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Journal Articles

Targeting of tumor antigen CD38 and stress antigens MICA/B by CAR T cells provides a unique approach for the comprehensive treatment of multiple myeloma

Free
Soheila Shirinbak, Shilpi Chandra, Brian Groff, Samad Ibitokou, Spas Markov, John Reiser, Bryan Hancock, Tom Daily, Alma Gutierrez, Miguel Meza, Tom Lee, Betsy Rezner, Ramzey Abujarour, Raedun Clarke, John Goulding, Karl-Johan Malmberg, Maksim Mamonkin, Kai Wucherpfennig, Bahram Valamehr, Jode Goodridge, Alex Garcia, Martin Hosking
Journal: Blood
Blood (2025) 146 (Supplement 1): 2350.
https://doi.org/10.1182/blood-2025-2350
Published: 2025
Journal Articles

Development of next generation multi-antigen targeting off-the-shelf CAR T cells for conditioning-free treatment of B-cell lymphoma

Free
Shilpi Chandra, John Reiser, Brian Groff, Carissa Dege, Bryan Hancock, Alison O'Connor, Alma Gutierrez, Angela Gentile, Tom Lee, Ramzey Abujarour, Raedun Clarke, Betsy Rezner, John Goulding, Jode Goodridge, Karl-Johan Malmberg, Maksim Mamonkin, Bahram Valamehr, Alex Garcia, Martin Hosking
Journal: Blood
Blood (2025) 146 (Supplement 1): 4121.
https://doi.org/10.1182/blood-2025-4121
Published: 2025
Journal Articles

The development of FT839: An off-the-shelf CD19xCD38 dual-CAR T cell for the treatment of multiple myeloma

Free
Spas Markov, John Reiser, Brian Groff, Shilpi Chandra, Soheila Shirinbak, Carissa Dege, Bryan Hancock, Dan Lu, Alma Gutierrez, Angela Gentile, Tom Lee, Ramzey Abujarour, Betsy Rezner, John Goulding, Karl-Johan Malmberg, Maksim Mamonkin, Bahram Valamehr, Jode Goodridge, Martin Hosking, Alex Garcia
Journal: Blood
Blood (2025) 146 (Supplement 1): 7631.
https://doi.org/10.1182/blood-2025-7631
Published: 2025
Journal Articles

The development of an off-the-shelf CAR T-cell therapy co-targeting CD19 and CD38 for broad application in autoimmune disease

Free
Mark Jelcic, Daniel Morales-Mantilla, John Reiser, Brian Groff, Alma Gutierrez, Rina Ngalame, Alan Williams, Carissa Dege, Shilpi Chandra, Spas Markov, Soheila Shirinbak, Bjoern Gaertner, Mochtar Pribadi, Karina Palomares, Loraine Campanati, Amanda Yzaguirre, Stephanie Kennedy, Angela Macia, Alison O'Connor, Bryan Hancock, Pei-Fang Tsai, Ramzey Abujarour, Tom Lee, Raedun Clarke, Karl-Johan Malmberg, Maksim Mamonkin, Bahram Valamehr, Vaneet Sandhu, Alex Garcia, Martin Hosking, John Goulding, Jode Goodridge
Journal: Blood
Blood (2025) 146 (Supplement 1): 5895.
https://doi.org/10.1182/blood-2025-5895
Published: 2025
Journal Articles

Alloimmune Defense Receptor Combined with Genetic Ablation of Adhesion Ligand CD58 Is a Comprehensive Approach to Promote Functional Persistence of Allogeneic Cell Therapies without Conditioning Chemotherapy

Free
Alan Williams, Rina Mbofung, Daniel Morales-Mantilla, Brian Groff, Alison O'Connor, Binzhong Li, Ramesh Janani, Betsy Rezner, Mark Jelcic, Yijia Pan, Tom Lee, Karl-Johan Malmberg, Maksim Mamonkin, John Goulding, Jode Goodridge, Bahram Valamehr
Journal: Blood
Blood (2024) 144 (Supplement 1): 503.
https://doi.org/10.1182/blood-2024-210846
Published: 2024
Journal Articles

Next-Generation Off-the-Shelf CAR T-Cell Therapy Developed to Eliminate a Broad Spectrum of Pathogenic Cells in Hematological Diseases in the Absence of Conditioning Chemotherapy

Free
John Goulding, Mark Jelcic, Daniel Morales-Mantilla, John Reiser, Alison O'Connor, Rina Mbofung, Alan Williams, Dan Lu, Bi-Huei Yang, Alma Gutierrez, Miguel Meza, Yijia Pan, Jonatan Tuncel, Bryan Hancock, Sean Sherman, Alec Witty, Eigen Peralta, Martin Hosking, Lilly Wong, Tom Lee, Jode Goodridge, Bahram Valamehr
Journal: Blood
Blood (2024) 144 (Supplement 1): 4801.
https://doi.org/10.1182/blood-2024-209465
Published: 2024
Journal Articles

Development of Induced Pluripotent Stem Cell-Derived T Cells Exhibiting Phenotypic and Functional Attributes of Primary CAR T Cells

Free
Bryan Hancock, Jonatan Tuncel, Kyla Omilusik, Alison O'Connor, Bi-Huei Yang, Matthew Haynes, Amanda Yzaguirre, Karina Palomares, Sandeep Kothapally Hanok, Matthew Denholtz, Martin Hosking, Eigen Peralta, Tom Lee, Raedun Clarke, Sjoukje Van Der Stegen, John Goulding, Jode Goodridge, Michel Sadelain, Bahram Valamehr
Journal: Blood
Blood (2024) 144 (Supplement 1): 3474.
https://doi.org/10.1182/blood-2024-210786
Published: 2024
Journal Articles

Multi-Antigen Targeting By Novel Combination of CAR-T Cells and hnCD16 Transgene, Yields in Complete Tumor Clearance Via Antibody Dependent Cellular Cytotoxicity

Free
Soheila Shirinbak, Joy Grant, Wen-I Yeh, Angela Gentile, Bishwas Shrestha, Bi-Huei Yang, Mochtar Pribadi, Shohreh Sikaroodi, Amit Mehta, Amanda D Yzaguirre, Yijia Pan, Chia-Wei Chang, Tom Lee, Layton Smith, Jianming Wu, Bruce Walcheck, Martin Hosking, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 10253–10254.
https://doi.org/10.1182/blood-2022-169462
Published: 2022
Journal Articles

A CD3 Fusion Receptor (CD3-FR) Uniquely Enables Compatibility of Allogeneic CAR-T and -NK Cells with T Cell Engagers to Enhance Antitumor Function and Limit Antigen Escape

Free
Eigen Peralta, Dan Lu, Mark Landon, Hui-yi Chu, Soo Park, Masanao Tsuda, Trevor Zarecki, Elena Demeester, Matthew Denholtz, Amit Mehta, Earl Avramis, Philip Chu, Jeffrey Chen, Eric Sung, Alec Witty, Tom Lee, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 7429–7430.
https://doi.org/10.1182/blood-2022-169887
Published: 2022
Journal Articles

Combined Genetic Ablation of CD54 and CD58 in CAR Engineered Cytotoxic Lymphocytes Effectively Averts Allogeneic Immune Cell Rejection

Free
Quirin Hammer, Karlo Perica, Rina M Mbofung, Hanna van Ooijen, Erika Varady, Mark Jelcic, Yijia Pan, Pouria Momayyezi, Brian Groff, Ramzey Abujarour, Silje Zandstra Krokeide, Tom Lee, Alan M Williams, Jode P Goodridge, Bahram Valamehr, Bjorn Onfelt, Michel Sadelain, Karl-Johan Malmberg
Journal: Blood
Blood (2022) 140 (Supplement 1): 1165–1166.
https://doi.org/10.1182/blood-2022-163086
Published: 2022
Journal Articles

Alloimmune Defense Receptor Harnesses Host Immune Cell Activation to Potentiate Functional Persistence and Anti-Tumor Activity of Off-the-Shelf, Cell-Based Cancer Therapy

Free
Alan M Williams, Ken L Hayama, Yijia Pan, Brian Groff, Rina M Mbofung, Amber Chang, Christine Chen, Lauren Fong, Nicholas Brookhouser, Berhan Mandefro, Ramzey Abujarour, Tom Lee, Maksim Mamonkin, Raedun Clarke, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 4547–4548.
https://doi.org/10.1182/blood-2022-167139
Published: 2022
Journal Articles

iPSC-Derived CD38-Null NK Cells in Combination with CD38-Targeted Antibody: A Dual Therapeutic Strategy to Enable ADCC and Eliminate Host Immune Cells in Multiple Myeloma

Free
Rina M Mbofung, Xingyue Zong, Erika Varady, Alan M Williams, Ken L Hayama, Yijia Pan, Sushil Devkota, Brian Groff, Miguel Meza, Thomas Dailey, Tom Lee, Lilly Wong, Sarah Cooley, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 7388–7389.
https://doi.org/10.1182/blood-2022-169817
Published: 2022
Journal Articles

Arming of iPSC-Derived NK Cells Expressing a Novel CD64 Fusion Receptor with Therapeutic Antibodies Represents a Novel Off-the-Shelf, Antigen-Targeting Strategy for Cancer

Free
Kate Dixon, Kristin Snyder, Melissa Khaw, Robert Hullsiek, Zachary Davis, Tom Lee, Hui-yi Chu, Paul Rogers, Ryan Bjordahl, Martin Hosking, Soheila Shirinbak, Jeffrey S. Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck
Journal: Blood
Blood (2021) 138 (Supplement 1): 406.
https://doi.org/10.1182/blood-2021-148642
Published: 2021
Journal Articles

Off-the-Shelf, Multiplexed-Engineered iPSC-Derived NK Cells Mediate Potent Multi-Antigen Targeting of B-Cell Malignancies with Reduced Cytotoxicity Against Healthy B Cells

Free
Frank Cichocki, Jode P Goodridge, Ryan Bjordahl, Svetlana Gaidarova, Sajid Mahmood, Ramzey Abujarour, Zachary Davis, Hongbo Wang, Katie Tuininga, Behiye Kodal, Martin Felices, Paul Rogers, Greg Bonello, Janel Huffman, Thomas Dailey, Tom Lee, Peter Szabo, Lilly Wong, Sarah Cooley, Bahram Valamehr, Jeffrey S. Miller
Journal: Blood
Blood (2021) 138 (Supplement 1): 407.
https://doi.org/10.1182/blood-2021-148654
Published: 2021
Journal Articles

Clinical Manufacture of FT819: Use of a Clonal Multiplexed-Engineered Master Induced Pluripotent Stem Cell Line to Mass Produce Off-the-Shelf CAR T-Cell Therapy

Free
Xu Yuan, Raedun Clarke, Yi-Shin Lai, Chia-Wei Chang, Bi-Huei Yang, Gloria Hsia, Ramzey Abujarour, Tom Lee, Sjoukje van der Stegen, Helena Shaked, Abubakar Jalloh, Stephanie Moreno, Jason ORourke, Eric Sung, Alma Gutierrez, Betsy Rezner, Meghan Eberhart, Rebecca Magdaleno, Xiuyan Wang, Brigitte Senechal, Devanjan S. Sikder, Dell Farnan, Mark Plavsic, Jerome Bressi, Isabelle Rivière, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 1766.
https://doi.org/10.1182/blood-2021-152985
Published: 2021
Journal Articles

Dual Chimeric Antigen Receptor Approach Combining Novel Tumor Targeting Strategies Circumvents Antigen Escape in Multiple Myeloma

Free
John Reiser, Ketan Mathavan, Sajid Mahmood, Yijia Pan, Bryan Hancock, Robert Blum, Wen-I Yeh, Andrew Houk, Chia-Wei Chang, Tom Lee, Uta Hopken, John Goulding, Armin Rehm, Kai W. Wucherpfennig, Jode P Goodridge, Ryan Bjordahl, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 1718.
https://doi.org/10.1182/blood-2021-154025
Published: 2021
Journal Articles

Combination of Three Unique Anti-Tumor Modalities Engineered into iPSC-Derived T Cells Demonstrate a Synergistic Effect in Overcoming Tumor Heterogeneity and Cancer Escape

Free
Bi-Huei Yang, Yu-Sheng Eason Lin, Soheila Shirinbak, Wen-I Yeh, Mochtar Pribadi, Hui-Yi Chu, Alma Gutierrez, Amit Mehta, Earl Avramis, Roseanna Petrovic, Benjamin Whitlock, Jason ORourke, Sjoukje van der Stegen, Tom Lee, Alec Witty, Eigen Peralta, Martin Hosking, Chia-Wei Chang, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 2793.
https://doi.org/10.1182/blood-2021-153268
Published: 2021
Journal Articles

Off-the-Shelf, iPSC-Derived CAR-NK Cells Multiplexed-Engineered for the Avoidance of Allogeneic Host Immune Cell Rejection

Free
Rina M Mbofung, Alan M Williams, Ken Hayama, Yijia Pan, Brian Groff, Thomas Dailey, Sonia Reyes, Sajid Mahmood, Ketan Mathavan, Greg Bonello, Quirin Hammer, Karl-Johan Malmberg, Tom Lee, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 2795.
https://doi.org/10.1182/blood-2021-153484
Published: 2021
Journal Articles

A Novel Stealth Strategy That Activates Adoptively Transferred Allogeneic Immune Cells and Avoids Rejection for Off-the-Shelf Cell-Based Cancer Therapy

Free
Alan M Williams, Ken Hayama, Yijia Pan, Brian Groff, Rina M Mbofung, Lauren Fong, Nicholas Brookhouser, Berhan Mandefro, Ramzey Abujarour, Tom Lee, Quirin Hammer, Karl-Johan Malmberg, Maksim Mamonkin, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 4800.
https://doi.org/10.1182/blood-2021-153614
Published: 2021
Journal Articles

Triple Gene-Modified iPSC-Derived NK Cells Combined with Daratumumab for Targeted Immunotherapy Against AML

Free
Frank Cichocki, PhD, Ryan Bjordahl, PhD, Karrune Woan, MD PhD, Zachary Davis, PhD BS, Greg Bonello, Sajid Mahmood, PhD, Paul Rogers, PhD, Moyar Q. Ge, PhD, Tom Lee, PhD, Martin Felices, PhD, Bruce Walcheck, PhD, Bruce R. Blazar, MD, Bahram Valamehr, PhD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 57–58.
https://doi.org/10.1182/blood-2020-137138
Published: 2020