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Volume 120, Issue 7

August 16 2012

Blood Cover Image for Volume 120, Issue 7

In this Issue

Inside Blood
Blood Work
Plenary paper
Perspectives
Review Article
How I Treat
Clinical Trials and Observations
Immunobiology
Lymphoid Neoplasia
Myeloid Neoplasia
Phagocytes, Granulocytes, and Myelopoiesis
Platelets and Thrombopoiesis
Thrombosis and Hemostasis
Vascular Biology
Correspondence
Retraction

Table of Contents

Inside Blood

IMMUNOBIOLOGY

Notch and PI3K: how is the road traveled?

Will Bailis,Warren S. Pear

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IMMUNOBIOLOGY

Leaky gut, clotting, and vasculopathy in SIV

Peter W. Hunt

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INSIDE BLOOD

CCR1 blockade and myeloma bone disease

Michael Sebag

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PHAGOCYTES & GRANULOCYTES

Has Ly6G finally found a job?

Michael J. Hickey

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THROMBOSIS & HEMOSTASIS

Thrombophilia screening: whom to test?

Aisha Bruce,M. Patricia Massicotte

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Blood Work

Meningeal myelomatosis

Saiyed Anwer,Alexander Sternberg

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Plenary paper

IMMUNOBIOLOGY

Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates

Ivona Pandrea,Elaine Cornell,Cara Wilson,Ruy M. Ribeiro,Dongzhu Ma,Jan Kristoff,Cuiling Xu,George S. Haret-Richter,Anita Trichel,Cristian Apetrei,Alan Landay,Russell Tracy

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Perspectives

Allogeneic hematopoietic cell transplantation for myelofibrosis in the era of JAK inhibitors

Vikas Gupta,Parameswaran Hari,Ronald Hoffman

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Review Article

NFAT control of innate immunity

Jan Fric,Teresa Zelante,Alicia Y. W. Wong,Alexandra Mertes,Hong-Bing Yu,Paola Ricciardi-Castagnoli

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How I Treat

How I treat newly diagnosed chronic phase CML

Jorge Cortes,Hagop Kantarjian

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Clinical Trials and Observations

Five-group cytogenetic risk classification, monosomal karyotype, and outcome after hematopoietic cell transplantation for MDS or acute leukemia evolving from MDS
Clinical Trials & Observations

H. Joachim Deeg,Bart L. Scott,Min Fang,Howard M. Shulman,Boglarka Gyurkocza,David Myerson,John M. Pagel,Uwe Platzbecker,Aravind Ramakrishnan,Jerald P. Radich,Brenda M. Sandmaier,Mohamed Sorror,Derek L. Stirewalt,Wendy A. Wilson,Rainer Storb,Frederick R. Appelbaum,Ted Gooley

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Supplemental data

Correlation of blood counts with vascular complications in essential thrombocythemia: analysis of the prospective PT1 cohort
Brief Report

Peter J. Campbell,Cathy MacLean,Philip A. Beer,Georgina Buck,Keith Wheatley,Jean-Jacques Kiladjian,Cecily Forsyth,Claire N. Harrison,Anthony R. Green

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Brentuximab vedotin for relapsed or refractory CD30⁺ hematologic malignancies: the German Hodgkin Study Group experience
Brief Report

Achim Rothe,Stephanie Sasse,Helen Goergen,Dennis A. Eichenauer,Andreas Lohri,Ulrich Jäger,Christopher Bangard,Boris Böll,Michael von Bergwelt Baildon,Sebastian Theurich,Peter Borchmann,Andreas Engert

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Immunobiology

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

Bart Everts,Eyal Amiel,Gerritje J. W. van der Windt,Tori C. Freitas,Robert Chott,Kevin E. Yarasheski,Erika L. Pearce,Edward J. Pearce

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Supplemental data

The race for the prize: T-cell trafficking strategies for optimal surveillance

Minyi Lee,Judith N. Mandl,Ronald N. Germain,Andrew J. Yates

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Supplemental data

Lymphoid Neoplasia

Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

Alan G. Ramsay,Andrew J. Clear,Rewas Fatah,John G. Gribben

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Supplemental data

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes

Gladys W. Wong,Gisele C. Knowles,Tak W. Mak,Adolfo A. Ferrando,Juan Carlos Zúñiga-Pflücker

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Supplemental data

CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

Daniel J. Dairaghi,Babatunde O. Oyajobi,Anjana Gupta,Brandon McCluskey,Shichang Miao,Jay P. Powers,Lisa C. Seitz,Yu Wang,Yibin Zeng,Penglie Zhang,Thomas J. Schall,Juan C. Jaen

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Supplemental data

S1PR1 is an effective target to block STAT3 signaling in activated B cell–like diffuse large B-cell lymphoma

Yong Liu,Jiehui Deng,Lin Wang,Heehyoung Lee,Brian Armstrong,Anna Scuto,Claudia Kowolik,Lawrence M. Weiss,Stephen Forman,Hua Yu

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Supplemental data

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with T_FH-like features and adverse clinical parameters
Brief Report

François Lemonnier,Lucile Couronné,Marie Parrens,Jean-Philippe Jaïs,Marion Travert,Laurence Lamant,Olivier Tournillac,Therese Rousset,Bettina Fabiani,Rob A. Cairns,Tak Mak,Christian Bastard,Olivier A. Bernard,Laurence de Leval,Philippe Gaulard

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Supplemental data

Myeloid Neoplasia

Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML

Miao-Chia Lo,Luke F. Peterson,Ming Yan,Xiuli Cong,Fulai Jin,Wei-Jong Shia,Shinobu Matsuura,Eun-Young Ahn,Yukiko Komeno,Minh Ly,Hans B. Ommen,I-Ming Chen,Peter Hokland,Cheryl L. Willman,Bing Ren,Dong-Er Zhang

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Supplemental data

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia
Brief Report

Sayoko Doisaki,Hideki Muramatsu,Akira Shimada,Yoshiyuki Takahashi,Makiko Mori-Ezaki,Masanori Sato,Hiroyuki Kawaguchi,Akitoshi Kinoshita,Manabu Sotomatsu,Yasuhide Hayashi,Yoko Furukawa-Hibi,Kiyofumi Yamada,Hideaki Hoshino,Hitoshi Kiyoi,Nao Yoshida,Hirotoshi Sakaguchi,Atsushi Narita,Xinan Wang,Olfat Ismael,Yinyan Xu,Nobuhiro Nishio,Makito Tanaka,Asahito Hama,Kenichi Koike,Seiji Kojima

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Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Ly6G ligation blocks recruitment of neutrophils via a β2-integrin–dependent mechanism

Jun-Xia Wang,Angela M. Bair,Sandra L. King,Ruslan Shnayder,Ya-Fang Huang,Chi-Chang Shieh,Roy J. Soberman,Robert C. Fuhlbrigge,Peter A. Nigrovic

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Supplemental data

Platelets and Thrombopoiesis

Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia

Kazunobu Kiyomizu,Hirokazu Kashiwagi,Tsuyoshi Nakazawa,Seiji Tadokoro,Shigenori Honda,Yuzuru Kanakura,Yoshiaki Tomiyama

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Supplemental data

Thrombosis and Hemostasis

Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: an observational study
Clinical Trials & Observations

Susanne Holzhauer,Neil A. Goldenberg,Ralf Junker,Christine Heller,Monika Stoll,Daniela Manner,Rolf Mesters,Anne Krümpel,Michael Stach,Ulrike Nowak-Göttl

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Vascular Biology

Pericytes promote selective vessel regression to regulate vascular patterning

Nicole Simonavicius,Matthew Ashenden,Antoinette van Weverwijk,Siân Lax,David L. Huso,Christopher D. Buckley,Ivo J. Huijbers,Helen Yarwood,Clare M. Isacke

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Supplemental data

Correspondence

Circulating microparticles do not all share biophysical light scatter properties with immune complexes when analyzed by flow cytometry

Philip Hexley,Chad T. Robinson,Andrew R. Osterburg,George F. Babcock

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Ruxolitinib inhibits transforming JAK2 fusion proteins in vitro and induces complete cytogenetic remission in t(8;9)(p22;p24)/PCM1-JAK2–positive chronic eosinophilic leukemia

Els Lierman,Dominik Selleslag,Sanne Smits,Johan Billiet,Peter Vandenberghe

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Treatment with bosentan in a patient with thalassemia intermedia and pulmonary arterial hypertension

Anastasia Anthi,Iraklis Tsangaris,Eftichia S. Hamodraka,John Lekakis,Apostolos Armaganidis,Stylianos E. Orfanos

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Retraction

Linger RMA, DeRyckere D, Brandão L, Sawczyn KK, Jacobsen KM, Liang X, Keating AK, Graham DK. Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia. Blood. 2009;114(13):2678–2687.

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Cover Image

Cover Image

The confocal image shows a cytotoxic T lymphocyte from a chronic lymphocytic leukemia patient forming an actin-polarized immunologic synapse (in red) with an autologous tumor cell (in blue) after down-regulation of tumor cell–inhibitory molecule expression using the immunomodulatory drug lenalidomide. See the article by Ramsay et al on page 1412.
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