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Journal Articles

A Novel Selective BCL2 Inhibitor with Limited Immune Suppression and Improved Safety Compared to Venetoclax

Free
Chia Sharpe, Sara Elgamal, Sydney Fobare, Casie Furby, Marissa Long, Kinsey Bryant, Carolyn Cheney, James R. Lerma, Megan E. Johnstone, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Volodymyr Kysil, Hovhannes Gukasyan, Oleg Mitkin, Ruben Karapetian, Alexey Ryakhovskiy, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Kate Dokukina, Alexei Pushechnikov, Nikolay Savchuk, Iain Dukes, Amy Burd, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 4153.
https://doi.org/10.1182/blood-2023-189266
Published: 2023
Journal Articles

Therapeutic Targeting of FLT3 Gate Keeper Mutation with E2082-0047 in Traditional and a Novel Immunocompetent Murine Adoptive Transfer Model of AML

Free
Ola A. Elgamal, Juan Carlos Zapata, Haishan Li, Chia Sharpe, Sydney Fobare, Blaise Stearns, James R. Lerma, Kinsey Bryant, Casie Furby, Marissa Long, Kaytlynn Fyock, Megan E. Johnstone, Thomas M. Sesterhenn, Benjamin Wronowski, Jianmin Pan, Shesh N. Rai, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Alexei Pushechnikov, Nikolay Savchuk, Volodymyr Kysil, Hovhannes Gukasyan, Iain Dukes, Kate Dokukina, Oleg Mitkin, Ruben Karapetian, Alexey Ryakhovskiy, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Daniel T. Starczynowski, Amy Burd, C. David Pauza, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 1544.
https://doi.org/10.1182/blood-2023-189259
Published: 2023
Journal Articles

Development of a Fully Immunocompetent Adoptive Transfer In Vivo Model of Npm1 cA ;Idh2 R140Q ;Flt3 ITD AML

Free
Chia Sharpe, Mariah Johnson, Sydney Fobare, Ola A. Elgamal, Bonnie K. Harrington, Allison Mustonen, Kinsey Bryant, Carolyn Cheney, James R. Lerma, Jean Truxall, Casie Furby, Marissa Long, Kaytlynn Fyock, Alan Shih, Ross L Levine, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 1386.
https://doi.org/10.1182/blood-2023-189975
Published: 2023
Journal Articles

Elucidating the Mechanism of Action (MOA) of Navtemadlin, an MDM2 Inhibitor, and Its Synergy with Gilteritinib in Myeloid Malignancies

Free
Sara Elgamal, Tracy Clevenger, Michael Gulrajani, Jean Cheung, Erin G. Jeremy, Sydney Fobare, Shelley Orwick, Ellen J. Sass, Erin Hertlein, Karilyn T. Larkin, Todd Covey, Wayne P. Rothbaum, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 5936–5938.
https://doi.org/10.1182/blood-2022-159568
Published: 2022
Journal Articles

Identification of PTPN11 mutations As Early Events in the Development of Acute Myeloid Leukemia

Free
Sydney Fobare, Shelley Orwick, Jessica Kohlschmidt, Tom Sesterhenn, Krzysztof Mrózek, Ben Wronowski, Megan Johnstone, Andrew J. Carroll, Richard M. Stone, Eunice S. Wang, Jonathan E. Kolitz, Bayard L. Powell, John P Perentesis, Ann-Kathrin Eisfeld, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 743–744.
https://doi.org/10.1182/blood-2022-160323
Published: 2022
Journal Articles

A Novel Ptpn11 E76K / Npm1 cA Murine Model of AML Identifies a Unique Immune Population Relevant to Human Disease

Free
Sydney Fobare, Chia Sharpe, Carolyn Cheney, Allison Mullaney, Casie Furby, Marissa Long, Jean Truxall, Megan Johnstone, Ann-Kathrin Eisfeld, John C. Byrd, Erin Hertlein
Journal: Blood
Blood (2022) 140 (Supplement 1): 5831–5832.
https://doi.org/10.1182/blood-2022-160093
Published: 2022
Journal Articles

Clinical and Prognostic Implications of PTPN11 Mutations in Acute Myeloid Leukemia (Alliance)

Free
Sydney Fobare, Jessica Kohlschmidt, PhD, Hatice Gulcin Ozer, PhD, Krzysztof Mrózek, MDPhD, Deedra Nicolet, MS, Alice S. Mims, MD, Ramiro Garzon, MD, James S. Blachly, MD, Shelley Orwick, BS, Andrew J Carroll, PhD, Richard M. Stone, MD, Eunice S. Wang, MD, Jonathan E. Kolitz, MD, Bayard L. Powell, MD, Christopher C. Oakes, PhD, Ann-Kathrin Eisfeld, MD, Erin Hertlein, PhD, John C. Byrd, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
https://doi.org/10.1182/blood-2020-135887
Published: 2020