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Cesar Rodriguez Valdes
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Journal Articles

Restarting etentamig therapy after dosing delays or interruptions: Population pharmacokinetics (PopPK) and PK/PD simulations and supporting clinical data

Free
Sneha Rathi, Vanessa Schmitt, Heiko Babel, Peter Voorhees, Cesar Rodriguez Valdes, Ziyi Jin, Anders Svensson, Chetasi Talati, Benjamin Engelhardt, Akshanth Polepally
Journal: Blood
Blood (2025) 146 (Supplement 1): 2266.
https://doi.org/10.1182/blood-2025-2266
Published: 2025
Journal Articles

Prolonged cytopenias after BCMA CAR‑T are associated with impaired endogenous T cell recovery characterized by decreased CD8+ T cell diversity

Free
Abigail Chutnik, Zachary Avigan, Ramy Mahmoud, Alessandro Lagana, Matthew Croken, Meenakshi Mehrotra, Zahra Moinfar, Adriana Rossi, Shambavi Richard, Gurbakhash Kaur, Joshua Richter, Larysa Sanchez, Cesar Rodriguez Valdes, Hearn Cho, Sundar Jagannath, Mesude Bicak, Nina Bhardwaj, Jane Houldsworth, Santiago Thibaud, Samir Parekh
Journal: Blood
Blood (2025) 146 (Supplement 1): 2290.
https://doi.org/10.1182/blood-2025-2290
Published: 2025
Journal Articles

Etentamig plus pomalidomide-dexamethasone combination therapy in relapsed or refractory multiple myeloma: A phase 1b dose-escalation and safety expansion study

Free
Peter Voorhees, Anita D'Souza, Hang Quach, Sabine Gaerditz, Estrella Carrillo-Cruz, Michał Mielnik, Tomasz Wrobel, Matthew Pianko, Dickran Kazandjian, M Hasib Sidiqi, Valerio De Stefano, Cesar Rodriguez Valdes, Shonali Midha, Ariel Grajales-Cruz, Hideki Goto, Satoshi Ito, Claudio Cerchione, Ziyi Jin, Shane Lee, Akshanth Polepally, Sneha Rathi, Ross La Motte-Mohs, Kristin D'Amico, Thomas Doerr, Chetasi Talati, Leanne Lash Fleming, Linda Ho, Katja Weisel, Marek Hus, Joaquin Martinez-Lopez
Journal: Blood
Blood (2025) 146 (Supplement 1): 247.
https://doi.org/10.1182/blood-2025-247
Published: 2025
Journal Articles

Spatially resolved transcriptomics reveals immunosuppressive niches and clonal diversity in extramedullary disease in multiple myeloma refractory to immunotherapy

Free
Junia Vieira, Reyka Jayasinghe, Tarek Mouhieddine, Jordan Lu, Hajer Merarda, Darwin D'Souza, Hyo Jeong Nam, Adolfo Aleman, Meghana Ram, Zhihong Chen, Seunghee Kim-Schulze, Gaurav Bhatt, Julie Fortier, Michael Slade, Alina Dulau Florea, Rachel Brody, Larysa Sanchez, Cesar Rodriguez Valdes, Joshua Richter, Shambavi Richard, Adriana Rossi, Sundar Jagannath, Ravi Vij, Li Ding, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2025) 146 (Supplement 1): 3949.
https://doi.org/10.1182/blood-2025-3949
Published: 2025
Journal Articles

Shared immune features correspond to high-risk multiple myeloma across multiple human subtypes and murine models

Free
Junia Vieira, Fnu Nabuqi, Alison Park, Alessia D'Anna, Tarek Mouhieddine, Kiana Chen, Erik Guillen, Roshan Mathews, Gregoire Lauvau, Jing Zhang, Katerina Kappes, Rudra Prasad Dutta, Julie Fortier, Chad Bjorklund, Michael Amatangelo, Anita Gandhi, Zhihong Chen, Seunghee Kim-Schulze, Michael Slade, Udo Oppermann, Rena Feinman, Santiago Thibaud, Joshua Richter, Shambavi Richard, Cesar Rodriguez Valdes, Adriana Rossi, Hearn Cho, Fotios Asimakopoulos, David Siegel, Ravi Vij, Sundar Jagannath, Samir Parekh, David Fooksman, Alessandro Lagana
Journal: Blood
Blood (2025) 146 (Supplement 1): 5723.
https://doi.org/10.1182/blood-2025-5723
Published: 2025
Journal Articles

Ultra-sensitive detection of clonal m-protein by mass spectrometry enhances detection of residual disease: Results from A phase 1 study of etentamig monotherapy in patients with relapsed or refractory multiple myeloma

Free
Aarif Ahsan, Adam Luo, Cesar Rodriguez Valdes, Peter Voorhees, Anita D'Souza, Alfred Chung, Sascha Tuchman, Hana Safah, John Mckay, Katja Weisel, Raphael Teipel, Neha Korde, Ravi Vij, Shaji Kumar, Thomas Doerr, Rajvineeth Kumar Pothacamury, Chetasi Talati, Brenda Chyla, Jeremy Ross
Journal: Blood
Blood (2025) 146 (Supplement 1): 5813.
https://doi.org/10.1182/blood-2025-5813
Published: 2025
Journal Articles

S100A8/A9 drives T cell exhaustion and compromises the therapeutic efficacy of bispecific antibodies in multiple myeloma.

Free
Adolfo Aleman, Oliver Van Oekelen, Shriya Desai, Sidorela Reci, Leah Grossman, Rudra Prasad Dutta, Mathieu Desaunay, Junia Vieira, Rongbao Zhao, Rahul Sanawar, Mani Mohindru, Tarek Mouhieddine, Alessandro Lagana, Marta Larrayoz, Poulikos Poulikakos, Gurbakhash Kaur, Larysa Sanchez, Cesar Rodriguez Valdes, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Joshua Richter, Hearn Cho, Jose A. Martinez-Climent, Amit Verma, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2025) 146 (Supplement 1): 916.
https://doi.org/10.1182/blood-2025-916
Published: 2025
Journal Articles

Development of predictive relapse indicators for myeloma T cell engagers (PRIME) model for myeloma patients receiving BCMA- and GPRC5D-targeting T cell engagers

Free
Tarek Mouhieddine, Tianxiang Sheng, Junia Vieira, Adolfo Aleman, Zachary Avigan, Ariel Siegel, Mujahid Quidwai, Jordan Lu, Mohammad Rattu, Santiago Thibaud, Gurbakhash Kaur, Shambavi Richard, Adriana Rossi, Hearn Cho, Alessandro Lagana, Samantha Stclair, Dalia Abdel Azim, Larysa Sanchez, Joshua Richter, Cesar Rodriguez Valdes, Christian Salib, Erin Moshier, Samir Parekh, Sundar Jagannath
Journal: Blood
Blood (2025) 146 (Supplement 1): 3996.
https://doi.org/10.1182/blood-2025-3996
Published: 2025