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Megan Johnstone
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Journal Articles

A randomized placebo-controlled Phase 1 trial in healthy volunteers investigating safety, pharmacokinetics and pharmacodynamics of a novel menin inhibitor, balomenib (ZE63-0302): Interim analysis.

Free
Amy Burd, Brian Ledwith, Megan Johnstone, Erin Hertlein, Alexander Khvat, Ola Elgamal, Ruben Karapetian, Kate Dokukina, Fraser Pickersgill, Peter Schrader, Nikolay Savchuk, Iain Dukes, John Byrd
Journal: Blood
Blood (2025) 146 (Supplement 1): 5067.
https://doi.org/10.1182/blood-2025-5067
Published: 2025
Journal Articles

The B2M–LILRB1 axis as a novel myeloid immune checkpoint and therapeutic target in multiple myeloma

Free
Marcello Turi, Pietro Folino, Francesca Barello, Tallya Maciel, Selma Cifric, Paola Rampa, Mehmet Samur, Giovanni De Nola, Rita Starace, Vanessa Favasuli, Alessandro Salatino, Sofia Pasparaki, Carlo Campa, Delaney Vinaixa, Cole Clericuzio, Priya Thurman, Megan Johnstone, Francesca Bonello, Abigail Lytton-Jean, Cirino Botta, Eugenio Morelli, Nikhil Munshi, Kenneth Anderson, Annamaria Gulla
Journal: Blood
Blood (2025) 146 (Supplement 1): 1032.
https://doi.org/10.1182/blood-2025-1032
Published: 2025
Journal Articles

A novel: Plasma apoptosis assay to demonstrate CLL cell target engagement in first-in-human study of a highly selective oral bcl-2 inhibitor lonitoclax (ZE50-0134)

Free
John Byrd, Brian Ledwith, Fraser Pickersgill, Kate Dokukina, Ruben Karapetian, Chia Sharpe, Erin Hertlein, Megan Johnstone, Alexei Pushechnikov, Christopher Argent, Nikolay Savchuk, Iain Dukes, Amy Burd
Journal: Blood
Blood (2025) 146 (Supplement 1): 6819.
https://doi.org/10.1182/blood-2025-6819
Published: 2025
Journal Articles

A healthy volunteer study with lomonitinib predicts pharmacokinetics and pharmacodynamics in a relapsed refractory AML study

Free
John Byrd, Brian Ledwith, Fraser Pickersgill, Kate Dokukina, Ruben Karapetian, Megan Johnstone, Erin Hertlein, Ola Elgamal, Alexei Pushechnikov, Carolyn Grove, Shaun Fleming, Stephen Ting, Genevieve Douglas, Tara Lin, Joshua Zeidner, Alice Mims, Peter Schrader, Iain Dukes, Nikolay Savchuk, Amy Burd
Journal: Blood
Blood (2025) 146 (Supplement 1): 6781.
https://doi.org/10.1182/blood-2025-6781
Published: 2025
Journal Articles

ZE74-0282 is a novel JH2 domain JAK2 inhibitor with promising pre-clinical activity in JAK2 V617F mutant diseases

Free
Shailaja Hegde, Alexander Khvat, Ruben Karapetian, Brian Ledwith, Fraser Pickersgill, Megan Johnstone, Eric Vick, Emily Curran, Iain Dukes, Amy Burd, Nikolay Savchuk, Vladislav Parchincky, Igor Rezekin, Erin Hertlein, John Byrd
Journal: Blood
Blood (2025) 146 (Supplement 1): 1988.
https://doi.org/10.1182/blood-2025-1988
Published: 2025
Journal Articles

Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma

Free
Annamaria Gulla, Eugenio Morelli, Megan Johnstone, Marcello Turi, Mehmet K. Samur, Cirino Botta, Selma Cifric, Pietro Folino, Delaney Vinaixa, Francesca Barello, Cole Clericuzio, Vanessa Katia Favasuli, Domenico Maisano, Srikanth Talluri, Rao Prabhala, Giada Bianchi, Mariateresa Fulciniti, Kenneth Wen, Keiji Kurata, Jiye Liu, Johany Penailillo, Alberto Bragoni, Anna Sapino, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2024) 143 (25): 2612–2626.
https://doi.org/10.1182/blood.2023022777
Published: 2024
Includes: Supplemental data
Journal Articles

A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth

Free
Eugenio Morelli, Mariateresa Fulciniti, Mehmet K. Samur, Caroline F. Ribeiro, Leon Wert-Lamas, Jon E. Henninger, Annamaria Gullà, Anil Aktas-Samur, Katia Todoerti, Srikanth Talluri, Woojun D. Park, Cinzia Federico, Francesca Scionti, Nicola Amodio, Giada Bianchi, Megan Johnstone, Na Liu, Doriana Gramegna, Domenico Maisano, Nicola A. Russo, Charles Lin, Yu-Tzu Tai, Antonino Neri, Dharminder Chauhan, Teru Hideshima, Masood A. Shammas, Pierfrancesco Tassone, Sergei Gryaznov, Richard A. Young, Kenneth C. Anderson, Carl D. Novina, Massimo Loda, Nikhil C. Munshi
Journal: Blood
Blood (2023) 141 (4): 391–405.
https://doi.org/10.1182/blood.2022016892
Published: 2023
Includes: Supplemental data
Journal Articles

Bioprocessing of MIR17HG Results in Long and Short Noncoding RNAs with Targetable Tumor-Promoting Activity in Multiple Myeloma

Free
Eugenio Morelli, Annamaria Gulla, Na Liu, Domenico Maisano, Anil Aktas-Samur, Nicola Amodio, Caroline Ribeiro, Leon Wert-Lamas, Jonathan Henninger, Srikanth Talluri, Megan Johnstone, Doriana Gramegna, Delaney Vinaixa, Antonino Neri, Dharminder Chauhan, Teru Hideshima, Masood A. Shammas, Pierfrancesco Tassone, Sergei Gryaznov, Richard A. Young, Kenneth C. Anderson, Carl D. Novina, Massimo Loda, Mariateresa Fulciniti, Mehmet K. Samur, Nikhil C Munshi
Journal: Blood
Blood (2022) 140 (Supplement 1): 1551–1552.
https://doi.org/10.1182/blood-2022-167604
Published: 2022
Journal Articles

Long Noncoding RNA LINC01410 Interacts with the Minichromosome Maintenance (MCM) Complex to Promote Tumor Cell Growth in Multiple Myeloma

Free
Doriana Gramegna, Na Liu, Yao Yao, Megan Johnstone, Domenico Maisano, Annamaria Gulla, Anil Aktas-Samur, Aldo Roccaro, Mehmet K. Samur, Mariateresa Fulciniti, Eugenio Morelli, Nikhil C Munshi
Journal: Blood
Blood (2022) 140 (Supplement 1): 4191–4192.
https://doi.org/10.1182/blood-2022-169185
Published: 2022
Journal Articles

Identification of PTPN11 mutations As Early Events in the Development of Acute Myeloid Leukemia

Free
Sydney Fobare, Shelley Orwick, Jessica Kohlschmidt, Tom Sesterhenn, Krzysztof Mrózek, Ben Wronowski, Megan Johnstone, Andrew J. Carroll, Richard M. Stone, Eunice S. Wang, Jonathan E. Kolitz, Bayard L. Powell, John P Perentesis, Ann-Kathrin Eisfeld, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 743–744.
https://doi.org/10.1182/blood-2022-160323
Published: 2022
Journal Articles

Targeting Autophagy to Overcome Resistance to Immunogenic Chemotherapy in High-Risk Multiple Myeloma

Free
Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Megan Johnstone, Cirino Botta, Delaney Vinaixa, Marcello Turi, Mariateresa Fulciniti, Kenneth Wen, Selma Cifric, Srikanth Talluri, Giada Bianchi, Rao Prabhala, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 7114–7115.
https://doi.org/10.1182/blood-2022-162653
Published: 2022
Journal Articles

A Novel Ptpn11 E76K / Npm1 cA Murine Model of AML Identifies a Unique Immune Population Relevant to Human Disease

Free
Sydney Fobare, Chia Sharpe, Carolyn Cheney, Allison Mullaney, Casie Furby, Marissa Long, Jean Truxall, Megan Johnstone, Ann-Kathrin Eisfeld, John C. Byrd, Erin Hertlein
Journal: Blood
Blood (2022) 140 (Supplement 1): 5831–5832.
https://doi.org/10.1182/blood-2022-160093
Published: 2022
Journal Articles

Gabarap Loss Mediates Immune Escape in High Risk Multiple Myeloma

Free
Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Cirino Botta, Megan Johnstone, Giada Bianchi, Mariateresa Fulciniti, Leona Yamamoto, Rao Prabhala, Kenneth Wen, Paul G. Richardson, Yu-Tzu Tai, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 891.
https://doi.org/10.1182/blood-2021-148621
Published: 2021
Journal Articles

Identifying Long Noncoding RNA Dependencies Using CRISPR Interference (CRISPRi)-Based Platform in Multiple Myeloma

Free
Eugenio Morelli, Anil Aktas-Samur, Mehmet K. Samur, Annamaria Gulla, Leon Wert-Lamas, Caroline Ribeiro, Jonathan E Henninger, Woojun D Park, Nicola Amodio, Doriana Gramegna, Megan Johnstone, Pierfrancesco Tassone, Yu-Tzu Tai, Carl D. Novina, Richard A. Young, Massimo Loda, Masood A. Shammas, Sergei Gryaznov, Mariateresa Fulciniti, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood
Blood (2021) 138 (Supplement 1): 894.
https://doi.org/10.1182/blood-2021-151705
Published: 2021