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Journal Articles

New evidence indicates that the NLRP3 inflammasome in hematopoietic stem and progenitor cells (HSPCs) maintains proper mitochondrial electron transport chain function and affects both cellular trafficking and metabolism through a gasdermin pore-mediated, alarmin-release-dependent mechanism

Magdalena Kucia, Michalina Kazek, Justyna Jarczak, Emilia Waraksa-Zasada, Patrycja Kieszek, Mariusz Ratajczak

Blood (2025) 146 (Supplement 1): 2314.

https://doi.org/10.1182/blood-2025-2314

Published: 2025

Journal Articles

Unsupervised proteomic and metabolomic longitudinal serum profiling of anti-CD19 CAR-T cell therapy recipients reveals clinically distinct groups

Jaromir Tomasik, Kannathasan Thetchinamoorthy, Diana Wierzbicka, Agnieszka Tomaszewska, Piotr Kacprzyk, Joanna Drozd-Sokołowska, Rafał Machowicz, Mariusz Ratajczak, Magdalena Kucia, Grzegorz Basak

Blood (2025) 146 (Supplement 1): 5926.

https://doi.org/10.1182/blood-2025-5926

Published: 2025

Journal Articles

Novel evidence shows that intracellular complement (complosome) expressed in hematopoietic stem cell progenitor cells regulates hematopoiesis at both the mitochondrial and cellular metabolism levels.

Magdalena Kucia, Justyna Jarczak, Michalina Kazek, Emilia Waraksa-Zasada, Patrycja Kieszek, Mariusz Ratajczak

Blood (2025) 146 (Supplement 1): 3155.

https://doi.org/10.1182/blood-2025-3155

Published: 2025

Journal Articles

The first integrated proteomic and lipidomic profiling reveals immune, metabolic, and membrane remodeling signatures in patients experiencing cytokine release storm (CRS) undergoing CAR-T cell therapy and serves as a new predictive and prognostic factor.

Kannathasan Thetchinamoorthy, Diana Wierzbicka, Jaromir Tomasik, Grzegorz Basak, Mariusz Z Ratajczak, Magdalena Kucia

Blood (2025) 146 (Supplement 1): 3557.

https://doi.org/10.1182/blood-2025-3557

Published: 2025

Journal Articles

New evidence that complement activation and NLRP3 inflammasome signaling work together to cause cytokine release syndrome after CAR-T cell therapy

Diana Wierzbicka, Kannathasan Thetchinamoorthy, Jaromir Tomasik, Mariusz Z Ratajczak, Magdalena Kucia

Blood (2025) 146 (Supplement 1): 2328.

https://doi.org/10.1182/blood-2025-2328

Published: 2025

Journal Articles

The Pro-Mobilizing Effects of UDP-Glucose-P2Y14 Purinergic Receptor Signaling Are Explained By Promoting Membrane Lipid Raft Formation to Optimize Hspcs' Responsiveness to Chemoattractants-a Potential Strategy to Optimize Hematopoietic Transplantation and Improve Transplant Outcomes

Kamila Bujko, Mateusz Admiak, Kannathasan Thetchinamoorthy, Arjun Thapa, Diana Wierzbicka, Magdalena Molenda, Mariusz Z Ratajczak, Magdalena Kucia

Blood (2024) 144 (Supplement 1): 4034.

https://doi.org/10.1182/blood-2024-204825

Published: 2024

Journal Articles

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

Mateusz Adamiak, PhD, Arjun Thapa, Kamila Bujko, MSc, Valentina Pensato, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-137123

Published: 2020

Journal Articles

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Katarzyna Sielatycka, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 8.

https://doi.org/10.1182/blood-2020-137083

Published: 2020

Journal Articles

Unexpected Novel Findings That Caspase-1-KO Mice Are Poor Mobilizers and Engraft Poorly with Wild Type Bone Marrow Cells - Indicating a Presence of an Autocrine Feedback Loop Involving Interleukin 1b and Interleukin 18 Signaling That Potentiates Nlrp3 Inflammasome Activity, Both in HSPCs and in the BM Microenvironment for Optimal Stem Cell Trafficking

Arjun Thapa, Janina Ratajczak, MD PhD DSci, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-137495

Published: 2020

Journal Articles

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Arjun Thapa, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 3.

https://doi.org/10.1182/blood-2020-137102

Published: 2020

Journal Articles

Novel Evidence That the Pannexin 1 Channel Is Involved in Adenosine Triphosphate (ATP) Release from Cells for Optimal Mobilization of Hematopoietic Stem Progenitor Cells, and the Pannexin 1 SNP 5 (Rs3020015) T/C Polymorphism Characterizes Poor Mobilizer Status in Patients

Monika Cymer, MS, Mateusz Adamiak, PhD, Marta Skoda, PhD, Marta Antonina Libura, MD PhD, Elzbieta Urbanowska, PhD, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 3248.

https://doi.org/10.1182/blood-2019-125883

Published: 2019

Journal Articles

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Alison Domingues, MS, Kamila Bujko, MS, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4882.

https://doi.org/10.1182/blood-2019-125819

Published: 2019

Journal Articles

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Mateusz Adamiak, PhD, Anna Lenkiewicz, PhD, Kamila Bujko, MS, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4468.

https://doi.org/10.1182/blood-2019-125838

Published: 2019

Journal Articles

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Kamila Bujko, MS, Mateusz Adamiak, PhD, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4472.

https://doi.org/10.1182/blood-2019-125858

Published: 2019

Journal Articles

Novel Evidence That Extracellular Nucleotides and Nucleosides Regulate the Expression of Heme Oxygenase 1 (HO-1) in Opposite Ways in Hematopoietic Stem/Progenitor Cells (HSPCs), Which Explains Why ATP Enhances Mobilization of HSPCs, While Its Metabolite Adenosine Inhibits This Process

Mateusz Adamiak, PhD, Kamila Bujko, MS, Monika Plonka, MD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSci

Blood (2018) 132 (Supplement 1): 4528.

https://doi.org/10.1182/blood-2018-99-110634

Published: 2018

Journal Articles

Novel Evidence That the Ectonucleotidases CD39 and CD73, Which Are Expressed on Hematopoietic Stem/Progenitor Cells (HSPCs), Regulate Mobilization and Homing - Studies in CD39-/- and CD73-/- Mice and with Small-Molecule CD39 and CD73 Inhibitors

Mateusz Adamiak, PhD, Kamila Bujko, MS, Anna Lenkiewicz, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSci

Blood (2018) 132 (Supplement 1): 2060.

https://doi.org/10.1182/blood-2018-99-110631

Published: 2018

Journal Articles

Efficient Ex Vivo Expansion of Human Umbilical Cord Blood-Derived Small CD133 + lin - CD45 - Stem Cells Expressing Pluripotency Markers in Presence of Histone Deacethylase Inhibitors—As a New Challenging Strategy to Obtain Multipotent Cells for Regenerative Medicine

Janina Ratajczak, MD PhD DSci, Malwina Suszynska, PhD, Kamila Bujko, MS, Donald M Miller, MD PhD, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 3761.

https://doi.org/10.1182/blood.V130.Suppl_1.3761.3761

Published: 2017

Journal Articles

The Effect of Bioactive Phospholipids on Normal and Malignant Hematopoiesis—Modulation of Their Effects By Downregulating the Activities of Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS)

Ahmed Abdelbaset-Ismail, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 3803.

https://doi.org/10.1182/blood.V130.Suppl_1.3803.3803

Published: 2017

Journal Articles

Novel Evidence That the Mannan-Binding Lectin (MBL) Pathway of Complement Activation Plays a Pivotal Role in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells By Activation of Both the Complement and Coagulation Cascades

Mateusz Adamiak, Malwina Suszynska, PhD, Ahmed Abdel-Latif, MD PhD, Ahmed Abdelbaset-Ismail, PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3371.

https://doi.org/10.1182/blood.V128.22.3371.3371

Published: 2016

Journal Articles

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Mateusz Adamiak, MS, Ahmed Abdelbaset Ismail, PhD, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3342.

https://doi.org/10.1182/blood.V128.22.3342.3342

Published: 2016

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New evidence indicates that the NLRP3 inflammasome in hematopoietic stem and progenitor cells (HSPCs) maintains proper mitochondrial electron transport chain function and affects both cellular trafficking and metabolism through a gasdermin pore-mediated, alarmin-release-dependent mechanism

Unsupervised proteomic and metabolomic longitudinal serum profiling of anti-CD19 CAR-T cell therapy recipients reveals clinically distinct groups

Novel evidence shows that intracellular complement (complosome) expressed in hematopoietic stem cell progenitor cells regulates hematopoiesis at both the mitochondrial and cellular metabolism levels.

The first integrated proteomic and lipidomic profiling reveals immune, metabolic, and membrane remodeling signatures in patients experiencing cytokine release storm (CRS) undergoing CAR-T cell therapy and serves as a new predictive and prognostic factor.

New evidence that complement activation and NLRP3 inflammasome signaling work together to cause cytokine release syndrome after CAR-T cell therapy

The Pro-Mobilizing Effects of UDP-Glucose-P2Y14 Purinergic Receptor Signaling Are Explained By Promoting Membrane Lipid Raft Formation to Optimize Hspcs' Responsiveness to Chemoattractants-a Potential Strategy to Optimize Hematopoietic Transplantation and Improve Transplant Outcomes

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

Novel Evidence That the Pannexin 1 Channel Is Involved in Adenosine Triphosphate (ATP) Release from Cells for Optimal Mobilization of Hematopoietic Stem Progenitor Cells, and the Pannexin 1 SNP 5 (Rs3020015) T/C Polymorphism Characterizes Poor Mobilizer Status in Patients

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Novel Evidence That Extracellular Nucleotides and Nucleosides Regulate the Expression of Heme Oxygenase 1 (HO-1) in Opposite Ways in Hematopoietic Stem/Progenitor Cells (HSPCs), Which Explains Why ATP Enhances Mobilization of HSPCs, While Its Metabolite Adenosine Inhibits This Process

Novel Evidence That the Ectonucleotidases CD39 and CD73, Which Are Expressed on Hematopoietic Stem/Progenitor Cells (HSPCs), Regulate Mobilization and Homing - Studies in CD39-/- and CD73-/- Mice and with Small-Molecule CD39 and CD73 Inhibitors

Efficient Ex Vivo Expansion of Human Umbilical Cord Blood-Derived Small CD133 + lin - CD45 - Stem Cells Expressing Pluripotency Markers in Presence of Histone Deacethylase Inhibitors—As a New Challenging Strategy to Obtain Multipotent Cells for Regenerative Medicine

The Effect of Bioactive Phospholipids on Normal and Malignant Hematopoiesis—Modulation of Their Effects By Downregulating the Activities of Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS)

Novel Evidence That the Mannan-Binding Lectin (MBL) Pathway of Complement Activation Plays a Pivotal Role in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells By Activation of Both the Complement and Coagulation Cascades

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

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