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Journal Articles

Constitutive PRMT5 Expression Drives Spontaneous Lymphoblastic Lymphoma In Vivo

Lynda Villagomez, Porsha Smith, Fengting Yan, Victor Chen, Shelby Sloan, John T. Patton, Mackenzie Long, Fiona Brown, Elshafa H. Ahmed, Natarajan Muthusamy, Vincenzo Coppola, Anjali Mishra, Kris Vaddi, Peggy Scherle, Rosa Lapalombella, Lapo Alinari, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6381–6382.
https://doi.org/10.1182/blood-2022-168160
Published: 2022
Journal Articles

PRMT5 Transgenic Mice Develop Aggressive Lymphoblastic Lymphomas

Porsha L. Smith, PhD, Fengting Yan, MD PhD, John T. Patton, PhD, Lapo Alinari, MD PhD, Vrajesh Karkhanis, PhD, Leona Ayers, MD, Natarajan Muthusamy, DVM, PhD, Anjali Mishra, PhD, Elshafa Ahmed, DVM, Said Sif, PhD, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2936.
https://doi.org/10.1182/blood.V128.22.2936.2936
Published: 2016
Journal Articles

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Lapo Alinari, Kiran V. Mahasenan, Fengting Yan, Vrajesh Karkhanis, Ji-Hyun Chung, Emily M. Smith, Carl Quinion, Porsha L. Smith, Lisa Kim, John T. Patton, Rosa Lapalombella, Bo Yu, Yun Wu, Satavisha Roy, Alessandra De Leo, Stefano Pileri, Claudio Agostinelli, Leona Ayers, James E. Bradner, Selina Chen-Kiang, Olivier Elemento, Tasneem Motiwala, Sarmila Majumder, John C. Byrd, Samson Jacob, Said Sif, Chenglong Li, Robert A. Baiocchi
Journal: Blood
Blood (2015) 125 (16): 2530–2543.
https://doi.org/10.1182/blood-2014-12-619783
Published: 2015
Includes: Supplemental data
Journal Articles

Epstein-Barr Virus Kinase-Targeted Therapy for Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder

James Dugan, MD MS, Bradley M. Haverkos, MD MPH, Ludmila Katherine Martin, MD, Marisa F. Martin, Mark E Lustberg, MD PhD, John T. Patton, PhD, Gerard Nuovo, MD, Fengting Yan, MD, PhD, Robert Cavaliere, MD, Shannon C. Kenney, MD, Joyce Fingeroth, MD, Gerard Lozanski, MD, Juan Carlos Ramos, MD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD, Robert A. Baiocchi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1750.
https://doi.org/10.1182/blood.V124.21.1750.1750
Published: 2014
Journal Articles

Protein Arginine Methyltransferase 5 (PRMT5) Over-Expression Is Essential for Epstein-Barr Virus-Driven B-Cell Transformation.

Lapo Alinari, MD., Ph.D., Fengting Yan, M.D., Ph.D., Porsha Smith, John T. Patton, Carl Quinion, Bo Yu, Ph.D, Christian Tyler Earl, Mark E Lustberg, MD, PhD, Lynda Villagomez, Erin K Hertlein, PhD, John C. Byrd, MD, Leona Ayers, MD, Tasneem Motiwala, PhD, Sarmila Majumder, PhD, Chenglong Li, Ph.D., Said Sif, Ph.D., Samson T. Jacob, PhD, Robert A. Baiocchi, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 2378.
https://doi.org/10.1182/blood.V120.21.2378.2378
Published: 2012
Journal Articles

Successful Treatment of Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder (PCNS-PTLD) with Zidovudine (AZT), Ganciclovir (GCV), Rituximab and Dexamethasone: A Single-Institution Case Series

Ludmila Katherine Martin, MD, Mark E Lustberg, MD, PhD, Fengting Yan, M.D., Ph.D., John T. Patton, Pierluigi Porcu, MD, Gerard Nuovo, M.D., Robert Cavaliere, MD, Robert A. Baiocchi, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 3067.
https://doi.org/10.1182/blood.V118.21.3067.3067
Published: 2011
Journal Articles

Developing a Novel Class of Drug to Inhibit Protein Arginine Methyltransferase 5 (PRMT5) Enzyme Dysregulation in Mantle Cell Lymphoma

Fengting Yan, M.D., Ph.D., Porsha Smith, Lapo Alinari, MD., Ph.D., John Ryu, Bo Yu, Ph.D., Vrajesh Karkhanis, Ph.D., Sookil Tae, Ph.D., John T. Patton, Emily E. Wilding, Kate Gordon, Kiran Mahasenan, Ph.D., Deepak Bhasin, Ph.D., Claudio Agostinelli, M.D., Ph.D., Stefano A. Pileri, M.D., John C. Byrd, MD, Said Sif, Ph.D., Pui-kai Li, Ph.D., Chenglong Li, Ph.D., Robert A. Baiocchi, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 595.
https://doi.org/10.1182/blood.V118.21.595.595
Published: 2011
Journal Articles

Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma

Lapo Alinari, Bo Yu, Beth A. Christian, Fengting Yan, Jungook Shin, Rosa Lapalombella, Erin Hertlein, Mark E. Lustberg, Carl Quinion, Xiaoli Zhang, Gerard Lozanski, Natarajan Muthusamy, Mette Prætorius-Ibba, Owen A. O'Connor, David M. Goldenberg, John C. Byrd, Kristie A. Blum, Robert A. Baiocchi
Journal: Blood
Blood (2011) 117 (17): 4530–4541.
https://doi.org/10.1182/blood-2010-08-303354
Published: 2011
Includes: Supplemental data
Journal Articles

Co-Treatment with Milatuzumab (Anti-CD74 mAb) and Rituximab (Anti-CD20 mAb) Results in the Induction of Mantle Cell Lymphoma Cell Death That Is Dependent On Actin Polymerization and Inhibition of NF-Kb.

Lapo Alinari, MD, Beth Christian, MD, Bo Yu, Jungook Shin, Erin K Hertlein, PhD, Rosa Lapalombella, PhD, Fengting Yan, MD, PhD, Gregory Lesinski, PhD, Xiaoli Zhang, PhD, Gerard Lozanski, MD, Natarajan Muthusamy, PhD, David M. Goldenberg, ScD, MD, John C. Byrd, MD, Robert A. Baiocchi, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 1694.
https://doi.org/10.1182/blood.V114.22.1694.1694
Published: 2009
Journal Articles

FTY720 Demonstrates Promising in-Vitro and in-Vivo Pre-Clinical Activity by Down-Modulation of Cyclin D1 and Pakt in Mantle Cell Lymphoma.

Lapo Alinari, MD, Qing Liu, PhD, Ching-Shih Chen, PhD, Fengting Yan, MD, PhD, James T Dalton, PhD, Rosa Lapalombella, PhD, Xiaoli Zhang, PhD, Teresa Lin, BS, John C. Byrd, MD, Robert A. Baiocchi, MD, PhD, Natarajan Muthusamy, PhD
Journal: Blood
Blood (2009) 114 (22): 3728.
https://doi.org/10.1182/blood.V114.22.3728.3728
Published: 2009
Journal Articles

Combination Anti-CD74 (Milatuzumab) and CD20 (Rituximab) Monoclonal Antibody Therapy Has in Vitro and in Vivo Activity in Mantle Cell Lymphoma

Lapo Alinari, MD, Erin Hertlein, PhD, David M. Goldenberg, ScD, MD, Rosa Lapalombella, PhD, Fengting Yan, MD, PhD, Xiaoli Zhang, PhD, David M. Lucas, PhD, Natarajan Muthusamy, PhD, John C. Byrd, MD, Robert A. Baiocchi, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 886.
https://doi.org/10.1182/blood.V112.11.886.886
Published: 2008