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Volume 107, Issue 12

June 15 2006

In this Issue

INSIDE BLOOD
PERSPECTIVES
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
RETRACTIONS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

CLINICAL OBSERVATIONS

Reconsidering how we treat severe congenital neutropenia

Kevin Shannon

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CLINICAL OBSERVATIONS

Two tales of infant leukemia

Ching-Hon Pui

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CLINICAL OBSERVATIONS

How did we get here from there?

Elihu Estey

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HEMATOPOIESIS

An anaerobic home for the stem cell proteome

Kateri Moore

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HEMATOPOIESIS

Why target the WT1 gene?

Morris Kletzel

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HEMOSTASIS

ICAM-2 and PECAM-1: 2 steps in leukocyte transmigration

Dietmar Vestweber

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HEMOSTASIS

A package for VWD endothelial cells

Robert R. Montgomery

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IMMUNOBIOLOGY

Do not Rho tight junctions (or they become leaky)

Michal Toborek

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HEMOSTASIS

PTPs seize the spotlight from RTKs in vasculogenesis

Christopher J. Drake,W. Scott Argraves

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PERSPECTIVES

Ribosomes and marrow failure: coincidental association or molecular paradigm?

Johnson M. Liu,Steven R. Ellis

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REVIEW IN TRANSLATIONAL HEMATOLOGY

Role of transforming growth factor-β in hematologic malignancies

Mei Dong,Gerard C. Blobe

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CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8⁺ T-cell responses

Roberta Schiavo,Dolgor Baatar,Purevdorj Olkhanud,Fred E. Indig,Nicholas Restifo,Dennis Taub,Arya Biragyn

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Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481
Clinical Trials & Observations

Gita V. Massey,Alvin Zipursky,Myron N. Chang,John J. Doyle,Suhail Nasim,Jeffrey W. Taub,Yaddanapudi Ravindranath,Gary Dahl,Howard J. Weinstein

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Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of G-CSF and ATRA are not beneficial: results of the MRC AML-HR randomized trial
Clinical Trials & Observations

Donald W. Milligan,Keith Wheatley,Timothy Littlewood,Jenny I. O. Craig,Alan K. Burnett,for the NCRI Haematological Oncology Clinical Studies Group

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Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma
Clinical Trials & Observations

Douglas A. Stewart,Nizar Bahlis,Karen Valentine,Alex Balogh,Lynn Savoie,Donald G. Morris,Allan Jones,Chris Brown,James A. Russell

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The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy
Clinical Trials & Observations

Philip S. Rosenberg,Blanche P. Alter,Audrey A. Bolyard,Mary Ann Bonilla,Laurence A. Boxer,Bonnie Cham,Carol Fier,Melvin Freedman,George Kannourakis,Sally Kinsey,Beate Schwinzer,Connie Zeidler,Karl Welte,David C. Dale,for the Severe Chronic Neutropenia International Registry

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Long-term results and competing risk analysis of the H89 trial in patients with advanced-stage Hodgkin lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte (GELA)
Clinical Trials & Observations

Christophe Fermé,Nicolas Mounier,Olivier Casasnovas,Pauline Brice,Marine Divine,Anne Sonet,Fahdela Bouafia,Aspasia Bastard-Stamatoullas,Dominique Bordessoule,Laurent Voillat,Oumedaly Reman,Michel Blanc,Christian Gisselbrecht,for the Groupe d'Etude des Lymphomes de l'Adulte

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Splenic marginal zone lymphoma: a prognostic model for clinical use
Clinical Trials & Observations

Luca Arcaini,Mario Lazzarino,Nora Colombo,Sara Burcheri,Emanuela Boveri,Marco Paulli,Enrica Morra,Marcello Gambacorta,Sergio Cortelazzo,Alessandra Tucci,Marco Ungari,Achille Ambrosetti,Fabio Menestrina,Lorella Orsucci,Domenico Novero,Alessandro Pulsoni,Maurizio Frezzato,Gianluca Gaidano,Daniele Vallisa,Viviana Minardi,Claudio Tripodo,Vincenzo Callea,Luca Baldini,Francesco Merli,Massimo Federico,Vito Franco,Emilio Iannitto,for the Intergruppo Italiano Linfomi

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Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma
Clinical Trials & Observations

Richard F. Little,James M. Pluda,Kathleen M. Wyvill,Isaac R. Rodriguez-Chavez,Giovanna Tosato,Andrew T. Catanzaro,Seth M. Steinberg,Robert Yarchoan

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Eradication of minimal residual disease in hairy cell leukemia
Clinical Trials & Observations

Farhad Ravandi,Jeffrey L. Jorgensen,Susan M. O'Brien,Srdan Verstovsek,Charles A. Koller,Stefan Faderl,Francis J. Giles,Alessandra Ferrajoli,William G. Wierda,Shirley Odinga,Xuelin Huang,Deborah A. Thomas,Emil J. Freireich,Dan Jones,Michael J. Keating,Hagop M. Kantarjian

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Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group
Clinical Trials & Observations

Jun Nagayama,Daisuke Tomizawa,Katsuyoshi Koh,Yoshihisa Nagatoshi,Noriko Hotta,Tomoko Kishimoto,Yoshihiro Takahashi,Tomoko Kuno,Kanji Sugita,Takashi Sato,Kohji Kato,Atsushi Ogawa,Tatsutoshi Nakahata,Shuki Mizutani,Keizo Horibe,Eiichi Ishii

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Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24 000 years ago
Clinical Trials & Observations

Ariella Zivelin,Ronit Mor-Cohen,Victoria Kovalsky,Nurit Kornbrot,Jacqueline Conard,Flora Peyvandi,Paul A. Kyrle,Rogier Bertina,Ferial Peyvandi,Joseph Emmerich,Uri Seligsohn

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GENE THERAPY

Antibody-dependent cellular cytotoxicity (ADCC) is mediated by genetically modified antigen-specific human T lymphocytes

Béatrice Clémenceau,Nicolas Congy-Jolivet,Géraldine Gallot,Régine Vivien,Joëlle Gaschet,Gilles Thibault,Henri Vié

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HEMATOPOIESIS

The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation

Claude Capron,Yann Lécluse,Anna Lila Kaushik,Adlen Foudi,Catherine Lacout,Dalila Sekkai,Isabelle Godin,Olivier Albagli,Isabelle Poullion,Fedor Svinartchouk,Elisabeth Schanze,William Vainchenker,Fred Sablitzky,Annelise Bennaceur-Griscelli,Dominique Duménil

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Supplemental data

Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells

Richard D. Unwin,Duncan L. Smith,David Blinco,Claire L. Wilson,Crispin J. Miller,Caroline A. Evans,Ewa Jaworska,Stephen A. Baldwin,Kay Barnes,Andrew Pierce,Elaine Spooncer,Anthony D. Whetton

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Supplemental data

The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy

Lesley A. Simpson,Emily A. Burwell,Kida A. Thompson,Samira Shahnaz,Allen R. Chen,David M. Loeb

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Coordination of erythropoiesis by the transcription factor c-Myb

Alexandros Vegiopoulos,Paloma García,Nikla Emambokus,Jon Frampton

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False-positive detection of recombinant human erythropoietin in urine following strenuous physical exercise
Clinical Trials & Observations Brief Report

Monique Beullens,Joris R. Delanghe,Mathieu Bollen

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RETRACTIONS

Erratum for vol. 89, p. 3582

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Endothelial-cell apoptosis induced by cleaved high-molecular-weight kininogen (HKa) is matrix dependent and requires the generation of reactive oxygen species

Danyu Sun,Keith R. McCrae

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ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1–independent transmigration

Miao-Tzu Huang,Karen Y. Larbi,Christoph Scheiermann,Abigail Woodfin,Nicole Gerwin,Dorian O. Haskard,Sussan Nourshargh

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Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor

Simon F. De Meyer,Karen Vanhoorelbeke,Marinee K. Chuah,Inge Pareyn,Veerle Gillijns,Robert P. Hebbel,Désiré Collen,Hans Deckmyn,Thierry VandenDriessche

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Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a –8-kb enhancer

John E. Pimanda,W.Y. Iris Chan,Ian J. Donaldson,Mark Bowen,Anthony R. Green,Berthold Göttgens

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Cellular localization and trafficking of tissue factor

Samir K. Mandal,Usha R. Pendurthi,L. Vijaya Mohan Rao

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Supplemental data

Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development

Sebastian Bäumer,Linda Keller,Astrid Holtmann,Ruth Funke,Benjamin August,Alexander Gamp,Hartwig Wolburg,Karen Wolburg-Buchholz,Urban Deutsch,Dietmar Vestweber

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Supplemental data

IMMUNOBIOLOGY

Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals

Thomas Luft,Elena Rodionova,Eugene Maraskovsky,Michael Kirsch,Michael Hess,Christian Buchholtz,Martin Goerner,Max Schnurr,Radek Skoda,Anthony D. Ho

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Supplemental data

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)

Yuri Persidsky,David Heilman,James Haorah,Marina Zelivyanskaya,Raisa Persidsky,Gregory A. Weber,Hiroaki Shimokawa,Kozo Kaibuchi,Tsuneya Ikezu

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8⁺ T cells

Michael R. Betts,Martha C. Nason,Sadie M. West,Stephen C. De Rosa,Stephen A. Migueles,Jonathan Abraham,Michael M. Lederman,Jose M. Benito,Paul A. Goepfert,Mark Connors,Mario Roederer,Richard A. Koup

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Interferons limit inflammatory responses by induction of tristetraprolin

Ines Sauer,Barbara Schaljo,Claus Vogl,Irene Gattermeier,Thomas Kolbe,Mathias Müller,Perry J. Blackshear,Pavel Kovarik

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Use of CD44 by CD4⁺ Th1 and Th2 lymphocytes to roll and adhere

Claudine S. Bonder,Stephen R. Clark,M. Ursula Norman,Pauline Johnson,Paul Kubes

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Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival

Diana Starlets,Yael Gore,Inbal Binsky,Michal Haran,Nurit Harpaz,Lev Shvidel,Shirly Becker-Herman,Alain Berrebi,Idit Shachar

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Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ

Jennifer L. Chan,Katherine C. Tang,Anoop P. Patel,Larissa M. Bonilla,Nicola Pierobon,Nicholas M. Ponzio,Pranela Rameshwar

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Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression
Clinical Trials & Observations

Claudia Pastori,Barbara Weiser,Claudia Barassi,Caterina Uberti-Foppa,Silvia Ghezzi,Renato Longhi,Giliola Calori,Harold Burger,Kimdar Kemal,Guido Poli,Adriano Lazzarin,Lucia Lopalco

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Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis

Andrew E. Schade,Jennifer J. Powers,Marcin W. Wlodarski,Jaroslaw P. Maciejewski

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PKCθ and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3⁺ T lymphocytes

Natascha Hermann-Kleiter,Nikolaus Thuille,Christa Pfeifhofer,Thomas Gruber,Michaela Schäfer,Christof Zitt,Armin Hatzelmann,Christian Schudt,Michael Leitges,Gottfried Baier

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M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice

Dominik Schenten,Angela Egert,Manolis Pasparakis,Klaus Rajewsky

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Innate immunity defects in Hermansky-Pudlak type 2 syndrome

Stefania Fontana,Silvia Parolini,William Vermi,Sarah Booth,Federico Gallo,Marta Donini,Marzia Benassi,Francesca Gentili,Daniela Ferrari,Lucia D. Notarangelo,Patrizia Cavadini,Emanuela Marcenaro,Stefano Dusi,Marco Cassatella,Fabio Facchetti,Gillian M. Griffiths,Alessandro Moretta,Luigi D. Notarangelo,Raffaele Badolato

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Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections
Clinical Trials & Observations

Tom Sprong,Dirk Roos,Corry Weemaes,Chris Neeleman,Christel L. M. Geesing,Tom Eirik Mollnes,Marcel van Deuren

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NEOPLASIA

Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia
Clinical Trials & Observations

Mariano Monzo,Salut Brunet,Alvaro Urbano-Ispizua,Alfons Navarro,Granada Perea,Jordi Esteve,Rosa Artells,Miquel Granell,Juan Berlanga,Josep M. Ribera,Javier Bueno,Andreu Llorente,Ramon Guardia,Mar Tormo,Pio Torres,Josep F. Nomdedéu,Emili Montserrat,Jordi Sierra,for CETLAM

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Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines

Xiao-Fang Che,Chun-Lei Zheng,Satsuki Owatari,Masato Mutoh,Takenari Gotanda,Hei-Cheul Jeung,Tatsuhiko Furukawa,Ryuji Ikeda,Masatatsu Yamamoto,Misako Haraguchi,Naomichi Arima,Shin-ichi Akiyama

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A common phosphotyrosine signature for the Bcr-Abl kinase

Valerie L. Goss,Kimberly A. Lee,Albrecht Moritz,Julie Nardone,Erik J. Spek,Joan MacNeill,John Rush,Michael J. Comb,Roberto D. Polakiewicz

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Supplemental data

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation

Andrea Hoelbl,Boris Kovacic,Marc A. Kerenyi,Olivia Simma,Wolfgang Warsch,Yongzhi Cui,Hartmut Beug,Lothar Hennighausen,Richard Moriggl,Veronika Sexl

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Supplemental data

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

Esther A. Obeng,Louise M. Carlson,Delia M. Gutman,William J. Harrington, Jr,Kelvin P. Lee,Lawrence H. Boise

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STAT5 signaling is required for the efficient induction and maintenance of CML in mice

Dan Ye,Nicholas Wolff,Li Li,Shumin Zhang,Robert L. Ilaria, Jr

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Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID
Clinical Trials & Observations Brief Report

Remco Dijkman,Cornelis P. Tensen,Maike Buettner,Gerald Niedobitek,Rein Willemze,Maarten H. Vermeer

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Supplemental data

PHAGOCYTES

IL-10–producing macrophages preferentially clear early apoptotic cells

Wei Xu,Anja Roos,Nicole Schlagwein,Andrea M. Woltman,Mohamed R. Daha,Cees van Kooten

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E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils

Sarah R. McMeekin,Ian Dransfield,Adriano G. Rossi,Christopher Haslett,Trevor R. Walker

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Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X₇ receptor

Ben J. Gu,James S. Wiley

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Supplemental data

TRANSPLANTATION

Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer

Elisabeth H. Slager,M. Willy Honders,Edith D. van der Meijden,Simone A. P. van Luxemburg-Heijs,Freke M. Kloosterboer,Michel G. D. Kester,Inge Jedema,W. A. Erik Marijt,M. Ron Schaafsma,Roel Willemze,J. H. Frederik Falkenburg

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Outcomes after HLA-matched sibling transplantation or chemotherapy in children with B-precursor acute lymphoblastic leukemia in a second remission: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research
Clinical Trials & Observations

Mary Eapen,Elizabeth Raetz,Mei-Jie Zhang,Catherine Muehlenbein,Meenakshi Devidas,Thomas Abshire,Amy Billett,Alan Homans,Bruce Camitta,William L. Carroll,Stella M. Davies,for the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research

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CORRESPONDENCE

Linkage and mutational analysis of the CDAN1 gene reveals genetic heterogeneity in congenital dyserythropoietic anemia type I

Momin R. Ahmed,Aref Chehal,Laila Zahed,Ali Taher,Joud Haidar,Ali Shamseddine,Anne-Marie O'Hea,Nicola Bienz,Orly Dgany,Nili Avidan,Jacqui S. Beckmann,Hannah Tamary,Douglas Higgs,Paresh Vyas,William G. Wood,Sunitha N. Wickramasinghe

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Helicobacter pylori, iron deficiency, and gastric autoimmunity

Roland Rad,Roland M. Schmid,Christian Prinz

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Liver therapy in anemia: a motion picture by William P. Murphy

Neeraj Kumar,Christopher J. Boes,Martin A. Samuels

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Supplemental data

The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib)

Nikolas von Bubnoff,Sivahari Prasad Gorantla,Silvia Thöne,Christian Peschel,Justus Duyster

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Supplemental data

Bevacizumab therapy for POEMS syndrome

Oddbjørn Straume,Jann Bergheim,Peter Ernst

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Does the serpin PI-9 protect tumor cells?

Michael Bots,Rienk Offringa,Jan Paul Medema

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Does modulation of P-glycoprotein have clinical relevance in pediatric acute myeloid leukemia?

Christian Michel Zwaan,Monique L. den Boer,Karin M. Kazemier,Karel Hählen,Anne H. Loonen,Dirk Reinhardt,Ursula Creutzig,Gertjan J. L. Kaspers,Rob Pieters

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Issue Archive

Table of Contents

INSIDE BLOOD

Reconsidering how we treat severe congenital neutropenia Free

Two tales of infant leukemia Free

How did we get here from there? Free

An anaerobic home for the stem cell proteome Free

Why target the WT1 gene? Free

ICAM-2 and PECAM-1: 2 steps in leukocyte transmigration Free

A package for VWD endothelial cells Free

Do not Rho tight junctions (or they become leaky) Free

PTPs seize the spotlight from RTKs in vasculogenesis Free

PERSPECTIVES

Ribosomes and marrow failure: coincidental association or molecular paradigm? Free

REVIEW IN TRANSLATIONAL HEMATOLOGY

Role of transforming growth factor-β in hematologic malignancies Free

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8+ T-cell responses Free

CLINICAL TRIALS AND OBSERVATIONS

A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481 Free Clinical Trials & Observations

Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of G-CSF and ATRA are not beneficial: results of the MRC AML-HR randomized trial Free Clinical Trials & Observations

Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma Free Clinical Trials & Observations

The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy Free Clinical Trials & Observations

Long-term results and competing risk analysis of the H89 trial in patients with advanced-stage Hodgkin lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte (GELA) Free Clinical Trials & Observations

Splenic marginal zone lymphoma: a prognostic model for clinical use Free Clinical Trials & Observations

Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma Free Clinical Trials & Observations

Eradication of minimal residual disease in hairy cell leukemia Free Clinical Trials & Observations

Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group Free Clinical Trials & Observations

Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24 000 years ago Free Clinical Trials & Observations

GENE THERAPY

Antibody-dependent cellular cytotoxicity (ADCC) is mediated by genetically modified antigen-specific human T lymphocytes Free

HEMATOPOIESIS

The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation Free

Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells Free

The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy Free

Coordination of erythropoiesis by the transcription factor c-Myb Free

False-positive detection of recombinant human erythropoietin in urine following strenuous physical exercise Free Clinical Trials & Observations Brief Report

RETRACTIONS

Erratum for vol. 89, p. 3582 Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Endothelial-cell apoptosis induced by cleaved high-molecular-weight kininogen (HKa) is matrix dependent and requires the generation of reactive oxygen species Free

ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1–independent transmigration Free

Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor Free

Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a –8-kb enhancer Free

Cellular localization and trafficking of tissue factor Free

Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development Free

IMMUNOBIOLOGY

Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals Free

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE) Free

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells Free

Interferons limit inflammatory responses by induction of tristetraprolin Free

Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere Free

Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival Free

Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ Free

Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression Free Clinical Trials & Observations

Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis Free

PKCθ and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes Free

M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice Free

Innate immunity defects in Hermansky-Pudlak type 2 syndrome Free

Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections Free Clinical Trials & Observations

NEOPLASIA

Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia Free Clinical Trials & Observations

Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines Free

A common phosphotyrosine signature for the Bcr-Abl kinase Free

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation Free

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells Free

STAT5 signaling is required for the efficient induction and maintenance of CML in mice Free

Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID Free Clinical Trials & Observations Brief Report

PHAGOCYTES

IL-10–producing macrophages preferentially clear early apoptotic cells Free

E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils Free

Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor Free

TRANSPLANTATION

Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer Free

CORRESPONDENCE

Linkage and mutational analysis of the CDAN1 gene reveals genetic heterogeneity in congenital dyserythropoietic anemia type I Free

Helicobacter pylori, iron deficiency, and gastric autoimmunity Free

Liver therapy in anemia: a motion picture by William P. Murphy Free

The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib) Free

Bevacizumab therapy for POEMS syndrome Free

Reconsidering how we treat severe congenital neutropenia

Two tales of infant leukemia

How did we get here from there?

An anaerobic home for the stem cell proteome

Why target the WT1 gene?

ICAM-2 and PECAM-1: 2 steps in leukocyte transmigration

A package for VWD endothelial cells

Do not Rho tight junctions (or they become leaky)

PTPs seize the spotlight from RTKs in vasculogenesis

Ribosomes and marrow failure: coincidental association or molecular paradigm?

Role of transforming growth factor-β in hematologic malignancies

Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8⁺ T-cell responses

A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481
Clinical Trials & Observations

Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of G-CSF and ATRA are not beneficial: results of the MRC AML-HR randomized trial
Clinical Trials & Observations

Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma
Clinical Trials & Observations

The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy
Clinical Trials & Observations

Long-term results and competing risk analysis of the H89 trial in patients with advanced-stage Hodgkin lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte (GELA)
Clinical Trials & Observations

Splenic marginal zone lymphoma: a prognostic model for clinical use
Clinical Trials & Observations

Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma
Clinical Trials & Observations

Eradication of minimal residual disease in hairy cell leukemia
Clinical Trials & Observations

Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group
Clinical Trials & Observations

Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24 000 years ago
Clinical Trials & Observations

Antibody-dependent cellular cytotoxicity (ADCC) is mediated by genetically modified antigen-specific human T lymphocytes

The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation

Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells

The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy

Coordination of erythropoiesis by the transcription factor c-Myb

False-positive detection of recombinant human erythropoietin in urine following strenuous physical exercise
Clinical Trials & Observations Brief Report

Erratum for vol. 89, p. 3582

Endothelial-cell apoptosis induced by cleaved high-molecular-weight kininogen (HKa) is matrix dependent and requires the generation of reactive oxygen species

ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1–independent transmigration

Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor

Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a –8-kb enhancer

Cellular localization and trafficking of tissue factor

Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development

Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8⁺ T cells

Interferons limit inflammatory responses by induction of tristetraprolin

Use of CD44 by CD4⁺ Th1 and Th2 lymphocytes to roll and adhere

Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival

Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ

Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression
Clinical Trials & Observations

Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis

PKCθ and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3⁺ T lymphocytes

M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice

Innate immunity defects in Hermansky-Pudlak type 2 syndrome

Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections
Clinical Trials & Observations

Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia
Clinical Trials & Observations

Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines

A common phosphotyrosine signature for the Bcr-Abl kinase

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

STAT5 signaling is required for the efficient induction and maintenance of CML in mice

Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID
Clinical Trials & Observations Brief Report

IL-10–producing macrophages preferentially clear early apoptotic cells

E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils

Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X₇ receptor

Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer

Linkage and mutational analysis of the CDAN1 gene reveals genetic heterogeneity in congenital dyserythropoietic anemia type I

Helicobacter pylori, iron deficiency, and gastric autoimmunity

Liver therapy in anemia: a motion picture by William P. Murphy

The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib)

Bevacizumab therapy for POEMS syndrome

Does the serpin PI-9 protect tumor cells?

Does modulation of P-glycoprotein have clinical relevance in pediatric acute myeloid leukemia?