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Journal Articles

MLL-AF9-Induced Leukaemia Changes during Ontogenic Stages

Meaad Saeed Almowaled, Lijun Liu, Karen Dunn, Myint Myat Khine Aung, Gillian Horne, Juerg Schwaller, Karen Keeshan

Blood (2023) 142 (Supplement 1): 2761.

https://doi.org/10.1182/blood-2023-185911

Published: 2023

Journal Articles

Superenhancing AML with Trib1

Karen Keeshan

Blood (2021) 137 (1): 8–9.

https://doi.org/10.1182/blood.2020008315

Published: 2021

Journal Articles

A Synthetic Lethal Approach to Eradicate AML Via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors

Blood (2020) 136 (Supplement 1): 14.

https://doi.org/10.1182/blood-2020-143079

Published: 2020

Journal Articles

BET Inhibitors Potentiate Activation of p53 and Killing of AML By MDM2 Inhibitors — a Candidate Combination Therapy

Peter D Adams, Anne Louise Latif, Ashley Newcombe, Neil Robertson, Maria Terradas, Helen Stewart, Claire Reid, Loveena Rishi Delori, Timothy Chevassut, Xu Huang, BSc, PhD, Karen Keeshan, Karen Blyth, Mhairi Copland

Blood (2018) 132 (Supplement 1): 3912.

https://doi.org/10.1182/blood-2018-99-115509

Published: 2018

Journal Articles

Functional SCD1 Is Critical for Acute Lymphoblastic Leukaemia Maintenance in the Central Nervous System

Orianne Olivares, Antony Cousins, Elke Markert, Sergey Tumanov, Gillian Mackay, Jurre Kamphorst, Karen Keeshan, Pawel Herzyk, Eyal Gottlieb, Christina Halsey

Blood (2017) 130 (Supplement 1): 2608.

https://doi.org/10.1182/blood.V130.Suppl_1.2608.2608

Published: 2017

Journal Articles

The Bone Marrow Niche Distinguishes Young and Old Leukemia

Shahzya S Chaudhury, MBBChir, MA (cantab), Helen Wheadon, PhD, Brenda Gibson, MD PhD, Karen Keeshan, PhD

Blood (2016) 128 (22): 1548.

https://doi.org/10.1182/blood.V128.22.1548.1548

Published: 2016

Journal Articles

Dual Inhibition of MDM2 and BET Cooperate to Eradicate Acute Myeloid Leukemia

Anne-Louise Latif, MBChB, John J Cole, Joana Monteiro Campos, William Clark, Lynn McGarry, PhD, Claire Brock, Ashley Newcombe, Karen Keeshan, PhD, Mhairi Copland, BSc (Hons) MB ChB PhDFRCP FRCPath, Peter D Adams, PhD

Blood (2015) 126 (23): 674.

https://doi.org/10.1182/blood.V126.23.674.674

Published: 2015

Journal Articles

Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

Loveena Rishi, Maura Hannon, Mara Salomè, Marie Hasemann, Anne-Katrine Frank, Joana Campos, Jennifer Timoney, Caitriona O’Connor, Mary R. Cahill, Bo Porse, Karen Keeshan

Blood (2014) 123 (15): 2389–2400.

https://doi.org/10.1182/blood-2013-07-511683

Published: 2014

Includes: Supplemental data

Journal Articles

Elucidation and Therapeutic Targeting Of The Molecular Mechanism Of TRIB2-Mediated Acute Myeloid Leukaemia

Fiona Lohan, Ciaran Forde, Mara Salome, Caitriona O'Connor, Fiona Bailey, Mary R Cahill, MD FRCPath, Ruud Delwel, Patrick Eyers, Patrick Kiely, Karen Keeshan

Blood (2013) 122 (21): 3792.

https://doi.org/10.1182/blood.V122.21.3792.3792

Published: 2013

Journal Articles

Elucidation and Therapeutic Targeting Of The Molecular Mechanism Of TRIB2-Mediated Acute Myeloid Leukaemia

Fiona Lohan, Ciaran Forde, Mara Salome, Caitriona O'Connor, Fiona Bailey, Mary R Cahill, MD FRCPath, Ruud Delwel, Patrick Eyers, Patrick Kiely, Karen Keeshan

Blood (2013) 122 (21): 3799.

https://doi.org/10.1182/blood.V122.21.3799.3799

Published: 2013

Journal Articles

Tribbles in acute leukemia

Kai Ling Liang, Loveena Rishi, Karen Keeshan

Blood (2013) 121 (21): 4265–4270.

https://doi.org/10.1182/blood-2012-12-471300

Published: 2013

Includes: Supplemental data

Journal Articles

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Karen Keeshan, Will Bailis, Priya H. Dedhia, Maria E. Vega, Olga Shestova, Lanwei Xu, Kristin Toscano, Sacha N. Uljon, Stephen C. Blacklow, Warren S. Pear

Blood (2010) 116 (23): 4948–4957.

https://doi.org/10.1182/blood-2009-10-247361

Published: 2010

Includes: Supplemental data

Journal Articles

Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia

Priya H. Dedhia, Karen Keeshan, Sacha Uljon, Lanwei Xu, Maria E. Vega, Olga Shestova, Meirav Zaks-Zilberman, Candice Romany, Stephen C. Blacklow, Warren S. Pear

Blood (2010) 116 (8): 1321–1328.

https://doi.org/10.1182/blood-2009-07-229450

Published: 2010

Includes: Supplemental data

Journal Articles

Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia

Priya Dedhia, Karen Keeshan, Maria Vega, Sacha Uljon, M.D., Ph.D., Lanwei Xu, Olga Shestova, Candice Romany, Stephen C Blacklow, M.D., Ph.D., Warren S. Pear, MD, PhD

Blood (2008) 112 (11): 2950.

https://doi.org/10.1182/blood.V112.11.2950.2950

Published: 2008

Journal Articles

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Bas J. Wouters, Meritxell Alberich Jordà, Karen Keeshan, Irene Louwers, Claudia A. J. Erpelinck-Verschueren, Dennis Tielemans, Anton W. Langerak, Yiping He, Yumi Yashiro-Ohtani, Pu Zhang, Christopher J. Hetherington, Roel G. W. Verhaak, Peter J. M. Valk, Bob Löwenberg, Daniel G. Tenen, Warren S. Pear, Ruud Delwel

Blood (2007) 110 (10): 3706–3714.

https://doi.org/10.1182/blood-2007-02-073486

Published: 2007

Includes: Supplemental data

Journal Articles

Tribbles Homolog 2 (Trib2) Inactivates C/EBPalpha and Causes Acute Myelogenous Leukemia.

Karen Keeshan, PhD, Yiping He, PhD, Bas J. Wouters, Olga Shestova, Lanwei Xu, Hong Sai, Carlos G. Rodriguez, Ivan Maillard, Peter Valk, Martin Carroll, Jon C. Aster, Rudd Delwel, Warren S. Pear

Blood (2006) 108 (11): 776.

https://doi.org/10.1182/blood.V108.11.776.776

Published: 2006

Journal Articles

Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPα

Giovanna Ferrari-Amorotti, Karen Keeshan, Michela Zattoni, Clara Guerzoni, Giorgio Iotti, Sara Cattelani, Nick J. Donato, Bruno Calabretta

Blood (2006) 108 (4): 1353–1362.

https://doi.org/10.1182/blood-2006-01-011833

Published: 2006

Journal Articles

Transcription activation function of C/EBPα is required for induction of granulocytic differentiation

Karen Keeshan, Giorgia Santilli, Francesca Corradini, Danilo Perrotti, Bruno Calabretta

Blood (2003) 102 (4): 1267–1275.

https://doi.org/10.1182/blood-2003-02-0477

Published: 2003

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MLL-AF9-Induced Leukaemia Changes during Ontogenic Stages

Superenhancing AML with Trib1

A Synthetic Lethal Approach to Eradicate AML Via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors

BET Inhibitors Potentiate Activation of p53 and Killing of AML By MDM2 Inhibitors — a Candidate Combination Therapy

Functional SCD1 Is Critical for Acute Lymphoblastic Leukaemia Maintenance in the Central Nervous System

The Bone Marrow Niche Distinguishes Young and Old Leukemia

Dual Inhibition of MDM2 and BET Cooperate to Eradicate Acute Myeloid Leukemia

Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

Elucidation and Therapeutic Targeting Of The Molecular Mechanism Of TRIB2-Mediated Acute Myeloid Leukaemia

Elucidation and Therapeutic Targeting Of The Molecular Mechanism Of TRIB2-Mediated Acute Myeloid Leukaemia

Tribbles in acute leukemia

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia

Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Tribbles Homolog 2 (Trib2) Inactivates C/EBPalpha and Causes Acute Myelogenous Leukemia.

Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPα

Transcription activation function of C/EBPα is required for induction of granulocytic differentiation

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