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Journal Articles

NPM-ALK Oncoprotein Suppresses Anti-Tumor Immune Responses Partially through Cgas-Sting Pathway in ALK+ Anaplastic Large Cell Lymphoma

Ioanna Xagoraris, Ying Yang, Dora Trogrlic, Alma Mansson, Christina Plastira, Vasiliki Leventaki, Hong Qian, Andreas Lundqvist, George Z. Rassidakis

Blood (2024) 144 (Supplement 1): 2999.

https://doi.org/10.1182/blood-2024-205772

Published: 2024

Journal Articles

Modulation of the CGAS-Sting Anti-Tumor Immune Response Pathway in an NF-KB-Dependent or -Independent Manner As a Potential Therapeutic Target in Classical Hodgkin Lymphoma (cHL)

Ioanna Xagoraris, Konstantina Stathopoulou, Persa Xyderou, Marzia Palma, Elias Drakos, Theodoros P. Vassilakopoulos, George Z. Rassidakis

Blood (2022) 140 (Supplement 1): 3579–3580.

https://doi.org/10.1182/blood-2022-164497

Published: 2022

Journal Articles

The NPM-ALK Oncogenic Kinase Suppresses CGAS-Sting-Associated Anti-Tumor Immune Responses through STAT3 Activation in Anaplastic Large Cell Lymphoma (ALCL)

Ioanna Xagoraris, Georgia Kokaraki, Christina Plastira, Konstantina Stathopoulou, Vasiliki Leventaki, Elias Drakos, Jeffrey Medeiros, Anders Österborg, George Z. Rassidakis

Blood (2021) 138 (Supplement 1): 1338.

https://doi.org/10.1182/blood-2021-149257

Published: 2021

Journal Articles

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

Håkan Mellstedt, MD PhD Prof., Amineh Ghaderi, MSc, Johanna Aschan, MSc, Fariba Mozaffari, MSc,PhD, Ali Moshfegh, MSc,PhD, Birgitta Sander, MD PhD Prof., Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Mohammad Hojjat-Farsangi, MSc,PhD

Blood (2019) 134 (Supplement_1): 5312.

https://doi.org/10.1182/blood-2019-129773

Published: 2019

Journal Articles

NPM-ALK Upregulates Jab1/Csn5 through STAT3 Activation in Anaplastic Large Cell Lymphoma: A Novel Function of NPM-ALK That Contributes to PD1/PD-L1 Immune Checkpoint Regulation

Elias Drakos, MD PhD Prof., Konstantina Stathopoulou, MSc., Lingxiao Li, PhD, Daniel Bilbao, Vasiliki Leventaki, Pedro Farrajota Neves Da Silva, MD, Vasileios Atsaves, PhD, Anders Österborg, MD PhD, L. Jeffrey Medeiros, MD, Francisco Vega, MD PhD, Jonathan H. Schatz, MD, Francois Claret, PhD, George Z. Rassidakis, MD PhD Prof.

Blood (2019) 134 (Supplement_1): 2796.

https://doi.org/10.1182/blood-2019-130457

Published: 2019

Journal Articles

Diffuse Large B Cell Lymphoma (DLBCL) Expresses ROR1 and a ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Tumor Cells

Mohammad Hojjat-Farsangi, MSc,PhD, Amineh Ghaderi, MSc, AmirHossein Daneshmanesh, MD PhD, Jemina Lehto, MSc, Ali Moshfegh, MSc,PhD, Parviz Kokhaei, MSc,PhD, Jan Vågberg, MSc,PhD, Elisabeth Olsson, MSc,PhD, Charlotta Löfberg, MSc,PhD, Charlotta Carina Norström, MSc,PhD, Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Håkan Mellstedt, MD PhD Prof.

Blood (2019) 134 (Supplement_1): 2565.

https://doi.org/10.1182/blood-2019-126801

Published: 2019

Journal Articles

Encouraging Outcomes with Intensive Chemotherapy for Patients with Primary Mediastinal B-Cell Lymphoma - a Swedish Lymphoma Register Study

Tove Wästerlid, MD PhD, George Z. Rassidakis, MD PhD Prof., Birgitta Sander, MD PhD Prof., Karin E. Smedby, MD PhD

Blood (2019) 134 (Supplement_1): 1618.

https://doi.org/10.1182/blood-2019-122819

Published: 2019

Journal Articles

The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways

Megan S. Lim, Mary L. Carlson, David K. Crockett, G. Chris Fillmore, David R. Abbott, Olaotan F. Elenitoba-Johnson, Sheryl R. Tripp, George Z. Rassidakis, L. Jeffrey Medeiros, Philippe Szankasi, Kojo S. J. Elenitoba-Johnson

Blood (2009) 114 (8): 1585–1595.

https://doi.org/10.1182/blood-2009-02-204735

Published: 2009

Includes: Supplemental data

Journal Articles

NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma

Vasiliki Leventaki, Elias Drakos, L. Jeffrey Medeiros, Megan S. Lim, Kojo S. Elenitoba-Johnson, Francois X. Claret, George Z. Rassidakis

Blood (2007) 110 (5): 1621–1630.

https://doi.org/10.1182/blood-2006-11-059451

Published: 2007

Includes: Supplemental data

Journal Articles

Nutlin-3A, an MDM2 Antagonist, Induces p53-Dependent Cell Cycle Arrest and Apoptosis in Hodgkin Lymphoma (HL).

Elias Drakos, MD, Athanasios Thomaides, MD, Jiang Li, MD,PhD, Marina Konopleva, MD,PhD, L. Jeffrey Medeiros, MD, Michael Andreeff, MD,PhD, George Z. Rassidakis, MD,PhD

Blood (2006) 108 (11): 2506.

https://doi.org/10.1182/blood.V108.11.2506.2506

Published: 2006

Journal Articles

Overexpression of CXCR4 in Acute Myeloid Leukemia Predicts Adverse Overall and Progression-Free Survival Independently of FLT3 Gene Mutation.

Sergej Konoplev, MD, PhD, George Z. Rassidakis, MD,PhD, Elihu H. Estey, MD, Hagop M. Kantarjian, MD, Xuelin Huang, PhD, Lianchun Xiao, Michael Andreeff, MD,PhD, Marina Konopleva, MD,PhD, L. Jeffrey Medeiros, MD

Blood (2006) 108 (11): 1890.

https://doi.org/10.1182/blood.V108.11.1890.1890

Published: 2006

Journal Articles

Prospective Management of Primary Testicular Lymphoma (PTL) with Doxorubicin-Based Chemotherapy, Prophylactic Intrathecal (IT) Methotrexate and Radiotherapy (RT), but without Rituximab: Results from IELSG.

Andreas H. Sarris, Umberto Vitolo, Emanuele Zucca, George Z. Rassidakis, Jeffrey Medeiros, Maria Giuseppina Cabras, Alice Di Rocco, Barbara Pro, Mary K. Gospodarowicz, Franco Cavalli

Blood (2006) 108 (11): 2454.

https://doi.org/10.1182/blood.V108.11.2454.2454

Published: 2006

Journal Articles

NPM-ALK Promotes Cell Cycle Progression through Activation of JNK and c-Jun in Anaplastic Large Cell Lymphoma.

Vasiliki Leventaki, MD, Elias Drakos, MD, Megan Lim, MD, Kojo S. Elenitoba-Johnson, MD, Francois-Xavier Claret, PhD, L. Jeffrey Medeiros, MD, George Z. Rassidakis, MD,PhD

Blood (2006) 108 (11): 2057.

https://doi.org/10.1182/blood.V108.11.2057.2057

Published: 2006

Journal Articles

c-FLIP confers resistance to FAS-mediated apoptosis in anaplastic large-cell lymphoma

Mauricio P. Oyarzo, L. Jeffrey Medeiros, Coralyn Atwell, Marianna Feretzaki, Vasiliki Leventaki, Elias Drakos, Hesham M. Amin, George Z. Rassidakis

Blood (2006) 107 (6): 2544–2547.

https://doi.org/10.1182/blood-2005-06-2601

Published: 2006

Includes: Supplemental data

Journal Articles

Impact of LMP-1 expression on clinical outcome in age-defined subgroups of patients with classical Hodgkin lymphoma

Marco Herling, George Z. Rassidakis, Theodoros P. Vassilakopoulos, L. Jeffrey Medeiros, Andreas H. Sarris, on behalf of the International Hodgkin Lymphoma Study Group

Blood (2006) 107 (3): 1240–1241.

https://doi.org/10.1182/blood.V107.3.1240.1240

Published: 2006

Journal Articles

Inhibition of AKT/mTOR Signaling Pathway Induces Cell Cycle Arrest and Apoptosis in Acute Myelogenous Leukemia.

Weina Chen, MD, PhD, Ioannis Grammatikakis, BS, Jiang Li, MD, Vassiliki Leventaki, MD, L. Jeffrey Medeiros, MD, George Z. Rassidakis, MD, PhD

Blood (2005) 106 (11): 2355.

https://doi.org/10.1182/blood.V106.11.2355.2355

Published: 2005

Journal Articles

Differential Expression of the Homeobox Gene MIXL1 in Non Hodgkin (NHL) and Hodgkin Lymphomas (HL).

Elias Drakos, MD, George Z. Rassidakis, MD, PhD, Wei Guo, PhD, L. Jeffrey Medeiros, MD, Lalitha Nagarajan, PhD

Blood (2005) 106 (11): 3014.

https://doi.org/10.1182/blood.V106.11.3014.3014

Published: 2005

Journal Articles

Heat Shock Protein 90 (HSP90) Inhibition by the Small Molecule 17-AAG Induces Cell Cycle Arrest and Apoptosis in Anaplastic Large Cell Lymphoma (ALCL) Irrespective of ALK Expression: Role of Akt, ERK and ALK Kinases in the Molecular Mechanisms of 17-AAG Anti-Tumor Activity.

Georgios V. Georgakis, MD, Yang Li, MS, George Z. Rassidakis, MD, PhD, Felipe Samaniego, MD, L. Jeffrey Medeiros, MD, Anas Younes, MD

Blood (2005) 106 (11): 2811.

https://doi.org/10.1182/blood.V106.11.2811.2811

Published: 2005

Journal Articles

Activation of mTOR Signaling Pathway Contributes to Tumoral Cell Survival in ALK-Positive Anaplastic Large Cell Lymphoma.

Francisco Vega, MD, PhD, L. Jeffrey Medeiros, MD, Coralyn Atwell, BS, Jeong Hee Cho, MD, PhD, Ling Tian, PhD, Francois-Xavier Claret, PhD, George Z. Rassidakis, MD, PhD

Blood (2005) 106 (11): 2419.

https://doi.org/10.1182/blood.V106.11.2419.2419

Published: 2005

Journal Articles

Heat Shock Protein 90 (HSP90) Is Overexpressed in Primary and Cultured Hodgkin Lymphoma (HL) Cells: Role of Therapeutic Targeting Using the Small Molecule Inhibitor 17-AAG.

Georgios V. Georgakis, MD, Yang Li, MS, George Z. Rassidakis, MD, PhD, L. Jeffrey Medeiros, MD, Anas Younes, MD

Blood (2005) 106 (11): 2422.

https://doi.org/10.1182/blood.V106.11.2422.2422

Published: 2005

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NPM-ALK Oncoprotein Suppresses Anti-Tumor Immune Responses Partially through Cgas-Sting Pathway in ALK+ Anaplastic Large Cell Lymphoma

Modulation of the CGAS-Sting Anti-Tumor Immune Response Pathway in an NF-KB-Dependent or -Independent Manner As a Potential Therapeutic Target in Classical Hodgkin Lymphoma (cHL)

The NPM-ALK Oncogenic Kinase Suppresses CGAS-Sting-Associated Anti-Tumor Immune Responses through STAT3 Activation in Anaplastic Large Cell Lymphoma (ALCL)

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

NPM-ALK Upregulates Jab1/Csn5 through STAT3 Activation in Anaplastic Large Cell Lymphoma: A Novel Function of NPM-ALK That Contributes to PD1/PD-L1 Immune Checkpoint Regulation

Diffuse Large B Cell Lymphoma (DLBCL) Expresses ROR1 and a ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Tumor Cells

Encouraging Outcomes with Intensive Chemotherapy for Patients with Primary Mediastinal B-Cell Lymphoma - a Swedish Lymphoma Register Study

The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways

NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma

Nutlin-3A, an MDM2 Antagonist, Induces p53-Dependent Cell Cycle Arrest and Apoptosis in Hodgkin Lymphoma (HL).

Overexpression of CXCR4 in Acute Myeloid Leukemia Predicts Adverse Overall and Progression-Free Survival Independently of FLT3 Gene Mutation.

Prospective Management of Primary Testicular Lymphoma (PTL) with Doxorubicin-Based Chemotherapy, Prophylactic Intrathecal (IT) Methotrexate and Radiotherapy (RT), but without Rituximab: Results from IELSG.

NPM-ALK Promotes Cell Cycle Progression through Activation of JNK and c-Jun in Anaplastic Large Cell Lymphoma.

c-FLIP confers resistance to FAS-mediated apoptosis in anaplastic large-cell lymphoma

Impact of LMP-1 expression on clinical outcome in age-defined subgroups of patients with classical Hodgkin lymphoma

Inhibition of AKT/mTOR Signaling Pathway Induces Cell Cycle Arrest and Apoptosis in Acute Myelogenous Leukemia.

Differential Expression of the Homeobox Gene MIXL1 in Non Hodgkin (NHL) and Hodgkin Lymphomas (HL).

Heat Shock Protein 90 (HSP90) Inhibition by the Small Molecule 17-AAG Induces Cell Cycle Arrest and Apoptosis in Anaplastic Large Cell Lymphoma (ALCL) Irrespective of ALK Expression: Role of Akt, ERK and ALK Kinases in the Molecular Mechanisms of 17-AAG Anti-Tumor Activity.

Activation of mTOR Signaling Pathway Contributes to Tumoral Cell Survival in ALK-Positive Anaplastic Large Cell Lymphoma.

Heat Shock Protein 90 (HSP90) Is Overexpressed in Primary and Cultured Hodgkin Lymphoma (HL) Cells: Role of Therapeutic Targeting Using the Small Molecule Inhibitor 17-AAG.

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