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Volume 95, Issue 9

May 1 2000

In this Issue

PLENARY PAPERS
ERRATA
PERSPECTIVES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
PHOTOGRAPHS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
BRIEF REPORTS
CORRESPONDENCE
17
13

PLENARY PAPERS

Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506

David Peters,Masahiro Tsuchida,Eric R. Manthei,Tausif Alam,Clifford S. Cho,Stuart J. Knechtle,Majed M. Hamawy

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Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells

Cristina Sanz,Adalberto Benito,Naohiro Inohara,Daryoush Ekhterae,Gabriel Nunez,Jose Luis Fernandez-Luna

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Role of SUMO-1–modified PML in nuclear body formation

Sue Zhong,Stefan Müller,Simona Ronchetti,Paul S. Freemont,Anne Dejean,Pier Paolo Pandolfi

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ERRATA

Erratum in Tournamille et al. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fyx individuals. Blood. 1998;92:2147-2156.

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PERSPECTIVES

The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation
Clinical Trials & Observations

Geoffrey R. Hill,James L. M. Ferrara

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CHEMOKINES

HTLV-II down-regulates HIV-1 replication in IL-2–stimulated primary PBMC of coinfected individuals through expression of MIP-1α

Claudio Casoli,Elisa Vicenzi,Andrea Cimarelli,Giacomo Magnani,Paolo Ciancianaini,Ercole Cattaneo,PierPaolo Dall'Aglio,Guido Poli,Umberto Bertazzoni

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy
Clinical Trials & Observations

Lutz Löning,Martin Zimmermann,Alfred Reiter,Peter Kaatsch,Günter Henze,Hansjörg Riehm,Martin Schrappe

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Safety and efficacy of subcutaneous bolus injection of deferoxamine in adult patients with iron overload
Clinical Trials & Observations

Massimo Franchini,Giorgio Gandini,Marzia de Gironcoli,Aurora Vassanelli,Caterina Borgna-Pignatti,Giuseppe Aprili

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Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis
Clinical Trials & Observations

José Manuel Soria,Laura Almasy,Juan Carlos Souto,Isabel Tirado,Montserrat Borell,José Mateo,Susan Slifer,William Stone,John Blangero,Jordi Fontcuberta

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Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features
Clinical Trials & Observations

Francesca R. Mauro,Robert Foa,Raffaella Cerretti,Diana Giannarelli,Serelina Coluzzi,Franco Mandelli,Gabriella Girelli

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PHOTOGRAPHS

Photograph

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GENE THERAPY

Improvement of erythropoiesis in β-thalassemic mice by continuous erythropoietin delivery from muscle

Delphine Bohl,Assumpció Bosch,Ana Cardona,Anna Salvetti,Jean Michel Heard

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Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin

Steven S. Fakharzadeh,Yue Zhang,Rita Sarkar,Haig H. Kazazian, Jr

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HEMATOPOIESIS

Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-α

Steven F. A. Weekx,Hans W. Snoeck,Fritz Offner,Magda De Smedt,Dirk R. Van Bockstaele,Griet Nijs,Marc Lenjou,Adriaan Moulijn,Inez Rodrigus,Zwi N. Berneman,Jean Plum

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Isolation and characterization of human CD34⁻Lin⁻ and CD34⁺Lin⁻ hematopoietic stem cells using cell surface markers AC133 and CD7

Lisa Gallacher,Barbara Murdoch,Dongmei M. Wu,Francis N. Karanu,Mike Keeney,Mickie Bhatia

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Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors

Tatsuya Kinoshita,Kenichi Koike,Hadija Hemed Mwamtemi,Susumu Ito,Shuichi Ishida,Yozo Nakazawa,Yumi Kurokawa,Kazuo Sakashita,Tsukasa Higuchi,Kouichi Takeuchi,Nobukuni Sawai,Masaaki Shiohara,Takehiko Kamijo,Shigeyuki Kawa,Tetsuji Yamashita,Atsushi Komiyama

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Effects of cell cycle activation on the short-term engraftment properties of ex vivo expanded murine hematopoietic cells

Stephen J. Szilvassy,Todd E. Meyerrose,Barry Grimes

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REDK, a novel human regulatory erythroid kinase

Kenneth A. Lord,Caretha L. Creasy,Andrew G. King,Caroline King,Brian M. Burns,John C. Lee,Susan B. Dillon

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Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

Kohshi Ohishi,Barbara Varnum-Finney,David Flowers,Claudio Anasetti,David Myerson,Irwin D. Bernstein

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis

Nico H. van Tilburg,Frits R. Rosendaal,Rogier M. Bertina

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IMMUNOBIOLOGY

Shortage of circulating naive CD8⁺ T cells provides new insights on immunodeficiency in aging

Francesco F. Fagnoni,Rosanna Vescovini,Giovanni Passeri,Giovanni Bologna,Mario Pedrazzoni,Giampaolo Lavagetto,Amos Casti,Claudio Franceschi,Mario Passeri,Paolo Sansoni

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Role of IL-16 in delayed-type hypersensitivity reaction

Takayuki Yoshimoto,Chrong-Reen Wang,Toshihiko Yoneto,Akio Matsuzawa,William W. Cruikshank,Hideo Nariuchi

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Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells

Janne Komi,Olli Lassila

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Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas

Nadia Guerra,Maryvonne Guillard,Eric Angevin,Hamid Echchakir,Bernard Escudier,Alessandro Moretta,Salem Chouaib,Anne Caignard

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Defensins are dominant HLA-DR-associated self-peptides from CD34⁻ peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia)

Thomas M. Halder,Martin Blüggel,Susanne Heinzel,Graham Pawelec,Helmut E. Meyer,Hubert Kalbacher

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NEOPLASIA

P-glycoprotein plays a drug-efflux–independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway

Monica Pallis,Nigel Russell

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Autocrine nerve growth factor is essential for cell survival and viral maturation in HHV-8–infected primary effusion lymphoma cells

Francesca Pica,Antonio Volpi,Annalucia Serafino,Marzia Fraschetti,Ornella Franzese,Enrico Garaci

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Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases

Robert C. Quackenbush,Gary W. Reuther,Juli P. Miller,Kevin D. Courtney,Warren S. Pear,Ann Marie Pendergast

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Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load

Wilhelmina M. Aarts,Richard J. Bende,Eric J. Steenbergen,Philip M. Kluin,Engelbert C. M. Ooms,Steven T. Pals,Carel J. M. van Noesel

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MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma

Frédéric Gilles,André Goy,Yvonne Remache,Peter Shue,Andrew D. Zelenetz

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Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN

Julia J. Scarisbrick,Alison J. Woolford,Robin Russell-Jones,Sean J. Whittaker

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PHAGOCYTES

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

Roberto Lorenzi,Paul M. Brickell,David R. Katz,Christine Kinnon,Adrian J. Thrasher

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Differential expression and regulation of GTPases (RhoA and Rac2) and GDIs (LyGDI and RhoGDI) in neutrophils from patients with severe congenital neutropenia

Brigitte Kasper,Nicola Tidow,Dirk Grothues,Karl Welte

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Importance of L-selectin–dependent leukocyte–leukocyte interactions in human whole blood

Debra J. Mitchell,Pauline Li,Paul H. Reinhardt,Paul Kubes

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RED CELLS

Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: a study of L5178Y mouse lymphoma cell lines differentially sensitive to H₂O₂

Pawel Lipiński,Jean-Claude Drapier,Leonor Oliveira,Hanna Retmańska,Barbara Sochanowicz,Marcin Kruszewski

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Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta

Ralph M. Bohmer,Thomas A. Campbell,Diana W. Bianchi

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The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation

William Breuer,Aharon Ronson,Itzchak N. Slotki,Ayala Abramov,Chaim Hershko,Z. Ioav Cabantchik

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TRANSFUSION MEDICINE

Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans

Petra Jilma Stohlawetz,Larisa Dzirlo,Nicole Hergovich,Edith Lackner,Christa Mensik,Hans Georg Eichler,Eva Kabrna,Klaus Geissler,Bernd Jilma

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BRIEF REPORTS

Quantitative measure of c-abl andp15 methylation in chronic myelogenous leukemia: biological implications
Brief Report

TuDung T. Nguyen,Ann F. Mohrbacher,Yvonne C. Tsai,John Groffen,Nora Heisterkamp,Peter W. Nichols,Mimi C. Yu,Michael Lübbert,Peter A. Jones

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CORRESPONDENCE

Normal T, B, and NK cell counts in healthy donors at 1 year after blood stem cell harvesting

Jan Storek,Monja A. Dawson,David G. Maloney

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17

Donor lymphocyte infusions for CML: possible effects of age and mobilization
Clinical Trials & Observations

Vijay Reddy,Jan Moreb,Paulette Mehta

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13

Benzene and multiple myeloma: appraisal of the scientific evidence

Daniel Thau Teitelbaum,Nachman Brautbar,Myron Mehlman,Joseph LaDou

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DAP-kinase CpG island methylation in acute myeloid leukemia: methodology versus biology?

Anni Aggerholm,Peter Hokland,Per Guldberg

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Issue Archive

Table of Contents

PLENARY PAPERS

Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506 Free

Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells Free

Role of SUMO-1–modified PML in nuclear body formation Free

ERRATA

Erratum in Tournamille et al. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fyx individuals. Blood. 1998;92:2147-2156. Free

PERSPECTIVES

The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation Free Clinical Trials & Observations

CHEMOKINES

HTLV-II down-regulates HIV-1 replication in IL-2–stimulated primary PBMC of coinfected individuals through expression of MIP-1α Free

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy Free Clinical Trials & Observations

Safety and efficacy of subcutaneous bolus injection of deferoxamine in adult patients with iron overload Free Clinical Trials & Observations

Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis Free Clinical Trials & Observations

Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features Free Clinical Trials & Observations

PHOTOGRAPHS

Photograph Free

GENE THERAPY

Improvement of erythropoiesis in β-thalassemic mice by continuous erythropoietin delivery from muscle Free

Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin Free

HEMATOPOIESIS

Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-α Free

Isolation and characterization of human CD34−Lin− and CD34+Lin− hematopoietic stem cells using cell surface markers AC133 and CD7 Free

Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors Free

Effects of cell cycle activation on the short-term engraftment properties of ex vivo expanded murine hematopoietic cells Free

REDK, a novel human regulatory erythroid kinase Free

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1 Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis Free

IMMUNOBIOLOGY

Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging Free

Role of IL-16 in delayed-type hypersensitivity reaction Free

Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells Free

Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas Free

Defensins are dominant HLA-DR-associated self-peptides from CD34− peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia) Free

NEOPLASIA

P-glycoprotein plays a drug-efflux–independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway Free

Autocrine nerve growth factor is essential for cell survival and viral maturation in HHV-8–infected primary effusion lymphoma cells Free

Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases Free

Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load Free

MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma Free

Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN Free

PHAGOCYTES

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis Free

Differential expression and regulation of GTPases (RhoA and Rac2) and GDIs (LyGDI and RhoGDI) in neutrophils from patients with severe congenital neutropenia Free

Importance of L-selectin–dependent leukocyte–leukocyte interactions in human whole blood Free

RED CELLS

Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: a study of L5178Y mouse lymphoma cell lines differentially sensitive to H2O2 Free

Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta Free

The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation Free

TRANSFUSION MEDICINE

Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans Free

BRIEF REPORTS

Quantitative measure of c-abl andp15 methylation in chronic myelogenous leukemia: biological implications Free Brief Report

CORRESPONDENCE

Normal T, B, and NK cell counts in healthy donors at 1 year after blood stem cell harvesting Free

17

Donor lymphocyte infusions for CML: possible effects of age and mobilization Free Clinical Trials & Observations

13

Benzene and multiple myeloma: appraisal of the scientific evidence Free

DAP-kinase CpG island methylation in acute myeloid leukemia: methodology versus biology? Free

Email alerts

ASH Publications

American Society of Hematology

Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506

Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells

Role of SUMO-1–modified PML in nuclear body formation

Erratum in Tournamille et al. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fyx individuals. Blood. 1998;92:2147-2156.

The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation
Clinical Trials & Observations

HTLV-II down-regulates HIV-1 replication in IL-2–stimulated primary PBMC of coinfected individuals through expression of MIP-1α

Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy
Clinical Trials & Observations

Safety and efficacy of subcutaneous bolus injection of deferoxamine in adult patients with iron overload
Clinical Trials & Observations

Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis
Clinical Trials & Observations

Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features
Clinical Trials & Observations

Photograph

Improvement of erythropoiesis in β-thalassemic mice by continuous erythropoietin delivery from muscle

Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin

Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-α

Isolation and characterization of human CD34⁻Lin⁻ and CD34⁺Lin⁻ hematopoietic stem cells using cell surface markers AC133 and CD7

Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors

Effects of cell cycle activation on the short-term engraftment properties of ex vivo expanded murine hematopoietic cells

REDK, a novel human regulatory erythroid kinase

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis

Shortage of circulating naive CD8⁺ T cells provides new insights on immunodeficiency in aging

Role of IL-16 in delayed-type hypersensitivity reaction

Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells

Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas

Defensins are dominant HLA-DR-associated self-peptides from CD34⁻ peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia)

P-glycoprotein plays a drug-efflux–independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway

Autocrine nerve growth factor is essential for cell survival and viral maturation in HHV-8–infected primary effusion lymphoma cells

Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases

Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load

MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma

Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

Differential expression and regulation of GTPases (RhoA and Rac2) and GDIs (LyGDI and RhoGDI) in neutrophils from patients with severe congenital neutropenia

Importance of L-selectin–dependent leukocyte–leukocyte interactions in human whole blood

Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: a study of L5178Y mouse lymphoma cell lines differentially sensitive to H₂O₂

Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta

The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation

Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans

Quantitative measure of c-abl andp15 methylation in chronic myelogenous leukemia: biological implications
Brief Report

Normal T, B, and NK cell counts in healthy donors at 1 year after blood stem cell harvesting

Donor lymphocyte infusions for CML: possible effects of age and mobilization
Clinical Trials & Observations

Benzene and multiple myeloma: appraisal of the scientific evidence

DAP-kinase CpG island methylation in acute myeloid leukemia: methodology versus biology?