Issue Archive

HEALTH SERVICES AND OUTCOMES

Factors associated with early quality-of-life response to palliative care during hematopoietic cell transplantation

Richard Newcomb,Hermioni L. Amonoo,Alison R. Kavanaugh,Kristin C. Wharton,Michaela Rowland,James Fausto,Jason Webb,Vicki Jackson,Joseph A. Greer,Jennifer S. Temel,Porsha Lark,Dustin J. Rabideau,Karen O’Brien,Thomas W. LeBlanc,Stephanie J. Lee,Areej El-Jawahri

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RESEARCH LETTER

Long-term efficacy of immune checkpoint inhibitors for relapsed primary mediastinal B-cell lymphoma: a real-world study

Beatrice Casadei,Lisa Argnani,Alessandro Broccoli,Martina Cantelli,Gabriele Gugliotta,Marianna Gentilini,Matteo Carella,Vittorio Stefoni,Cinzia Pellegrini,Nicole Fabbri,Giulia Gabrielli,Camilla Mazzoni,Pierluca Maglio,Gianmarco Bagnato,Pier Luigi Zinzani

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Supernumerary ring chromosome 1 syndrome leads to fusion-driven B-cell acute lymphoblastic leukemia in monozygotic twins

Jesús Gutiérrez-Abril,Gunes Gundem,Elise Fiala,Konstantinos Liosis,Noushin Farnoud,Dan Leongamornlert,Anu Amallraja,Juan E. Arango-Ossa,Dylan Domenico,Max Levine,Juan S. Medina-Martínez,Emily Stockfisch,Daoqi You,Mike Walsh,Sylwia Jasinski,Andrew L. Kung,Neerav N. Shukla,William L. Carroll,Elli Papaemmanuil

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Treatment holidays in patients with Erdheim-Chester disease receiving vemurafenib: a prospective pilot study

Francesco Pegoraro,Francesco Catamerò,Federica Allegretta,Giulia Palazzini,Francesco Peyronel,Eli L. Diamond,Augusto Vaglio

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Prior exposure to belantamab mafodotin influences outcomes with idecabtagene vicleucel in patients with multiple myeloma

Bhavesh Mohan Lal,Marah Alzubi,Jawad Alrawabdeh,John D. Shaughnessy, Jr.,Fenghuang Zhan,Eric R. Siegel,Carolina Schinke,Sharmilan Thanendrarajan,Maurizio Zangari,Frits van Rhee,Samer Al Hadidi

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Diffuse lung involvement as a rare presentation of systemic AL amyloidosis: a retrospective cohort study

Amy Song,George Mellgard,Claudia Bellofiore,Marco Basset,Mario Nuvolone,Andrea Foli,Giampaolo Merlini,Mathew S. Maurer,Markus Y. Mapara,Divaya Bhutani,Suzanne Lentzsch,Hiram Shaish,Giovanni Palladini,Rajshekhar Chakraborty,Paolo Milani

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Neutrophil recruitment depends on platelet-derived leukotriene B4

Christian Hackenbroch,Tugce Cimen,Carina Gross,Stefanie Rubenzucker,Philipp Burkard,Niklas Groß,Robert Ahrends,Tamara Girbl,David Stegner

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Key role of long-duration cardiac rhythm monitoring in patients with sickle cell disease with atrial hyperexcitability

Clinical Trials & Observations

Thuy Linh Dang,Thibaut Moulin,Gonzalo de Luna,Sihem Iles,Anaïs Lamadieu,David Calvet,Geneviève Derumeaux,Pablo Bartolucci,Nicolas Lellouche,Thomas d’Humières

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BR or R-CHOP induction with rituximab maintenance in untreated, transplant-ineligible patients with mantle cell lymphoma

Clinical Trials & Observations

Katja Gutmair,Diego Villa,Nicholas Cunningham,Elisabeth Silkenstedt,Lisa Rimsza,Colleen Ramsower,David W. Scott,Alina S. Gerrie,Hanneke C. Kluin-Nelemans,Martin Dreyling,Eva Hoster

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Universal driving restrictions beyond 4 weeks appear unnecessary following CAR-T therapy in multiple myeloma

Rahul Banerjee,Alicia Richards,Shonali Midha,Aimaz Afrough,Faiz Anwer,Djordje Atanackovic,Shebli Atrash,Veronika Bachanova,Amer M. Beitinjaneh,Evguenia Bhurtel,Omar Castaneda Puglianini,Saurabh Chhabra,Kara I. Cicero,James A. Davis,Binod Dhakal,Danai Dima,Christopher J. Ferreri,Peter A. Forsberg,Ciara L. Freeman,Megan M. Herr,Tania Jain,Murali Janakiram,Jack Khouri,Mehmet H. Kocoglu,Anupama Kumar,Yuxin Liu,Frederick Locke,Joseph P. McGuirk,Lekha Mikkilineni,Omar Nadeem,Ricardo D. Parrondo,Oren Pasvolsky,Lauren C. Peres,Sneha Purvey,Shahzad Raza,Ran Reshef,Shambavi Richard,Adriana C. Rossi,Douglas W. Sborov,Leyla Shune,Charlotte B. Wagner,Saurabh S. Zanwar,Surbhi Sidana,Krina K. Patel,Doris K. Hansen,Shaji K. Kumar,Yi Lin,Thomas G. Martin,Peter M. Voorhees,Larry D. Anderson, Jr,Andrew J. Cowan,Gurbakhash Kaur

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REVIEW ARTICLE

Systemic mastocytosis: current status and challenges in 2024

Celalettin Ustun,Fatma Keklik Karadag,Michael A. Linden,Peter Valent,Cem Akin

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Fitness assessment in acute myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

Adriano Venditti,Raffaele Palmieri,Luca Maurillo,Christoph Röllig,Agnieszka Wierzbowska,David de Leeuw,Fabio Efficace,Antonio Curti,Lok Lam Ngai,Jesse Tettero,Lionel Adès,Antonio Almeida,Lars Bullinger,Mike Dennis,Jordi Esteve,Felicetto Ferrara,Michael Heuser,Gerwin Huls,Michael Lübbert,Priyanka Mehta,Pau Montesinos,Thomas Pabst,Christian Récher,Giuseppe Rossi,Nigel Russell,Jorge Sierra,Reinhard Stauder,Norbert Vey,Roland B. Walter,Eunice Wang,Samantha Nier,Carolina Garcez Martins,Gert Ossenkoppele

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CLINICAL TRIALS AND OBSERVATIONS

Feasibility and favorable responses after investigational CAR T-cell therapy for relapsed and refractory infant ALL

Clinical Trials & Observations

Colleen Annesley,Adam Lamble,Corinne Summers,Michael A. Pulsipher,Alan S. Wayne,Julie Rivers,Wenjun Huang,Ashley Wilson,Qian Vicky Wu,Kristy Seidel,Stephanie Mgebroff,Christopher Brown,Catherine Lindgren,Julie R. Park,Michael Jensen,Rebecca Gardner

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Single-cell dynamics of breakthrough toxicities after anakinra prophylaxis for axicabtagene ciloleucel in lymphoma

Clinical Trials & Observations

Matthew J. Frigault,Ning Yao,Trisha R. Berger,Marc Wehrli,Kathleen M. E. Gallagher,Nora Horick,Charlotte E. Graham,Caron A. Jacobson,Yi-Bin Chen,Mark B. Leick,Zachariah DeFilipp,Areej R. El-Jawahri,P. Connor Johnson,Maria Dolaher,Katelin Katsis,Austin I. Kim,Jennifer Crombie,Reid W. Merryman,Daniella Cook,Michael Trailor,Hana Cho,Richard Jeffrey, III,Rhine Shen,Simone Filosto,Jenny Nater,Gad Getz,Nicholas J. Haradhvala,Marcela V. Maus

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Randomized phase 2 study to assess the role of single-agent nivolumab to maintain remission in acute myeloid leukemia

Clinical Trials & Observations

Athalia R. Pyzer,Laura W. Dillon,Elad Sharon,Theodore G. Karrison,Yuanyuan Zha,Noreen Fulton,Gege Gui,Georgia Andrew,Howard Streicher,Kendra Sweet,George Yaghmour,Jane Jijun Liu,Brian A. Jonas,Aaron D. Schimmer,Steven Grant,Amer M. Zeidan,Gerhard C. Hildebrandt,Christopher H. Lowrey,Ryan J. Mattison,Neil Palmisiano,Amandeep Salhotra,Dimitrios Tzachanis,Maria R. Baer,Tara L. Lin,Prapti Patel,Helen Chen,Walter M. Stadler,Olatoyosi Odenike,Richard A. Larson,Thomas F. Gajewski,Christopher S. Hourigan,Wendy Stock,Hongtao Liu

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Interim PET after 4 cycles predicts outcome in histomolecularly confirmed primary mediastinal B-cell lymphoma

Clinical Trials & Observations

Vincent Camus,Thierry Molina,Fabienne Desmots,Paul Blanc-Durand,Salim Kanoun,Amine Moslemi,Philippe Ruminy,Steven Le Gouill,Hervé Ghesquières,Lucie Oberic,Franck Morschhauser,Hervé Tilly,Vincent Ribrag,Roch Houot,Catherine Thieblemont,Hervé Maisonneuve,Fabien Claves,Krimo Bouabdallah,Corinne Haioun,Gandhi Laurent Damaj,Luc-Matthieu Fornecker,Robin Noel,Pierre Feugier,David Sibon,Guillaume Cartron,Christophe Bonnet,Wivine Bernard,Françoise Kraeber-Bodéré,Caroline Bodet-Milin,Jean-Philippe Jais,Josette Brière,Cedric Rossi,Mad-Hélénie Elsensohn,Loïc Chartier,Emmanuel Itti,Fabrice Jardin,Thierry Fest

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T cell exhaustion and an immunosuppressive microenvironment is a hallmark of CTCL. Durvalumab combined with lenalidomide has the potential to enhance anti-tumor immunity in CTCL.

Phase 1 trial of durvalumab (anti–PD-L1) combined with lenalidomide in relapsed/refractory cutaneous T-cell lymphoma

Clinical Trials & Observations

Christiane Querfeld,Joycelynne Palmer,Zhen Han,Xiwei Wu,Yate-Ching Yuan,Min-Hsuan Chen,Chingyu Su,Ni-Chun Tsai,D. Lynne Smith,Samantha N. Hammond,Liliana Crisan,Joo Y. Song,Raju Pillai,Steven T. Rosen,Jasmine Zain

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THROMBOSIS AND HEMOSTASIS

Metabolically aberrant extracellular mitochondria induce oxidative endotheliopathy in traumatic brain injury

Xiaoxi Lu,Lujia Tang,Yingang Wu,Tristan Hilton,Xin Chen,Katie Houck,Sarah Fulton,Cha Han,Sophia Romero,Yi Wang,Rosemary Kozar,Jessica C. Cardenas,Xiaoyun Fu,Jianning Zhang,Zilong Zhao,Jing-fei Dong

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Red Cells, Iron, and Erythropoiesis

Cellular and biochemical heterogeneity contributes to the phenotypic diversity of transfusion-dependent β-thalassemia

Konstantina Theocharaki,Alkmini T. Anastasiadi,Sophia Delicou,Vassilis L. Tzounakas,Ioanna Barla,Stella Rouvela,Evgenia Kazolia,Georgia Tzafa,George Mpekoulis,Theodore Gousdovas,Efthymia Pavlou,Ioannis V. Kostopoulos,Athanassios D. Velentzas,Nikolaos Simantiris,Aikaterini Xydaki,Niki Vassilaki,Ersi Voskaridou,Ioanna-Katerina Aggeli,Efrosyni Nomikou,Ourania Tsitsilonis,Efstathia Papageorgiou,Nikolaos Thomaidis,Evangelos Gikas,Marianna Politou,Veroniki Komninaka,Marianna H. Antonelou

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Interplay between iron metabolism, inflammation, and EPO-ERFE-hepcidin axis in RDEB-associated chronic anemia

Lucía Quintana-Castanedo,Rocío Maseda,Isabel Pérez-Conde,Nora Butta,Elena Monzón-Manzano,Paula Acuña-Butta,María G. Crespo,Antonio Buño-Soto,Eva Jiménez,Jaris Valencia,María C. Arriba,Pilar Zuluaga,Raúl de Lucas,Marcela del Río,Ángeles Vicente,María J. Escámez,Rosa Sacedón

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SYSTEMATIC REVIEW

MYELOID NEOPLASIA

A pharmacokinetic and safety study of oral arsenic trioxide in patients with acute promyelocytic leukemia

Farhad Ravandi,Sravanti Rangaraju,Hagop Kantarjian,Guillermo Garcia-Manero,Musa Yilmaz,Kristen Baker,Terence Hall,Joy Grabenstein,Pourab Roy,Beth A. Zamboni,William C. Zamboni,Erica Warlick,Michael Kelly,David A. Roth,Gabriel Ghiaur

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Inside Blood Advances

Lymphoid Neoplasia

TP53 mutations are associated with CD19⁻ relapse and inferior outcomes after blinatumomab in adults with ALL

Ibrahim Aldoss,Shanpeng Li,Jianying Zhang,Mary C. Clark,Vaibhav Agrawal,Hoda Pourhassan,Paul Koller,Ahmed Aribi,Haris Ali,Amanda Blackmon,Salman Otoukesh,Karamjeet Sandhu,Brian Ball,Shukaib Arslan,Andrew Artz,Idoroenyi Amanam,Monzr M. Al Malki,Amandeep Salhotra,Tibor Kovacsovics,Lindsey Murphy,Michelle Afkhami,Dat Ngo,Jose Tinajero,Zhaohui Gu,Pamela S. Becker,Ryotaro Nakamura,Anthony Stein,Guido Marcucci,Stephen J. Forman,Vinod Pullarkat

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Maximum tumor diameter is associated with relapse risk in limited-stage Hodgkin lymphoma: an international study

Clinical Trials & Observations

Elizabeth H. Phillips,Nicholas Counsell,Tim Illidge,Marc Andre,Igor Aurer,Valeria Fiaccadori,Catherine Fortpied,Anouk Neven,Massimo Federico,Sally F. Barrington,John Raemaekers,John Radford

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Definitions and use of tumor bulk in phase 3 lymphoma trials: a comprehensive literature review

Clinical Trials & Observations

Luke Wang,Eliza Chung,Cameron Wellard,Allison Barraclough,Belinda A. Campbell,Geoffrey Chong,Pietro R. Di Ciaccio,Gareth P. Gregory,Greg Hapgood,Anna M. Johnston,Constantine Tam,Stephen Opat,Erica M. Wood,Zoe K. McQuilten,Eliza A. Hawkes

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Presentation of CXCL12γ by heparan sulfate proteoglycans activates CXCR4 without desensitization in normal and malignant B cells

Hildo C. Lantermans,Fangxue Ma,Annemieke Kuil,Martin F. M. de Rooij,Nick D. Bergkamp,Werner van der Meer,Jaap D. van Buul,Martine J. Smit,Marie José Kersten,Marcel Spaargaren,Steven T. Pals

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REGULAR ARTICLE

TRANSPLANTATION

Cutaneous dysbiosis characterizes the post–allogeneic hematopoietic stem cell transplantation period

Clinical Trials & Observations

Adela R. Cardones,Akintunde Emiola,Russell P. Hall, III,Anthony D. Sung,Jennifer Zhang,Amy J. Petty,Charles Puza,Lauren M. Bohannon,Amy T. Bush,Meagan V. Lew,Elizabeth Fleming,Yingai J. Jin,Krista Rowe Nichols,Vaibhav Jain,Simon G. Gregory,Keith M. Sullivan,Nelson J. Chao,Julia Oh

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Hematopoiesis and Stem Cells

Late-onset telomere biology disorders in adults: clinical insights and treatment outcomes from a retrospective registry cohort

Mareike Tometten,Fabian Beier,Martin Kirschner,Yannic Schumacher,Jeanette Walter,Margherita Vieri,Kim Kricheldorf,Alexander Röth,Uwe Platzbecker,Markus Radsak,Philippe Schafhausen,Selim Corbacioglu,Britta Höchsmann,Stefan Balabanov,Claas Hinze,Jörg Chromik,Michael Heuser,Michael Kreuter,Marcin W. Wlodarski,Miriam Elbracht,Ingo Kurth,Steffen Koschmieder,Jens Panse,Susanne Isfort,Robert Meyer,Tim H. Brümmendorf

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In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands

Christian A. Di Buduo,Francesca Careddu,Samuele Metti,Marco Lunghi,Santo Diprima,Virginia Camilotto,Giovanna Bruni,Umberto Gianelli,Delfina Tosi,Cesare Perotti,Claudia Del Fante,Mario Cazzola,Paola Braghetta,David L. Kaplan,Giampaolo Minetti,Luca Malcovati,Alessandra Balduini

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DNMT3A regulates murine megakaryocyte-biased hematopoietic stem cell fate decisions

Sarah M. Waldvogel,Virginia Camacho,Dandan Fan,Anna G. Guzman,Alejandra Garcia-Martell,Elmira Khabusheva,Jacey Rodriguez Pridgen,Josephine De La Fuente,Rachel Rau,Ashlyn G. Laidman,Maria N. Barrachina,Estelle Carminita,Justin A. Courson,Michael R. Williamson,Joanne I. Hsu,Chun-Wei Chen,Jaime Reyes,Subhashree Pradhan,Rolando E. Rumbaut,Alan R. Burns,Benjamin Deneen,Jianzhong Su,Kellie R. Machlus,Margaret A. Goodell

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ERRATUM