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Michael Amatangelo
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Journal Articles

Longitudinal analysis of MRD negativity and immune dynamics in patients with transplant-ineligible newly diagnosed multiple myeloma treated with iberdomide, daratumumab, and dexamethasone from the CC-220-MM-001 trial

Free
Danny Jeyaraju, Sanhita Sengupta, Paulo Maciag, Anna Sureda Balarí, Niels W.C.J. van de Donk, Sagar Lonial, Anita Gandhi, Michael Amatangelo
Journal: Blood
Blood (2025) 146 (Supplement 1): 2255.
https://doi.org/10.1182/blood-2025-2255
Published: 2025
Journal Articles

Mezigdomide overcomes CRBN mutations emerging post IMiD therapy

Free
Edmond Watson, Chad Bjorklund, Nicholas Stong, Scott Hollingsworth, Olivia Pierce, Yilin Meng, Veerabahu Shanmugasundaram, Ting-Hsiang Huang, Vinidhra Sridharan, Tracy Chow, Michael Amatangelo, Patrick Hagner, Anita Gandhi
Journal: Blood
Blood (2025) 146 (Supplement 1): 436.
https://doi.org/10.1182/blood-2025-436
Published: 2025
Journal Articles

Pharmacodynamic activity and clinical benefits of mezigdomide in high-risk biomarker subgroups from the CC-92480-MM-001 study

Free
Tracy Chow, Nicholas Stong, Keyur Desai, Saleh Tamim, Chad Bjorklund, Joseph Hadala, Cynthia Donahue, Phillip Koo, Erica Petrlik, Jessica Katz, Anita Gandhi, Suzanne Trudel, Nizar Bahlis, Paul Richardson, Michael Amatangelo
Journal: Blood
Blood (2025) 146 (Supplement 1): 5697.
https://doi.org/10.1182/blood-2025-5697
Published: 2025
Journal Articles

Shared immune features correspond to high-risk multiple myeloma across multiple human subtypes and murine models

Free
Junia Vieira, Fnu Nabuqi, Alison Park, Alessia D'Anna, Tarek Mouhieddine, Kiana Chen, Erik Guillen, Roshan Mathews, Gregoire Lauvau, Jing Zhang, Katerina Kappes, Rudra Prasad Dutta, Julie Fortier, Chad Bjorklund, Michael Amatangelo, Anita Gandhi, Zhihong Chen, Seunghee Kim-Schulze, Michael Slade, Udo Oppermann, Rena Feinman, Santiago Thibaud, Joshua Richter, Shambavi Richard, Cesar Rodriguez Valdes, Adriana Rossi, Hearn Cho, Fotios Asimakopoulos, David Siegel, Ravi Vij, Sundar Jagannath, Samir Parekh, David Fooksman, Alessandro Lagana
Journal: Blood
Blood (2025) 146 (Supplement 1): 5723.
https://doi.org/10.1182/blood-2025-5723
Published: 2025
Journal Articles

Selinexor, mezigdomide, and dexamethasone in patients with Relapsed/Refractory multiple myeloma who relapsed or are ineligible for T-cell–redirecting therapy: Stomp Phase 1 results

Free
Clifton Mo, Cristina Gasparetto, Cristiana Costa, Andrew Cowan, Tomer Mark, Yi Chai, Trinayan Kashyap, Jessica Katz, Michael Amatangelo, Paul Richardson
Journal: Blood
Blood (2025) 146 (Supplement 1): 4010.
https://doi.org/10.1182/blood-2025-4010
Published: 2025
Journal Articles

Elotuzumab-Iberdomide-Dexamethasone Combination Therapy Activates T and NK Cells within the Immune Microenvironment of Multiple Myeloma Patients

Free
Lucia Y Chen, Michael Amatangelo, Adolfo Aleman, Oliver Van Oekelen, Tania Nevers, Yongliang Sun, William E. Pierceall, Katerina Kappes, Anna Blangiardo, Sundar Jagannath, Cesar Rodriguez, Samir Parekh
Journal: Blood
Blood (2024) 144 (Supplement 1): 6860.
https://doi.org/10.1182/blood-2024-211651
Published: 2024
Journal Articles

Biomarker Analyses of the CC-92480-MM-001 Trial to Guide Combinatorial Strategies for Mezigdomide

Free
Tracy T. Chow, Nicholas Stong, Saleh Tamim, Chad C. Bjorklund, Antonina Kurtova, Keyur Desai, Joseph T. Hadala, Cynthia Donahue, Phillip Koo, Yue Zhu, Jessica Katz, Anita K. Gandhi, Suzanne Trudel, Nizar J. Bahlis, Paul G. Richardson, Michael Amatangelo
Journal: Blood
Blood (2024) 144 (Supplement 1): 3261.
https://doi.org/10.1182/blood-2024-199019
Published: 2024
Journal Articles

Development of a Spatial Multiomics Platform to Integrate Genomic, Transcriptomic and Proteomic Features for Translational Research in Multiple Myeloma

Free
Sarah Gooding, Chen-Yi Wang, Warren Baker, Edmund Watson, Simon Davis, Roman Fischer, Oliver McCallion, Joanna Hester, Fadi Issa, Srinivasa Rao, Nick Athanasou, Anjan Thakurta, Karthik Ramasamy, Chad C. Bjorklund, Michael Amatangelo, Anita K. Gandhi, Adam P Cribbs, Alessandro Lagana, Udo Oppermann
Journal: Blood
Blood (2024) 144 (Supplement 1): 6848.
https://doi.org/10.1182/blood-2024-205264
Published: 2024
Journal Articles

Iberdomide, Daratumumab, and Dexamethasone Shows Deep Antimyeloma Activity across Molecular Patient Subsets with Transplant-Ineligible Newly Diagnosed Multiple Myeloma from the CC-220-MM-001 Trial

Free
Michael Amatangelo, Nicholas Stong, Paulo Maciag, Anna Sureda Balari, Niels W.C.J. van de Donk, Sagar Lonial, Anita K. Gandhi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1973.
https://doi.org/10.1182/blood-2024-199016
Published: 2024
Journal Articles

RRMM and Post-BCMA Treated Subjects from the CC-220-MM-001 Study Show Increased Genomic Aberrations Associated with High-Risk and Significant Dysfunction in CD4+ T-Cell Compartment Compared to NDMM Subjects

Free
Michael Amatangelo, Erin Flynt, Nicholas Stong, Maria Ortiz, Pradipta Ray, Maria Wang, Niels W.C.J. van de Donk, Sagar Lonial, Aparna Raval, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4665.
https://doi.org/10.1182/blood-2023-178912
Published: 2023
Journal Articles

Preclinical and Translational Biomarker Analyses to Inform Clinical Development of Mezigdomide (CC-92480) in Combination with Dexamethasone and Daratumumab in Multiple Myeloma

Free
Tracy T. Chow, Michael Amatangelo, Peilin Ma, Chad C. Bjorklund, Krista Wollerman, Tiziana Civardi, Phillip Koo, Yue Zhu, Paulo Maciag, Jessica Katz, Aparna Raval, Albert Oriol, Robert Z. Orlowski, Darrell White, Paul G. Richardson, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3318.
https://doi.org/10.1182/blood-2023-178881
Published: 2023
Journal Articles

Iberdomide Enhances Dara Mediated Cytotoxicity through Upregulation of CDC Activity and Elevated NK Cell Mediated ADCC

Free
Peilin Ma, Vinidhra Sridharan, Krista Wollerman, Debjani Dutta, Ram Kumar Singh, Sambuddo Mukherjee, Chad C. Bjorklund, Patrick R Hagner, Michael Amatangelo, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3289.
https://doi.org/10.1182/blood-2023-189423
Published: 2023
Journal Articles

Mezigdomide Treatment in Relapsed-Refractory Myeloma Patients Shifts Bone Marrow NK and T Cell Populations from Exhaustion to Activation

Free
Lucia Y Chen, Oliver Van Oekelen, Michael Amatangelo, Tracy T. Chow, Bhaskar Upadhyaya, Alessandro Lagana, Geoffrey Kelly, Seunghee Kim-Schulze, Adolfo Aleman, Antonina Kurtova, Sarah Gooding, Sundar Jagannath, Erin Flynt, Anita K. Gandhi, Udo Oppermann, Anjan Thakurta, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 4686.
https://doi.org/10.1182/blood-2023-187748
Published: 2023
Journal Articles

Mezigdomide (CC-92480), a Potent, Novel Cereblon E3 Ligase Modulator (CELMoD), Combined with Dexamethasone (DEX) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Preliminary Results from the Dose-Expansion Phase of the CC-92480-MM-001 Trial

Free
Paul G. Richardson, Suzanne Trudel, Hang Quach, Rakesh Popat, Sagar Lonial, Robert Z. Orlowski, Kihyun Kim, María-Victoria Mateos, Charlotte Pawlyn, Karthik Ramasamy, Joaquín Martinez-Lopez, Alessia Spirli, Ignacio Casas-Avilés, Jing Gong, Michael Amatangelo, Jessica Katz, Paulo Maciag, Teresa Peluso, Nizar J. Bahlis
Journal: Blood
Blood (2022) 140 (Supplement 1): 1366–1368.
https://doi.org/10.1182/blood-2022-157945
Published: 2022
Journal Articles

Iberdomide (IBER) in Combination with Dexamethasone (DEX) in Relapsed/Refractory Multiple Myeloma (RRMM): Results from the Anti-B-Cell Maturation Antigen (BCMA)-Exposed Cohort of the CC-220-MM-001 Trial

Free
Sagar Lonial, Al-Ola Abdallah, Faiz Anwer, Ashraf Z. Badros, Manisha Bhutani, Abdullah Khan, Brea Lipe, Albert Oriol, Darrell White, Michael Amatangelo, Kexin Jin, Mark Masin, Vi Nguyen, Alpesh Amin, Paulo Maciag, Niels WCJ Van De Donk
Journal: Blood
Blood (2022) 140 (Supplement 1): 4398–4400.
https://doi.org/10.1182/blood-2022-158180
Published: 2022
Journal Articles

CC-92480 Enhances Cell-Autonomous Cytotoxicity through Blockade of G 2 /M Transition When Combined with Bortezomib/Dexamethasone in Pre-Clinical Multiple Myeloma

Free
Chad C Bjorklund, Michael Amatangelo, Jian Kang, Hsiling Chiu, Archana Mukhopadhyay, Krista Wollerman, Michael Pourdehnad, Patrick Hagner, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 2669.
https://doi.org/10.1182/blood-2021-153907
Published: 2021
Journal Articles

Large-Scale Mass Cytometry Reveals Significant Activation of Innate and Adaptive Immunity in Bone Marrow Tumor Microenvironment of Iberdomide-Treated Myeloma Patients

Free
Oliver Van Oekelen, Michael Amatangelo, Manman Guo, Bhaskar Upadhyaya, Geoffrey Kelly, Manishkumar Patel, Seunghee Kim-Schulze, Alessandro Lagana, Sarah Gooding, Sundar Jagannath, William E. Pierceall, Udo Oppermann, Samir Parekh, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 730.
https://doi.org/10.1182/blood-2021-151542
Published: 2021
Journal Articles

Pre-Clinical and Clinical Immunomodulatory Effects of Pomalidomide or CC-92480 in Combination with Bortezomib in Multiple Myeloma

Free
Chad C Bjorklund, Michael Amatangelo, Hsiling Chiu, Jian Kang, Tiziana Civardi, Jessica Katz, Paulo Maciag, Patrick Hagner, Michael Pourdehnad, Nizar J. Bahlis, Paul G. Richardson, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 1613.
https://doi.org/10.1182/blood-2021-153994
Published: 2021
Journal Articles

CC-92480, a Potent, Novel Cereblon E3 Ligase Modulator (CELMoD) Agent, in Combination with Dexamethasone (DEX) and Bortezomib (BORT) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Preliminary Results from the Phase 1/2 Study CC-92480-MM-002

Free
Paul G. Richardson, Enrique Ocio, Noopur S. Raje, Tara Gregory, Darrell White, Albert Oriol, Irwindeep Sandhu, Marc-Steffen Raab, Richard LeBlanc, Cesar Rodriguez, Suzanne Trudel, Ralph Wäsch, Aurore Perrot, Nizar J. Bahlis, Zehua Zhou, Manisha Lamba, Michael Amatangelo, Tiziana Civardi, Jessica Katz, Paulo Maciag, Teresa Peluso, Meletios A. Dimopoulos
Journal: Blood
Blood (2021) 138 (Supplement 1): 2731.
https://doi.org/10.1182/blood-2021-147812
Published: 2021
Journal Articles

First Results of Iberdomide (IBER; CC-220) in Combination with Dexamethasone (DEX) and Daratumumab (DARA) or Bortezomib (BORT) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Free
Niels W.C.J. van de Donk, MD PhD, Rakesh Popat, Jeremy Larsen, Monique C. Minnema, Sundar Jagannath, MD, Albert Oriol, Jeffrey Zonder, Paul G. Richardson, MD, Paula Rodriguez-Otero, MD PhD, Ashraf Z. Badros, MD, Edward Stadtmauer, Sara Bringhen, MD, Erica Campagnaro, MD, David S. Siegel, MD PhD, Barbara Gamberi, Mercedes Gironella Mesa, Pieter Sonneveld, MD PhD, Tuong Vi Nguyen, Antonia Di Micco, April Sorrell, Min Chen, Michael Amatangelo, Elisabeth Kueenburg, Sagar Lonial, MD FACP
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137743
Published: 2020