aldoss, Ghayas C. Issa, Michael Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander Perl, David S. Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G. Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-5.
https://doi.org/10.1182/blood-2023-192042
Published: 2023
Journal Articles

First-in-Human Study of the CD123 NK Cell Engager SAR443579 in Relapsed or Refractory Acute Myeloid Leukemia, B-Cell Acute Lymphoblastic Leukemia or High Risk-Myelodysplasia: Updated Safety, Efficacy, Pharmacokinetics and Pharmacodynamics

Free
Ashish Bajel, Sylvain Garciaz, Pinkal Desai, Gerwin A Huls, Abhishek Maiti, Mojca Jongen-Lavrencic, Nicolas Boissel, Stephane De Botton, David C. de Leeuw, Shaun Fleming, C. Michel Zwaan, Martha Arellano, David Avigan, Jennifer N. Saultz, Ioannis Mantzaris, Kyle Jensen, Timothy Wagenaar, Gu Mi, Samira Ziti-Ljajic, Dobrin Draganov, Giovanni Abbadessa, Anthony Selwyn Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 3474.
https://doi.org/10.1182/blood-2023-173162
Published: 2023
Journal Articles

Influence of Pre-Treatment Features and Therapy Choice By Physicians on Overall Survival in Older Adults with Acute Myeloid Leukemia: A Report from the Beat AML Master Trial

Free
Uma M. Borate, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L Lin, Yazan F. Madanat, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F. Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Alice Mims, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 4332.
https://doi.org/10.1182/blood-2023-181886
Published: 2023
Journal Articles

Obecabtagene Autoleucel (obe-cel, AUTO1) for Relapsed/Refractory Adult B-cell Acute Lymphoblastic Leukemia (R/R B-ALL): Pooled Analysis of the Ongoing FELIX Phase Ib/II Study

Free
Claire Roddie, Karamjeet S. Sandhu, Eleni Tholouli, Paul Shaughnessy, Pere Barba, Manuel Guerreiro, Michael R. Bishop, Jean A. Yared, Armin Ghobadi, Deborah Yallop, Aaron C. Logan, Amer M. Beitinjaneh, Jeremy M. Pantin, Martha Arellano, Sridhar Chaganti, Ram Malladi, Tobias Menne, Virginia Escamilla Gómez, Katharine Hodby, Krishna Gundabolu, Luke Mountjoy, Kristen M. O'Dwyer, Sameem Abedin, Hassan Alkhateeb, Bijal D. Shah, Pierre Lao-Sirieix, Gianfranco Pittari, Kapil Saxena, Yiyun Zhang, Wolfram Brugger, Martin A. Pule, Jae H. Park, Daniel J. DeAngelo, Elias Jabbour
Journal: Blood
Blood (2023) 142 (Supplement 1): 222.
https://doi.org/10.1182/blood-2023-179454
Published: 2023
Journal Articles

Beat AML S8 Group 2: Gilteritinib (GILT) in Combination with Decitabine (DEC) and Venetoclax (VEN) in Untreated FLT3 Mutated Acute Myeloid Leukemia (AML) Patients Age ≥60 with High and Low Variant Allele Frequency (VAF)

Free
Qiuying (Selina) Liu, Rina Li Welkie, Ying Huang, Ronan T. Swords, Tara L Lin, Kristin L Koenig, Yazan F. Madanat, Prapti A. Patel, Robert H. Collins, William Blum, Martha Arellano, Maria R. Baer, Wendy Stock, Tibor J. Kovacsovics, Rebecca Olin, Emily K Curran, Eytan M. Stein, Gary J. Schiller, Joshua F. Zeidner, Robert L. Redner, Nyla A. Heerema, Molly Martycz, Leonard Rosenberg, Sonja Gullen Marcus, Timothy Chen, Mona Stefanos, Ross L Levine, Brian J. Druker, Ashley Owen Yocum, Amy Burd, Alice Mims, Uma M. Borate, John C. Byrd, Elie Traer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5933.
https://doi.org/10.1182/blood-2023-179609
Published: 2023
Journal Articles

Revumenib Maintenance Therapy Following Revumenib-Induced Remission and Transplant

Free
Andrius Zucenka, Ghayas C. Issa, Martha Arellano, Sajad Khazal, Nandita Khera, Wendy Stock, Branko Cuglievan, Yu Gu, Huy Van Nguyen, Angela R. Smith, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 4950.
https://doi.org/10.1182/blood-2023-189036
Published: 2023
Journal Articles

Tuspetinib Myeloid Kinase Inhibitor Safety and Efficacy As Monotherapy and Combined with Venetoclax in Phase 1/2 Trial of Patients with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML)

Free
Naval Daver, Kyoo Hyung Lee, Yunsuk Choi, Brian A. Jonas, Martha Arellano, Paul B. Koller, Chul W. Jung, Sang Kyun Sohn, Amir T. Fathi, Jeong-Ok Lee, Sung-Soo Yoon, Justin M. Watts, Pankit Vachhani, Ho-Jin Shin, Jia Hu, Ranjeet Sinha, Nawazish Khan, William G. Rice, Rafael Bejar
Journal: Blood
Blood (2023) 142 (Supplement 1): 162.
https://doi.org/10.1182/blood-2023-182296
Published: 2023
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study

Free
Ibrahim Aldoss, Ghayas C. Issa, Michael J Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel Mannis, Alexander Perl, David Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2023-189762
Published: 2023
Journal Articles

Genomic Characterization of Newly Diagnosed Acute Myeloid Leukemia in Patients Age 60 Years and Older; A Report from the Beat AML Master Trial

Free
Fieke W Hoff, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L Lin, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F. Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Uma M. Borate, Alice Mims, John C. Byrd, Yazan F. Madanat
Journal: Blood
Blood (2023) 142 (Supplement 1): 4296.
https://doi.org/10.1182/blood-2023-187044
Published: 2023
Journal Articles

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

Free
Clinical Trials & Observations
Courtney D. DiNardo, Keith Pratz, Vinod Pullarkat, Brian A. Jonas, Martha Arellano, Pamela S. Becker, Olga Frankfurt, Marina Konopleva, Andrew H. Wei, Hagop M. Kantarjian, Tu Xu, Wan-Jen Hong, Brenda Chyla, Jalaja Potluri, Daniel A. Pollyea, Anthony Letai
Journal: Blood
Blood (2019) 133 (1): 7–17.
https://doi.org/10.1182/blood-2018-08-868752
Published: 2019
Includes: Supplemental data
Journal Articles

Outcomes after Sequential Tyrosine Kinase Inhibitors Treatment in Chronic Phase Chronic Myeloid Leukemia

Free
Jee Hyun Kong, Elliott F. Winton, MD, Leonard Heffner, MD, Manila Gaddh, MD, Brittany Hill, PA-C, MMSc, MSc, MPH, Martha Arellano, MD, Fuad El-Rassi, Audrey Kim, Anand Jillella, MD, Vamsi K Kota
Journal: Blood
Blood (2017) 130 (Supplement 1): 1607.
https://doi.org/10.1182/blood.V130.Suppl_1.1607.1607
Published: 2017
Journal Articles

A Prospective Multi-Center Trial Shows Reduction of Early Deaths (ED) and Improved Survival in Elderly Acute Promyelocytic Leukemia (APL) Patients (>60 years). Results of Using a Simplified Treatment Algorithm and Expert Support in Georgia, South Carolina and Neighboring States

Free
Vamsi Kota, MD, Prachi Karkhanis, Rashmi Sharma, Sheldon Bolds, Kaitlin Sitchenko, Anima Shrestha, Veeraen Jonnalagadda, Manila Gaddh, MD, Leon Bernal-Mizrachi, MD, Leonard T. Heffner, MD, Elliott F. Winton, MD, Morgan L. McLemore, MD, Amelia Langston, MD, Jacques Galipeau, MD, Imre Bodó, MD PhD, Zaid Al-Kadhimi, MD, Asad Bashey, MD PhD, Robert K. Stuart, MD, Sarah I. Vidito, DO, Asim Pati, MD, Jonathan M. Gerber, MD, Michael R. Grunwald, MD, Kyle T. Bradley, MD MS, Jose Tongol, MD, Mohamed El-Geneidy, Hanna Jean Khoury, MD, Martha Arellano, MD, Anand Jillella, MD
Journal: Blood
Blood (2016) 128 (22): 1622.
https://doi.org/10.1182/blood.V128.22.1622.1622
Published: 2016
Journal Articles

A Phase 2 Study of Pracinostat and Azacitidine in Elderly Patients with Acute Myeloid Leukemia (AML) Not Eligible for Induction Chemotherapy: Response and Long-Term Survival Benefit

Free
Guillermo Garcia Manero, Ehab Atallah, MD, Samer K Khaled, MD, Martha Arellano, MD, Mrinal M Patnaik, MBBS, Olatoyosi Odenike, MD, Hamid Sayar, MD, Mohan Tummala, Prapti A. Patel, MD, Richard G. Ghalie, MD, Bruno C. Medeiros, MD
Journal: Blood
Blood (2016) 128 (22): 100.
https://doi.org/10.1182/blood.V128.22.100.100
Published: 2016
Journal Articles

A Multi-Center Prospective Study Utilizing a Simplified Treatment Algorithm Complemented By Expert Support Decreases Induction Mortality and Improves Survival in Acute Promyelocytic Leukemia (APL). Results of the APL Trial in Georgia, South Carolina and Neighboring States

Free
Anand Jillella, MD, Prachi Karkhanis, Rashmi Sharma, Sheldon Bolds, Anima Shrestha, Kaitlin Sitchenko, Veeraen Jonnalagadda, Manila Gaddh, MD, Leon Bernal-Mizrachi, MD, Leonard T. Heffner, MD, Elliott F. Winton, MD, Morgan L. McLemore, MD, Amelia Langston, MD, Jacques Galipeau, MD, Imre Bodó, MD PhD, Zaid Al-Kadhimi, MD, Asad Bashey, MD PhD, Robert K. Stuart, MD, Sarah I. Vidito, DO, Asim Pati, MD, Jonathan M. Gerber, MD, Michael R. Grunwald, MD, Kyle T. Bradley, MD MS, Jose Tongol, MD, Mohamed El-Geneidy, Hanna Jean Khoury, MD, Martha Arellano, MD, Vamsi Kota, MD
Journal: Blood
Blood (2016) 128 (22): 2793.
https://doi.org/10.1182/blood.V128.22.2793.2793
Published: 2016
Journal Articles

Outcomes of Chronic Phase Chronic Myeloid Leukemia Patients Following Tyrosine Kinase Inhibitors Dose-Reductions

Free
Jee Hyun Kong, MD, Hanna Jean Khoury, MD, Elliott F. Winton, MD, Leonard T. Heffner, MD, Manila Gaddh, MD, Martha Arellano, MD, Fuad El-Rassi, MD, Audrey S Kim, RN, Anand Jillella, MD, Imre Bodó, MDPhD, Vamsi Kota, MD
Journal: Blood
Blood (2016) 128 (22): 3093.
https://doi.org/10.1182/blood.V128.22.3093.3093
Published: 2016
Journal Articles

Poor Outcomes with Hyper CVAD Induction for T-Cell Lymphoblastic Leukemia/Lymphoma

Free
Vamsi K Kota, MD, Amanda Redden Hathaway, MD, Bijal D. Shah, MD, Deniz Peker, MD, Ling Zhang, MD, David L. Jaye, MD, Martha Arellano, MD, H Jean Khoury, Anand P Jillella, MD, Elliott F. Winton, MD, Leonard T Heffner, Jr., MD, Uma Borate, MD
Journal: Blood
Blood (2015) 126 (23): 3762.
https://doi.org/10.1182/blood.V126.23.3762.3762
Published: 2015