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Benjamin G Barwick
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Journal Articles

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells

Open Access
Corynn Kasap, Adila Izgutdina, Bonell Patiño-Escobar, Amrik Singh Kang, Nikhil Chilakapati, Naomi Akagi, Ananya Mishu Manoj, Haley Johnson, Tasfia Rashid, Juwita Werner, Abhilash Barpanda, Huimin Geng, Yu-Hsiu Tony Lin, Sham Rampersaud, Daniel Gil-Alós, Amin Sobh, Daphné Dupéré-Richer, Adolfo Aleman, Gianina Wicaksono, K.M. Kawehi Kelii, Radhika Dalal, Emilio Ramos, Anjanaa Vijayanarayanan, Kiran Lakhani, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, ons Zakraoui, Isa Tariq, Ajai Chari, Alfred Chung, Anupama Deepa Kumar, Thomas Martin, Jeffrey Lee Wolf, Sandy Wong, Veronica Steri, Mala Shanmugam, Lawrence H Boise, Tanja Kortemme, Samir Parekh, Elliot Stieglitz, Jonathan D Licht, William Karlon, Benjamin G Barwick, Arun Wiita
Journal: Blood
Blood blood.2024025536.
https://doi.org/10.1182/blood.2024025536
Published: 2025
Includes: Supplemental data
Journal Articles

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

Available to Purchase
Remya Nair, An H. Vu, Abigail K. Freer, Karanpreet S. Bhatia, Dongxue Wang, Milan R. Savani, Shannon M. Matulis, Sagar Lonial, David L. Jaye, Lawrence H. Boise, Seung-Yong Seo, Timothy W. Corson, Ajay K. Nooka, Shruti Bhatt, Samuel K. McBrayer, Vikas A. Gupta, Xin Hu, Benjamin G. Barwick, Amit R. Reddi, Mala Shanmugam
Journal: Blood
Blood (2025) 145 (7): 732–747.
https://doi.org/10.1182/blood.2024025690
Published: 2025
Includes: Supplemental data
Journal Articles

Ectopic NSD2 Remodels H3K36me2 and DNA Methylation to Promote Oncogenic Gene Expression in Multiple Myeloma

Free
Robert M Chavez, Doris R. Powell, Kiran Lakhani, John Attelah, Erin Flynt, Terry Connolly, Mark Hamilton, George Mulligan, Daniel Auclair, Jonathan Keats, Paula M Vertino, Lawrence H. Boise, Sagar Lonial, Karen N Conneely, Benjamin G. Barwick
Journal: Blood
Blood (2024) 144 (Supplement 1): 1359.
https://doi.org/10.1182/blood-2024-210929
Published: 2024
Journal Articles

DNA Methylation Analysis of Commpass Reveals Distinct Epigenetic Programs of High-Risk Disease

Free
Benjamin G. Barwick, Robert M Chavez, Doris R. Powell, Yu Zhang, Mark Hamilton, Daniel Auclair, George Mulligan, Karen N Conneely, Jonathan J Keats, Paula M Vertino, Lawrence H. Boise, Sagar Lonial
Journal: Blood
Blood (2024) 144 (Supplement 1): 251.
https://doi.org/10.1182/blood-2024-201447
Published: 2024
Journal Articles

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

Free
Shannon M Matulis, Robert M Chavez, Rebecca Owens, Arun P Wiita, Mala Shanmugam, Ricardo De Matos Simoes, Constantine S Mitsiades, Nisha S. Joseph, Craig C. Hofmeister, Jonathan L. Kaufman, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Vikas A. Gupta, Jonathan D. Licht, Benjamin G. Barwick, Lawrence H. Boise
Journal: Blood
Blood (2024) 144 (Supplement 1): 4663.
https://doi.org/10.1182/blood-2024-210441
Published: 2024
Journal Articles

KDM6A regulates immune response genes in multiple myeloma

Available to Purchase
Daphné Dupéré-Richer, Alberto Riva, Benjamin G. Barwick, Sayantan Maji, Heidi Casellas Román, Jianping Li, Umasankar De, Amin Sobh, Gabrielle Quickstad, Crissandra Piper, Marta Kulis, Teresa Ezponda, José Ignacio Martín-Subero, Giovanni Tonon, Weizhou Zhang, Constantine S. Mitsiades, Lawrence H. Boise, Richard L. Bennett, Jonathan D. Licht
Journal: Blood
Blood (2024) 144 (14): 1508–1520.
https://doi.org/10.1182/blood.2024024518
Published: 2024
Includes: Supplemental data
Journal Articles

The epigenetic spectrum of IgM gammopathies

Free
Benjamin G. Barwick
Journal: Blood
Blood (2024) 144 (12): 1240–1241.
https://doi.org/10.1182/blood.2024025698
Published: 2024
Journal Articles

NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome

Available to Purchase
Amin Sobh, Elena Encinas, Alisha Patel, Greeshma Surapaneni, Emilie Bonilla, Charlotte Kaestner, Janai Poullard, Monica Clerio, Karthik Vasan, Tzipporah Freeman, Dongwen Lv, Daphné Dupéré-Richer, Alberto Riva, Benjamin G. Barwick, Daohong Zhou, Lawrence H. Boise, Constantine S. Mitsiades, Baek Kim, Richard L. Bennett, Navdeep S. Chandel, Jonathan D. Licht
Journal: Blood
Blood (2024) 144 (3): 283–295.
https://doi.org/10.1182/blood.2023022859
Published: 2024
Includes: Supplemental data
Journal Articles

Integrated epigenetic and transcriptional single-cell analysis of t(11;14) multiple myeloma and its BCL2 dependency

Free
Noémie Leblay, Sungwoo Ahn, Rémi Tilmont, Mansour Poorebrahim, Ranjan Maity, Holly Lee, Elie Barakat, Jean-Baptiste Alberge, Sarthak Sinha, Arzina Jaffer, Benjamin G. Barwick, Lawrence H. Boise, Nizar Bahlis, Paola Neri
Journal: Blood
Blood (2024) 143 (1): 42–56.
https://doi.org/10.1182/blood.2023020276
Published: 2024
Includes: Supplemental data
Journal Articles

Natural Killer Cells Are Active Against Myeloma, Leukemia or Lymphoma Cells with Loss of Tumor Suppressor Genes

Free
Olga Dashevsky, Sara Gandolfi, Olli Dufva, Ricardo De Matos Simoes, Jani Huuhtanen, Benjamin G. Barwick, Ryosuke Shirasaki, Michal Sheffer, Aidan Culhane, Jonathan D. Licht, Christine-Ivy Liacos, Evangelos Terpos, Efstathios Kastritis, Meletios Athanasios Dimopoulos, Lawrence H. Boise, Francisca Vazquez, Matti Kankainen, Satu Mustjoki, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 6842.
https://doi.org/10.1182/blood-2023-189570
Published: 2023
Journal Articles

SDC2 Expression Is Increased in Myeloma Cells in Response to Loss of Pro-Survival Surface Proteins, CD28 and CD86

Free
Veronica Canarte, Tyler Moser-Katz, Catherine Gavile, Benjamin G. Barwick, Kelvin P. Lee, Lawrence H. Boise
Journal: Blood
Blood (2023) 142 (Supplement 1): 3299.
https://doi.org/10.1182/blood-2023-190453
Published: 2023
Journal Articles

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Free
Corynn Kasap, Adila Izgutdina, Bonell Patino Escobar, Yu-Hsiu Tony Lin, Huimin Geng, Gianina Wicaksono, Daphne Dupere-Richer, Emilio Ramos, Abhilash Barpanda, Anjanaa Vijayanarayanan, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, William Karlon, Mala Shanmugam, Lawrence H. Boise, Benjamin G. Barwick, Jonathan D. Licht, Arun P Wiita
Journal: Blood
Blood (2023) 142 (Supplement 1): 465.
https://doi.org/10.1182/blood-2023-182578
Published: 2023
Journal Articles

Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Free
Pulkit Gupta, Heather Lin, Remya Nair, Ruby Freeman, Dejah Blake, Kiran Lakhani, Doris R. Powell, Sagar Lonial, Benjamin G. Barwick, Ajay K. Nooka, Sarwish Rafiq, Mala Shanmugam
Journal: Blood
Blood (2023) 142 (Supplement 1): 6807.
https://doi.org/10.1182/blood-2023-186634
Published: 2023
Journal Articles

IMiDs Synergize with EP300 Inhibition to Disrupt the Ikzf/MYC/IRF4 Axis in Multiple Myeloma

Free
Seth J Welsh, Benjamin G Barwick, Erin Meermeier, Daniel Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E Sharik, Megan T Du, Victoria Marie Garbitt, Caleb K Stein, Joachim L Petit, Nathalie Meurice, Rodrigo Fonseca, Kennedi Todd, Sochilt Brown, Yuliza Tafoya Alvarado, Zachary Hammond, Nicklus Cuc, Courtney Wittenberg, Camille Herzog, Lawrence H. Boise, Nizar J. Bahlis, Paola Neri, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2022) 140 (Supplement 1): 12997.
https://doi.org/10.1182/blood-2022-169920
Published: 2022
Journal Articles

Disrupting Mitohormesis As a Novel Therapeutic Strategy for Multiple Myeloma (MM) Including Those with High Risk Disease and Proteosome Inhibitor Resistance

Free
Serges P Tsofack, Danielle C Croucher, Benjamin G Barwick, Zhihua Li, Ahmed Aman, Dennis Tao, Ellen nong Wei, Laura Garcia Prat, Aaron D Schimmer, Suzanne Trudel
Journal: Blood
Blood (2021) 138 (Supplement 1): 722.
https://doi.org/10.1182/blood-2021-148673
Published: 2021
Journal Articles

Functional Genomic and Immune Response Characterization of PTEN Loss: Therapeutic Implications for Myeloma

Free
Olga Dashevsky, Ricardo De Matos Simoes, Benjamin G Barwick, Sara Gandolfi, Ryosuke Shirasaki, Michal Sheffer, Aedin Culhane, Richard WJ Groen, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 1612.
https://doi.org/10.1182/blood-2021-153870
Published: 2021
Journal Articles

Disrupting Ectopic Super-Enhancers to Treat Multiple Myeloma

Free
Seth Welsh, Daniel Riggs, Erin Meermeier, Chang-Xin Shi, Victoria Garbitt, Meaghen E Sharik, Megan Du, Kennedi Todd, Zachary Hammond, Sochilt Brown, Caleb K Stein, Paola Neri, Nizar J. Bahlis, Benjamin G Barwick, Larry H. Boise, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2021) 138 (Supplement 1): 1593.
https://doi.org/10.1182/blood-2021-147551
Published: 2021
Journal Articles

Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma

Free
Aditi Sharma, Abhinav Achreja, Remya Nair, Pulkit Gupta, Claudia L Edgar, Olamide Animasahun, Anjali Mittal, Bhakti Dwivedi, Manoj Bhasin, Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Sagar Lonial, Lawrence H. Boise, David L Jaye, Arun P Wiita, Ajay K. Nooka, Deepak Nagrath, Mala Shanmugam
Journal: Blood
Blood (2021) 138 (Supplement 1): 1611.
https://doi.org/10.1182/blood-2021-153744
Published: 2021
Journal Articles

Functional Oncogenomic and Immune Response Landscape for Genes Recurrently Mutated in Myeloma

Free
Ricardo De Matos Simoes, Benjamin G Barwick, Ryosuke Shirasaki, Olga Dashevsky, Sara Gandolfi, Huihui Tang, Brian Glassner, Richard W.J. Groen, Daniel Auclair, Aedin Culhane, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 1589.
https://doi.org/10.1182/blood-2021-154359
Published: 2021
Journal Articles

BRAF Mutations and Inflammatory Gene Expression in Myeloma Cells from Patients with Renal Dysfunction

Free
Theodora Alese, Benjamin G Barwick, Vikas A. Gupta, Nisha Joseph, Craig C. Hofmeister, Mala Shanmugam, Jonathan L. Kaufman, Madhav V Dhodapkar, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise
Journal: Blood
Blood (2021) 138 (Supplement 1): 1624.
https://doi.org/10.1182/blood-2021-154092
Published: 2021