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Journal Articles

Clonal hematopoiesis is clonally unrelated to multiple myeloma and is associated with specific microenvironmental changes

Open Access
Marta Lionetti, Margherita Scopetti, Antonio Matera, Akihiro Maeda, Alessio Marella, Francesca Lazzaroni, Giancarlo Castellano, Sonia Fabris, Stefania Pioggia, Silvia Lonati, Alfredo Marchetti, Alessandra Cattaneo, Marta Tornese, Antonino Neri, Claudia Leoni, Loredana Pettine, Valentina Traini, Ilaria Silvestris, Marzia Barbieri, Giuseppina Fabbiano, Domenica Ronchetti, Elisa Taiana, Claudio De Magistris, Matteo C. Da Vià, Francesco Passamonti, Niccolò Bolli
Journal: Blood
Blood (2025) 146 (5): 571–584.
https://doi.org/10.1182/blood.2024026236
Published: 2025
Includes: Supplemental data
Journal Articles

A phase 1 trial of fully human BCMA CAR-T therapy for relapsed/refractory multiple myeloma with 5-year follow-up

Available to Purchase
Clinical Trials & Observations
Sherilyn A. Tuazon, Andrew J. Portuguese, Margot J. Pont, Andrew J. Cowan, Gabriel O. Cole, Blythe D. Sather, Xiaoling Song, Sushma Thomas, Brent L. Wood, Michelle Blake, Melissa G. Works, Mazyar Shadman, Emily C. Liang, Qian V. Wu, Jenna M. Voutsinas, Ted A. Gooley, Cameron J. Turtle, Brian G. Till, David G. Coffey, David G. Maloney, Stanley R. Riddell, Damian J. Green
Journal: Blood
Blood (2025) 146 (5): 535–545.
https://doi.org/10.1182/blood.2024027681
Published: 2025
Includes: Supplemental data
Journal Articles

NKG2D-mediated cytotoxicity of CD4 cytotoxic T cells in multiple myeloma

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Sojeong Kim, Jeong-Eun Kwak, June-Young Koh, Ji Eun Lee, Hye Won Kook, Minchae Kim, Haerim Chung, Yu Ri Kim, Soo Jeong Kim, Jin Seok Kim, June-Won Cheong, Min Goo Lee, Hoyoung Lee, Su-Hyung Park, Eui-Cheol Shin, Saeam Shin, Sun Och Yoon, Il-Kyu Choi, Jeong Seok Lee, Hyunsoo Cho
Journal: Blood
Blood (2025) 146 (4): 456–470.
https://doi.org/10.1182/blood.2024025875
Published: 2025
Includes: Supplemental data
Journal Articles

Genetic and epigenetic mechanisms of GPRC5D loss after anti-GPRC5D CAR T-cell therapy in multiple myeloma

Available to Purchase
Sha Ma, Jieyun Xia, Miao Zhang, Wenyu Li, Meng Xiao, Yuqian Sha, Wenya Wang, Jianteng Zhou, Ying Wang, Kunming Qi, Chunling Fu, Zengtian Sun, Dian Zhou, Qian Sun, Tingting Qiu, Zhiling Yan, Feng Zhu, Wei Chen, Hai Cheng, Wei Sang, Jiang Cao, Depeng Li, Zhenyu Li, Mariateresa Fulciniti, Yao Yao, Kailin Xu, Mingshan Niu
Journal: Blood
Blood (2025) 146 (2): 178–190.
https://doi.org/10.1182/blood.2024026622
Published: 2025
Includes: Supplemental data
Journal Articles

Standard-of-care idecabtagene vicleucel for relapsed/refractory multiple myeloma

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Clinical Trials & Observations
Surbhi Sidana, Nausheen Ahmed, Othman Salim Akhtar, Ruta Brazauskas, Temitope Oloyede, Matthew Bye, Doris Hansen, Christopher Ferreri, Ciara L. Freeman, Aimaz Afrough, Larry D. Anderson, Jr, Binod Dhakal, Devender Dhanda, Lohith Gowda, Hamza Hashmi, Melanie J. Harrison, Amani Kitali, Heather Landau, Abu-Sayeef Mirza, Pallavi Patwardhan, Muzaffar Qazilbash, Saad Usmani, Krina Patel, Taiga Nishihori, Siddhartha Ganguly, Marcelo C. Pasquini
Journal: Blood
Blood (2025) 146 (2): 167–177.
https://doi.org/10.1182/blood.2024026216
Published: 2025
Includes: Supplemental data
Journal Articles

Loss of BCL7A permits IRF4 transcriptional activity and cellular growth in multiple myeloma

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Chandraditya Chakraborty, Srikanth Talluri, Moritz Binder, Eugenio Morelli, Jessica Encinas Mayoral, Sanika Derebail, Anil Aktas Samur, Charles Epstein, Kenneth C. Anderson, Masood Shammas, Mehmet K. Samur, Mariateresa Fulciniti, Nikhil C. Munshi
Journal: Blood
Blood (2025) 146 (1): 104–114.
https://doi.org/10.1182/blood.2024026588
Published: 2025
Includes: Supplemental data
Journal Articles

Isatuximab, carfilzomib, lenalidomide, and dexamethasone induction in newly diagnosed myeloma: analysis of the MIDAS trial

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Clinical Trials & Observations
Aurore Perrot, Cyrille Touzeau, Jerome Lambert, Cyrille Hulin, Denis Caillot, Lionel Karlin, Bertrand Arnulf, Philippe Rey, Laurent Garderet, Margaret Macro, Martine Escoffre Barbe, Julie Gay, Thomas Chalopin, Romain Gounot, Jean-Marc Schiano, Mourad Tiab, Mohamad Mohty, Frederique Kuhnowski, Jean Fontan, Salomon Manier, Frederique Orsini-Piocelle, Laure Vincent, Sophie Rigaudeau, Xavier Leleu, Benjamin Hebraud, Laurent Flet, Jean-Valere Malfuson, Caroline Jacquet, Driss Chaoui, Nathalie Meuleman, Wajed Abarah, Lydia Montes, Riad Benramdane, Cecile Sonntag, Hacene Zerazhi, Alina Danu, Olivier Allangba, Mamoun Dib, Murielle Roussel, Sophie Cereja, Julien Depaus, Nicolas Branche, Helene Demarquette, Valentine Richez, Brieuc Cherel, Laurent Frenzel, Marie-Christiane Vekemans, Noemie Bigot, Herve Avet-Loiseau, Jill Corre, Philippe Moreau
Journal: Blood
Blood (2025) 146 (1): 52–61.
https://doi.org/10.1182/blood.2024026230
Published: 2025
Journal Articles

Large-scale dependency and drug screens to characterize the therapeutic vulnerabilities of multiple myeloma with 1q+

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Romanos Sklavenitis-Pistofidis, Elizabeth D. Lightbody, Mairead Reidy, Junko Tsuji, Jean-Baptiste Alberge, Michelle P. Aranha, Daniel Heilpern-Mallory, Harvey G. Roweth, Daisy Huynh, Stephen J. F. Chong, Anna Y. Chung, Jeremy Zhang, Liam Hackett, Nicholas J. Haradhvala, Ting Wu, Nang K. Su, Brianna Berrios, Saveliy Belkin, Ankit K. Dutta, Ryan A. Knudson, Carolyn Brandt, Patricia T. Greipp, Matthew S. Davids, Maria Papaioannou, Gad Getz, Irene M. Ghobrial, Salomon Manier
Journal: Blood
Blood (2025) 146 (1): 89–103.
https://doi.org/10.1182/blood.2024025102
Published: 2025
Includes: Supplemental data
Journal Articles

Aberrant single-cell phenotype and clinical implications of genotypically defined polyclonal plasma cells in myeloma

Open Access
Matteo Claudio Da Vià, Francesca Lazzaroni, Antonio Matera, Alessio Marella, Akihiro Maeda, Claudio De Magistris, Loredana Pettine, Antonio Giovanni Solimando, Vanessa Desantis, Giuseppe M. Peretti, Laura Mangiavini, Riccardo Giorgino, Sonia Fabris, Stefania Pioggia, Alfredo Marchetti, Marzia Barbieri, Silvia Lonati, Alessandra Cattaneo, Marta Tornese, Margherita Scopetti, Emanuele Calvi, Nayyer Latifinavid, Giancarlo Castellano, Federica Torricelli, Antonino Neri, Cathelijne Fokkema, Tom Cupedo, Marta Lionetti, Francesco Passamonti, Niccolò Bolli
Journal: Blood
Blood (2025) 145 (26): 3124–3138.
https://doi.org/10.1182/blood.2024025643
Published: 2025
Includes: Supplemental data
Journal Articles

The bone marrow NK-cell profile predicts MRD negativity in patients with multiple myeloma treated with daratumumab-based therapy

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Clinical Trials & Observations Brief Report
Charlotte L. B. M. Korst, Sabrin Tahri, Carolien Duetz, Wassilis S. C. Bruins, A. Vera de Jonge, Madelon E. de Jong, Cathelijne Fokkema, Febe Smits, Kaz Groen, Christie P. M. Verkleij, Kristine A. Frerichs, Natalie Papazian, Mark van Duin, Gregory van Beek, Remco Hoogenboezem, Thomas Baardemans, Giada Dal Collo, Elodie C. G. Stoetman, Meliha Cosovic, Inoka Twickler, Rosa Rentenaar, Merve Eken, Paola M. Homan-Weert, Elona Saraci, Mattia D’Agostino, Vincent H. J. van der Velden, Mathijs A. Sanders, Francesca Gay, Annemiek Broijl, Philippe Moreau, Pieter Sonneveld, Sonja Zweegman, Tuna Mutis, Tom Cupedo, Niels W. C. J. van de Donk
Journal: Blood
Blood (2025) 145 (25): 3007–3014.
https://doi.org/10.1182/blood.2024026455
Published: 2025
Includes: Supplemental data
Journal Articles

Targeting caseinolytic mitochondrial matrix peptidase, a novel contributor to the pathobiology of high-risk multiple myeloma

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Li Qin, Luz Yurany Moreno Rueda, Upasana Ray, Iqbal Mahmud, Lin Tan, Philip L. Lorenzi, Suyu Liu, Heather Lin, David E. Mery, Fenghuang Zhan, John D. Shaughnessy, Jr., Qing Yi, Maria Jose Acevedo Calado, Hua Wang, Elisabet E. Manasanch, Hans C. Lee, Krina K. Patel, Isere Kuiatse, David E. Symer, Robert Z. Orlowski
Journal: Blood
Blood (2025) 145 (22): 2614–2629.
https://doi.org/10.1182/blood.2024024781
Published: 2025
Includes: Supplemental data
Journal Articles

Evaluating the impact of CRBN mutations on response to immunomodulatory drugs and novel cereblon E3 ligase modulators in myeloma

Open Access
Yakinthi Chrisochoidou, Andrea Scarpino, Salomon Morales, Shannon Martin, Sarah Bird, Yigen Li, Brian Walker, John Caldwell, Yann-Vaï Le Bihan, Charlotte Pawlyn
Journal: Blood
Blood (2025) 145 (22): 2630–2644.
https://doi.org/10.1182/blood.2024025861
Published: 2025
Includes: Supplemental data
Journal Articles

Classic hairy cell leukemia and concomitant smoldering myeloma

Free
Husam Jum’ah, David Viswanatha
Journal: Blood
Blood (2025) 145 (21): 2533.
https://doi.org/10.1182/blood.2025028465
Published: 2025
Journal Articles

Sustained bone marrow and imaging MRD negativity for 3 years drives discontinuation of maintenance post-ASCT in myeloma

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CME Clinical Trials & Observations
Evangelos Terpos, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Ioannis V. Kostopoulos, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Vasiliki Spiliopoulou, Magdalini Migkou, Despina Fotiou, Foteini Theodorakakou, Efstathios Kastritis, Maria Gavriatopoulou, Ourania E. Tsitsilonis, Meletios-Athanasios Dimopoulos
Journal: Blood
Blood (2025) 145 (20): 2353–2360.
https://doi.org/10.1182/blood.2024027686
Published: 2025
Journal Articles

Myelodysplastic neoplasm with biallelic TP53 inactivation in a patient with plasma cell myeloma after cytotoxic therapy

Free
Rong He, Dong Chen
Journal: Blood
Blood (2025) 145 (19): 2230.
https://doi.org/10.1182/blood.2024028288
Published: 2025
Journal Articles

Targeting Enterobacter cloacae attenuates osteolysis by reducing ammonium in multiple myeloma

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Qin Yang, Yinghong Zhu, Xingxing Jian, Yi Qiu, Yan Zhu, Lia Zhao, Yanjuan He, Gang An, Lugui Qiu, Jiaojiao Guo, Nihan He, Huerxidan Abudumijiti, Cong Hu, Xun Chen, Siqing Huang, Xiangling Feng, Xin Li, Jing Liu, Yajing Xu, Wen Zhou
Journal: Blood
Blood (2025) 145 (17): 1876–1889.
https://doi.org/10.1182/blood.2024025694
Published: 2025
Includes: Supplemental data
Journal Articles

Salvage autologous transplant in relapsed multiple myeloma: long-term follow-up of the phase 3 GMMG ReLApsE trial

Open Access
Clinical Trials & Observations Brief Report
Marc-Andrea Baertsch, Jana Schlenzka, Thomas Hielscher, Marc S. Raab, Sandra Sauer, Maximilian Merz, Elias Karl Mai, Carsten Müller-Tidow, Steffen Luntz, Anna Jauch, Peter Brossart, Martin Goerner, Stefan Klein, Bertram Glass, Peter Reimer, Ullrich Graeven, Roland Fenk, Mathias Haenel, Ivana von Metzler, Hans W. Lindemann, Christof Scheid, Igor-Wolfgang Blau, Hans J. Salwender, Richard Noppeney, Britta Besemer, Katja C. Weisel, Hartmut Goldschmidt
Journal: Blood
Blood (2025) 145 (16): 1780–1787.
https://doi.org/10.1182/blood.2024027342
Published: 2025
Includes: Supplemental data
Journal Articles

Tumor burden quantified by soluble B-cell maturation antigen and metabolic tumor volume determines myeloma CAR-T outcomes

Available to Purchase
Ciara L. Freeman, Jerald Noble, Meghan Menges, Ricardo Villanueva, Justyn Y. Nakashima, Nicholas B. Figura, Rolf Petter Tonseth, Dietrich Werner Idiaquez, Lawrence Skelson, Eric Smith, Julieta Abraham-Miranda, Salvatore Corallo, Gabriel De Avila, Omar A. Castaneda Puglianini, Hien Liu, Melissa Alsina, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Brandon Blue, Ariel Grajales-Cruz, John M. Koomen, Reginald M. Atkins, Doris K. Hansen, Ariosto S. Silva, Jongphil Kim, Yoganand Balagurunathan, Frederick L. Locke
Journal: Blood
Blood (2025) 145 (15): 1645–1657.
https://doi.org/10.1182/blood.2024024965
Published: 2025
Includes: Supplemental data
Journal Articles

Efficacy and safety of daratumumab in intermediate/high-risk smoldering multiple myeloma: final analysis of CENTAURUS

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Clinical Trials & Observations
Ola Landgren, Ajai Chari, Yael C. Cohen, Andrew Spencer, Peter M. Voorhees, Irwindeep Sandhu, Matthew W. Jenner, Dean Smith, Michele Cavo, Niels W. C. J. van de Donk, Meral Beksac, Philippe Moreau, Hartmut Goldschmidt, Diego Vieyra, Linlin Sha, Liang Li, Els Rousseau, Robyn Dennis, Robin Carson, Craig C. Hofmeister
Journal: Blood
Blood (2025) 145 (15): 1658–1669.
https://doi.org/10.1182/blood.2024025897
Published: 2025
Includes: Supplemental data
Journal Articles

The ADAR1-regulated cytoplasmic dsRNA-sensing pathway is a novel mechanism of lenalidomide resistance in multiple myeloma

Open Access
Mun Yee Koh, Tae-Hoon Chung, Nicole Xin Ning Tang, Sabrina Hui Min Toh, Jianbiao Zhou, Tze King Tan, Leilei Chen, Wee Joo Chng, Phaik Ju Teoh
Journal: Blood
Blood (2025) 145 (11): 1164–1181.
https://doi.org/10.1182/blood.2024024429
Published: 2025
Includes: Supplemental data