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First Edition

Research Article June 10 2025
Expression of HERV-K and embryonic genes in chronic lymphocytic leukemia and their association with therapy regimens
Claudia Matteucci,Vita Petrone,Alessandro Giovinazzo,Roberta Laureana,Massimiliano Postorino,Livio Pupo,Chiara Cipriani,Nicola Toschi,Marialaura Fanelli,Antonella Minutolo,Giovangiacinto Paterno,Elisa Buzzatti,Paola Sinibaldi Vallebona,Antonella Zucchetto,Federico Pozzo,Valter Gattei,Giovanni Del Poeta,Adriano Venditti,Emanuela Balestrieri,Maria Ilaria Del Principe
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Research Article June 10 2025
Extramedullary plasmacytoma in children is a genetically distinct localized neoplasia curable by surgical resection
Ilske Oschlies,Julia Richter,Amelie Alfert,Fernando Chahud,Stephanie Mueller,Ingrid Simonitsch-Klupp,Hannah von Mersi,Andishe Attarbaschi,Karoline Koch,Christoph Schaefers,Monika Brüggemann,Cecilia Bozzetti,Wilhelm Woessmann,Birgit Burkhardt,Wolfram Klapper
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Supplementary data
Review Article June 9 2025
Blinatumomab Use in Pediatric B-ALL: Where are we now?
Anurekha G Hall,Rachel E Rau
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Research Article June 9 2025
Thyroid hormones contribute to JAK/STAT pathway abnormal activation promoting T-cell lymphoma dissemination
María Mercedes Debernardi,Alejandro Correa,Lucero Alvarado,María V. Revuelta,Helena Andrea Sterle,Gonzalo Gonzalez,Ingrid Larissa Melo Souza,Jorgelina Nelly Real, Dra,María Teresa Garcia de Dávila,Johanna Abigail Diaz Albuja,Cinthia Rosemblit,Leandro Cerchietti,Graciela A Cremaschi,Florencia Cayrol
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Research Article June 9 2025
Prebiotic fibre enteral supplementation post allogeneic transplantation; feasibility and impact on the microbiome
Sarah Andersen, PhD, Adv APD,Glen A Kennedy,Merrilyn Banks,Bernadine Mary Flanagan, BSc (Hons) PhD,Andrea S Henden
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Research Article June 5 2025
Indirect comparison of epcoritamab vs chemoimmunotherapy, mosunetuzumab, or odronextamab in follicular lymphoma
Alexey V Danilov,Swetha Thiruvengadam,Kim Linton,Karen Cumings,Viktor V Chirikov,Alex Mutebi,Savreet Bains Chawla,Anindit Chhibber,Fernando Rivas Navarro,Felipe Marques Gonçalves,Anthony Wang,Zhijie Ding,Abualbishr Alshreef,Elena Favaro,Daniela Hoehn,Anna Sureda
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Letter June 5 2025
Adult thymectomy is associated with increased mortality risk from cancer but not cardiovascular disease
Kameron Allen Kooshesh,Brody Harry Foy,Richard A Baylis,Karin Gustafsson,Daniel A Zlotoff,Tomas G Neilan,David T Scadden
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Review Article June 5 2025
To Pursue Gene Therapy or Not? Is ItFeasible After Graft Failure in Allogeneic Hematopoietic Cell Transplant Recipients
Akshay Sharma,Tami D. John
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Letter June 5 2025
The efficacy of rosuvastatin to reduce circulating tissue factor extracellular vesicles after ovarian cancer surgery
Soravis Osataphan,Rushad Patell,Mrigya Babuta,Rachel P Rosovsky,Yohei Hisada,Charly Edmiston,Pavania Elavalakanar,Michael A Pfeffer,Amy Bregar,Amanda Ramos,Leslie Garrett,Siyang Ren,Donna S. Neuberg,Gyongyi Szabo, Prof.,Robert Flaumenhaft,Nigel Mackman,Meghan Shea,Jeffrey I. Zwicker
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Research Article June 5 2025
Uncovering the Role of the Hsp40 Family Member, Cysteine String Protein-α, in Mouse Platelets
Alexis N. Smith,Hammodah R Alfar,Smita Joshi,Daniëlle Marije Coenen,Joshua T. Lykins,Isabelle C Becker,Brittany E Dong,Harry Chanzu,Chi Peng,Kanakanagavalli Shravani Prakhya,Linda Adannia Nneka Omali,Irina D. Pokrovskaya,Brian Storrie,Joseph E Italiano, Jr,Sidney Wally Whiteheart
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Research Article June 5 2025
National Alliance of Sickle Cell Centers Consensus Standards for Transition to Adult Care in Sickle Cell Disease
Stephanie Guarino,Akshat Jain,Mohan Madisetti,Kenneth A Rivlin,Payal Chandarana Desai,Julie Kanter,Sophie Lanzkron,Deepa G Manwani
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Research Article June 5 2025
Elucidating the dynamics of Integrin αIIbβ3 from native platelet membranes by cryo-EM with build and retrieve method
Xu Han,Zhemin Zhang,Chih-Chia Su,Meinan Lyu,Masaru Miyagi,Edward Yu,Marvin T. Nieman
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Research Article June 5 2025
Impact of Concomitant Azoles on Ruxolitinib Treatment in Patients With GVHD: Post Hoc Analyses of REACH2 and REACH3
Zahra Mahmoudjafari,Emily Kintsch,Zhenyi Xue,Valkal Bhatt,John Galvin,Franco Locatelli,Robert Zeiser
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Research Article June 5 2025
Prospective study of immunogenicity to SARS-CoV-2 booster vaccines in multiple myeloma and Waldenström macroglobulinemia
Andrew R. Branagan,Clifton C Mo,Matthew M Lei,Joshua Gustine,Andrew J. Yee,Elizabeth O'Donnell,Jorge J. Castillo,Omar Nadeem,Catherine Flynn,Zachary Bernstein,Rie Nakamoto-Matsubara,Kirsten E. Meid,Rakesh Verma,Zachary R Hunter,Maria Luisa Guerrera,Galit Alter,Jill N. Burke,Cynthia C. Harrington,Emerentia A. Agyemang,Marilyn T. Gammon,Kathleen J. Lively,Lisette Packer,Nora Horick,Jacob P Laubach,Constantine S. Mitsiades,Nikhil C. Munshi,Kenneth C. Anderson,Steven P. Treon,Paul G Richardson,Noopur S. Raje,Shayna Sarosiek
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Research Article May 29 2025
BCLAF1 restrains stress responses in hematopoietic stem cells to support expansion and repopulation
Stephanie J Crowley,Wei Yang,Lynn S White,Jun Wu,Yanan Li,Haley Schmidt,Kyunghee Choi,Jeffrey A Magee,Jeffrey J Bednarski
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Letter May 28 2025
Emergent BAX-mutated clonal hematopoiesis after venetoclax-based therapy for breast cancer
Ing-Soo S Tiong,Tamia Nguyen,Chong Chyn Chua,Charis E Teh,Christine Muttiah,Sarah Ftouni,John F Seymour,Daniel H D Gray,Andrew W Roberts,Sarah-Jane Dawson,Geoffrey J Lindeman,Piers Blombery
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Research Article May 28 2025
Infection after CD19 chimeric antigen receptor T cell therapy for large B cell lymphoma: Real-world analysis from CIBMTR
Kitsada Wudhikarn,Megan M. Herr,Min Chen,Michael J. Martens,John H. Baird,Lohith Gowda,Hemalatha G. Rangarajan,Muhammad Bilal Abid,Mohamed A Kharfan-Dabaja,Kristen M. Williams,Siddhartha Ganguly,Jo-Anne H. Young,Akshay Sharma,Giancarlo Fatobene,Tania Jain,Christopher G. Kanakry,Dipenkumar Modi,Natalie S. Grover,Baheyeldin Salem,Marjorie Vieira Batista,Paschalis Vergidis,Dwight E. Yin,Amer M. Beitinjaneh,Amar H. Kelkar,Taiga Nishihori,Jennifer Holter-Chakrabarty,Usama Gergis,Melody Smith,Zeinab El Boghdadly,Christopher E. Dandoy,Hemant S. Murthy,Anna R. Huppler,Miguel-Angel Perales,Roy F. Chemaly,Joshua A. Hill,Marcie Riches,Jeff J. Auletta
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Research Article May 23 2025
Inaccuracies of Venous Thromboembolism Risk Assessment and Prevention Practices Among Medically Ill Patients
Brandyn Lau,Aditya Bhave,Jennifer C Yui,Rakhi P. Naik,Kathryn E. Dane,John P Lindsley,Dauryne Shaffer,Peggy S Kraus,Erik H Hoyer,Elliott R Haut,Michael B. Streiff
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Research Article May 22 2025
A Revised Prognostic Model for Patients with Acute Myeloid Leukemia and First Relapse
Niek G. Van Der Maas,Dimitri A. Breems,Clara P.W. Klerk,Thomas Pabst,Patrycja Gradowska,Abin Thomas,Bart J. Biemond,Jürgen Kuball,Catharina H.M.J. van Elssen,Otto J. Visser,Marie-Christiane Madeleine Vekemans,Carlos Graux,Johan A. Maertens,Steven Knapper,Mike Dennis,Sylvie D Freeman,Ian Thomas,Berna H Beverloo,Gerwin A Huls,Charles Craddock,Peter J.M. Valk,Paresh Vyas,Nigel H. Russell,Gert J Ossenkoppele,Bob Löwenberg,Jan J. Cornelissen,Jurjen Versluis
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Research Article May 22 2025
Impact of SARS-CoV-2 infection on bispecific antibody treatment in patients with B-cell lymphoproliferative disorders
Ángel Serna,Víctor Navarro,Moraima Jimenez,Josu Iraola-Truchuelo,Marc Bosch,Cristina García-Herce,Anna Falcó Roget,Adaia Albasanz-Puig,Isabel Ruiz-Camps,Cristina Andrés,Andrés Antón,Juliana Esperalba,Ainara Ferrero,Tomas Garcia-Cerecedo,Cecilia Carpio,Marta Crespo,Gloria Iacoboni,Ana Marín-Niebla,Francesc Bosch,Pau Abrisqueta
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Research Article May 22 2025
The SAMD1 transcription factor coordinates hematopoietic lineage differentiation and H3K4 methylation status
Meg A Schaefer,Samantha L Gomez,Venkatasai Rahul Dogiparthi,Yichao J Zhou,Pooja Roy,Suhita J Ray,Linda Chee,Sandipan Brahma, sbrahma@unmc.edu,Robert Liefke,Kyle J Hewitt
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Research Article May 22 2025
PRIDE-FTG Advances Academic Careers of Underrepresented Early-Stage Investigators Performing Blood Disorders Research
Betty Sue Pace,Oluwatoyosi Onwuemene,Athena Starlard-Davenport,Rhea-Beth Markowitz,Vahé Heboyan,Petar Datsov,Treva Rice
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Research Article May 22 2025
Circulating Tumor DNA Determinants of Response and Outcome in Relapsed/Refractory Mantle Cell Lymphoma
Leo Meriranta,Rasmus Rask Kragh Jørgensen,Annika Pasanen,Arne Kolstad,Martin Hutchings,Carsten Utoft Niemann,Tarec Christoffer El Galaly,Jon Riise,Jacob Haaber Christensen,Kristina Sonnevi,Lone Bredo Pedersen,Karin Fahl Wader,Ingrid Glimelius,Sirpa Leppä,Mats Jerkeman
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Research Article May 22 2025
Single-cell sequencing on PBMCs from HA & HB patients with inhibitors reveals different immune responses to FVIII & FIX
Enhao Li,Zekun Li,Jinzeng Wang,Haoyang Wu,Yilun Xue,Can Lou,Zhenping Chen,Feng Liu,Wenman Wu,Qiulan Ding,Runhui Wu,Xuefeng Wang,Jing Dai
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Letter May 22 2025
RAS Mutation Identifies a Poor Prognostic Molecular Subtype of Therapy-Related Myeloid Neoplasm
Chung Hoow Kok,Aref Al-Kali,Daniel Thomas,Rong He,Monika M Kutyna,Hassan B Alkhateeb,Kelly Lim,Antoine N. Saliba,Carla Toop,Aasiya Matin,Hamish S Scott,Naseema Gangat,Anna L Brown,Abhishek A. Mangaonkar,Christopher N Hahn,Kebede Begna,Kevin Hung,Patricia T. Greipp,William J Hogan,Mrinal M. Patnaik,Mithun Vinod Shah,Devendra K. Hiwase
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Letter May 22 2025
Molecular profiling of primary renal diffuse large B-cell lymphoma unravels a proclivity for immune-privileged tropism
Axel Künstner,Vera von Kopylow,Philipp Lohneis,Matthias Kümmel,Hanno M. Witte, Dr,Lorenz Bastian,Veronica Bernard, Dr,Stephanie Stölting,Kathrin Kusch,Nikolas von Bubnoff,Konrad Steinestel,Annette Arndt,Hartmut Merz, Prof,Hauke Busch,Alfred C. Feller,Niklas Gebauer
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Research Article May 16 2025
Inequalities in CAR T-Cell Therapy Access for US Patients with Relapsed/Refractory DLBCL: A SEER-Medicare Data Analysis
Andrea Chung,Jason Shafrin,Sachin Vadgama,Kristen Hurley,Miguel-Angel Perales,Leonard Clarkson Alsfeld,Sanjana Muthukrishnan,Anik R Patel,Gunjan L Shah,Richard T. Maziarz
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Letter May 14 2025
Drug development for leukemia: comprehensive analysis of clinical trials from first report to drug approval
Kellen Cristine Tjioe,Marisol Miranda Galvis,Kenza Mamouni,Thalyta Freitas,Muhannad Sharara,Brenda Santellano,Claudia Guillen,Jorge Cortes
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Research Article May 14 2025
Extramedullary Myeloma is Genomically Complex and Characterized by Near-Universal MAPK Pathway Alterations
Saurabh Zanwar,Joseph Novak,Wilson I Gonsalves,Michael Howe,Esteban Braggio,S. Vincent Rajkumar,Moritz Binder,Dragan Jevremovic,Surendra Dasari,Shaji K Kumar
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Reply May 14 2025
Response to "It might not be whether you get knocked down, but whether you..."
Wei Ying Jen,Nicholas J Short
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Letter May 14 2025
SGLT2i-associated erythrocytosis: Closing the evidence gap
Benjamin Chin-Yee,Cyrus C. Hsia
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Research Article May 12 2025
Real-World Survival Outcomes in First-Line Ibrutinib-Treated Patients with High-Risk CLL/SLL
John N. Allan,Tao Ran,Zhijie Ding,Jinghua He,Alex Bokun,Zaina P. Qureshi,Susan M. O'Brien
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Letter May 12 2025
Fatal Recurrence of IEC-HS Following Autologous Stem Cell Boost in Patients Receiving BCMA CAR-T Cell Therapy
Snegha Ananth,Nancy Eunice Torres,Bita Sahaf,Lakha Mikkilineni,Sebastian Fernandez-Pol,Darren Salmi,Robert S. Negrin,Parveen Shiraz,Melody Smith,Sushma Bharadwaj,Wen-Kai Weng,Vanessa E Kennedy,Saurabh Dahiya,Lori S. Muffly,David B Miklos,Matthew J Frank,Hitomi Hosoya,Surbhi Sidana
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Research Article May 12 2025
Global Survey on Practice Changes and Barriers to the Use of Direct Oral Anticoagulants in Children
Laura Avila,Erica Di Ruggiero,Jennifer Vincelli,Leonardo R. Brandão
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Research Article May 12 2025
The CLUE Post-Surgery VTE Risk Instrument for Abdominal and Pelvic Surgery: Validation of Patient Risk Factor Component
Kari A.O. Tikkinen,Deborah M Siegal,PJ Devereaux,Sara V Tornberg,Flavia K Borges,Sandra Ofori,Jehonathan Pinthus,Bobby Shayegan,Lauri I Lavikainen,Gordon H Guyatt,Pavel S Roshanov
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Review Article May 12 2025
Advancements in Complement Inhibition for PNH and Primary Complement Mediated Thrombotic Microangiopathy
Thalia Padilla Kelley,Hannah L King,Aditya Malhotra,Thomas G. DeLoughery,Kylee L Martens,Joseph J Shatzel
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Research Article May 9 2025
HCAR2 is a novel receptor for heme
Anne Grunenwald,Julie Peliconi,Alessandra Zarantonello,Jordan D Dimitrov,Lubka T Roumenina,Nicolas S Merle
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Letter May 9 2025
Molecular profiling of primary renal Marginal Zone Lymphoma reveals overlapping features with extranodal Marginal Zone Lymphoma
Axel Künstner,Vera von Kopylow,Philipp Lohneis,Matthias Kümmel,Hanno M. Witte, Dr,Veronica Bernard, Dr,Stephanie Stölting,Kathrin Kusch,Sivahari Prasad Gorantla,Manuela Krokowski,Nikolas von Bubnoff,Hartmut Merz, Prof,Hauke Busch,Alfred C. Feller,Niklas Gebauer
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Letter May 9 2025
Conflating polycythemia vera with essential thrombocytosis
Jerry L. Spivak, MD, MACP
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Research Article May 7 2025
Zanubrutinib is well tolerated and effective in CLL/SLL patients intolerant of ibrutinib/acalabrutinib: Updated results
Mazyar Shadman,John M. Burke,Jennifer Cultrera,Habte A. Yimer,Syed F. Zafar,Jamal Misleh,Subramanya S. Rao,Charles M. Farber,Aileen Cleary Cohen,Hui Yao,Adam Idoine,Qi An,Ian W. Flinn,Jeff P. Sharman
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Research Article May 7 2025
Outcomes of Brexucabtagene Autoleucel in Relapsed/Refractory Acute Lymphoblastic Leukemia Patients with CNS Involvement.
Ibrahim N. Muhsen,Gregory W. Roloff,Rawan G. Faramand,Tamer Othman,Yannis K. Valtis,Noam E. Kopmar,Simone E. Dekker,Matthew Connor,Santiago Mercadal,Timothy E. O'Connor,Kaitlyn C. Dykes,Mohamed Ahmed,Nikeshan Jeyakumar,Amy Zhang,Katharine Miller,Katherine C. Sutherland,Caitlin Guzowski,Vishal K. Gupta,Navneet S Majhail,Minoo Battiwalla,Melhem M. Solh,Shahbaz A. Malik,John Mathews,Caspian Oliai,Paul J Shaughnessy,Luke Mountjoy,Catherine J Lee,Aaron C Logan,Stephanie B. Tsai,Jessica T. Leonard,Marc S. Schwartz,Joshua P Sasine,Muthu Kumaran,Noelle V Frey,Jae H Park,Divya Koura,Ryan D. Cassaday,Bijal D Shah,Ibrahim Aldoss,Lori S. Muffly,LaQuisa C Hill
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Research Article May 7 2025
Pivotal Results of SELECT-MDS-1 Phase 3 Study of Tamibarotene with Azacitidine in Newly Diagnosed Higher-Risk MDS
Amy E. DeZern,Sylvain Thepot,Stéphane De Botton,Andrea Patriarca,Dries Deeren,Jose Miguel Torregrose Diaz,Giovanni Marconi,Teresa Bernal del Castillo,Juan Miguel Bergua Burgues,Blanca Xicoy,Anna Jonasova,Amer M. Zeidan,Sophie Dimicoli-Salazar,Célestine Simand,David Valcárcel,María Díez-Campelo,Wanxing Chai-Ho,Lalit Saini,Alice Garnier,Klaus Geissler,Yishai Ofran,Zsolt Nagy,Pramila Krishnamurthy,Michael Lübbert,Grzegorz W. Basak,Hetty E Carraway,David A. Sallman,Uma Borate,Valeria Santini,Victoria Campbell,Pierre Fenaux,Thorsten Braun,Francesco Lanza,Jan Maciej Zaucha,David A Roth,Sofia Paul,Pourab Roy,Michael Kelly,Angela Volkert,Jaime Chisolm,Tanya Abdul Malak,Virginia Klimek,Thomas Cluzeau
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Research Article May 7 2025
Asciminib remained superior vs bosutinib in late-line CML-CP after nearly 4 years of follow-up in ASCEMBL
Michael J. Mauro, MD,Yosuke Minami,Andreas Hochhaus,Elza Lomaia,Sergey Voloshin,Anna Turkina,Dong-Wook Kim,Jane F Apperley,Jorge Cortes,Andre Abdo,Laura Maria Fogliato,Dennis Dong Hwan Kim,Philipp le Coutre,Susanne Saussele,Mario Annunziata,Timothy P Hughes,Naeem Chaudhri,Lynette Chee,Valentin Garcia-Gutierrez,Koji Sasaki,Carla Boquimpani,Shruti Kapoor,Noemi Espurz-Abad,Vishal Dhamal,Delphine Rea
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Letter May 7 2025
Intrathecal chemotherapy for ciltacabtagene autoleucel-associated movement and neurocognitive toxicity
Kaitlin Kelly,Jennifer Cooperrider,Michael R. Bishop,Satyajit Kosuri,Andrzej Jakubowiak,Benjamin A. Derman
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Research Article May 7 2025
Clec12a is required for the pathogenesis of NUP98::NSD1 AML
Sagarajit Mohanty,Fiorella Charles Cano,Razif Gabdoulline,Courteney K Lai,Basem Othman,Harish Sudarsanam,Thomas Eder,Florian Grebien,Daniel B. Lipka,Reinhard Henschler,Michael Heuser
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Research Article May 7 2025
ADORE: an open platform study of ruxolitinib in combination with other novel therapies in patients with myelofibrosis
David M. Ross,Florian H Heidel,Andrew C Perkins,Andreas Reiter,Carl Claudius Crodel,Caroline Hasselbalch Riley,María Teresa Gómez Casares,Istvan Takacs,Heiko Becker,Thomas Lehmann,Olga Yu Vinogradova,Kate Burbury,Alessandro M. Vannucchi,Vikas Gupta,Marielle J Wondergem,Jean-Jacques Kiladjian,Grace Cleary,Angela Zhang,Jagannath Kota,Anirudh Cadapa Prahallad,Monika Wroclawska,Min Lu,Claire N. Harrison
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Letter May 7 2025
Dysregulated immune proteins in plasma in the UK Biobank predict Multiple Myeloma 12 years before clinical diagnosis
Joshua Fieggen,Anshul Thakur,Christopher C Butler,Karthik Ramasamy,Anjan Thakurta,David A Clifton,Lei Clifton
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Research Article May 2 2025
Eltrombopag in combination with immunosuppressive therapy in pediatric severe aplastic anemia: Phase 2 ESCALATE trial
Akiko Shimamura,Alexey Maschan,Caroyln Bennett,Sujith Samarasinghe,Jason E. Farrar,Chi-kong Li,Nongnuch Sirachainan,Bunchoo Pongtanakul,Patcharee Komvilaisak,Liudmila Zubarovskaya,Jennifer A Rothman,Kelly Walkovich,Taizo A Nakano,Alison A. Bertuch,Anabela Ferrao,Rukhmi Bhat,Rabi Hanna,Kathleen M Overholt,Jessica Boklan,Tze Fang Wong,Qinxia Wang,Patrick Urban,Brigitte Strahm,Winfred Wang,Adrianna Vlachos,David A Williams
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Research Article May 2 2025
Impact of shared HLA determinants between patient and losing cord blood unit on relapse after double cord blood transplantation
Robert Wynn,Fernanda Volt,Philippe Guardiola,Srividhya Senthil,Graziana Maria Scigliuolo,Chantal Kenzey,Barbara Cappelli,Annalisa Ruggeri,Ryad Tamouza,Vanderson G. Rocha,Chloe Anthias,Régis Peffault De Latour,Katherine Clesham,Anna Castleton,Michel Schaap,Persis J. Amrolia,Marc B Bierings,Jan J. Cornelissen,Kay Victoria Poulton, FRCPath,Eliane Gluckman
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Research Article May 2 2025
Outcomes in Frail Patients Receiving BCMA-directed Bispecific Antibodies for Relapsed/Refractory Multiple Myeloma
Benjamin O Adegbite,Carlyn Rose Tan,Tala Shekarkhand,Ross S Firestone,Eric Matthew Jurgens,Kevin C. Miller,Alexander M Lesokhin,Gunjan L Shah,Neha Korde,Sridevi Rajeeve,Heather J Landau,Michael Scordo,Hani Hassoun,Kylee H. Maclachlan,Urvi A Shah,Malin L Hultcrantz,Issam S. Hamadeh,Andriy Derkach,David Nemirovsky,Sergio A. Giralt,Sham Mailankody,Saad Z Usmani,Hamza Hashmi
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