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Journal Articles

Effect of avapritinib on skin lesions in patients with advanced systemic mastocytosis using a novel, artificial intelligence-based technology

Free
Deepti Radia, Tracy George, Ivan Alvarez-Twose, Francesco Mannelli, Michael Deininger, Kristen Pettit, Celalettin Ustun, Cristina Bulai Livideanu, Ingunn Dybedal, Elizabeth O. Hexner, Hui-Min Lin, Ilda Bidollari, Amber King, Saša Dimitrijević, Javier I. Muñoz-González, Brian D'Alessandro, Mira Patel, Anthony Melione, Jason Gotlib, Andreas Reiter, Daniel Deangelo, Frank Siebenhaar, Sigurd Broesby-Olsen, Karin Hartmann
Journal: Blood
Blood (2025) 146 (Supplement 1): 2030.
https://doi.org/10.1182/blood-2025-2030
Published: 2025
Journal Articles

Avapritinib achieves deep and durable symptom control with a well-tolerated safety profile in ism: Long-term outcomes from pioneer

Free
Tsewang Tashi, Hanneke Oude Elberink, Cem Akin, Mariana Castells, Jens Panse, Deepti Radia, Frank Siebenhaar, Cristina Bulai Livideanu, Karin Hartmann, Sigurd Broesby-Olsen, Tracy George, Vito Sabato, Paul van Daele, Sonia Cerquozzi, Ingunn Dybedal, Joseph Jurcic, Stéphane Barete, Andreas Reiter, Thanai Pongdee, Ruchi Desai, Philippe Schafhausen, Celalettin Ustun, Prithviraj Bose, Peter Vadas, Massimo Triggiani, Patrizia Bonadonna, Daniel Deangelo, Lindsay Rein, Pankit Vachhani, Ilda Bidollari, Hui-Min Lin, Janet Hong, Benjamin Lampson, Ashley Doyle, Ivan Alvarez-Twose, Jason Gotlib
Journal: Blood
Blood (2025) 146 (Supplement 1): 2024.
https://doi.org/10.1182/blood-2025-2024
Published: 2025
Journal Articles

Changes in long-term bone health in patients receiving avapritinib for the treatment of indolent systemic mastocytosis in the pioneer study

Free
Mariana Castells, Vishnu Sundaresh, Jason Gotlib, Tsewang Tashi, Vito Sabato, Cristina Bulai Livideanu, Cem Akin, Deepti Radia, Frank Siebenhaar, Daniel Deangelo, Tracy George, Hui-Min Lin, Janet Hong, Ashley Doyle, Guang Yang, Rachel Erlich, Kate Newberry, Benjamin Lampson, Ivan Alvarez-Twose
Journal: Blood
Blood (2025) 146 (Supplement 1): 5582.
https://doi.org/10.1182/blood-2025-5582
Published: 2025
Journal Articles

An analysis of clonal dynamics in patients with indolent systemic mastocytosis treated with avapritinib in the pioneer study

Free
Jens Panse, Tsewang Tashi, Jason Gotlib, Mariana Castells, Ivan Alvarez-Twose, Cem Akin, Cristina Bulai Livideanu, Vito Sabato, Juliana Schwaab, Andreas Reiter, Sigurd Broesby-Olsen, Frank Siebenhaar, Hui-Min Lin, Janet Hong, Benjamin Lampson, Guang Yang, Tracy George, Deepti Radia
Journal: Blood
Blood (2025) 146 (Supplement 1): 5573.
https://doi.org/10.1182/blood-2025-5573
Published: 2025
Journal Articles

Improved overall survival in patients with advanced systemic mastocytosis treated with avapritinib versus real-world therapy based on mutation-adjusted risk score (MARS) stratification

Free
Andreas Reiter, Johannes Luebke, Jason Gotlib, Ivan Alvarez-Twose, Deepti Radia, Priyanka Bobbili, Aolin Wang, Saša Dimitrijević, Olivier Ponet, Erin Sullivan, Juliana Schwaab, Ilene Galinsky, Cecelia Perkins, Wolfgang Sperr, Priya Sriskandarajah, Manasi Mohan, Anyu Zhu, Mei Sheng Duh, Peter Valent, Daniel Deangelo, Julien Rossignol, Olivier Hermine
Journal: Blood
Blood (2025) 146 (Supplement 1): 5595.
https://doi.org/10.1182/blood-2025-5595
Published: 2025
Journal Articles

A multicentre UK snapshot audit of symptom burden in patients with indolent systemic mastocytosis utilising the ISM-SAF ©

Free
Shyamala Chinnabhandara, Sneha Fernandes, Rory FD Morrice, Mahmoud Hassan, Rashmi Chandrashekar, Susan Asirvatham, Jonathan Lambert, Chun Teh, Frances Wadelin, Clive Grattan, Scott Veitch, Deepti Radia
Journal: Blood
Blood (2025) 146 (Supplement 1): 7313.
https://doi.org/10.1182/blood-2025-7313
Published: 2025
Journal Articles

Avapritinib treatment of patients with advanced systemic mastocytosis: 4-year safety, effect on bone and first-line efficacy results of the pathfinder clinical study

Free
Andreas Reiter, Tracy George, Deepti Radia, Michael Deininger, Johannes Luebke, Hui-Min Lin, Ilda Bidollari, Joana Caetano-Lopes, Guang Yang, Amber King, Saša Dimitrijević, Daniel Deangelo, Jason Gotlib
Journal: Blood
Blood (2025) 146 (Supplement 1): 1022.
https://doi.org/10.1182/blood-2025-1022
Published: 2025
Journal Articles

Efficacy and safety results from the primary analysis of the pivotal summit trial: Bezuclastinib in adults with non-advanced systemic mastocytosis

Free
Lindsay Rein, Nathan Boggs, Prithviraj Bose, Brian Modena, Vito Sabato, Karin Hartmann, Cem Akin, Tracy George, Cecilia Arana Yi, Hanneke Oude Elberink, Deepti Radia, Andreas Reiter, Miguel Piris-Villaespesa, Ingunn Dybedal, Jens Panse, Stephen Oh, Pankit Vachhani, Anthony Hunter, Mariana Castells, Cristina Bulai Livideanu, Paul van Daele, Arnold Kirshenbaum, Ivan Alvarez-Twose, Jennifer Vaughn, Minakshi Taparia, Sonia Cerquozzi, Andrzej Mital, Marek Hus, ALESSANDRA ROMANO, John Fahrenholz, Frederick Lansigan, Cristina Papayannidis, Helena Pomares, Michela Rondoni, Celalettin Ustun, Richard Herrscher, Michael Manning, Stéphane Barete, Mar Guilarte, Candido Rivera, Jonathan Bernstein, Peter Vadas, Chiara Elena, Derek McCulloch, Nina Orfali, Clodagh Keohane, Francesco Mannelli, Philippe Schafhausen, Amanda Pilla, Jenna Zhang, Lei Sun, Nisha Shah, Hina Jolin, Rachael Easton, Jessica Sachs, Frank Siebenhaar, Daniel Deangelo
Journal: Blood
Blood (2025) 146 (Supplement 1): 80.
https://doi.org/10.1182/blood-2025-80
Published: 2025
Journal Articles

UK Single Institution Experience of Mastocytosis: Guy's and St Thomas' NHS Foundation Trust

Free
Clare Oni, MD, Mufaddal Moonim, MD, Joana Desterro, MD, Clive Grattan, MD, Natalia Curto-Garcia, MD, Claire Woodley, Monika Ciesielska, Deimante Drasutyte, Yvonne Francis, Jennifer O'Sullivan, MD, Thompson Olaoni, Anna Green, MD, Miki Yurina, MD, Mark Ong, MD, Nick C.P. Cross, Professor, Donal P. McLornan, MB, BCh (Hons), MRCP, PhD FRCPath, Deepti Radia
Journal: Blood
Blood (2019) 134 (Supplement_1): 2960.
https://doi.org/10.1182/blood-2019-130477
Published: 2019
Journal Articles

Interim Analysis of a Prospective Multicentre Study Using Next Generation Sequencing for Kinase Domain Mutational Analysis in CML Patients on First or Subsequent TKI Therapy

Free
Hugues De Lavallade, Sophie Jackson, BSc, Heather Oakervee, BSc, MBBS, MD MRCP, FRCPath, Sebastian Francis, MBChB, MRCP, Edward Belsham, FRCPath, MB, Paul Cahalin, MA MRCP FRCPath, Joanne Ewing, PhDBMBS BSc FRPATH, Jenny Byrne, MD PhD, Kate Rothwell, BA MB BChir, PhD, Sandra Hassan, MBBS, MRCP, FRCPath, MDRes), Srinivas Pillai, MBBS,MD MRCP, FRCPath, Priyanka Mehta, Anshu Garg, MBBS,MDMRCP,FRCPath, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Oliver Ottmann, Prof, MD, Deepti Radia, Patrick Harrington, MRCP, FRCPath, Rachel Greig, Nicholas Lea, PhD, Michael Thompson, Aytug Kizilors, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2935.
https://doi.org/10.1182/blood-2019-129825
Published: 2019
Journal Articles

Pioneer: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy

Free
Cem Akin, MD PhD, Vito Sabato, Jason Gotlib, MD MS, Mariana Castells, Michael W. Deininger, Hanneke Oude Elberink, Mark L Heaney, Paul van Daele, Deepti Radia, Massimo Triggiani, Daniel J. DeAngelo, MD, Iván Alvarez-Twose, Sigurd Broesby-Olsen, Tracy I. George, MD, Karin Hartmann, Siebenhaar Frank, Andreas Reiter, Peter Vadas, Patrizia Bonadonna, Jens P. Panse, Petra Staubach-Renz, Knut Brockow, Diamant Thaci, Hui-Min Lin, Andrew Morrison, Brenton Mar, Marcus Maurer
Journal: Blood
Blood (2019) 134 (Supplement_1): 2950.
https://doi.org/10.1182/blood-2019-126035
Published: 2019
Journal Articles

Outcomes of Patients Receiving Direct Oral Anticoagulants for Myeloproliferative Neoplasm Associated Venous Thromboembolism

Free
Andrew Doyle, MBBS, BSc, FRPATH, Karen Breen, MD, Donal P. McLornan, MB, BCh (Hons), MRCP, PhD FRCPath, Deepti Radia, Beverley J. Hunt, Gavin Ling, MBBS, BSc, FRCPath, Claire N Harrison, Professor, Natalia Curto Garcia, MD MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4183.
https://doi.org/10.1182/blood-2019-128170
Published: 2019
Journal Articles

Attenuated Immune Responses to the Annual Influenza A Vaccine in Patients with Myeloproliferative Neoplasms

Free
Samah Alimam, FRCPath, Jessica Ann Timms, Richard Dillon, MA, PhD MRCP, FRCPath, Tracey Mare, Deepti Radia, Hugues De Lavallade, Claire N Harrison, Professor, Shahram Kordasti, MD PhD, Donal P. McLornan, MB, BCh (Hons), MRCP, PhD FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 1673.
https://doi.org/10.1182/blood-2019-129091
Published: 2019
Journal Articles

Mechanistic Insights into the Inhibition of T Regulatory Cells By Dasatinib May Predict Immunostimulatory Effects in CML Patients

Free
Patrick Harrington, MRCP, FRCPath, Richard Dillon, MA, PhD MRCP, FRCPath, Philippe Rousselot, MD PhD, Deepti Radia, Yvonne Francis, Claire N Harrison, Professor, Shahram Kordasti, MD PhD, Hugues De Lavallade
Journal: Blood
Blood (2019) 134 (Supplement_1): 1635.
https://doi.org/10.1182/blood-2019-129135
Published: 2019
Journal Articles

Single Center Retrospective Study of Essential Thrombocythaemia Diagnosed Patients Treated with Interferon - Benefit and Tolerability

Free
Joana Desterro, Donal P McLornan, MD PhD FRCP FRCPath, Natalia Curto-Garcia, Jennifer O'Sullivan, Kordasti Shahram, Claire Woodley, Yvonne Francis, Deepti Radia, MD, Claire N. Harrison, MD DM, FRCP, PRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 5458.
https://doi.org/10.1182/blood-2018-99-115021
Published: 2018
Journal Articles

Avapritinib, a Potent and Selective Inhibitor of KIT D816V, Improves Symptoms of Advanced Systemic Mastocytosis (AdvSM): Analyses of Patient Reported Outcomes (PROs) from the Phase 1 (EXPLORER) Study Using the (AdvSM) Symptom Assessment Form (AdvSM-SAF), a New PRO Questionnaire for (AdvSM)

Free
Jason R. Gotlib, MDMS, Deepti Radia, MD, Daniel J. DeAngelo, MD, Prithviraj Bose, MD, Mark W Drummond, PhDMD, Elizabeth O. Hexner, MDMS, William A Robinson, MD PhD, Maureen G. Conlan, MD, Ronny G. Oren, MS, Hongliang Shi, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 351.
https://doi.org/10.1182/blood-2018-99-112017
Published: 2018
Journal Articles

Myeloproliferative Neoplasm Quality of Life (MPN-QOL) Study Group: MPN Experimental Assessment of Symptoms By Utilizing Repetitive Evaluation (MEASURE) Trial

Free
Allison Gathany, MD, Robyn M. Scherber, MDMPH, Marlene Girardo, MS, Heidi E. Kosiorek, MS, Amylou C. Dueck, PhD, Holly Geyer, MD, Veena D. S. Fauble, MD, Alessandro M. Vannucchi, MD, Ana Kerguelen Fuentes, MD PhD, Christen Lykkegaard Andersen, MD, Elisabeth Ejerblad, MD, Gunnar Birgegard, MD PhD, Peter L. Johansson, MD PhD, Bjorn Andreasson, David M Ross, Federico Sackman, MD PhD, Jean-Loup Demory, MD PhD, Constantine S. Tam, MBBS, MD FRACP, FRCPA, Jan J. Michiels, PhD, Deepti Radia, MD, Joanne Ewing, PhD BMBS, BSc, FRPATH,, Frances Wadelin, MD, Robert N. Lown, MBBS, MRCP, MD, Mary Frances McMullin, MD, Wunna Swe, Jonathan O. Cullis, MD, Nigel Sargant, BSc, FRPATH, MRCP,, Paul Moreton, MD MRCP, FRCPath, Catherine Cargo, MB, FRCPath, Mallika Sekhar, MBBS, MD FRCPath, FRCP, Satareh Shekouhi, Ruben A. Mesa, MD FACP
Journal: Blood
Blood (2018) 132 (Supplement 1): 1762.
https://doi.org/10.1182/blood-2018-99-111559
Published: 2018
Journal Articles

Clinical Activity in a Phase 1 Study of Blu-285, a Potent, Highly-Selective Inhibitor of KIT D816V in Advanced Systemic Mastocytosis (AdvSM)

Free
Daniel J. DeAngelo, MD, Albert Thomas Quiery, MD, Deepti Radia, MD, Mark W Drummond, MB ChB, PhD FRCPath, Jason Gotlib, MD, William A Robinson, MD PhD, Elizabeth Hexner, MDMS, Srdan Verstovsek, MD PhD, Hongliang Shi, Terri Alvarez-Diez, Oleg Schmidt-Kittler, Erica Evans, PhD, Mary Ellen Healy, Beni B. Wolf, MD PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2.
https://doi.org/10.1182/blood.V130.Suppl_1.2.2
Published: 2017
Journal Articles

Myeloproliferative Neoplasm Quality of Life (MPN-QOL) Study Group: Results from the MPN Experimental Assessment of Symptoms By Utilizing Repetitive Evaluation (MEASURE) Trial

Free
Allison Scotch, MD MPH, Robyn M. Scherber, MD, Marlene Bruso, MS, Heidi Elizabeth Kosiorek, MS, Amylou C. Dueck, PhD, Holly Geyer, MD, Veena D. S. Fauble, MD, Alessandro M. Vannucchi, Ana Kerguelen Fuentes, Christen Lykkegaard Andersen, PhD, Elisabeth Ejerblad, MD, Gunnar Birgegard, MD PhD, Peter L. Johansson, MD PhD, Bjorn Andreasson, David M Ross, MBBS, PhD FRACP, FRCPA, Federico Sackman, MD PhD, Jean-Loup Demory, MD PhD, Constantine S. Tam, MBBS, MD FRACP, FRCPA, Jan J. Michiels, PhD, Deepti Radia, MD, Joanne Ewing, PhD BMBS, BSc, FRPATH,, Frances Wadelin, MD, Robert N. Lown, MBBS, MRCP, MD, Mary Frances McMullin, MB,Bch BAO, MD FRCPath, Wunna Swe, Jonathan O. Cullis, MD, Nigel Sargant, BSc, FRPATH, MRCP,, Paul Moreton, MD MRCP, FRCPath, Catherine Cargo, MB, FRCPath, Mallika Sekhar, MBBS, MD FRCPath, FRCP, Satareh Shekouhi, Ruben A Mesa, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1641.
https://doi.org/10.1182/blood.V130.Suppl_1.1641.1641
Published: 2017
Journal Articles

Preliminary Safety and Clinical Activity in a Phase 1 Study of Blu-285, a Potent, Highly-Selective Inhibitor of KIT D816V in Advanced Systemic Mastocytosis (SM)

Free
Mark W. Drummond, PhD MD, Daniel J. DeAngelo, MD PhD, Michael W. Deininger, MD PhD, Deepti Radia, MBBS, MRCPI, FRCPath MSc, MD, Albert Thomas Quiery, MD, Elizabeth O Hexner, MD, Hongliang Shi, MS, Terri Alvarez-Diez, PhD, Erica K. Evans, PhD, Mary Ellen Healy, MS, Beni B. Wolf, MD PhD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2016) 128 (22): 477.
https://doi.org/10.1182/blood.V128.22.477.477
Published: 2016