Jean-Jacques Lataillade,on behalf of the French INSERM and the European EUMNET Networks on Myelofibrosis,Olivier Pierre-Louis,on behalf of the French INSERM and the European EUMNET Networks on Myelofibrosis,Hans Carl Hasselbalch,on behalf of the French INSERM and the European EUMNET Networks on Myelofibrosis,Georges Uzan,on behalf of the French INSERM and the European EUMNET Networks on Myelofibrosis,Claude Jasmin,on behalf of the French INSERM and the European EUMNET Networks on Myelofibrosis,Marie-Claire Martyré,on behalf of the French INSERM and the European EUMNET Networks on Myelofibrosis,Marie-Caroline Le Bousse-Kerdilès,on behalf of the French INSERM and the European EUMNET Networks on Myelofibrosis

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation

James L. Gajewski,Viviana V. Johnson,S. Gerald Sandler,Antoine Sayegh,Thomas R. Klumpp

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

PI3Kgamma (PI3Kγ) is essential for efficient induction of CXCR3 on activated T cells
Brief Report

Joseph Barbi,Hannah E. Cummings,Bao Lu,Steve Oghumu,Thomas Rückle,Christian Rommel,William Lafuse,Caroline C. Whitacre,Abhay R. Satoskar

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

CLINICAL TRIALS AND OBSERVATIONS

Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia patients: a population-based study in Sweden
Clinical Trials & Observations

Sigurdur Y. Kristinsson,Magnus Björkholm,Lynn R. Goldin,Mary L. McMaster,Ingemar Turesson,Ola Landgren

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring
Clinical Trials & Observations

Ye-Xiong Li,Hui Fang,Qing-Feng Liu,Jiade Lu,Shu-Nan Qi,Hua Wang,Jing Jin,Wei-Hu Wang,Yue-Ping Liu,Yong-Wen Song,Shu-Lian Wang,Xin-Fan Liu,Xiao-Li Feng,Zi-Hao Yu

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera
Clinical Trials & Observations

Jean-Jacques Kiladjian,Bruno Cassinat,Sylvie Chevret,Pascal Turlure,Nathalie Cambier,Murielle Roussel,Sylvia Bellucci,Bernard Grandchamp,Christine Chomienne,Pierre Fenaux

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations

Gregory A. Yanik,Vincent T. Ho,John E. Levine,Eric S. White,Thomas Braun,Joseph H. Antin,Joel Whitfield,Joseph Custer,Dawn Jones,James L. M. Ferrara,Kenneth R. Cooke

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation
Clinical Trials & Observations

Suzanne O. Arulogun,H. Miles Prince,Jonathan Ng,Stephen Lade,Gail F. Ryan,Odette Blewitt,Christopher McCormack

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
Clinical Trials & Observations

Ken H. Young,Karen Leroy,Michael B. Møller,Gisele W. B. Colleoni,Margarita Sánchez-Beato,Fábio R. Kerbauy,Corinne Haioun,Jens C. Eickhoff,Allen H. Young,Philippe Gaulard,Miguel A. Piris,Terry D. Oberley,William M. Rehrauer,Brad S. Kahl,James S. Malter,Elias Campo,Jan Delabie,Randy D. Gascoyne,Andreas Rosenwald,Lisa Rimsza,James Huang,Rita M. Braziel,Elaine S. Jaffe,Wyndham H. Wilson,Louis M. Staudt,Julie M. Vose,Wing C. Chan,Dennis D. Weisenburger,Timothy C. Greiner

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories
Clinical Trials & Observations

Régis Peffault de Latour,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Jean Yves Mary,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Célia Salanoubat,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Louis Terriou,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Gabriel Etienne,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Mohamad Mohty,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Sophie Roth,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Sophie de Guibert,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Sebastien Maury,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Jean Yves Cahn,on behalf of the French Society of Hematology and of the French Association of Young Hematologists,Gerard Socié,on behalf of the French Society of Hematology and of the French Association of Young Hematologists

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Issue Archive

Table of Contents

INSIDE BLOOD

P53 mutations in lymphomas: position matters Free

Crossover confusion: MPT still best Free

Biology, treatment, and time Free

Good news for the aging population? Free

FVIIa: you've come a long way, baby! Free

Tregitopes switch on Tregs Free

Need akt? Some myelomas do Free

Unlocking the dysplasia puzzle Free

Blocks to paraffin get the CHOP, +R Free

Donor dendritic cells dance the do-si-do in allogeneic transplantation Free

Raising the spectra of T-cell profiling Free

ASH 50TH ANNIVERSARY REVIEW

The GPIIb/IIIa (integrin αIIbβ3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend Free

REVIEW ARTICLES

Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence Free

A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation Free

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

PI3Kgamma (PI3Kγ) is essential for efficient induction of CXCR3 on activated T cells Free Brief Report

CLINICAL TRIALS AND OBSERVATIONS

Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia patients: a population-based study in Sweden Free Clinical Trials & Observations

Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring Free Clinical Trials & Observations

Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera Free Clinical Trials & Observations

The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation Free Clinical Trials & Observations

Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation Free Clinical Trials & Observations

Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study Free Clinical Trials & Observations

Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories Free Clinical Trials & Observations

Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial Free Clinical Trials & Observations

Thalidomide arm of Total Therapy 2 improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities Free Clinical Trials & Observations

Seven-year median time to progression with thalidomide for smoldering myeloma: partial response identifies subset requiring earlier salvage therapy for symptomatic disease Free Brief Report

The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival Free Brief Report

Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group Free Brief Report

Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia Free Brief Report

GENE THERAPY

Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors Free

HEMATOPOIESIS AND STEM CELLS

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl−/− mice Free

BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling Free

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling Free

Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance Free

Hematopoiesis is not clonal in healthy elderly women Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis Free

Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells Free

MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells Free

The glycoprotein Ib-IX-V complex contributes to tissue factor–independent thrombin generation by recombinant factor VIIa on the activated platelet surface Free

The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis Free

Functional analysis of the cytoplasmic domain of the integrin α1 subunit in endothelial cells Free

IMMUNOBIOLOGY

CCL25 increases thymopoiesis after androgen withdrawal Free

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement Free

IFN-γ–mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation Free

Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP Free

Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow Free

Activation of natural regulatory T cells by IgG Fc–derived peptide “Tregitopes” Free

NEOPLASIA

Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis Free

Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up Free

Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials Free

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α Free

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia Free

The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment Free

Differential pattern of CD4+ and CD8+ T-cell immunity to MAGE-A1/A2/A3 in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma Free

K-RasG12D–induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to γ-secretase inhibitors Free

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis Free

Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia Free

Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma Free

High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival Free

Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP Free

Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS Free

PHAGOCYTES

The tetraspanin CD63 is involved in granule targeting of neutrophil elastase Free

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx Free

RED CELLS

Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1 Free

Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium Free

TRANSPLANTATION

Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation Free

P53 mutations in lymphomas: position matters

Crossover confusion: MPT still best

Biology, treatment, and time

Good news for the aging population?

FVIIa: you've come a long way, baby!

Tregitopes switch on Tregs

Need akt? Some myelomas do

Unlocking the dysplasia puzzle

Blocks to paraffin get the CHOP, +R

Donor dendritic cells dance the do-si-do in allogeneic transplantation

Raising the spectra of T-cell profiling

The GPIIb/IIIa (integrin αIIbβ3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence

A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation

PI3Kgamma (PI3Kγ) is essential for efficient induction of CXCR3 on activated T cells
Brief Report

Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia patients: a population-based study in Sweden
Clinical Trials & Observations

Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring
Clinical Trials & Observations

Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera
Clinical Trials & Observations

The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations

Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation
Clinical Trials & Observations

Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
Clinical Trials & Observations

Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories
Clinical Trials & Observations

Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial
Clinical Trials & Observations

Thalidomide arm of Total Therapy 2 improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities
Clinical Trials & Observations

Seven-year median time to progression with thalidomide for smoldering myeloma: partial response identifies subset requiring earlier salvage therapy for symptomatic disease
Brief Report

The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival
Brief Report

Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group
Brief Report

Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia
Brief Report

Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl^−/− mice

BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling

Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance

Hematopoiesis is not clonal in healthy elderly women

Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis

Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells

MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells

The glycoprotein Ib-IX-V complex contributes to tissue factor–independent thrombin generation by recombinant factor VIIa on the activated platelet surface

The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis

Functional analysis of the cytoplasmic domain of the integrin α1 subunit in endothelial cells

CCL25 increases thymopoiesis after androgen withdrawal

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

IFN-γ–mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation

Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP

Selective accumulation of virus-specific CD8⁺ T cells with unique homing phenotype within the human bone marrow

Activation of natural regulatory T cells by IgG Fc–derived peptide “Tregitopes”

Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis

Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up

Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts T_reg cells via regulation of MIP-3α

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia

The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment

Differential pattern of CD4⁺ and CD8⁺ T-cell immunity to MAGE-A1/A2/A3 in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma

K-Ras^G12D–induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to γ-secretase inhibitors

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia

Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma

High-resolution whole genome tiling path array CGH analysis of CD34⁺ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival

Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP

Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS

The tetraspanin CD63 is involved in granule targeting of neutrophil elastase

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR⁺ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1

Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium

Generation of HIV-1–specific CD8⁺ cell responses following allogeneic hematopoietic cell transplantation

Temporal, quantitative, and functional characteristics of single-KIR–positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation

Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

Overlap between in vitro donor antihost and in vivo posttransplantation TCR Vβ use: a new paradigm for designer allogeneic blood and marrow transplantation

Platelet count in essential thrombocythemia: the more the better?

Response: Thrombocytosis in low-risk ET patients

About reporting clinical trials

Response: Design and reporting of clinical trials in LCH

Matsuyama et al. TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus. Blood. 2004;104:184-191.

Tan et al. Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. Blood. 2005;106:2936-2943.

Wei et al. Regulatory T-cell compartmentalization and trafficking. Blood. 2006;108:426-431.

Tun et al. Pathway analysis of primary central nervous system lymphoma. Blood. 2008; 111:3200-3210.