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Bruce Walcheck
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Journal Articles

Dual antigen–targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia

Free
Frank Cichocki, Jodie P. Goodridge, Ryan Bjordahl, Sajid Mahmood, Zachary B. Davis, Svetlana Gaidarova, Ramzey Abujarour, Brian Groff, Alec Witty, Hongbo Wang, Katie Tuininga, Behiye Kodal, Martin Felices, Greg Bonello, Janel Huffman, Thomas Dailey, Tom T. Lee, Bruce Walcheck, Bahram Valamehr, Jeffrey S. Miller
Journal: Blood
Blood (2022) 140 (23): 2451–2462.
https://doi.org/10.1182/blood.2021015184
Published: 2022
Includes: Supplemental data
Journal Articles

Multi-Antigen Targeting By Novel Combination of CAR-T Cells and hnCD16 Transgene, Yields in Complete Tumor Clearance Via Antibody Dependent Cellular Cytotoxicity

Free
Soheila Shirinbak, Joy Grant, Wen-I Yeh, Angela Gentile, Bishwas Shrestha, Bi-Huei Yang, Mochtar Pribadi, Shohreh Sikaroodi, Amit Mehta, Amanda D Yzaguirre, Yijia Pan, Chia-Wei Chang, Tom Lee, Layton Smith, Jianming Wu, Bruce Walcheck, Martin Hosking, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 10253–10254.
https://doi.org/10.1182/blood-2022-169462
Published: 2022
Journal Articles

Arming of iPSC-Derived NK Cells Expressing a Novel CD64 Fusion Receptor with Therapeutic Antibodies Represents a Novel Off-the-Shelf, Antigen-Targeting Strategy for Cancer

Free
Kate Dixon, Kristin Snyder, Melissa Khaw, Robert Hullsiek, Zachary Davis, Tom Lee, Hui-yi Chu, Paul Rogers, Ryan Bjordahl, Martin Hosking, Soheila Shirinbak, Jeffrey S. Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck
Journal: Blood
Blood (2021) 138 (Supplement 1): 406.
https://doi.org/10.1182/blood-2021-148642
Published: 2021
Journal Articles

Engineered iPSC-Derived NK Cells Expressing Recombinant CD64 for Enhanced ADCC

Free
Kate Dixon, PhD, Robert Hullsiek, Kristin Snyder, Zachary Davis, PhD BS, Melissa Khaw, Tom Lee, PhD, Hui-Yi Chu, PhD, Ramzey Abujarour, PhD, Jason Dinella, PhD, Paul Rogers, PhD, Ryan Bjordahl, PhD, Jeffrey S. Miller, MD, Bahram Valamehr, PhD, Jianming Wu, PhD, Bruce Walcheck, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-139760
Published: 2020
Journal Articles

Triple Gene-Modified iPSC-Derived NK Cells Combined with Daratumumab for Targeted Immunotherapy Against AML

Free
Frank Cichocki, PhD, Ryan Bjordahl, PhD, Karrune Woan, MD PhD, Zachary Davis, PhD BS, Greg Bonello, Sajid Mahmood, PhD, Paul Rogers, PhD, Moyar Q. Ge, PhD, Tom Lee, PhD, Martin Felices, PhD, Bruce Walcheck, PhD, Bruce R. Blazar, MD, Bahram Valamehr, PhD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 57–58.
https://doi.org/10.1182/blood-2020-137138
Published: 2020
Journal Articles

FT576: Multi-Specific Off-the-Shelf CAR-NK Cell Therapy Engineered for Enhanced Persistence, Avoidance of Self-Fratricide and Optimized Mab Combination Therapy to Prevent Antigenic Escape and Elicit a Deep and Durable Response in Multiple Myeloma

Free
Jode P Goodridge, PhD, Ryan Bjordahl, PhD, Sajid Mahmood, PhD, John Reiser, PhD, Svetlana Gaidarova, MS, Robert Blum, MS, Frank Cichocki, PhD, Hui-yi Chu, PhD, Greg Bonello, PhD, Tom Lee, PhD, Brian Groff, Miguel Meza, BS, Yu-Waye Chu, MD, Bruce Walcheck, PhD, Karl-Johan Malmberg, MD PhD, Jeffrey S. Miller, MD, Armin Rehm, Uta Hopken, Bahram Valamehr, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-142750
Published: 2020
Journal Articles

Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Free
Huang Zhu, Robert H. Blum, Ryan Bjordahl, Svetlana Gaidarova, Paul Rogers, Tom Tong Lee, Ramzey Abujarour, Gregory B. Bonello, Jianming Wu, Pei-Fang Tsai, Jeffrey S. Miller, Bruce Walcheck, Bahram Valamehr, Dan S. Kaufman
Journal: Blood
Blood (2020) 135 (6): 399–410.
https://doi.org/10.1182/blood.2019000621
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies

Free
Jode P Goodridge, PhD, Sajid Mahmood, PhD, Huang Zhu, PhD, Svetlana Gaidarova, MS, Robert Blum, Ryan Bjordahl, PhD, Frank Cichocki, PhD, Hui-yi Chu, PhD, Greg Bonello, PhD, Tom Lee, PhD, Brian Groff, Miguel Meza, BS, Bruce Walcheck, PhD, Karl-Johan Malmberg, MD PhD, Jeffrey S. Miller, MD, Dan S Kaufman, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 301.
https://doi.org/10.1182/blood-2019-129319
Published: 2019
Journal Articles

Off-the-Shelf Natural Killer Cells with Multi-Functional Engineering Using a Novel Anti-CD19 Chimeric Antigen Receptor Combined with Stabilized CD16 and IL15 Expression to Enhance Directed Anti-Tumor Activity

Free
Dan S Kaufman, MD PhD, Ryan Bjordahl, PhD, Huang Zhu, PhD, Robert Blum, Andres Bahena, Sajid Mahmood, PhD, Greg Bonello, PhD, Tom Lee, PhD, Bruce Walcheck, PhD, Frank Cichocki, PhD, Jeffrey S. Miller, MD, Bahram Valamehr, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4541.
https://doi.org/10.1182/blood-2018-99-113701
Published: 2018
Journal Articles

Genetically Engineered Pluripotent Cell-Derived Natural Killer Cell Therapy Provides Enhanced Antibody Dependent Cellular Cytotoxicity Against Hematologic Malignancies and Solid Tumors in Combination with Monoclonal Antibody Therapy

Free
Huang Zhu, PhD, Ryan Bjordahl, PhD, Svetlana Gaidarova, Paul Rogers, Robert Blum, Dan Kaufman, MD, Bruce Walcheck, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4452.
https://doi.org/10.1182/blood.V130.Suppl_1.4452.4452
Published: 2017
Journal Articles

Engineering Human Pluripotent Stem Cell-Derived Natural Killer Cells to Prevent CD16a Shedding for Enhanced Anti-Tumor Killing

Free
Robert Blum, MS, Aadithya Arumugam, PhD, Jianming Wu, DVM, PhD, Bruce Walcheck, PhD, Dan Kaufman, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1336.
https://doi.org/10.1182/blood.V128.22.1336.1336
Published: 2016
Journal Articles

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

Free
Rizwan Romee, Bree Foley, Todd Lenvik, Yue Wang, Bin Zhang, Dave Ankarlo, Xianghua Luo, Sarah Cooley, Mike Verneris, Bruce Walcheck, Jeffrey Miller
Journal: Blood
Blood (2013) 121 (18): 3599–3608.
https://doi.org/10.1182/blood-2012-04-425397
Published: 2013
Includes: Supplemental data
Journal Articles

ADAM17, a Novel Metalloproteinase, Mediates CD16 and CD62L Shedding in Human NK Cells and Modulates IFNγ Responses

Free
Rizwan Romee, MD, Todd Lenvik, Yue Wang, Bruce Walcheck, Michael R Verneris, MD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2011) 118 (21): 2184.
https://doi.org/10.1182/blood.V118.21.2184.2184
Published: 2011
Journal Articles

ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding

Free
Ying Li, Jennifer Brazzell, Amy Herrera, Bruce Walcheck
Journal: Blood
Blood (2006) 108 (7): 2275–2279.
https://doi.org/10.1182/blood-2006-02-005827
Published: 2006
Journal Articles

The monoclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialyl-Lewis x, which is a functional glycan ligand for P-selectin

Free
Bruce Walcheck, Anne Leppanen, Richard D. Cummings, Randall N. Knibbs, Lloyd M. Stoolman, Shelia R. Alexander, Polly E. Mattila, Rodger P. McEver
Journal: Blood
Blood (2002) 99 (11): 4063–4069.
https://doi.org/10.1182/blood-2001-12-0265
Published: 2002