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Journal Articles

Sinusoidal Obstruction Syndrome in Children with CD22+ B-Cell Precursors Acute Lymphoblastic Leukemia (BCP-ALL) Treated with Inotuzumab Ozogamicin in Trial ITCC-059: Risk Factors and Outcomes

Free
Erica Brivio, Edoardo Pennesi, Yilin Jang, Anneke Ammerlaan, Susana Rives, Inge M. van der Sluis, Caroline Lindemans, Bella Bielorai, Cristina Díaz De Heredia, Andrej Lissat, Claudia Rossig, Arnaud Petit, Fanny Rialland Battisti, Carmelo Rizzari, Anna B Nilsson, Benedicte Bruno, Alba Rubio-san-Simón, Lucie Sramkova, Gernot Engstler, Uta Dirksen, Benoit Brethon, Barbara De Moerloose, Marlène Pasquet, Peter McCarthy, Karsten Nysom, Carine Halfon-Domenech, Nicoletta Bertorello, Jochen Büchner, Franco Locatelli, C. Michel Zwaan
Journal: Blood
Blood (2024) 144 (Supplement 1): 310.
https://doi.org/10.1182/blood-2024-193946
Published: 2024
Journal Articles

Inotuzumab Ozogamicin (InO) Combined with UKALL-R3 Modified Chemotherapy in Pediatric Patients with B-Cell Precursor CD22+ Acute Lymphoblastic Leukemia (BCP-ALL) - Results from the ITCC-059 Phase 1B Trial

Free
Edoardo Pennesi, Erica Brivio, Anneke C.J. Ammerlaan, Yilin Jiang, Vincent H.J. van der Velden, Berna Beverloo, Barbara Sleight, Susana Rives, Cristina Díaz de Heredia Rubio, Francisco J. Bautista Sirvent, Alba Rubio-San-Simón, Fanny Rialland, Carmelo Rizzari, Bella Bielorai, Arnaud Petit, Bénédicte Bruno, Ingrid Øra, Anna Nilsson, Gernot Engstler, Claudia Rossig, Benoit Brethon, Franco Locatelli, Christian M. Zwaan
Journal: Blood
Blood (2022) 140 (Supplement 1): 8976–8978.
https://doi.org/10.1182/blood-2022-163056
Published: 2022
Journal Articles

Population Pharmacokinetics of Inotuzumab Ozogamicin (InO) As Single Agent in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia - Results from the ITCC-059 Phase IA and Phase II Trial

Free
Edoardo Pennesi, Erica Brivio, Kathleen B. Pelletier, Ying Chen, Alwin D.R. Huitema, Yilin Jiang, Anneke C.J. Ammerlaan, Barbara Sleight, Franco Locatelli, Inge M. Van Der Sluis, Claudia Rossig, Christiane Chen-Santel, Bella Bielorai, Arnaud Petit, Jan Stary, Lucie Sramkova, Cristina Díaz de Heredia Rubio, Susana Rives, Aengus O'Marcaigh, Carmelo Rizzari, Gernot Engstler, Karsten Nysom, Alba Rubio-San-Simón, Francisco J. Bautista Sirvent, Bénédicte Bruno, Yives Bertrand, Benoit Brethon, Fanny Rialland, Genevieve Plat, Uta Dirksen, May Garrett, Christian M. Zwaan
Journal: Blood
Blood (2022) 140 (Supplement 1): 8845–8847.
https://doi.org/10.1182/blood-2022-165954
Published: 2022
Journal Articles

Minimal Residual Disease and Outcome Characteristics in Infant KMT2A-Germline Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Free
Janine Stutterheim, Paola De Lorenzo, Inge M. Van Der Sluis, Julia Alten, Philip Ancliffe, Andishe Attarbaschi, Luis Alberto Aversa, Judith M. Boer, Andrea Biondi, Benoit Brethon, Paulina Diaz, Giovanni Gazzaniga, Gabriele Escherich, Alina Ferster, Rishi S Kotecha, Birgitte Lausen, Alex WK Leung, Franco Locatelli, Lewis B. Silverman, Jan Stary, Tomasz Szczepanski, Vincent H.J. Van Der Velden, Ajay Vora, Jan Zuna, Martin Schrappe, Maria Grazia Valsecchi, Rob Pieters
Journal: Blood
Blood (2021) 138 (Supplement 1): 2383.
https://doi.org/10.1182/blood-2021-145058
Published: 2021
Journal Articles

A Phase 2 Study to Test the Feasibility, Safety and Efficacy of the Addition of Blinatumomab to the Interfant06 Backbone in Infants with Newly Diagnosed KMT2A -Rearranged Acute Lymphoblastic Leukemia. a Collaborative Study of the Interfant Network

Free
Inge M. Van Der Sluis, Paola De Lorenzo, Rishi Sury Kotecha, Andishe Attarbaschi, Gabriele Escherich, Karsten Nysom, Jan Stary, Alina Ferster, Benoit Brethon, Phillip Ancliff, Andrea Biondi, Maria Grazia Valsecchi, Rob Pieters
Journal: Blood
Blood (2021) 138 (Supplement 1): 361.
https://doi.org/10.1182/blood-2021-144843
Published: 2021
Journal Articles

A phase 1 study of inotuzumab ozogamicin in pediatric relapsed/refractory acute lymphoblastic leukemia (ITCC-059 study)

Free
Clinical Trials & Observations
Erica Brivio, Franco Locatelli, Marta Lopez-Yurda, Andrea Malone, Cristina Díaz-de-Heredia, Bella Bielorai, Claudia Rossig, Vincent H. J. van der Velden, Anneke C. J. Ammerlaan, Adriana Thano, Inge M. van der Sluis, Monique L. den Boer, Ying Chen, Barbara Sleight, Benoit Brethon, Karsten Nysom, Lucie Sramkova, Ingrid Øra, Luciana Vinti, Christiane Chen-Santel, Christian Michel Zwaan
Journal: Blood
Blood (2021) 137 (12): 1582–1590.
https://doi.org/10.1182/blood.2020007848
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical Implications of Minimal Residual Disease Detection in Infants with KMT2A -Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Free
Janine Stutterheim, MDPhD, Inge M. van der Sluis, MD PhD, Paola De Lorenzo, Julia Alten, MD, Philip Ancliff, MD, Andishe Attarbaschi, MD, Benoit Brethon, MD, Andrea Biondi, MD, Myriam Campbell, MD, Giovanni Cazzaniga, PhD, Gabriele Escherich, MD, Alina Ferster, MD, Rishi Sury Kotecha, MBBChir, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Luca Lo Nigro, PhDMD, Franco Locatelli, MD PhD, Rolf Marschalek, PhD, Martin Schrappe, MDPhD, Jan Stary, MD PhD, Ajay Vora, MD, Jan Zuna, PhD, Vincent H.J. Van Der Velden, PhD, Tomasz Szczepanski, MD PhD, Maria Grazia Valsecchi, PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-134303
Published: 2020
Journal Articles

Blinatumomab in Children with Relapsed or Refractory B-Precursor Acute Lymphoblastic Leukemia (R/R-ALL): Final Results of 110 Patients Treated in an Expanded Access Study (RIALTO)

Free
Franco Locatelli, MD PhD, Gerhard Zugmaier, Noemi Mergen, MD, Peter Bader, MD, Sima Jeha, MD, Paul-Gerhardt Schlegel, Jean-Pierre Bourquin, MD PhD, Rupert Handgretinger, MD, Benoit Brethon, MD, Claudia Rössig, William Kormany, MD, Puneeth Viswagnachar, Christiane Chen-Santel
Journal: Blood
Blood (2020) 136 (Supplement 1): 24–25.
https://doi.org/10.1182/blood-2020-141336
Published: 2020
Journal Articles

Blinatumomab in Pediatric Patients with Relapsed/Refractory B-Cell Precursor and Molecularly Resistant Acute Lymphoblastic Leukemia (R/R ALL): Updated Analysis of 110 Patients Treated in an Expanded Access Study (RIALTO)

Free
Franco Locatelli, MD, Gerhard Zugmaier, Peter Bader, MD, Sima Jeha, MD, Paul-Gerhardt Schlegel, Jean-Pierre Bourquin, MD PhD, Rupert Handgretinger, MD, Benoit Brethon, MD, Claudia Rossig, Christiane Chen-Santel
Journal: Blood
Blood (2019) 134 (Supplement_1): 1294.
https://doi.org/10.1182/blood-2019-121615
Published: 2019
Journal Articles

A Phase I Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Preliminary Results of the ITCC-059 Study

Free
Erica Brivio, MD, Marta Lopez-Yurda, PhD, Cormac Ownes, MD, Cristina Díaz de Heredia, MD PhD, Bella Bielorai, MD, Claudia Rossig, Vincent van der Velden, PhD, Anneke C.J. Ammerlaan, Inge M. van der Sluis, MD PhD, Monique L. Den Boer, PhD, Ying Chen, Barbara Sleight, MD, Benoit Brethon, MD, Karsten Nysom, Jan Stary, Prof., MD PhD, Ingrid Øra, Christiane Chen-Santel, Luciana Vinti, MD, Franco Locatelli, MD PhD, Christian Michel Zwaan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2629.
https://doi.org/10.1182/blood-2019-122411
Published: 2019
Journal Articles

Azacitidine in Pediatric Hematologic Myeloid Malignancies: A Retrospective Study

Free
Emilie Saucier, Florence Rabian, MD, Hélène Boutroux, MD, Marion Strullu, MD, Karine Morand, MD, Florian Chevillon, MD, Benoit Brethon, MD, Nicolas Boissel, MD PhD, Guy Leverger, MD, André Baruchel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5130.
https://doi.org/10.1182/blood-2019-131062
Published: 2019
Journal Articles

High Molecular Remission Rate in Pediatric Patients (pts) with Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia (r/r ALL) Treated with Blinatumomab: Rialto an Open-Label, Multicenter, Expanded Access Study

Free
Franco Locatelli, Gerhard Zugmaier, Peter Bader, MD PhD, Sima Jeha, MD, Paul-Gerhardt Schlegel, MD, Jean-Pierre Bourquin, MD PhD, Rupert Handgretinger, MD PhD, Benoit Brethon, Claudia Rossig, MD, Christiane Chen-Santel, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1375.
https://doi.org/10.1182/blood-2018-99-109855
Published: 2018
Journal Articles

Inotuzumab Ozogamicin Compassionate Use for French Pediatric Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia

Free
Charlotte Calvo, Benoit Brethon, Aurelie Cabannes-Hamy, MD, Dalila Adjaoud, MD, Benedicte Bruno, MD, Laurence Blanc, MD, Nicolas Boissel, MD PhD, Marie-Dominique Tabone, MD, Andre Baruchel, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5203.
https://doi.org/10.1182/blood-2018-99-116360
Published: 2018
Journal Articles

Outcome of Infants Younger Than 1 Year with Acute Lymphoblastic Leukemia Treated with the Interfant-06 Protocol; Results from an International Randomised Study

Free
Rob Pieters, MDPhDMSc, Paola De Lorenzo, PhD, Philip Ancliffe, Luis Alberto Aversa, MD, Benoit Brethon, Andrea Biondi, MD, Myriam Campbell, Gabriele Escherich, Alina Ferster, MD, Rebecca Gardner, MD, Rishi Sury Kotecha, MBBChir, MRCP, FRACP, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Franco Locatelli, Andishe Attarbaschi, Christina Peters, MD, Jeffrey Rubnitz, MD PhD, Lewis B. Silverman, MD, Jan Stary, MD PhD, Tomasz Szczepanski, MD PhD, Ajay Vora, MD, Martin Schrappe, MD PhD, Maria Grazia Valsecchi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 655.
https://doi.org/10.1182/blood-2018-99-112854
Published: 2018
Journal Articles

Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia

Free
CME Clinical Trials & Observations
Arnaud Petit, Amélie Trinquand, Sylvie Chevret, Paola Ballerini, Jean-Michel Cayuela, Nathalie Grardel, Aurore Touzart, Benoit Brethon, Hélène Lapillonne, Claudine Schmitt, Sandrine Thouvenin, Gerard Michel, Claude Preudhomme, Jean Soulier, Judith Landman-Parker, Guy Leverger, Elizabeth Macintyre, André Baruchel, Vahid Asnafi
Journal: Blood
Blood (2018) 131 (3): 289–300.
https://doi.org/10.1182/blood-2017-04-778829
Published: 2018
Includes: Supplemental data
Journal Articles

Immunophenotypic Profiling of Childhood B-Cell Precursor Acute Lymphoblastic Helps Identifying Genetic Subtypes, Including Recently Identified Ones

Free
Elodie Lainey, PharmD/PhD, Aurelie Caye-Eude, PharmD, Lucile Broseus, Emmanuelle Clappier, PharmD, PhD, Wendy Cuccuini, MD PhD, Cristina Leschi, PharmD, Odile Fenneteau, PharmD, Jimmy Mullaert, Amandine Chaye, Ahlene Emam, Benoit Brethon, MD, Thierry Leblanc, MD, Andre Baruchel, MD, Helene Cave, PharmD, PhD
Journal: Blood
Blood (2016) 128 (22): 2910.
https://doi.org/10.1182/blood.V128.22.2910.2910
Published: 2016
Journal Articles

Safety and Efficacy of Blinatumomab Used in Children with B-Precursor Acute Lymphoblastic Leukemia (ALL) Treated in French Hematological Centers

Free
Anne-Flore Derache, MD, Fanny Rialland, MD, Gerard Michel, MD, Yves Perel, MD, Virginie Gandemer, MD PhD, Pascale Blouin, MD, Odile Minckes, MD, Arnaud Petit, MD PhD, Andre Baruchel, MD PhD, Benoit Brethon, MD
Journal: Blood
Blood (2016) 128 (22): 5190.
https://doi.org/10.1182/blood.V128.22.5190.5190
Published: 2016
Journal Articles

Oncogenetic Risk Classification Based on NOTCH1/FBXW7/RAS/PTEN Mutation Profiles Improves Outcome Prediction in Pediatric T-Cell Acute Lymphoblastic Leukemia, Treated According the Fralle 2000 T Guidelines

Free
Arnaud Petit, MD PhD, Amélie Trinquand, MD, Sylvie Chevret, MD PhD, Paola Fabiola Ballerini, MD PhD, Jean-Michel Cayuela, MD, Nathalie Grardel, MD, Aurore Touzart, MD, Benoit Brethon, MD, Hélène Lapillonne, MD PhD, Pascal Chastagner, MD, Claire Berger, MD, Gerard Michel, MD, Claude Preudhomme, MD PhD, Jean Soulier, MD PhD, Judith Landman-Parker, MD, Guy Leverger, MD, Elizabeth Macintyre, MD PhD, Andre Baruchel, MD PhD, Vahid Asnafi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1083.
https://doi.org/10.1182/blood.V128.22.1083.1083
Published: 2016
Journal Articles

Late Effects in Survivors of Infantile Acute Leukemia Are Less Severe Than Expected: A Study of the L.E.a Program

Free
Virginie Gandemer, MDPhD, Jacinthe Bonneau, MD, Caroline Oudin, MD, Julie Berbis, MD, Yves Bertrand, MD PhD, Marie-Dominique Tabone, MD, Stephane Ducassou, Pascal Chastagner, MD, Benoit Brethon, MD, Jean-Hugues Dalle, MD PhD Prof., Sandrine Thouvenin, Maryline Poiree, MD, Dominique Plantaz, Justyna Kanold, Nicolas Sirvent, Patrick Lutz, Zeinab Hamidou, Andre Baruchel, MDPhD, Guy Leverger, MD, Pascal Auquier, Gerard Michel, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3571.
https://doi.org/10.1182/blood.V128.22.3571.3571
Published: 2016
Journal Articles

A Phase 1/2, Open-Label, Dose-Escalation Study of Midostaurin in Pediatric Patients (Pts) with Relapsed or Refractory (R/R) Acute Leukemia: Final Results of Study ITCC-024 (CPKC412A2114)

Free
C. Michel Zwaan, MD PhD, Stefan Söderhäll, MD PhD, Benoit Brethon, MD, Matteo Luciani, MD, Carmelo Rizzari, MD, David Sternberg, MD PhD, Emmanuelle Besse, Catherine Dutreix, MD, Franca Fagioli, MD, Phoenix Ho, MD, Carlo Dufour, MD, Rob Pieters, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2564.
https://doi.org/10.1182/blood.V126.23.2564.2564
Published: 2015