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Journal Articles

Novel Evidence That Intracellular Complement Network (complosome) Is Expressed in Hematopoietic Stem Cells (HSPCs) and Regulates Their Trafficking, Metabolism, and Proliferation in an Intracrine-Dependent Manner By Engaging Pattern Recognition Receptor Nlrp3 Inflammasome

Vira Chumak, Andrzej Ciechanowicz, Mateusz Adamiak, Arjun Thapa, Ahmed Abdelbaset-Ismail, Kamila Bujko, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2022) 140 (Supplement 1): 1987–1988.

https://doi.org/10.1182/blood-2022-158573

Published: 2022

Journal Articles

Novel Evidence That the P2X1 Purinergic Receptor - Nlrp3 Inflammasome Axis Orchestrates Optimal Trafficking of Hematopoietic Stem Progenitors Cells (HSPCs)

Kamila Bujko, Mateusz Adamiak, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2022) 140 (Supplement 1): 7567.

https://doi.org/10.1182/blood-2022-158594

Published: 2022

Journal Articles

Novel Evidence That NADPH Oxidase 2 (Nox-2) Enhances Trafficking of Hematopoietic Stem Progenitor Cells (HSPCs) By Involving ROS Mediated Activation of Nlrp3 Inflammasome

Kamila Bujko, Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak

Blood (2022) 140 (Supplement 1): 11397.

https://doi.org/10.1182/blood-2022-159672

Published: 2022

Journal Articles

Modulation of Purinergic Signaling Prior to Transplantation Both in Hematopoietic Stem Progenitor Cells (HSPCs) or Recipient Bone Marrow (BM) Microenvironment - As Novel Strategies to Accelerate and Facilitate HSPCs Homing and Engraftment

Mateusz Adamiak, Arjun Thapa, Kamila Bujko, Katarzyna Brzeźniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2021) 138 (Supplement 1): 3809.

https://doi.org/10.1182/blood-2021-148733

Published: 2021

Journal Articles

Novel Evidence That Alternative Activation Pathway of Complement Cascade (ComC) Regulates Optimal Homing and Engraftment of Hematopoietic Stem/Progenitor Cells (HSPCs) in Reactive Oxygen Species (ROS) - Nlrp3 Inflammasome-Dependent Manner

Mateusz Adamiak, Andrzej Ciechanowicz, Kamila Bujko, Katarzyna Brzeźniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2021) 138 (Supplement 1): 1683.

https://doi.org/10.1182/blood-2021-148818

Published: 2021

Journal Articles

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

Mateusz Adamiak, PhD, Arjun Thapa, Kamila Bujko, MSc, Valentina Pensato, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-137123

Published: 2020

Journal Articles

Novel Evidence That the Pannexin 1 Channel Is Involved in Adenosine Triphosphate (ATP) Release from Cells for Optimal Mobilization of Hematopoietic Stem Progenitor Cells, and the Pannexin 1 SNP 5 (Rs3020015) T/C Polymorphism Characterizes Poor Mobilizer Status in Patients

Monika Cymer, MS, Mateusz Adamiak, PhD, Marta Skoda, PhD, Marta Antonina Libura, MD PhD, Elzbieta Urbanowska, PhD, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 3248.

https://doi.org/10.1182/blood-2019-125883

Published: 2019

Journal Articles

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Mateusz Adamiak, PhD, Anna Lenkiewicz, PhD, Kamila Bujko, MS, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4468.

https://doi.org/10.1182/blood-2019-125838

Published: 2019

Journal Articles

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Kamila Bujko, MS, Mateusz Adamiak, PhD, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4472.

https://doi.org/10.1182/blood-2019-125858

Published: 2019

Journal Articles

Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood

Mateusz Adamiak, PhD, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Marta Skoda, PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 1033.

https://doi.org/10.1182/blood-2019-125853

Published: 2019

Journal Articles

Novel Evidence That the Ectonucleotidases CD39 and CD73, Which Are Expressed on Hematopoietic Stem/Progenitor Cells (HSPCs), Regulate Mobilization and Homing - Studies in CD39-/- and CD73-/- Mice and with Small-Molecule CD39 and CD73 Inhibitors

Mateusz Adamiak, PhD, Kamila Bujko, MS, Anna Lenkiewicz, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSci

Blood (2018) 132 (Supplement 1): 2060.

https://doi.org/10.1182/blood-2018-99-110631

Published: 2018

Journal Articles

Novel Evidence That Extracellular Nucleotides and Nucleosides Regulate the Expression of Heme Oxygenase 1 (HO-1) in Opposite Ways in Hematopoietic Stem/Progenitor Cells (HSPCs), Which Explains Why ATP Enhances Mobilization of HSPCs, While Its Metabolite Adenosine Inhibits This Process

Mateusz Adamiak, PhD, Kamila Bujko, MS, Monika Plonka, MD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSci

Blood (2018) 132 (Supplement 1): 4528.

https://doi.org/10.1182/blood-2018-99-110634

Published: 2018

Journal Articles

Sphingosine Kinase 2 (SphK2) Deficiency Does Not Lower but Instead Surprisingly Increases the Level of Sphingosine-1-Phosphate (S1P) in Peripheral Blood, Providing a Novel Strategy for Stimulating Hematopoietic Stem Cell Mobilization By Inhibiting SphK2 Activity

Mateusz Adamiak, PhD, Lakshman Chelvarajan, Webster Santos, PhD, Kevin R Lynch, PhD, Ahmed Abdel-Latif, MD PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 4477.

https://doi.org/10.1182/blood.V130.Suppl_1.4477.4477

Published: 2017

Journal Articles

Novel Evidence That the Mannan-Binding Lectin (MBL) Pathway of Complement Activation Plays a Pivotal Role in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells By Activation of Both the Complement and Coagulation Cascades

Mateusz Adamiak, Malwina Suszynska, PhD, Ahmed Abdel-Latif, MD PhD, Ahmed Abdelbaset-Ismail, PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3371.

https://doi.org/10.1182/blood.V128.22.3371.3371

Published: 2016

Journal Articles

Unexpected Evidence That Inducible Nitric Oxide Synthase (iNOS) Is a Negative Regulator of Hematopoietic Stem/Progenitor Cell Mobilization

Mateusz Adamiak, MS, Ahmed Abdelbaset-Ismail, PhD, Marcin Wysoczynski, PhD, Ahmed Abdel-Latif, MD PhD, Joseph B Moore, IV, MS, Janina Ratajczak, MD PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3372.

https://doi.org/10.1182/blood.V128.22.3372.3372

Published: 2016

Journal Articles

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Mateusz Adamiak, MS, Ahmed Abdelbaset Ismail, PhD, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3342.

https://doi.org/10.1182/blood.V128.22.3342.3342

Published: 2016

Journal Articles

Heme Oxygenase 1 (HO-1) Is a Novel Negative Regulator of Normal and Malignant Hematopoietic Cell Trafficking

Mateusz Adamiak, MS, Ahmed Abdelbaset-Ismail, PhD, Joseph B Moore, IV, MS, Ahmed Abdel-Latif, MD PhD, Marcin Wysoczynski, PhD, Magdalena Kucia, PhD, Janina Ratajczak, MD PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 2150.

https://doi.org/10.1182/blood.V128.22.2150.2150

Published: 2016

Journal Articles

Novel Evidence That a Lipolytic Enzyme - Hematopoietic-Specific Phospholipase C Beta 2 - Promotes Mobilization of Hematopoietic Stem Cells By Decreasing Their Lipid Raft-Mediated Bone Marrow Retention and Increasing the Pro-Mobilizing Effects of Granulocytes

Mateusz Adamiak, MS, Agata Poniewierska-Baran, PhD, Gabriela Schneider, PhD, Ahmed Abdelbaset-Ismail, PhD, Malwina Suszynska, PhD, Ahmed Abdel-Latif, MD PhD, Magdalena Kucia, PhD, Janina Ratajczak, MD PhD, Mariusz Z Ratajczak, MD PhD

Blood (2015) 126 (23): 1896.

https://doi.org/10.1182/blood.V126.23.1896.1896

Published: 2015

Journal Articles

A Novel and Pivotal Role of the Mannose-Binding Lectin (MBL) Pathway of Complement Cascade (ComC) Activation in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells (HSPCs)

Mateusz Adamiak, MS, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD, Mariusz Z Ratajczak, MD PhD

Blood (2015) 126 (23): 4301.

https://doi.org/10.1182/blood.V126.23.4301.4301

Published: 2015

Journal Articles

Transient Ex Vivo Inhibition of Heme Oxygenase 1 (HO-1) in Hematopoietic Stem/Progenitor Cells (HSPCs) By Small-Molecule Inhibitors Enhances Their Migratory Responsiveness to Bone Marrow (BM)-Secreted Chemoattractants a Novel and Simple Strategy to Improve Homing of HSPCs

Mateusz Adamiak, MS, Joseph B Moore IV, PhD, John Zhao, BS, Ahmed Abdelbaset-Ismail, PhD, Marcin Wysoczynski, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2015) 126 (23): 4272.

https://doi.org/10.1182/blood.V126.23.4272.4272

Published: 2015

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Novel Evidence That Intracellular Complement Network (complosome) Is Expressed in Hematopoietic Stem Cells (HSPCs) and Regulates Their Trafficking, Metabolism, and Proliferation in an Intracrine-Dependent Manner By Engaging Pattern Recognition Receptor Nlrp3 Inflammasome

Novel Evidence That the P2X1 Purinergic Receptor - Nlrp3 Inflammasome Axis Orchestrates Optimal Trafficking of Hematopoietic Stem Progenitors Cells (HSPCs)

Novel Evidence That NADPH Oxidase 2 (Nox-2) Enhances Trafficking of Hematopoietic Stem Progenitor Cells (HSPCs) By Involving ROS Mediated Activation of Nlrp3 Inflammasome

Modulation of Purinergic Signaling Prior to Transplantation Both in Hematopoietic Stem Progenitor Cells (HSPCs) or Recipient Bone Marrow (BM) Microenvironment - As Novel Strategies to Accelerate and Facilitate HSPCs Homing and Engraftment

Novel Evidence That Alternative Activation Pathway of Complement Cascade (ComC) Regulates Optimal Homing and Engraftment of Hematopoietic Stem/Progenitor Cells (HSPCs) in Reactive Oxygen Species (ROS) - Nlrp3 Inflammasome-Dependent Manner

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

Novel Evidence That the Pannexin 1 Channel Is Involved in Adenosine Triphosphate (ATP) Release from Cells for Optimal Mobilization of Hematopoietic Stem Progenitor Cells, and the Pannexin 1 SNP 5 (Rs3020015) T/C Polymorphism Characterizes Poor Mobilizer Status in Patients

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood

Novel Evidence That the Ectonucleotidases CD39 and CD73, Which Are Expressed on Hematopoietic Stem/Progenitor Cells (HSPCs), Regulate Mobilization and Homing - Studies in CD39-/- and CD73-/- Mice and with Small-Molecule CD39 and CD73 Inhibitors

Novel Evidence That Extracellular Nucleotides and Nucleosides Regulate the Expression of Heme Oxygenase 1 (HO-1) in Opposite Ways in Hematopoietic Stem/Progenitor Cells (HSPCs), Which Explains Why ATP Enhances Mobilization of HSPCs, While Its Metabolite Adenosine Inhibits This Process

Sphingosine Kinase 2 (SphK2) Deficiency Does Not Lower but Instead Surprisingly Increases the Level of Sphingosine-1-Phosphate (S1P) in Peripheral Blood, Providing a Novel Strategy for Stimulating Hematopoietic Stem Cell Mobilization By Inhibiting SphK2 Activity

Novel Evidence That the Mannan-Binding Lectin (MBL) Pathway of Complement Activation Plays a Pivotal Role in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells By Activation of Both the Complement and Coagulation Cascades

Unexpected Evidence That Inducible Nitric Oxide Synthase (iNOS) Is a Negative Regulator of Hematopoietic Stem/Progenitor Cell Mobilization

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Heme Oxygenase 1 (HO-1) Is a Novel Negative Regulator of Normal and Malignant Hematopoietic Cell Trafficking

Novel Evidence That a Lipolytic Enzyme - Hematopoietic-Specific Phospholipase C Beta 2 - Promotes Mobilization of Hematopoietic Stem Cells By Decreasing Their Lipid Raft-Mediated Bone Marrow Retention and Increasing the Pro-Mobilizing Effects of Granulocytes

A Novel and Pivotal Role of the Mannose-Binding Lectin (MBL) Pathway of Complement Cascade (ComC) Activation in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells (HSPCs)

Transient Ex Vivo Inhibition of Heme Oxygenase 1 (HO-1) in Hematopoietic Stem/Progenitor Cells (HSPCs) By Small-Molecule Inhibitors Enhances Their Migratory Responsiveness to Bone Marrow (BM)-Secreted Chemoattractants a Novel and Simple Strategy to Improve Homing of HSPCs

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