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Journal Articles

WU-CART-007 (WT-7) Is an Effective Treatment for Adolescent Patients with Relapsed or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma (T-ALL/LBL) - Subgroup Analysis of WU-CART-007 1001

Free
Shannon L. Maude, Deepa Bhojwani, Alan S. Wayne, Friso G. J. Calkoen, André Baruchel, Christian Michel Zwaan, Michael P. Rettig, Ouiam Bakkacha, Justo L. Gonzalez, Deborah Masters, Maria del Rosario, Laura Simpson, Preeta Dasgupta, Tony Wu, Stephen Moran, Michael Munroe, Haley Irons, Eileen McNulty, Matthew L. Cooper, Alexander Hamil, John Muth, Brett Ramsey, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 3461.
https://doi.org/10.1182/blood-2024-201998
Published: 2024
Journal Articles

Characterizing the Bone Marrow Stromal Niche in Pediatric Acute Myeloid Leukemia

Free
Elizabeth K Schweighart, Cristoforo Grasso, Brigit M. te Pas, Mirjam E. Belderbos, Christian Michel Zwaan, Hendrik G. Stunnenberg, Olaf Heidenreich, Bianca F. Goemans
Journal: Blood
Blood (2024) 144 (Supplement 1): 4062.
https://doi.org/10.1182/blood-2024-204988
Published: 2024
Journal Articles

WU-CART-007 (WT-7), an Allogeneic CAR T-Cell Targeting CD7 in Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL/LBL): Phase 2 Results

Free
Armin Ghobadi, Ibrahim Aldoss, Shannon L. Maude, Deepa Bhojwani, Rawan Faramand, Ashish Bajel, Friso G. J. Calkoen, Alan S. Wayne, Bhagirathbhai Dholaria, Ryan J Mattison, Anita W. Rijneveld, Christian Michel Zwaan, André Baruchel, Nicolas Boissel, Michael P. Rettig, Maria del Rosario, Stephen Moran, Alexander Hamil, Ouiam Bakkacha, Deborah Masters, Justo L. Gonzalez, Michael Munroe, Laura Simpson, Preeta Dasgupta, Tony Wu, John Muth, Haley Irons, Brett Ramsey, Eileen McNulty, Matthew L. Cooper, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 3450.
https://doi.org/10.1182/blood-2024-202005
Published: 2024
Journal Articles

WUC007-03: A Phase 2 Study of Anti-CD7 Allogenic CAR-T Cells (WT-7) in Patients with Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL)/Lymphoblastic Lymphoma (LBL)

Free
Armin Ghobadi, Shannon L. Maude, Ibrahim Aldoss, Ashish Bajel, Ryan J Mattison, Deepa Bhojwani, Alan S. Wayne, Rawan Faramand, Bhagirathbhai Dholaria, Seong Lin Khaw, Anita W. Rijneveld, Friso G. J. Calkoen, Christian Michel Zwaan, André Baruchel, Nicolas Boissel, Andrej Lissat, Stefan Schwartz, Peter Bader, Fabian Lang, Michael P. Rettig, Haley Irons, Brett Ramsey, John Muth, Laura Simpson, Preeta Dasgupta, Stephen Moran, Michael Munroe, Maria del Rosario, Tony Wu, Ouiam Bakkacha, Justo L. Gonzalez, Deborah Masters, Alexander Hamil, Eileen McNulty, Matthew L. Cooper, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 7225.
https://doi.org/10.1182/blood-2024-201825
Published: 2024
Journal Articles

Gain or Amplification of 1q21 in Systemic Light Chain Amyloidosis Is Associated with Advanced Mayo Stage, Plasma Cell Disease and Worse Overall Survival

Free
Sara Oubari, Maria Papathanasiou, Lars Christian Michel, Tienush Rassaf, Andreas Thimm, Tim Hagenacker, Daniela Ehling, Stefan Wieczorek, Eyad Naser, Ulrich Duehrsen, Hans Christian Reinhardt, Alexander Carpinteiro
Journal: Blood
Blood (2024) 144 (Supplement 1): 3309.
https://doi.org/10.1182/blood-2024-202077
Published: 2024
Journal Articles

The Interplay between Macrophages and Pediatric AML Blasts

Free
Alicia Perzolli, Joost B. Koedijk, Elizabeth K Schweighart, Bianca F. Goemans, Christian Michel Zwaan, Olaf Heidenreich
Journal: Blood
Blood (2024) 144 (Supplement 1): 5653.
https://doi.org/10.1182/blood-2024-204948
Published: 2024
Journal Articles

Efficacy of Ropeginterferon Alpha 2b in Inducing Treatment Free Remission in Chronic Myeloid Leukemia - an International, Randomized Phase III Trial (ENDURE, CML-IX) of the German CML-Study Group

Free
Andreas Burchert, Susanne Saussele, Christian Michel, Stephan K Metzelder, Andreas Hochhaus, Norbert Gattermann, Martina Crysandt, Philippe Schafhausen, Matthias Bormann, Markus P. Radsak, Agnès Guerci-Bresler, Thomas Illmer, Maria E Goebeler, Peter Herhaus, Lino L. Teichmann, Georg-Nikolaus Franke, Fabian Lang, Stefan W. Krause, Robert Möhle, Martine Klausmann, Frank Stegelmann, Christoph Lutz, Gabriel Etienne, Andrea Stoltefuß, Joachim R Göthert, Thomas Ernst, Andreas Neubauer, Rüdiger Hehlmann, Behnaz Aminossadati, Michael Wittenberg, Markus Pfirrmann, Carmen Schade-Brittinger, Philipp le Coutre, Franck E. Nicolini
Journal: Blood
Blood (2022) 140 (Supplement 1): 1501–1503.
https://doi.org/10.1182/blood-2022-169324
Published: 2022
Journal Articles

Immunotherapy: genetically agnostic in BCP-ALL?

Free
Christian Michel Zwaan, Friso G. J. Calkoen
Journal: Blood
Blood (2022) 139 (14): 2093–2094.
https://doi.org/10.1182/blood.2022015618
Published: 2022
Journal Articles

A phase 1 study of inotuzumab ozogamicin in pediatric relapsed/refractory acute lymphoblastic leukemia (ITCC-059 study)

Free
Clinical Trials & Observations
Erica Brivio, Franco Locatelli, Marta Lopez-Yurda, Andrea Malone, Cristina Díaz-de-Heredia, Bella Bielorai, Claudia Rossig, Vincent H. J. van der Velden, Anneke C. J. Ammerlaan, Adriana Thano, Inge M. van der Sluis, Monique L. den Boer, Ying Chen, Barbara Sleight, Benoit Brethon, Karsten Nysom, Lucie Sramkova, Ingrid Øra, Luciana Vinti, Christiane Chen-Santel, Christian Michel Zwaan
Journal: Blood
Blood (2021) 137 (12): 1582–1590.
https://doi.org/10.1182/blood.2020007848
Published: 2021
Includes: Supplemental data
Journal Articles

A Phase II Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of the ITCC-059 Study

Free
Erica Brivio, MD, Franco Locatelli, MD, Adriana Thano, Arnaud Petit, MD PhD, Britta Julia Vormoor, MD, Susana Rives, Bella Bielorai, MD, Claudia Rossig, Carmelo Rizzari, Vincent H.J. Van Der Velden, PhD, Anneke C.J. Ammerlaan, Monique L. Den Boer, PhD, Barbara Sleight, MD, Gernot Engstler, Jan Stary, MD PhD, Francisco José Bautista Sirvent, MD PhD, Christiane Chen-Santel, Bénédicte Bruno, MD, Yves Bertrand, MD, Fanny Rialland, MD, Geneviève Plat, Dirk Reinhardt, MD, Luciana Vinti, MD, Arend von Stackelberg, MD, Christian Michel Zwaan
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-134774
Published: 2020
Journal Articles

Phase 2 study of nilotinib in pediatric patients with Philadelphia chromosome–positive chronic myeloid leukemia

Free
Clinical Trials & Observations
Nobuko Hijiya, Alexey Maschan, Carmelo Rizzari, Hiroyuki Shimada, Carlo Dufour, Hiroaki Goto, Hyoung Jin Kang, Terri Guinipero, Zeynep Karakas, Francisco Bautista, Stéphane Ducassou, Keon Hee Yoo, Christian Michel Zwaan, Frédéric Millot, Paola Aimone, Alex Allepuz, Sara Quenet, Florence Hourcade-Potelleret, Sabine Hertle, Darintr Sosothikul
Journal: Blood
Blood (2019) 134 (23): 2036–2045.
https://doi.org/10.1182/blood.2019000069
Published: 2019
Includes: Supplemental data
Journal Articles

A Retrospective Study on Inotuzumab Ozogamicin in Infants and Young Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Free
Erica Brivio, MD, Raoull Hoogendijk, MSc, Christophe Chantrain, MD PhD, Fanny Rialland, MD, Audrey Contet, Sarah Elitzur, MD, Luciano Dalla-Pozza, MBBS FRACP, Krisztian Kallay, MD, Chi Kong Li, MBBS,MD, Motohiro Kato, MD PhD, Inna V Markova, Dr., Kjeld Schmiegelow, Professor MD DMSc., Nicole Bodmer, Rob Pieters, MDPhDMSc, Christian Michel Zwaan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3890.
https://doi.org/10.1182/blood-2019-126472
Published: 2019
Journal Articles

Phase II Study of Midostaurin + Chemotherapy in Pediatric Patients with Untreated, Newly Diagnosed, FLT3 -Mutated Acute Myeloid Leukemia (AML)

Free
Dirk Reinhardt, MD, Christian Michel Zwaan, Albert Hoenekopp, Julie Niolat, Sophie Ifrah, Florence Noel-Baron, Franco Locatelli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3835.
https://doi.org/10.1182/blood-2019-128043
Published: 2019
Journal Articles

Safety, Efficacy, and PK of the BCL2 Inhibitor Venetoclax in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Phase 1 Study

Free
Seth E Karol, MD, Todd M Cooper, DO, Henrique Bittencourt, Lia Gore, MD, Maureen M O'Brien, MD, Christopher Fraser, MD, Marion Gambart, MD, Gunnar Cario, MD PhD, Christian Michel Zwaan, MD PhD, Jean-Pierre Bourquin, MD PhD, Mignon L. Loh, MD, Hubert Caron, MD PhD, Betty Prine, Ahmed Hamed Salem, PhD FCP, Kristina Unnebrink, Bo Tong, PhD, Tammy Palenski, PhD, Andrew E. Place, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2649.
https://doi.org/10.1182/blood-2019-129805
Published: 2019
Journal Articles

A Phase I Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Preliminary Results of the ITCC-059 Study

Free
Erica Brivio, MD, Marta Lopez-Yurda, PhD, Cormac Ownes, MD, Cristina Díaz de Heredia, MD PhD, Bella Bielorai, MD, Claudia Rossig, Vincent van der Velden, PhD, Anneke C.J. Ammerlaan, Inge M. van der Sluis, MD PhD, Monique L. Den Boer, PhD, Ying Chen, Barbara Sleight, MD, Benoit Brethon, MD, Karsten Nysom, Jan Stary, Prof., MD PhD, Ingrid Øra, Christiane Chen-Santel, Luciana Vinti, MD, Franco Locatelli, MD PhD, Christian Michel Zwaan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2629.
https://doi.org/10.1182/blood-2019-122411
Published: 2019
Journal Articles

Integrative Analysis of Pediatric Acute Leukemia Identifies Immature Subtypes That Span a T Lineage and Myeloid Continuum with Distinct Prognoses

Free
Tanja A. Gruber, MD PhD, Jing Ma, PhD, Sanne Noort, MD MSc, Yu Liu, PhD, Michael P Walsh, PhD, Stephanie Nance, PhD, Yanling Liu, PhD, Yuanyuan Wang, PhD, Guangchun Song, PhD, Tamara Lamprecht, BS, John Easton, PhD, Martina Pigazzi, PhD, Marie Jarosova, PhD, Kelaidi Charikleia, MD, Jeffrey Rubnitz, MD PhD, Dirk Reinhardt, MD, Marry M. van den Heuvel-Eibrink, Prof, MD PhD, Franco Locatelli, MD PhD, Henrik Hasle, Jeffery M. Klco, MD PhD, James R. Downing, MD, Stanley Pounds, PhD, Jinghui Zhang, PhD, Christian Michel Zwaan, MD PhD, Maarten Fornerod, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 918.
https://doi.org/10.1182/blood-2019-127411
Published: 2019
Journal Articles

Nuclear NFATc1 Causes Development of Fms-like Receptor Tyrosine Kinase 3 Receptor (FLT3) Internal Tandem Duplication Mutation-Positive (FLT3-ITD) Acute Myeloid Leukemia (AML) and Mediates Drug Resistance

Free
Maria A. Solovey, Ying Wang, MD, Stefan Gattenloehner, MD, Elisabeth Hessmann, MD, Stephan Metzelder, MD, Christian Michel, MD, Volker Ellenrieder, MD, Joachim R. Goethert, MD, Andreas Neubauer, Andreas Burchert, MD
Journal: Blood
Blood (2016) 128 (22): 1722.
https://doi.org/10.1182/blood.V128.22.1722.1722
Published: 2016
Journal Articles

Idelalisib Impairs TREM-1 and TLR Mediated Neutrophil Activation

Free
Astrid Hasibeder, Nicole Stadler, Pamela Aranda Lopez, Alexander Desuki, Oliver Kriege, Alexander N.R. Weber, Christian Michel, Daniel Teschner, Georg Hess, MD, Matthias Theobald, MD, Markus Radsak, MD
Journal: Blood
Blood (2016) 128 (22): 2510.
https://doi.org/10.1182/blood.V128.22.2510.2510
Published: 2016
Journal Articles

Ibrutinib Abrogates TREM-1 Mediated Neutrophil Activation

Free
Nicole Stadler, Astrid Hasibeder, Pamela Aranda Lopez, Alexander Desuki, Oliver Kriege, Alexander N.R. Weber, Christian Michel, Daniel Teschner, Georg Hess, MD, Matthias Theobald, MD, Markus Radsak, MD
Journal: Blood
Blood (2016) 128 (22): 3691.
https://doi.org/10.1182/blood.V128.22.3691.3691
Published: 2016
Journal Articles

The Impact of NFAT Inhibition on Neutrophil Effector Functions in Patients after Allogeneic Hematopoietic Stem Cell Transplantation and on Neutrophil Antifungal Defense and Myelopoiesis in Cyclosporin Α Treated and NFATc1 LysM Mice

Free
Daniel Teschner, Katharina Plein, Christian Michel, Steve Pruefer, PhD, Matthias Bros, PhD, Eva Maria Wagner, MD, Matthias Theobald, MD, Hansjoerg Schild, PhD Prof., Markus Radsak, MD
Journal: Blood
Blood (2016) 128 (22): 3679.
https://doi.org/10.1182/blood.V128.22.3679.3679
Published: 2016