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Journal Articles

Clinicopathologic features of myeloid neoplasms and pre-neoplasms with isolated ZRSR2 mutations

Free
Alma Oskarsdottir, Rong He, Jennifer Jiang, Mahmoud Yacout, Patricia Greipp, Mithun Shah, Hassan Alkhateeb, David Viswanatha, Fiona Craig, Katalin Kelemen, Aref Al-Kali, Dragan Jevremovic
Journal: Blood
Blood (2025) 146 (Supplement 1): 7394.
https://doi.org/10.1182/blood-2025-7394
Published: 2025
Journal Articles

Blast clearance dynamics and time to response across IDH1- and IDH2-mutated AML

Free
Mohamad Sheikh Najeeb, Oudai Alkabbani, Rong He, Dragan Jevremovic, Patricia Greipp, Aasiya Matin, Mehrdad Hefazi Torghabeh, Abhishek Mangaonkar, Mrinal Patnaik, Naseema Gangat, William Hogan, Mark Litzow, Cecilia Arana Yi, James Foran, Mithun Shah, Kebede Begna, Hassan Alkhateeb, Tariq Kewan, Antoine Saliba, Aref Al-Kali
Journal: Blood
Blood (2025) 146 (Supplement 1): 7045.
https://doi.org/10.1182/blood-2025-7045
Published: 2025
Journal Articles

Prevalence, clinical correlates and clonal inferences of concurrent splicing factor mutations in patients with myeloid neoplasms

Free
Nickolas Steinauer, Vihan Singh, Terra Lasho, Christy Finke, Alejandro Ferrer, Pankaj Pradeep, Jenna Fernandez, Clifford Csizmar, Aref Al-Kali, David Viswanatha, Rong He, Abhishek Mangaonkar, Xi Zhang, Mrinal Patnaik
Journal: Blood
Blood (2025) 146 (Supplement 1): 5650.
https://doi.org/10.1182/blood-2025-5650
Published: 2025
Journal Articles

Reduced overall survival in TP53-mutated ccus is driven by prior cytotoxic exposure and cytopenia rather than leukemic progression

Free
Steven Tessier, Yazan Jabban, Hassan Alkhateeb, William Hogan, Mrinal Patnaik, Laura Ongie, Antoine Saliba, Abhishek Mangaonkar, Naseema Gangat, James Foran, Talha Badar, Hemant Murthy, Cecilia Arana Yi, Nathan Punwani, Yael Kusne, Kebede Begna, Ayalew Tefferi, Devendra Hiwase, Aref Al-Kali, Mithun Shah
Journal: Blood
Blood (2025) 146 (Supplement 1): 5643.
https://doi.org/10.1182/blood-2025-5643
Published: 2025
Journal Articles

The prognostic significance (or lack) of achieving marrow complete remission (mCR) with hypomethylating agent-based therapy in patients with myelodysplastic syndrome

Free
Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica Stempel, Luca Lanino, Najla Al Ali, Amy DeZern, Mikkael Sekeres, Geoffrey Uy, Samuel Urrutia, Hetty Carraway, Pinkal Desai, Elizabeth Griffiths, Eytan Stein, Andrew Brunner, Christine McMahon, Rory Shallis, Joshua Zeidner, Michael Savona, Namrata Chandhok, Constantine Logothetis, Aram Bidikian, Theodore Getz, Gail Roboz, Eunice Wang, Maria Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan Madanat, Yasmin Abaza, Talha Badar, Jaclynn Campos, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop Enjeti, Kamal Alrabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Matteo Della Porta, Rami Komrokji, Amer Zeidan, Maximilian Stahl
Journal: Blood
Blood (2025) 146 (Supplement 1): 3865.
https://doi.org/10.1182/blood-2025-3865
Published: 2025
Journal Articles

ETNK1 mutations define a distinct subset of myeloid neoplasms with unique cytogenetic and molecular features

Free
Steven Tessier, Najla Al Ali, Michael Trinh, Andrew Brunner, Diletta Fontana, Carlo Gambacorti-Passerini, Rocco Piazza, David Sallman, Eric Padron, Zhuoer Xie, James Foran, Cecilia Arana Yi, Hassan Alkhateeb, Mithun Shah, Rami Komrokji, Aref Al-Kali
Journal: Blood
Blood (2025) 146 (Supplement 1): 3864.
https://doi.org/10.1182/blood-2025-3864
Published: 2025
Journal Articles

Clinical implications of TP53 mutations (TP53MT) in patients (pts) with higher risk Myelodysplastic Syndromes (HR-MDS) treated with hypomethylating agents (HMA) and allogeneic hematopoietic transplantation (allo-HCT): An analysis from the international consortium of MDS (icMDS) validate database

Free
Tariq Kewan, Jan Philipp Bewersdorf, Luca Lanino, Ondrej Blaha, Jessica Stempel, Najla Al Ali, Amy DeZern, Mikkael Sekeres, Geoffrey Uy, Samuel Urrutia, Hetty Carraway, Pinkal Desai, Elizabeth Griffiths, Eytan Stein, Andrew Brunner, Christine McMahon, Rory Shallis, Joshua Zeidner, Michael Savona, Namrata Chandhok, Constantine Logothetis, Aram Bidikian, Theodore Getz, Gail Roboz, Benjamin Rolles, Eunice Wang, Amyah Harris, Maria Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan Madanat, Yasmin Abaza, Talha Badar, Jaclynn Campos, Torsten Haferlach, Jaroslaw Maciejewski, Anoop Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Rami Komrokji, Maximilian Stahl, Matteo Della Porta, David Sallman, Amer Zeidan
Journal: Blood
Blood (2025) 146 (Supplement 1): 3863.
https://doi.org/10.1182/blood-2025-3863
Published: 2025
Journal Articles

Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

Free
Ted Getz, Kelly Pugh, Andrew Brunner, Jan Philipp Bewersdorf, Amy DeZern, Tariq Kewan, Uma Borate, Uwe Platzbecker, Mikkael Sekeres, Andrew Wei, Shahram Kordasti, Rena Buckstein, Gail Roboz, Michael Savona, Sanam Loghavi, Robert Hasserjian, Pierre Fenaux, David Sallman, Christopher Hourigan, Matteo Della Porta, Stephen Nimer, Richard Little, Valeria Santini, Fabio Efficace, Justin Taylor, Olatoyosi Odenike, Tae Kon Kim, Stephanie Halene, Rami Komrokji, Elizabeth Griffiths, Peter Greenberg, Mina Xu, Zhuoer Xie, Rafael Bejar, Guillermo Sanz, Mrinal Patnaik, Maria E. Figueroa, Hetty Carraway, Omar Abdel-Wahab, Daniel Starczynowski, Eric Padron, Jacqueline Boultwood, Steven Gore, Naval Daver, Jane Churpek, Ravi Majeti, John Bennett, Alan List, Adrian Mosquera Orgueira, Klaus Metzeler, Francesc Sole, Lisa Pleyer, Arjan Van de Loosdrecht, Thomas Cluzeau, David Steensma, Ghulam Mufti, Lionel Ades, Luca Lanino, Yazan Madanat, Anne Sophie Kubasch, Marie Sebert, R. Coleman Lindsley, Katharina S. Götze, Carmelo Gurnari, Yasushi Miyazaki, Aref Al-Kali, Abdulraheem Yacoub, Bing Li, Ioannis Kotsianidis, Maximilian Stahl, Amer Zeidan
Journal: Blood
Blood (2025) 146 (Supplement 1): 3852.
https://doi.org/10.1182/blood-2025-3852
Published: 2025
Journal Articles

Consideration of genomic determinants improves the diagnostic accuracy of oligomonocytic chronic myelomonocytic leukemia

Free
Guillermo Montalban-Bravo, Chong Wu, Juan Jose Rodriguez-Sevilla, Yue Wei, Kelly Chien, Ian Bouligny, Rashmi Kanagal-Shamanna, Anuya Natu, Mark Gurney, Alexandre Bazinet, Danielle Hammond, Alex Bataller, Gautam Borthakur, Nicholas Short, Courtney DiNardo, Tapan Kadia, Farhad Ravandi, Naval Daver, Naveen Pemmaraju, Elias Jabbour, Ghayas Issa, Sa Wang, Keyur Patel, Guilin Tang, L. Jeffrey Medeiros, Terra Lasho, Christy Finke, Aref Al-Kali, Clifford Csizmar, Hassan Alkhateeb, Naseema Gangat, Abhishek Mangaonkar, David Roman-Bravo, Leonor Arenillas, Ayalew Tefferi, Hagop Kantarjian, Guillermo Garcia-Manero, Xavier Calvo, Mrinal Patnaik, Sanam Loghavi
Journal: Blood
Blood (2025) 146 (Supplement 1): 3849.
https://doi.org/10.1182/blood-2025-3849
Published: 2025
Journal Articles

Refining the prognostic hierarchy of TP53 multihit alterations and isolated deletion of chromosome 5q in myelodysplastic syndromes

Free
Maria Julia Montoro, Pamela Acha, Claudia Haferlach, Onyee Chan, Raja Prince-Eladnani, Yasuo Kubota, Felicitas Schulz, Robert Briski, Najla Al Ali, Blanca Xicoy, Laura Palomo, Felix Lopez, Francesc Bosch Albareda, Manja Meggendorfer, Lea Naomi Eder, Andres Jerez, Yu-Hung Wang, Alessia Campagna, Beate Betz, Valeria Santini, Teresa Bernal Del Castillo, Esperanza Such, Anne Sophie Kubasch, Tariq Kewan, Carmelo Gurnari, Carla Zindel, Austin Kulasekararaj, Maria Teresa Voso, Mikkael Sekeres, Nicolas Diaz Varela, Aref Al-Kali, Antonella Pollini, Elisa Diral, Mara Memoli, Uwe Platzbecker, Detlef Haase, Amer Zeidan, Pierre Fenaux, Maria Diez-Campelo, Guillermo Garcia-Manero, Daniel Wiseman, Matteo Della Porta, Ulrich Germing, Jaroslaw Maciejewski, Rami Komrokji, Francesc Sole, Torsten Haferlach, David Valcarcel
Journal: Blood
Blood (2025) 146 (Supplement 1): 2068.
https://doi.org/10.1182/blood-2025-2068
Published: 2025
Journal Articles

Insights into clonal and CBC changes at disease evolution among ccus patients

Free
Yazan Jabban, Rong He, Kurt Bessonen, Patricia Greipp, Dragan Jevremovic, David Viswanatha, James Foran, Talha Badar, Cecilia Arana Yi, Yael Kusne, Antoine Saliba, Mehrdad Hefazi Torghabeh, Aasiya Matin, William Hogan, Abhishek Mangaonkar, Mithun Shah, Hassan Alkhateeb, Mrinal Patnaik, Aref Al-Kali
Journal: Blood
Blood (2025) 146 (Supplement 1): 5621.
https://doi.org/10.1182/blood-2025-5621
Published: 2025
Journal Articles

Prospective study of patient-reported depression, and cognitive and functional impairment, and impact on survival and induction mortality in fit adults age ≥60 years receiving intensive chemotherapy (IC) for Acute Myeloid Leukemia (AML): Prospective geriatric assessment (GA) report from ECOG-ACRIN (EA) E2906 randomized study

Free
James Foran, Li Chen, Selina Luger, Zhuoxin Sun, Heidi Klepin, Catherine Lai, David Claxton, Hillard Lazarus, Daniel Arber, Jacob Rowe, Elisabeth Paietta, Janis Racevskis, Francine Garrett-Bakelman, Yanming Zhang, Jessica Altman, Aref Al-Kali, Hong Zheng, Keith Pratz, Kristen O'Dwyer, Edward Broun, Bayard Powell, John Godwin, Yishai Ofran, Efrat Dotan, Mark Litzow, Martin Tallman, Lynne Wagner
Journal: Blood
Blood (2025) 146 (Supplement 1): 882.
https://doi.org/10.1182/blood-2025-882
Published: 2025
Journal Articles

Causes of death in DDX41-mutated myeloid neoplasms: A retrospective study

Free
Nadia Toumeh, Yazan Jabban, Rong He, David Viswanatha, Dragan Jevremovic, Patricia Greipp, James Foran, Talha Badar, Hemant Murthy, Cecilia Arana Yi, Yael Kusne, Antoine Saliba, Mehrdad Hefazi Torghabeh, Aasiya Matin, William Hogan, Kebede Begna, Mithun Shah, Abhishek Mangaonkar, Mrinal Patnaik, Hassan Alkhateeb, Aref Al-Kali
Journal: Blood
Blood (2025) 146 (Supplement 1): 7370.
https://doi.org/10.1182/blood-2025-7370
Published: 2025
Journal Articles

Fetal hemoglobin dysregulation in inherited and acquired bone marrow failure syndromes

Free
Victoria Heigh, Maymona Abdelmagid, Laura Ongie, Kristen McCullough, Jenna Fernandez, Terra Lasho, Christy Finke, Anand Srinivasan, Mira Kohorst, Asmaa Ferdjallah, William Hogan, Ronald Go, David Dingli, Naseema Gangat, Aref Al-Kali, Kebede Begna, Hassan Alkhateeb, Mithun Shah, Mark Litzow, Mehrdad Hefazi Torghabeh, Aasiya Matin, Kaaren Reichard, Joanna Dalland, Yael Kusne, James Foran, Alejandro Ferrer, Mrinal Patnaik, Abhishek Mangaonkar
Journal: Blood
Blood (2025) 146 (Supplement 1): 6750.
https://doi.org/10.1182/blood-2025-6750
Published: 2025
Journal Articles

MC210807: Phase 1 clinical trial assessing the safety and efficacy of onvansertib, a novel, oral, PLK1 inhibitor in Relapsed/Refractory myeloproliferative chronic myelomonocytic leukemia (CMML).

Free
Abhishek Mangaonkar, Kristen McCullough, Susan Geyer, Ashya Burgess, Kimberly Rice, Eric Asmus, Patricia Koenig, Terra Lasho, Christy Finke, Rachel Reither, Ryan Carr, Jenna Fernandez, Antoine Saliba, Aref Al-Kali, Martin Fernandez-Zapico, Mrinal Patnaik
Journal: Blood
Blood (2025) 146 (Supplement 1): 5634.
https://doi.org/10.1182/blood-2025-5634
Published: 2025
Journal Articles

The synonymous IDH1 p.Gly105Gly (rs11554137) variant associates with AML post-transplant relapse via aberrant signal transduction pathways

Free
Olisaemeka Ogbue, Emma St. Martin, Oudai Alkabbani, Naseema Gangat, Mithun Shah, Aasiya Matin, Abhishek Mangaonkar, Mehrdad Hefazi Torghabeh, Kebede Begna, Dong Chen, Mark Litzow, Dragan Jevremovic, William Hogan, James Foran, Cecilia Arana Yi, Scott Kaufmann, Mrinal Patnaik, Rong He, Hassan Alkhateeb, Aref Al-Kali, Antoine Saliba
Journal: Blood
Blood (2025) 146 (Supplement 1): 1699.
https://doi.org/10.1182/blood-2025-1699
Published: 2025
Journal Articles

Treatment-specific prognostic performance of ELN 2022, ELN 2024, and beat AML 2024: A real-world AML validation study

Free
Tariq Kewan, Oudai Alkabbani, Rong He, Dragan Jevremovic, Patricia Greipp, Antoine Saliba, Aasiya Matin, Mehrdad Hefazi Torghabeh, Abhishek Mangaonkar, Naseema Gangat, William Hogan, Mrinal Patnaik, Hassan Alkhateeb, Cecilia Arana Yi, James Foran, Mark Litzow, Mithun Shah, Kebede Begna, Aref Al-Kali
Journal: Blood
Blood (2025) 146 (Supplement 1): 996.
https://doi.org/10.1182/blood-2025-996
Published: 2025
Journal Articles

Molecular association with elevated LDH levels in patients with AML

Free
Oudai Alkabbani, Yazan Jabban, Rong He, David Viswanatha, Kurt Bessonen, Patricia Greipp, Dragan Jevremovic, Antoine Saliba, Mehrdad Hefazi Torghabeh, Aasiya Matin, William Hogan, Abhishek Mangaonkar, Hassan Alkhateeb, Mrinal Patnaik, Mithun Shah, Kebede Begna, Aref Al-Kali
Journal: Blood
Blood (2025) 146 (Supplement 1): 7039.
https://doi.org/10.1182/blood-2025-7039
Published: 2025
Journal Articles

Outcomes of patients (pts) with higher-risk myelodysplastic syndromes (HR-MDS) treated with hypomethylating agents (HMA) + venetoclax (VEN) – a large analysis from the international consortium for MDS (icMDS) validate database

Free
Jan Philipp Bewersdorf, Tariq Kewan, Luca Lanino, Wei Wei, Najla Al Ali, Amy DeZern, Mikkael Sekeres, Geoffrey Uy, Samuel Urrutia, Hetty Carraway, Pinkal Desai, Elizabeth Griffiths, Eytan Stein, Andrew Brunner, Christine McMahon, Rory Shallis, Joshua Zeidner, Michael Savona, Hayley Hawkins, Namrata Chandhok, Constantine Logothetis, Aram Bidikian, Theodore Getz, Gail Roboz, Benjamin Rolles, Eunice Wang, Amyah Harris, Maria Amaya, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan Madanat, Yasmin Abaza, Jaclynn Campos, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop Enjeti, Kamal Alrabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Max Stahl, Matteo Della Porta, Rami Komrokji, Amer Zeidan
Journal: Blood
Blood (2025) 146 (Supplement 1): 606.
https://doi.org/10.1182/blood-2025-606
Published: 2025
Journal Articles

Systemic mastocytosis with associated lymphoid neoplasms (SM-ALN): A distinct subset with indolent clinical course and favorable outcomes

Free
Angel Luis OROSCO TTAMINA, Javier Munoz, Katalin Kelemen, Jeanne Palmer, Aref Al-Kali, Candido Rivera, Naseema Gangat, Animesh Pardanani, Ayalew Tefferi, Cecilia Arana Yi
Journal: Blood
Blood (2025) 146 (Supplement 1): 7315.
https://doi.org/10.1182/blood-2025-7315
Published: 2025