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Atezolizumab consolidation in patients with high-risk diffuse large B-cell lymphoma in complete remission after R-CHOP
Completion of phase 2b trial of etranacogene dezaparvovec gene therapy in patients with hemophilia B over 5 years
Prognostic significance of monocytic-like phenotype in patients with AML treated with venetoclax and azacytidine
NTRK1-rearranged histiocytosis: clinicopathologic and molecular features
Belumosudil reduces oral chronic graft-versus-host disease tissue inflammation and fibrosis: a ROCKstar companion study
Impact of posttransplant cyclophosphamide-based GVHD prophylaxis in patients 70 years and older: an update from BMT CTN 1703
Issue Archive
July 22 2025
In this Issue
Table of Contents
INSIDE BLOOD ADVANCES
REVIEW ARTICLE
SYSTEMATIC REVIEW
Chronic kidney disease in adults with sickle cell trait: a systematic review and meta-analysis
Yagahira E. Castro-Sesquen,Gelida Barboza Justiniano,Diego J. Aparcana-Granda,Andres R. Aquino,Pierre Luckens Adelson,Ronald D. Mondragón,John Kwagyan,Vimal K. Derebail,Mehdi Nouraie,Santosh L. Saraf,Marina Jerebtsova
CLINICAL TRIALS AND OBSERVATIONS
Atezolizumab consolidation in patients with high-risk diffuse large B-cell lymphoma in complete remission after R-CHOP
Clinical Trials & Observations
Marcel Nijland,Djamila E. Issa,Johanna A. A. Bult,Dries Deeren,Gerjo A. Velders,Marten R. Nijziel,Yorick Sandberg,Vibeke Vergote,Margriet Oosterveld,Rob Fijnheer,Rolf E. Brouwer,Rinske S. Boersma,Kalung Wu,Laurens Nieuwenhuizen,Joost S. P. Vermaat,Roel J. W. van Kampen,Wim E. Terpstra,Sylvia Snauwaert,Marjolein W. van der Poel,Eva de Jongh,Marc F. Durian,Leonie Strobbe,Aart Beeker,Alain Gadisseur,Roos S. van Rijn,Otto Visser,Jeanette K. Doorduijn,Tjeerd J. F. Snijders,Matthijs H. Silbermann,Daphne de Jong,Martine Chamuleau,Rogier Mous,Hilde Jalving,Heleen Visser-Wisselaar,Sonja Jansen van de Bergh,Gerben J. C. Zwezerijnen,Edwin Bremer,Mirian Brink,Arjan Diepstra,Dana A. Chitu,Harry R. Koene,Josée M. Zijlstra
GENE THERAPY
Completion of phase 2b trial of etranacogene dezaparvovec gene therapy in patients with hemophilia B over 5 years
Clinical Trials & Observations
Annette von Drygalski,Esteban Gomez,Adam Giermasz,Giancarlo Castaman,Nigel S. Key,Susan U. Lattimore,Frank W. G. Leebeek,Wolfgang A. Miesbach,Michael Recht,Paul E. Monahan,Sandra Le Quellec,Steven W. Pipe
HEMATOPOIESIS AND STEM CELLS
BMP-2 generates a functional bone marrow niche by inducing the differentiation of local mesenchymal cells into CAR cells
Ikue Tosa,Mitsuaki Ono,Anh Tuan Dang,Ziyi Wang,Maiko Kimura,Wakana Kitagawa,Kei Ishibashi,Hang Thuy Do,Kun Zhao,Emilio Satoshi Hara,Noboru Asada,Takashi Nagasawa,Toshitaka Oohashi,Naoya Ohara,Takuo Kuboki
LYMPHOID NEOPLASIA
Lymphoma B cells remodel bone marrow stromal cells into extracellular matrix–producing cancer-associated fibroblasts
Elise Dessauge,Baptiste Brauge,Simon Léonard,Alicia Beyou,Camille Laurent,Valentin Isen,Nicolas Barbier,Céline Monvoisin,Thomas Lejeune,Jérôme Destin,Florence Jouan,Judikael Saout,Francisco Llamas-Gutierrez,Franck Morschhauser,Sandrine Roulland,David Roulois,Frédéric Mourcin,Karin Tarte
Statin use and survival in CLL/SLL treated with ibrutinib: pooled analysis of 4 randomized controlled trials
Ahmad Y. Abuhelwa,Sara A. Almansour,Jennifer R. Brown,Humaid O. Al-Shamsi,Ziad Abuhelwa,Zelal Kharaba,Yasser Bustanji,Mohammad H. Semreen,Salma Ali,Ahmad Alhuraiji,Ross A. McKinnon,Michael J. Sorich,Karem H. Alzoubi,Ashley M. Hopkins
Venetoclax-based regimens in octogenarian patients with CLL: efficacy, safety, and comparison to BTKi in a multicenter cohort
Andrea Serafin,Alessandro Cellini,Enrica Antonia Martino,Federica Mazzetto,Francesco Angotzi,Anna Maria Frustaci,Monia Marchetti,Riccardo Moia,Alessandro Sanna,Costantino Riemma,Francesca Cibien,Alessandro Noto,Enrico Lista,Myriam Foglietta,Candida Vitale,Vanessa Innao,Martina Bullo,Ester Lovato,Isacco Ferrarini,Costanza Andriola,Laura Ballotta,Idanna Innocenti,Alberto Fresa,Gianmarco Favrin,Marzia Varettoni,Elisa Santambrogio,Lorella Orsucci,Raffaella Pasquale,Massimo Moratti,Luca Laurenti,Marta Coscia,Paolo Sportoletti,Roberto Marasca,Francesca Romana Mauro,Caterina Patti,Enrico Derenzini,Lydia Scarfò,Paolo Ghia,Antonio Cuneo,Alessandra Tedeschi,Livio Trentin,Massimo Gentile,Andrea Visentin
MYELOID NEOPLASIA
Prognostic significance of monocytic-like phenotype in patients with AML treated with venetoclax and azacytidine
Clinical Trials & Observations
Lin-Pierre Zhao,Typhaine Dumas-Rivero,Lauren Barette,Lorea Aguinaga,Arij Cheffai,Clémentine Chauvel,Reinaldo Dal Bello,Emmanuel Raffoux,Emmanuelle Clappier,Matthieu Duchmann,Pierre Fenaux,Pierre Lemaire,Stephanie Mathis,Marie Sébert,Lionel Adès,Raphaël Itzykson
NTRK1-rearranged histiocytosis: clinicopathologic and molecular features
Clinical Trials & Observations
Rivers Fragneau,Sylvie Fraitag,Paul G. Kemps,Zofia Hélias-Rodzewicz,Somak Roy,Benjamin Bonsang,Allison L. Bartlett,Subhra Dhar,Martin Jankofsky,Jozef Zlocha,Karel Svojgr,Lenka Krsková,Andrica C. H. de Vries,Robert M. Verdijk,Jan A. M. van Laar,Roos J. Leguit,Philippe Drabent,Eric D. Carlsen,Jonhan Ho,Arivarasan D. Karunamurthy,Mariarita Santi,Marie-Laure Jullié,Florian Babor,Robert Lorsbach,Astrid G. S. van Halteren,Sébastien Héritier,Eli L. Diamond,Benjamin H. Durham,Ashish R. Kumar,Arunaloke Bhattacharya,Julien Haroche,Jean Donadieu,Arndt Borkhardt,Jennifer L. Picarsic,Jean-François Emile
PLASMA CELL DISORDERS
Teclistamab for patients with heavily pretreated relapsed/refractory multiple myeloma and renal impairment
Danai Dima,Aimaz Afrough,Utkarsh Goel,Ariel F. Grajales-Cruz,Jack Khouri,Kelley Julian,Oren Pasvolsky,Rahul Banerjee,Beatrice Razzo,Christopher J. Ferreri,Mariola A. Vazquez-Martinez,James A. Davis,Aishwarya Sannareddy,Omar Castaneda,Shahzad Raza,Andrew J. Portuguese,Mahmoud R. Gaballa,Masooma S. Rana,Alex Lieberman-Cribbin,Shaun DeJarnette,Rebecca Gonzalez,Anna Chen,Megan M. Herr,Lekha Mikkilineni,Hitomi Hosoya,Evguenia Ouchveridze,Gurbakhash Kaur,Adriana Rossi,Leyla Shune,Faiz Anwer,Yi Lin,Shambavi Richard,Douglas W. Sborov,Rachid C. Baz,Alfred L. Garfall,Hans C. Lee,Larry D. Anderson, Jr.,Andrew J. Cowan,Krina K. Patel,Peter M. Voorhees,Surbhi Sidana,Doris K. Hansen,Shebli Atrash,Sandra P. Susanibar-Adaniya
Longitudinal analysis of gut microbiome and metabolome correlates of response and toxicity with idecabtagene vicleucel
Satabdi Saha,Lubna Rehman,Abdur Rehman,Faezeh Darbaniyan,Donna M. Weber,Melody Becnel,Mahmoud Gaballa,Sheeba K. Thomas,Hans C. Lee,Chia-Chi Chang,Reetakshi Arora,Meghan Menges,Salvatore Corallo,Marco L. Davila,Frederick L. Locke,Mark R. Tanner,Sattva S. Neelapu,Elizabeth J. Shpall,Christopher R. Flowers,Robert Z. Orlowski,Robert R. Jenq,Michael D. Jain,Christine Peterson,Doris K. Hansen,Neeraj Y. Saini,Krina K. Patel
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
Factors associated with survival after allogeneic transplantation for myeloid neoplasms harboring TP53 mutations
Anmol Baranwal,Kimberly J. Langer,Vedavyas Gannamani,Danielle Rud,Alia Cibich,Caner Saygin,Mariam Nawas,Talha Badar,Mohamed A. Kharfan-Dabaja,Ernesto Ayala,Vivek Roy,James M. Foran,Hemant S. Murthy,Madiha Iqbal,Jeanne Palmer,Lisa Z. Sproat,Saurabh Chhabra,Nandita Khera,Mehrdad Hefazi,Abhishek Mangaonkar,William Hogan,Mark Litzow,Hassan Alkhateeb,Ayalew Tefferi,Chung Hoow Kok,Guru Subramanian Guru Murthy,Anand Patel,Ashish Bajel,Devendra K. Hiwase,Mithun Vinod Shah
Transplant outcomes using older matched sibling donors compared with young alternative donors: a CIBMTR analysis
Karthik Nath,Mei-Jie Zhang,Matthew Bye,Muhammad Bilal Abid,Cara Benjamin,Brian Betts,Neel S. Bhatt,Esteban Arrieta Bolaños,Yung-Tsi Bolon,Shahinaz M. Gadalla,Michael R. Grunwald,Maxwell M. Krem,Stephanie J. Lee,Steven G. E. Marsh,Rodrigo Martino,Parinda A. Mehta,Filippo Milano,Timothy Prestidge,Jennifer N. Saultz,Bronwen E. Shaw,Stephen R. Spellman,Hannah Choe,Brian C. Shaffer
Belumosudil reduces oral chronic graft-versus-host disease tissue inflammation and fibrosis: a ROCKstar companion study
Clinical Trials & Observations
Rubina Sharma,Noa G. Holtzman,Iskra Pusic,Corey Cutler,Nathaniel Treister,Rohtesh S. Mehta,Amin S. Alousi,Nadarajah Vigneswaran,Ayesha Javaid,Francis Boksa,Drashty P. Mody,Ana C. Costa-da-Silva,Olivier Schueller,Sandrine Macé,Yu Yao,Ran Ji,Beifang Hu,Kathy Marshall,Bruce R. Blazar,Stephanie J. Lee,Steven Z. Pavletic,Jacqueline W. Mays
Impact of posttransplant cyclophosphamide-based GVHD prophylaxis in patients 70 years and older: an update from BMT CTN 1703
Clinical Trials & Observations
Sameem Abedin,Michael J. Martens,Javier Bolaños-Meade,Monzr M. Al Malki,Qinghua Lian,Lyndsey Runaas,Hany Elmariah,Mahasweta Gooptu,Karilyn T. Larkin,Brian C. Shaffer,Alison W. Loren,Melhem Solh,Amin M. Alousi,Omer H. Jamy,Miguel-Angel Perales,Andrew Rezvani,Ami Bhatt,Najla El Jurdi,Janny M. Yao,Kristy Applegate,Leslie S. Kean,Yvonne A. Efebera,Ran Reshef,William Clark,Eric Leifer,Wael Saber,Mary M. Horowitz,Richard J. Jones,Shernan G. Holtan,Mehdi Hamadani
Delayed T-cell recovery after hematopoietic cell transplantation is associated with decreased overall survival in adults
Miguel-Angel Perales,Marcie Riches,Naya He,Michael J. Martens,Roy F. Chemaly,Christopher E. Dandoy,Joshua A. Hill,Miguel Angel Diaz,Shahrukh Hashmi,Susan Prockop,Hillard M. Lazarus,Amer M. Beitinjaneh,Gerhard C. Hildebrandt,Jeffery J. Auletta,Paul Szabolcs
RESEARCH LETTERS
Molecular profiling of primary renal marginal zone lymphoma reveals overlapping features with extranodal marginal zone lymphoma
Axel Künstner,Vera von Kopylow,Philipp Lohneis,Matthias Kümmel,Hanno M. Witte,Veronica Bernard,Stephanie Stölting,Kathrin Kusch,Sivahari Gorantla,Manuela Krokowski,Nikolas von Bubnoff,Hartmut Merz,Hauke Busch,Alfred C. Feller,Niklas Gebauer
LETTER TO THE EDITOR
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Cover Image
Cover Image
Immunofluorescence image showing bone marrow megakaryocytes (green), neutrophils (red), and cell nuclei (blue) in a mouse model of polycythemia vera. Emperipolesis is present with neutrophils inside megakaryocytes. Both emperipolesis and associated marrow fibrosis were corrected by CD24 blockade. See the article by Sharma et al.
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Getting closer to hemophilia gene therapy for all?
Clinical Trials & Observations