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Kristin Hope
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Journal Articles

Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia

Open Access
Brief Report
Cristiana O’Brien, Nirvana Nursimulu, Anit Tyagi, Rachel Culp-Hill, Andrea Arruda, Tracy Murphy, Mark D. Minden, Andrew Kent, Brett Stevens, Daniel A. Pollyea, Kristin Hope, Sushant Kumar, Julie A. Reisz, Angelo D'Alessandro, Courtney L. Jones
Journal: Blood
Blood (2025) 146 (21): 2589–2596.
https://doi.org/10.1182/blood.2025029132
Published: 2025
Includes: Supplemental data
Journal Articles

Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation

Open Access
Tianyi Ling, Cristiana O'Brien, Jonathan St-Germain, Vincent Rondeau, Mary Shi, Jacob M Berman, Adrianna Kinga Cepa, Paula Saez Raez, Mark Wunderlich, Katharine Carter, Cody Stillwell, Christina R Sexton, Rachel Culp-Hill, Julie A. Reisz, Saeer A Adeel, Andy G. X. Zeng, Suraj Bansal, Emily Tsao, He Tian Tony Chen, John E. Dick, Mark D Minden, Andrea Arruda, Maria L Amaya, Anastasia N Tikhonova, Kristin Hope, Angelo D'Alessandro, Brian Raught, Courtney L Jones
Journal: Blood
Blood blood.2025028933.
https://doi.org/10.1182/blood.2025028933
Published: 2025
Includes: Supplemental data
Journal Articles

Activating a Non-Genetic MYC-Regulating Pathway Sensitizes Acute Myeloid Leukemia to Bromodomain Inhibition

Free
Xinyue Zhou, Steven Moreira, Hong Wang, Pengcheng Zhang, Yang Zhou, Ravi Bhatia, Chunliang Li, Kristin Hope, Rui Lu
Journal: Blood
Blood (2022) 140 (Supplement 1): 8735.
https://doi.org/10.1182/blood-2022-167049
Published: 2022
Journal Articles

PLAGL2 Independently Drives Aberrant Erythropoiesis and Initiation of Preleukemic State

Free
Joshua Xu, Tony Chen, Ava Keyvani Chahi, Gabriela Krivdova, Sajid Marhon, Ana Vujovic, Nicholas Wong, John E. Dick, Kristin Hope
Journal: Blood
Blood (2021) 138 (Supplement 1): 3663.
https://doi.org/10.1182/blood-2021-153098
Published: 2021
Journal Articles

Inhibiting Mitochondrial Complex II Exposes a Novel Metabolic Vulnerability in Acute Myeloid Leukemia

Free
Alessia Roma, Matthew Tcheng, Nawaz Ahmed, Sarah Walker, Preethi Jayanth, Mark D. Minden, Kristin Hope, Praveen P. Nekkar Rao, Jessica Luc, Andrew C. Doxey, Julie A. Reisz, Angelo D'Alessandro, Paul A. Spagnuolo
Journal: Blood
Blood (2021) 138 (Supplement 1): 1300.
https://doi.org/10.1182/blood-2021-148708
Published: 2021
Journal Articles

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Free
Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard W. Smith, Preethi Jayanth, Mark D. Minden, Aaron D. Schimmer, David A. Hess, Kristin Hope, Kevin A. Rea, Tariq A. Akhtar, Eric Bohrnsen, Angelo D’Alessandro, Al-Walid Mohsen, Jerry Vockley, Paul A. Spagnuolo
Journal: Blood
Blood (2021) 137 (25): 3518–3532.
https://doi.org/10.1182/blood.2020008551
Published: 2021
Includes: Supplemental data
Journal Articles

RNA Processing in Benign and/or Malignant Hematology

Free
Kristin Hope, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): SCI5.
https://doi.org/10.1182/blood-2020-133024
Published: 2020
Journal Articles

Inhibiting Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Induces Selective Leukemia Cell Death

Free
Matthew Tcheng, BSc, Alessia Roma, BSc, Nawaz Ahmed, MSc, Richard Smith, PhD, Preethi Jayanth, PhD, Mark D. Minden, MD PhD, Rose Hurren, BSc, Aaron D Schimmer, MD PhD, Gale Bozzo, PhD, David Hess, PhD, Kristin Hope, PhD, Kevin Rea, MSc, Tariq A. Akhtar, PhD, Al-Walid Mohsen, PhD, Jerry Vockley, MD PhD, Paul A. Spagnuolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3922.
https://doi.org/10.1182/blood-2019-122262
Published: 2019
Journal Articles

The Splicing Factor RBM17 Supports Leukemia Stem Cell Self-Renewal

Free
Lina Liu, Ana Vujovic, Joshua Xu, Kristin Hope, PhD, Yu Lu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1238.
https://doi.org/10.1182/blood-2019-126287
Published: 2019
Journal Articles

Enforcing Post-Transcriptional Circuitries to Achieve Human Hematopoietic Stem Cell Expansion

Free
Kristin Hope, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): SCI-46.
https://doi.org/10.1182/blood.V130.Suppl_1.SCI-46.SCI-46
Published: 2017
Journal Articles

Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2

Free
Stephen B. Ting, Eric Deneault, Kristin Hope, Sonia Cellot, Jalila Chagraoui, Nadine Mayotte, Jonas F. Dorn, Jean-Philippe Laverdure, Michael Harvey, Edwin D. Hawkins, Sarah M. Russell, Paul S. Maddox, Norman N. Iscove, Guy Sauvageau
Journal: Blood
Blood (2012) 119 (11): 2510–2522.
https://doi.org/10.1182/blood-2011-11-393272
Published: 2012
Includes: Multimedia, Supplemental data
Journal Articles

RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity

Free
e-blood
Brian T. Wilhelm, Mathieu Briau, Pamela Austin, Amélie Faubert, Geneviève Boucher, Pierre Chagnon, Kristin Hope, Simon Girard, Nadine Mayotte, Josette-Renee Landry, Josée Hébert, Guy Sauvageau
Journal: Blood
Blood (2011) 117 (2): e27–e38.
https://doi.org/10.1182/blood-2010-07-293332
Published: 2011
Includes: Supplemental data
Journal Articles

High Levels of MicroRNA-126 Bioactivity Specify the LSC Compartment in AML

Free
Eric R Lechman, MS, PhD, Hidefumi Hiramatsu, MD, PhD, Bernhard Gentner, MD, Kristin Hope, PhD, Katsuto Takenaka, MD, Kolja Eppert, PhD, Mark D. Minden, MD, PhD, Luigi Naldini, John E. Dick, PhD
Journal: Blood
Blood (2008) 112 (11): 510.
https://doi.org/10.1182/blood.V112.11.510.510
Published: 2008