Gunnar Juliusson,for the Swedish Acute Leukemia Registry Group,Vladimir Lazarevic,for the Swedish Acute Leukemia Registry Group,Ann-Sofi Hörstedt,for the Swedish Acute Leukemia Registry Group,Oskar Hagberg,for the Swedish Acute Leukemia Registry Group,Martin Höglund,for the Swedish Acute Leukemia Registry Group

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Supplemental data

Review Article

Stem cell heterogeneity: implications for aging and regenerative medicine

Christa E. Muller-Sieburg,Hans B. Sieburg,Jeff M. Bernitz,Giulio Cattarossi

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Clinical Trials and Observations

Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia
CME

Wael Saber,Shaun Opie,J. Douglas Rizzo,Mei-Jie Zhang,Mary M. Horowitz,Jeff Schriber

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A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
Clinical Trials & Observations

Geoffrey L. Uy,Michael P. Rettig,Ibraheem H. Motabi,Kyle McFarland,Kathryn M. Trinkaus,Lindsay M. Hladnik,Shashikant Kulkarni,Camille N. Abboud,Amanda F. Cashen,Keith E. Stockerl-Goldstein,Ravi Vij,Peter Westervelt,John F. DiPersio

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Supplemental data

Gene Therapy

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
Clinical Trials & Observations

Brian G. Till,Michael C. Jensen,Jinjuan Wang,Xiaojun Qian,Ajay K. Gopal,David G. Maloney,Catherine G. Lindgren,Yukang Lin,John M. Pagel,Lihua E. Budde,Andrew Raubitschek,Stephen J. Forman,Philip D. Greenberg,Stanley R. Riddell,Oliver W. Press

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Hematopoiesis and Stem Cells

p85β regulatory subunit of class I_A PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Subha Krishnan,Raghuveer Singh Mali,Baskar Ramdas,Emily Sims,Peilin Ma,Joydeep Ghosh,Veerendra Munugalavadla,Philip Hanneman,Joal D. Beane,Reuben Kapur

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Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields
Brief Report

Daniel Lucas,Ingmar Bruns,Michela Battista,Simon Mendez-Ferrer,Claire Magnon,Yuya Kunisaki,Paul S. Frenette

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Immunobiology

Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection
Clinical Trials & Observations

Sarah K. Browne,Rifat Zaman,Elizabeth P. Sampaio,Kamonwan Jutivorakool,Lindsey B. Rosen,Li Ding,Minjal J. Pancholi,Lauren M. Yang,Debra Long Priel,Gulbu Uzel,Alexandra F. Freeman,Carlton E. Hayes,Roger Baxter,Stuart H. Cohen,Steven M. Holland

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Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function

Lisa S. Westerberg,Carin Dahlberg,Marisa Baptista,Christopher J. Moran,Cynthia Detre,Marton Keszei,Michelle A. Eston,Frederick W. Alt,Cox Terhorst,Luigi D. Notarangelo,Scott B. Snapper

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Supplemental data

Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1⁺CD11b⁺F4/80⁺ regulatory macrophages in mice

Xiangyue Zhang,Songfeng Yu,Katharina Hoffmann,Kai Yu,Reinhold Förster

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Supplemental data

Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor

Elisa Montaldo,Chiara Vitale,Francesca Cottalasso,Romana Conte,Timor Glatzer,Paolo Ambrosini,Lorenzo Moretta,Maria Cristina Mingari

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Supplemental data

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

Cindy S. Ma,Danielle T. Avery,Anna Chan,Marcel Batten,Jacinta Bustamante,Stephanie Boisson-Dupuis,Peter D. Arkwright,Alexandra Y. Kreins,Diana Averbuch,Dan Engelhard,Klaus Magdorf,Sara S. Kilic,Yoshiyuki Minegishi,Shigeaki Nonoyama,Martyn A. French,Sharon Choo,Joanne M. Smart,Jane Peake,Melanie Wong,Paul Gray,Matthew C. Cook,David A. Fulcher,Jean-Laurent Casanova,Elissa K. Deenick,Stuart G. Tangye

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Supplemental data

Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency
Brief Report

Rachel K. Shaw,Andrew C. Issekutz,Robert Fraser,Pierre Schmit,Barb Morash,Linda Monaco-Shawver,Jordan S. Orange,Conrad V. Fernandez

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Supplemental data

Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication
Brief Report

Kelly Hudspeth,Manuela Fogli,Daniel V. Correia,Joanna Mikulak,Alessandra Roberto,Silvia Della Bella,Bruno Silva-Santos,Domenico Mavilio

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Supplemental data

Lymphoid Neoplasia

The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines

Manuela Lemoine,Enrico Derenzini,Daniela Buglio,L. Jeffrey Medeiros,R. Eric Davis,Jiexin Zhang,Yuan Ji,Anas Younes

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Myeloid Neoplasia

SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML

Hannes Leischner,Corinna Albers,Rebekka Grundler,Elena Razumovskaya,Karsten Spiekermann,Stefan Bohlander,Lars Rönnstrand,Katharina Götze,Christian Peschel,Justus Duyster

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Phagocytes, Granulocytes, and Myelopoiesis

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

Giuseppe Zardo,Alberto Ciolfi,Laura Vian,Linda M. Starnes,Monia Billi,Serena Racanicchi,Carmen Maresca,Francesco Fazi,Lorena Travaglini,Nelida Noguera,Marco Mancini,Mauro Nanni,Giuseppe Cimino,Francesco Lo-Coco,Francesco Grignani,Clara Nervi

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Supplemental data

Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality

Hyun Sik Jun,Yuk Yin Cheung,Young Mok Lee,Brian C. Mansfield,Janice Y. Chou

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Platelets and Thrombopoiesis

A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1

Alexandre Kauskot,Michela Di Michele,Serena Loyen,Kathleen Freson,Peter Verhamme,Marc F. Hoylaerts

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Supplemental data

In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation

Bethan Psaila,James B. Bussel,Matthew D. Linden,Bracken Babula,Youfu Li,Marc R. Barnard,Chinara Tate,Kanika Mathur,Andrew L. Frelinger,Alan D. Michelson

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Red Cells, Iron, and Erythropoiesis

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)
Clinical Trials & Observations

Russell E. Ware,for the SWiTCH Investigators,Ronald W. Helms,for the SWiTCH Investigators

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Supplemental data

Thrombosis and Hemostasis

CD4⁺ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice

Katharina N. Steinitz,Pauline M. van Helden,Brigitte Binder,David C. Wraith,Sabine Unterthurner,Corinna Hermann,Maria Schuster,Rafi U. Ahmad,Markus Weiller,Christian Lubich,Maurus de la Rosa,Hans Peter Schwarz,Birgit M. Reipert

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Supplemental data

Transplantation

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era
Clinical Trials & Observations

Erica Warlick,Kwang Woo Ahn,Tanya L. Pedersen,Andrew Artz,Marcos de Lima,Michael Pulsipher,Gorgun Akpek,Mahmoud Aljurf,Jean-Yves Cahn,Mitchell Cairo,Yi-Bin Chen,Brenda Cooper,Abhinav Deol,Sergio Giralt,Vikas Gupta,H. Jean Khoury,Holbrook Kohrt,Hillard M. Lazarus,Ian Lewis,Richard Olsson,Joseph Pidala,Bipin N. Savani,Matthew Seftel,Gerard Socié,Martin Tallman,Celaettin Ustun,Ravi Vij,Lars Vindeløv,Daniel Weisdorf

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Errata

Ng C-H, Xu S, Lam K-P. Dok-3 plays a nonredundant role in negative regulation of B-cell activation. Blood. 2007;110(1):259–266.

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Mumford AD, Dawood BB, Daly ME, et al. A novel thromboxane A₂ receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood. 2010;115(2):363–369.

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Other Departments

Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML
CME

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Cover Image

Cover Image

A schematic representation elucidating the cycling pathway for glucose-6-phosphate (G6P) metabolism in macrophages. G6P participates in 4 major pathways: glycolysis, the hexose monophosphate shunt (HMS), glycogen synthesis, or endoplasmic reticulum (ER) cycling. In cycling, G6P enters the ER via glucose-6-phosphate transporter (G6PT) where it can accumulate until it is hydrolyzed to glucose by G6Pase-β and transported back into the cytoplasm. By limiting the cytoplasmic glucose/G6P availability, cycling regulates the other 3 cytoplasmic pathways for G6P metabolism. Disruption of this cycling in G6Pase-β–deficient macrophages results in impaired energy homeostasis and functionality. See the article by Jun et al on page 4047.
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Eliminating the need for sequential confirmation of response in multiple myeloma

Hitting the therapeutic bull’s-eye with targeted therapy for patients with chronic lymphocytic leukemia

Sequential combinations of rapid immunoassays for prompt recognition of heparin-induced thrombocytopenia

CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs

PERK signaling maintains hematopoietic stem cell pool integrity under endoplasmic reticulum stress by promoting proliferation

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Issue Archive

Table of Contents

Inside Blood

Get out—and stay out Free

To SWiTCH or not to SWiTCH? Free

CARs and cancers: questions and answers Free

Lymphocyte cytotoxicity: tug-of-war on microtubules Free

MicroRNAs function on a new level Free

Platelets and eltrombopag: a not-so-sticky situation Free

Blood Work

Pappenheimer bodies in a splenectomized patient with alcohol abuse Free

Plenary Paper

Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex Free

Perspectives

Acute myeloid leukemia in the real world: why population-based registries are needed Free

Review Article

Stem cell heterogeneity: implications for aging and regenerative medicine Free

Clinical Trials and Observations

Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia Free CME

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia Free Clinical Trials & Observations

Gene Therapy

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results Free Clinical Trials & Observations

Hematopoiesis and Stem Cells

p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis Free

Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields Free Brief Report

Immunobiology

Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection Free Clinical Trials & Observations

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function Free

Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1+CD11b+F4/80+ regulatory macrophages in mice Free

Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor Free

Functional STAT3 deficiency compromises the generation of human T follicular helper cells Free

Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency Free Brief Report

Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication Free Brief Report

Lymphoid Neoplasia

The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines Free

Myeloid Neoplasia

SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML Free

Phagocytes, Granulocytes, and Myelopoiesis

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression Free

Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality Free

Platelets and Thrombopoiesis

A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1 Free

In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation Free

Red Cells, Iron, and Erythropoiesis

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) Free Clinical Trials & Observations

Thrombosis and Hemostasis

CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice Free

Transplantation

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era Free Clinical Trials & Observations

Errata

Ng C-H, Xu S, Lam K-P. Dok-3 plays a nonredundant role in negative regulation of B-cell activation. Blood. 2007;110(1):259–266. Free

Mumford AD, Dawood BB, Daly ME, et al. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood. 2010;115(2):363–369. Free

Other Departments

Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML Free CME

Email alerts

ASH Publications

American Society of Hematology

Get out—and stay out

To SWiTCH or not to SWiTCH?

CARs and cancers: questions and answers

Lymphocyte cytotoxicity: tug-of-war on microtubules

MicroRNAs function on a new level

Platelets and eltrombopag: a not-so-sticky situation

Pappenheimer bodies in a splenectomized patient with alcohol abuse

Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex

Acute myeloid leukemia in the real world: why population-based registries are needed

Stem cell heterogeneity: implications for aging and regenerative medicine

Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia
CME

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
Clinical Trials & Observations

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
Clinical Trials & Observations

p85β regulatory subunit of class I_A PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields
Brief Report

Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection
Clinical Trials & Observations

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function

Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1⁺CD11b⁺F4/80⁺ regulatory macrophages in mice

Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency
Brief Report

Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication
Brief Report

The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines

SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality

A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1

In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)
Clinical Trials & Observations

CD4⁺ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era
Clinical Trials & Observations

Ng C-H, Xu S, Lam K-P. Dok-3 plays a nonredundant role in negative regulation of B-cell activation. Blood. 2007;110(1):259–266.

Mumford AD, Dawood BB, Daly ME, et al. A novel thromboxane A₂ receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood. 2010;115(2):363–369.

Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML
CME