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Catherine Coombs
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Journal Articles

Docirbrutinib (AS-1763), a novel non-COVALENT pan-mutant BTK inhibitor, demonstrates durable clinical responses in patients with previously treated B-cell malignancies: Data from an ongoing Phase 1b study

Free
Nitin Jain, Catherine Coombs, James D'Olimpio, Nirav Shah, Jacqueline Barrientos, Seung Tae Lee, Danielle Brander, John Nemunaitis, Andrew Gillis-Smith, Shuo Ma, Shirou Kirita, Koji Yoshida, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, William Wierda, Varsha Gandhi, Javier Pinilla-Ibarz
Journal: Blood
Blood (2025) 146 (Supplement 1): 3892.
https://doi.org/10.1182/blood-2025-3892
Published: 2025
Journal Articles

Pirtobrutinib vs ibrutinib in treatment-naïve and relapsed/refractory CLL/SLL: Results from the first randomized phase III study comparing a non-covalent and covalent BTK inhibitor

Free
Jennifer Woyach, Lugui Qiu, Sebastian Grosicki, Tomasz Wrobel, Marcelo Capra, Jaroslaw Czyz, Shuhua Yi, Ki-Seong Eom, Anna Panovská, Wojciech Jurczak, Kamel Laribi, Lutz Jacobasch, Ross Baker, Richy Agajanian, Alejandro Berkovits, Muhit Özcan, Stephane Lepretre, Catherine Coombs, Paula Cramer, Katharine Lewis, Marisa Hill, Katherine Bao, Yuanyuan Bian, Amy Ruppert Stark, Ching Ching Leow, William Wierda
Journal: Blood
Blood (2025) 146 (Supplement 1): 683.
https://doi.org/10.1182/blood-2025-683
Published: 2025
Journal Articles

Pirtobrutinib in post-cbtki CLL/SLL: Final update from the Phase 1/2 BRUIN study with more than 5 years follow-up

Free
William Wierda, Jennifer Brown, Paolo Ghia, Lindsey Roeker, Krish Patel, Toby Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine Tam, John Seymour, Benoit Tessoulin, Nirav Shah, Chaitra Ujjani, Bita Fakhri, Catherine Coombs, Ian Flinn, Manish Patel, Sunita Dwivedy Nasta, Jonathon Cohen, Alvaro Alencar, Chan Cheah, Shuo Ma, Joanna Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Österborg, Koji Izutsu, Noriko Fukuhara, Donald Tsai, Paolo Abada, Minna Balbas, Jian Li, Ying (denise) Wang, Wojciech Jurczak, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 2115.
https://doi.org/10.1182/blood-2025-2115
Published: 2025
Journal Articles

Real-world changes in CLL treatment patterns following collaborative educational initiatives delivered in community settings

Free
Carmine Deluca, Michael Beyer, Marina Wanes, Catherine Coombs, Deborah Stephens, Lee Jamison, Javier Pinilla-Ibarz, Meghan Thompson, Nitin Jain, Brett Blum, Hejiang Wu, Renee Pearl
Journal: Blood
Blood (2025) 146 (Supplement 1): 6430.
https://doi.org/10.1182/blood-2025-6430
Published: 2025
Journal Articles

Updated results from a Phase II study of minimal residual disease-guided venetoclax + obinutuzumab for the initial treatment of fit patients with chronic lymphocytic leukemia

Free
Meghan Thompson, Anthony Mato, Andrew Zelenetz, Jae Park, Mark Geyer, Andriy Derkach, David Nemirovsky, Deborah Stephens, Catherine Coombs, Prioty Islam, Christopher Jensen, Lorenzo Falchi, Lia Palomba, Anita Kumar, Gilles Salles, Eytan Stein, Jennifer Lue, Lauren Nogan, Bejal Kikani, Ryan Sutterby, Thu Quynh Nguyen, Alexandra Allen, Sumathy Sudhir, Gail Panton, Victoria Duffy, Dianna Tyznar, Jamila Brutus, Tenzin Nyima, Anmol Shah, Dhara Soni, Michael Silvestrone, Monica Shah, Miranda Harris, Megha Karnam, Claire Hutzler, Kevin David, Aaron Goldberg, Stephen Fleming, Giovanni Diaz, Habib Hamidi, Bita Fakhri, Lindsey Roeker
Journal: Blood
Blood (2025) 146 (Supplement 1): 3902.
https://doi.org/10.1182/blood-2025-3902
Published: 2025
Journal Articles

National practice patterns and preferences in the use of fixed-duration vs. treat-to-progression therapies for CLL

Free
Tisheeka Graham, Tariqa Ackbarali, Catherine Coombs, John Allan
Journal: Blood
Blood (2025) 146 (Supplement 1): 8095.
https://doi.org/10.1182/blood-2025-8095
Published: 2025
Journal Articles

Pirtobrutinib outcomes in second-line (2L) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) after first-line (1L) cBTKi therapy: A pooled analysis from the BRUIN LOXO-BTK-18001 and BRUIN CLL-321 studies

Free
Toby Eyre, Matthew S Davids, Jeff Sharman, Paul Barr, Catherine Coombs, Wojciech Jurczak, Koji Izutsu, Meghan Thompson, William Wierda, Ying (denise) Wang, Marisa Hill, Donald Tsai, Ching Ching Leow, Sarang Abhyankar, Paolo Ghia, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 5670.
https://doi.org/10.1182/blood-2025-5670
Published: 2025